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Aliases for MAP7D2 Gene

Aliases for MAP7D2 Gene

  • MAP7 Domain Containing 2 2 3 5

External Ids for MAP7D2 Gene

Previous GeneCards Identifiers for MAP7D2 Gene

  • GC0XM019935
  • GC0XM017770

Summaries for MAP7D2 Gene

GeneCards Summary for MAP7D2 Gene

MAP7D2 (MAP7 Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is MAP7.

Additional gene information for MAP7D2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP7D2 Gene

Genomics for MAP7D2 Gene

GeneHancer (GH) Regulatory Elements for MAP7D2 Gene

Promoters and enhancers for MAP7D2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI020116 Promoter 1.4 EPDnew Ensembl 550.8 +0.5 495 1 DMAP1 ZBTB8A ZNF2 ZNF48 ZNF7 ZNF547 ZBTB26 EZH2 ZBTB20 MAP7D2 BCLAF3 MIR23C
GH0XI020066 Enhancer 1 Ensembl ENCODE 12.8 +49.3 49253 1.8 ZBTB40 RAD21 ZNF143 FOS ZNF654 CEBPB REST ZEB2 SP1 ATF4 BCLAF3 MAP7D2 SH3KBP1 MIR23C
GH0XI019989 Enhancer 1 Ensembl ENCODE 12.4 +126.3 126295 2.4 RB1 ZNF76 SIN3A KLF5 RAD21 ZNF335 GLIS2 ZNF143 RCOR1 SP3 BCLAF3 LOC729609 MAP7D2
GH0XI019964 Promoter/Enhancer 1.1 EPDnew ENCODE 11 +149.6 149612 5.8 FOXA2 ZNF449 JUNB BATF ATF2 BCL11A IKZF1 ATF7 PRDM10 RUNX3 BCLAF3 SH3KBP1 MAP7D2 GC0XM019967 GC0XP019949
GH0XI020060 Enhancer 0.8 FANTOM5 ENCODE 13 +55.5 55472 1.9 CTCF ZNF687 RB1 IKZF1 EBF1 DPF2 IKZF2 RELA BCLAF3 MAP7D2 MIR23C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAP7D2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP7D2 gene promoter:

Genomic Locations for MAP7D2 Gene

Genomic Locations for MAP7D2 Gene
chrX:20,006,713-20,116,996
(GRCh38/hg38)
Size:
110,284 bases
Orientation:
Minus strand
chrX:20,024,831-20,135,114
(GRCh37/hg19)

Genomic View for MAP7D2 Gene

Genes around MAP7D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP7D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP7D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP7D2 Gene

Proteins for MAP7D2 Gene

  • Protein details for MAP7D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T17-MA7D2_HUMAN
    Recommended name:
    MAP7 domain-containing protein 2
    Protein Accession:
    Q96T17
    Secondary Accessions:
    • B7Z2J8
    • B7Z3S7
    • B9EGC7
    • C9JMA4
    • C9JYW0
    • Q5EBN1
    • Q5JPS7
    • Q6PIC7
    • Q8N792

    Protein attributes for MAP7D2 Gene

    Size:
    732 amino acids
    Molecular mass:
    81965 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05407.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP7D2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP7D2 Gene

Post-translational modifications for MAP7D2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MAP7D2 Gene

Domains & Families for MAP7D2 Gene

Gene Families for MAP7D2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAP7D2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96T17

UniProtKB/Swiss-Prot:

MA7D2_HUMAN :
  • Belongs to the MAP7 family.
Family:
  • Belongs to the MAP7 family.
genes like me logo Genes that share domains with MAP7D2: view

Function for MAP7D2 Gene

Gene Ontology (GO) - Molecular Function for MAP7D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IBA --
genes like me logo Genes that share ontologies with MAP7D2: view

Phenotypes for MAP7D2 Gene

genes like me logo Genes that share phenotypes with MAP7D2: view

miRNA for MAP7D2 Gene

miRTarBase miRNAs that target MAP7D2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP7D2 Gene

Localization for MAP7D2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP7D2 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP7D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015630 microtubule cytoskeleton IBA --
genes like me logo Genes that share ontologies with MAP7D2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP7D2 Gene

Pathways & Interactions for MAP7D2 Gene

SuperPathways for MAP7D2 Gene

No Data Available

Interacting Proteins for MAP7D2 Gene

Gene Ontology (GO) - Biological Process for MAP7D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
genes like me logo Genes that share ontologies with MAP7D2: view

No data available for Pathways by source and SIGNOR curated interactions for MAP7D2 Gene

Drugs & Compounds for MAP7D2 Gene

No Compound Related Data Available

Transcripts for MAP7D2 Gene

Unigene Clusters for MAP7D2 Gene

MAP7 domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP7D2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5:
SP6: - - - - - - - -
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - -
SP9:
SP10: - - -
SP11: - - - -
SP12: -
SP13: - - - - - - -
SP14:
SP15: - - -

ExUns: 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for MAP7D2 Gene

GeneLoc Exon Structure for
MAP7D2
ECgene alternative splicing isoforms for
MAP7D2

Expression for MAP7D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP7D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP7D2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.1), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for MAP7D2 Gene

This gene is overexpressed in Cervix (17.2), Testis (13.7), Monocytes (9.1), and Fetal Brain (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP7D2 Gene



Protein tissue co-expression partners for MAP7D2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP7D2 Gene:

MAP7D2

SOURCE GeneReport for Unigene cluster for MAP7D2 Gene:

Hs.127951

Evidence on tissue expression from TISSUES for MAP7D2 Gene

  • Nervous system(4.9)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MAP7D2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP7D2 Gene

Orthologs for MAP7D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP7D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP7D2 33 34
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia MAP7D2 33 34
  • 86.32 (n)
mouse
(Mus musculus)
Mammalia Map7d2 33 16 34
  • 79.43 (n)
rat
(Rattus norvegicus)
Mammalia Map7d2 33
  • 79.43 (n)
cow
(Bos Taurus)
Mammalia MAP7D2 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP7D2 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP7D2 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP7D2 33 34
  • 69.57 (n)
lizard
(Anolis carolinensis)
Reptilia MAP7D2 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map7d2 33
  • 63.51 (n)
Str.7455 33
zebrafish
(Danio rerio)
Actinopterygii map7d2a 34
  • 31 (a)
OneToMany
map7d2b 34
  • 31 (a)
OneToMany
Species where no ortholog for MAP7D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP7D2 Gene

ENSEMBL:
Gene Tree for MAP7D2 (if available)
TreeFam:
Gene Tree for MAP7D2 (if available)

Paralogs for MAP7D2 Gene

Paralogs for MAP7D2 Gene

genes like me logo Genes that share paralogs with MAP7D2: view

Variants for MAP7D2 Gene

Sequence variations from dbSNP and Humsavar for MAP7D2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
VAR_035450 A breast cancer sample p.Ala32Pro
rs1000001636 -- 20,096,442(-) A/G intron_variant
rs1000008761 -- 20,034,271(-) C/T intron_variant
rs1000066829 -- 20,056,834(-) C/G/T intron_variant
rs1000082521 -- 20,086,754(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP7D2 Gene

Variant ID Type Subtype PubMed ID
nsv6827 CNV deletion 18451855
nsv425374 CNV deletion 16902084
esv3573635 CNV loss 25503493
esv3573634 CNV loss 25503493

Variation tolerance for MAP7D2 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.25; 76.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP7D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP7D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP7D2 Gene

Disorders for MAP7D2 Gene

Additional Disease Information for MAP7D2

No disorders were found for MAP7D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP7D2 Gene

Publications for MAP7D2 Gene

  1. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S … Mohammed S (Analytical chemistry 2009) 3 4 58
  2. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 3 4 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for MAP7D2 Gene

Sources for MAP7D2 Gene

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