MAP7D2 Gene (Protein Coding)

MAP7 Domain Containing 2

GC0XM020024
GIFtS:
32
See more...

Aliases for MAP7D2 Gene

Aliases for MAP7D2 Gene

  • MAP7 Domain Containing 2 2 3 5
  • MAP7 Domain-Containing Protein 2 3 4
  • MAP7 Domain-Containing Protein 2 Brain Specific Variant 1 3
  • MAP7 Domain-Containing Protein 2 Brain Specific Variant 2 3
  • MAP7 Domain Containing 2 Protein Varaint 1 3
  • MAP7 Domain Containing 2 Protein Varaint 2 3
  • MAP7 Domain Containing 2 Brain 3
  • FLJ14503 2
  • MAP7D2 5

External Ids for MAP7D2 Gene

Previous GeneCards Identifiers for MAP7D2 Gene

  • GC0XM019935
  • GC0XM017770

Summaries for MAP7D2 Gene

GeneCards Summary for MAP7D2 Gene

MAP7D2 (MAP7 Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is MAP7.

Additional gene information for MAP7D2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP7D2 Gene

Genomics for MAP7D2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAP7D2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XJ020116 Promoter 1.2 EPDnew Ensembl 250.7 +0.3 307 1.6 GABPB1 DMAP1 BHLHE40 ZNF2 ZNF48 NRF1 ZNF547 ATF4 TRIM28 L3MBTL2 MAP7D2 BCLAF3 RF00017-8211 RF00017-8210
GH0XJ020130 Promoter 0.6 EPDnew 250.4 -13.6 -13627 0.1 CEBPB ZNF513 ATF3 HSALNG0136919 MAP7D2 BCLAF3 ENSG00000201882 EIF1AX RF00017-8210
GH0XJ020118 Enhancer 0.5 Ensembl 250.7 -1.7 -1694 0.8 FEZF1 PRDM6 GLIS1 PRDM4 ZBTB8A MAP7D2 BCLAF3 RF00017-8211 HSALNG0136919 EIF1AX RF00017-8210
GH0XJ020133 Promoter 0.3 EPDnew 250.4 -17.1 -17119 0.1 MAP7D2 ENSG00000201882 EIF1AX HSALNG0136919 RF00017-8210
GH0XJ019989 Promoter/Enhancer 1.2 ENCODE CraniofacialAtlas 12.4 +126.2 126206 2.4 ZBTB10 NR2C1 CTCF SIN3A REST VEZF1 SAP130 GABPA SMC3 RAD21 BCLAF3 LOC729609 MAP7D2 RF00017-8209 RF00017-8202 SH3KBP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP7D2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP7D2

Top Transcription factor binding sites by QIAGEN in the MAP7D2 gene promoter:
  • AhR
  • aMEF-2
  • Arnt
  • CUTL1
  • FOXJ2
  • FOXO1
  • FOXO1a
  • MEF-2
  • MEF-2A
  • SRY

Genomic Locations for MAP7D2 Gene

Latest Assembly
chrX:20,006,713-20,116,907
(GRCh38/hg38)
Size:
110,195 bases
Orientation:
Minus strand

Previous Assembly
chrX:20,024,831-20,135,025
(GRCh37/hg19 by Entrez Gene)
Size:
110,195 bases
Orientation:
Minus strand

chrX:20,024,831-20,135,035
(GRCh37/hg19 by Ensembl)
Size:
110,205 bases
Orientation:
Minus strand

Genomic View for MAP7D2 Gene

Genes around MAP7D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP7D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP7D2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAP7D2 Gene

Proteins for MAP7D2 Gene

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  1. Antibodies for research
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  3. Assay products for research

  • Protein details for MAP7D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T17-MA7D2_HUMAN
    Recommended name:
    MAP7 domain-containing protein 2
    Protein Accession:
    Q96T17
    Secondary Accessions:
    • B7Z2J8
    • B7Z3S7
    • B9EGC7
    • C9JMA4
    • C9JYW0
    • Q5EBN1
    • Q5JPS7
    • Q6PIC7
    • Q8N792

    Protein attributes for MAP7D2 Gene

    Size:
    732 amino acids
    Molecular mass:
    81965 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05407.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP7D2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP7D2 Gene

Protein Expression for MAP7D2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MAP7D2 Gene

  • Ubiquitination at Lys217
  • Modification sites at PhosphoSitePlus

Other Protein References for MAP7D2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP7D2 Gene

Domains & Families for MAP7D2 Gene

Gene Families for MAP7D2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAP7D2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP7D2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57335, weakly similar to Homo sapiens microtubule-associated protein 7 (MAP7), mRNA (B7Z3S7_HUMAN)
  • cDNA FLJ57681, weakly similar to Mus musculus microtubule-associated protein 7 (Mtap7), mRNA (B7Z895_HUMAN)
  • MAP7 domain-containing protein 2 (MA7D2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96T17

UniProtKB/Swiss-Prot:

MA7D2_HUMAN :
  • Belongs to the MAP7 family.
Family:
  • Belongs to the MAP7 family.
genes like me logo Genes that share domains with MAP7D2: view

Function for MAP7D2 Gene

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  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for MAP7D2 Gene

genes like me logo Genes that share phenotypes with MAP7D2: view

Animal Models for research

miRNA for MAP7D2 Gene

miRTarBase miRNAs that target MAP7D2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP7D2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP7D2 Gene

Localization for MAP7D2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP7D2 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP7D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015630 microtubule cytoskeleton IBA 21873635
genes like me logo Genes that share ontologies with MAP7D2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP7D2 Gene

Pathways & Interactions for MAP7D2 Gene

PathCards logo

SuperPathways for MAP7D2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP7D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA 21873635
genes like me logo Genes that share ontologies with MAP7D2: view

No data available for Pathways by source and SIGNOR curated interactions for MAP7D2 Gene

Drugs & Compounds for MAP7D2 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for MAP7D2 Gene

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mRNA/cDNA for MAP7D2 Gene

4 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP7D2

Alternative Splicing Database (ASD) splice patterns (SP) for MAP7D2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5:
SP6: - - - - - - - -
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - -
SP9:
SP10: - - -
SP11: - - - -
SP12: -
SP13: - - - - - - -
SP14:
SP15: - - -

ExUns: 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for MAP7D2 Gene

GeneLoc Exon Structure for
MAP7D2

Expression for MAP7D2 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP7D2 Gene

mRNA expression in normal human tissues for MAP7D2 Gene
mRNA expression by BioGPS for MAP7D2 GenemRNA expression by GTEx for MAP7D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP7D2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.1), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for MAP7D2 Gene

This gene is overexpressed in Cervix (17.2), Testis (13.7), Monocytes (9.1), and Fetal Brain (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP7D2 Gene



Protein tissue co-expression partners for MAP7D2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP7D2

SOURCE GeneReport for Unigene cluster for MAP7D2 Gene:

Hs.127951

Evidence on tissue expression from TISSUES for MAP7D2 Gene

  • Nervous system(4.9)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MAP7D2: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP7D2 Gene

Orthologs for MAP7D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP7D2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MAP7D2 30 31
  • 99.13 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MAP7D2 30 31
  • 86.32 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Map7d2 30
  • 79.43 (n)
Mouse
(Mus musculus)
 Mammalia Map7d2 30 17 31
  • 79.43 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MAP7D2 31
  • 73 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MAP7D2 31
  • 62 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia MAP7D2 31
  • 57 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves MAP7D2 30 31
  • 69.57 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MAP7D2 31
  • 60 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia map7d2 30
  • 63.51 (n)
Str.7455 30
Zebrafish
(Danio rerio)
 Actinopterygii map7d2a 31
  • 31 (a)
 OneToMany
map7d2b 31
  • 31 (a)
 OneToMany
Species where no ortholog for MAP7D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MAP7D2 Gene

ENSEMBL:
Gene Tree for MAP7D2 (if available)
TreeFam:
Gene Tree for MAP7D2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP7D2: view image

Paralogs for MAP7D2 Gene

Paralogs for MAP7D2 Gene

genes like me logo Genes that share paralogs with MAP7D2: view

Variants for MAP7D2 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP7D2 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs140304472 Benign: not provided 20,010,875(-) G/A
NM_001168465.2(MAP7D2):c.2250C>T (p.Asp750=) 		SYNONYMOUS
VAR_035450 A breast cancer sample p.Ala32Pro
rs34519770 - p.Asn182Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MAP7D2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MAP7D2 Gene

Variant ID Type Subtype PubMed ID
esv3573634 CNV loss 25503493
esv3573635 CNV loss 25503493
nsv425374 CNV deletion 16902084
nsv6827 CNV deletion 18451855

Variation tolerance for MAP7D2 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.25; 76.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP7D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP7D2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP7D2 Gene

Disorders for MAP7D2 Gene

Additional Disease Information for MAP7D2

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MAP7D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP7D2 Gene

Publications for MAP7D2 Gene

  1. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S … Mohammed S (Analytical chemistry 2009) 3 4
  2. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3

ExternalLinks

View latest publications for MAP7D2 gene in Mastermind

Products for MAP7D2 Gene

Sources for MAP7D2 Gene