Aliases for MAP7D1 Gene

Aliases for MAP7D1 Gene

  • MAP7 Domain Containing 1 2 3 5
  • Arginine/Proline-Rich Coiled-Coil Domain-Containing Protein 1 3 4
  • Proline/Arginine-Rich Coiled-Coil Domain-Containing Protein 1 3 4
  • Proline Arginine Rich Coiled Coil 1 2 3
  • Arginine/Proline Rich Coiled-Coil 1 2 3
  • MAP7 Domain-Containing Protein 1 3 4
  • PARCC1 3 4
  • RPRC1 3 4
  • FLJ10350 2
  • FLJ39022 2
  • KIAA1187 4
  • MAP7D1 5

External Ids for MAP7D1 Gene

Previous HGNC Symbols for MAP7D1 Gene

  • PARCC1
  • RPRC1

Previous GeneCards Identifiers for MAP7D1 Gene

  • GC01P036395
  • GC01P036621
  • GC01P034738

Summaries for MAP7D1 Gene

GeneCards Summary for MAP7D1 Gene

MAP7D1 (MAP7 Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is MAP7.

Additional gene information for MAP7D1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP7D1 Gene

Genomics for MAP7D1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MAP7D1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP7D1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP7D1

Top Transcription factor binding sites by QIAGEN in the MAP7D1 gene promoter:
  • aMEF-2
  • ARP-1
  • c-Myb
  • GATA-6
  • Lmo2
  • MEF-2A
  • MRF-2
  • MyoD
  • Nkx6-1
  • S8

Genomic Locations for MAP7D1 Gene

Genomic Locations for MAP7D1 Gene
chr1:36,155,579-36,180,849
(GRCh38/hg38)
Size:
25,271 bases
Orientation:
Plus strand
chr1:36,621,180-36,646,450
(GRCh37/hg19)
Size:
25,271 bases
Orientation:
Plus strand

Genomic View for MAP7D1 Gene

Genes around MAP7D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP7D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP7D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP7D1 Gene

Proteins for MAP7D1 Gene

  • Protein details for MAP7D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KQU3-MA7D1_HUMAN
    Recommended name:
    MAP7 domain-containing protein 1
    Protein Accession:
    Q3KQU3
    Secondary Accessions:
    • D3DPS4
    • Q7L8J5
    • Q8N905
    • Q8TAK0
    • Q9HBQ2
    • Q9NW29
    • Q9ULN3

    Protein attributes for MAP7D1 Gene

    Size:
    841 amino acids
    Molecular mass:
    92820 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG17244.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA86501.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP7D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP7D1 Gene

Post-translational modifications for MAP7D1 Gene

  • Ubiquitination at Lys268 and Lys272
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MAP7D1 Gene

Domains & Families for MAP7D1 Gene

Gene Families for MAP7D1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAP7D1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP7D1 Gene

GenScript: Design optimal peptide antigens:
  • MAP7D1 protein (A1L1B7_HUMAN)
  • Arginine/proline rich coiled-coil 1, isoform CRA_b (D3DPS3_HUMAN)
  • Proline/arginine-rich coiled-coil domain-containing protein 1 (MA7D1_HUMAN)
  • MAP7D1 protein (Q6NX58_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q3KQU3

UniProtKB/Swiss-Prot:

MA7D1_HUMAN :
  • Belongs to the MAP7 family.
Family:
  • Belongs to the MAP7 family.
genes like me logo Genes that share domains with MAP7D1: view

Function for MAP7D1 Gene

Phenotypes From GWAS Catalog for MAP7D1 Gene

genes like me logo Genes that share phenotypes with MAP7D1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP7D1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP7D1 Gene

Localization for MAP7D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP7D1 Gene

Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP7D1 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP7D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
GO:0015630 microtubule cytoskeleton IEA,IDA --
genes like me logo Genes that share ontologies with MAP7D1: view

Pathways & Interactions for MAP7D1 Gene

PathCards logo

SuperPathways for MAP7D1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP7D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA,IBA 21873635
genes like me logo Genes that share ontologies with MAP7D1: view

No data available for Pathways by source and SIGNOR curated interactions for MAP7D1 Gene

Drugs & Compounds for MAP7D1 Gene

No Compound Related Data Available

Transcripts for MAP7D1 Gene

mRNA/cDNA for MAP7D1 Gene

3 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP7D1

Alternative Splicing Database (ASD) splice patterns (SP) for MAP7D1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: -
SP3:
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MAP7D1 Gene

GeneLoc Exon Structure for
MAP7D1

Expression for MAP7D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP7D1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP7D1 Gene

This gene is overexpressed in Bone marrow stromal cell (13.8), Peripheral blood mononuclear cells (11.7), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP7D1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP7D1

SOURCE GeneReport for Unigene cluster for MAP7D1 Gene:

Hs.356096

Evidence on tissue expression from TISSUES for MAP7D1 Gene

  • Nervous system(4.8)
  • Heart(4.5)
  • Liver(4.2)
  • Bone(4)
  • Muscle(2.8)
  • Lung(2.7)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with MAP7D1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP7D1 Gene

Orthologs for MAP7D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP7D1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MAP7D1 30 31
  • 98.95 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MAP7D1 30 31
  • 89.84 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MAP7D1 30 31
  • 87.66 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Map7d1 30 17 31
  • 87.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Map7d1 30
  • 86.77 (n)
Oppossum
(Monodelphis domestica)
Mammalia MAP7D1 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MAP7D1 30 31
  • 66.9 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MAP7D1 31
  • 50 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rprc1 30
  • 60.35 (n)
Str.10677 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15665 30
Zebrafish
(Danio rerio)
Actinopterygii map7d1a 31 31
  • 47 (a)
OneToMany
map7d1b 31
  • 45 (a)
OneToMany
Dr.6204 30
Species where no ortholog for MAP7D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MAP7D1 Gene

ENSEMBL:
Gene Tree for MAP7D1 (if available)
TreeFam:
Gene Tree for MAP7D1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP7D1: view image

Paralogs for MAP7D1 Gene

Paralogs for MAP7D1 Gene

(2) SIMAP similar genes for MAP7D1 Gene using alignment to 6 proteins:

  • MA7D1_HUMAN
  • A1L1B7_HUMAN
  • C9JIR3_HUMAN
  • E9PLH3_HUMAN
  • H0YF21_HUMAN
  • Q6NX58_HUMAN
genes like me logo Genes that share paralogs with MAP7D1: view

Variants for MAP7D1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP7D1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
713175 Benign: not provided 36,171,234(+) C/T MISSENSE_VARIANT
769509 Benign: not provided 36,172,545(+) G/A MISSENSE_VARIANT
771114 Benign: not provided 36,171,173(+) G/A SYNONYMOUS_VARIANT
rs12563354 - p.Arg531Ser
rs2296266 - p.Arg104Trp

Additional dbSNP identifiers (rs#s) for MAP7D1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAP7D1 Gene

Variant ID Type Subtype PubMed ID
esv2671242 CNV deletion 23128226
esv2671893 CNV deletion 23128226
esv2746819 CNV deletion 23290073
esv2758931 CNV loss 17122850
esv3585730 CNV loss 21293372
nsv545992 CNV loss 21841781
nsv545993 CNV loss 21841781
nsv545994 CNV loss 21841781
nsv545995 CNV loss 21841781
nsv545996 CNV gain 21841781
nsv834691 CNV loss 17160897

Variation tolerance for MAP7D1 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.84; 79.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP7D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP7D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP7D1 Gene

Disorders for MAP7D1 Gene

No disorders were found for MAP7D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP7D1 Gene

Publications for MAP7D1 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. (PMID: 32353859) Gordon DE … Krogan NJ (Nature 2020) 3
  4. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3
  5. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3

Products for MAP7D1 Gene

Sources for MAP7D1 Gene