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Aliases for MAP4K5 Gene

Aliases for MAP4K5 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5 2 3 3 5
  • Kinase Homologous To SPS1/STE20 3 4
  • MAPK/ERK Kinase Kinase Kinase 5 3 4
  • Germinal Center Kinase-Related 2 3
  • MEK Kinase Kinase 5 3 4
  • MEKKK 5 3 4
  • KHS 3 4
  • EC 4
  • MAPKKKK5 3
  • GCKR 3
  • KHS1 3

External Ids for MAP4K5 Gene

Previous GeneCards Identifiers for MAP4K5 Gene

  • GC14M048208
  • GC14M044682
  • GC14M048875
  • GC14M049954
  • GC14M050885
  • GC14M031011

Summaries for MAP4K5 Gene

Entrez Gene Summary for MAP4K5 Gene

  • This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP4K5 Gene

MAP4K5 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5) is a Protein Coding gene. Diseases associated with MAP4K5 include Dysgraphia and Spastic Paraplegia 3. Among its related pathways are Signal transduction_JNK pathway and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for MAP4K5 Gene

  • May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Gene Wiki entry for MAP4K5 Gene

Additional gene information for MAP4K5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP4K5 Gene

Genomics for MAP4K5 Gene

GeneHancer (GH) Regulatory Elements for MAP4K5 Gene

Promoters and enhancers for MAP4K5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J050528 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 655.9 +30.0 29974 5.9 HDGF CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 MAP4K5 ATL1 CDKL1 SAV1 ENSG00000259113 LOC100419913
GH14J050559 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 +0.4 406 2.3 SIN3A ZNF335 GLIS2 ZNF366 SCRT2 EGR2 SP3 YY2 MIER2 ZNF398 MAP4K5 ATL1
GH14J049860 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 21.7 +698.8 698832 4.6 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ENSG00000278002 GC14M049865 GC14M049869 GC14P049865 RN7SL2 PIR56593 KLHDC1 NEMF VCPKMT MAP4K5
GH14J050395 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.8 +164.2 164176 3 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF48 GATA2 NFKBIZ SP3 MXD4 CDKL1 LOC105370487 VCPKMT MAP4K5 NEMF ATL1
GH14J050520 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18 +39.6 39560 2.5 PKNOX1 FOXA2 SIN3A STAT5A BMI1 BATF IRF4 ATF7 ETV6 FOS MAP4K5 CDKL1 FRMD6 ATL1 LOC100419913
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP4K5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP4K5 gene promoter:
  • CP2
  • MyoD
  • FOXO1a
  • FOXO1
  • CUTL1
  • STAT3
  • NF-kappaB1
  • LCR-F1
  • Arnt
  • AP-1

Genomic Locations for MAP4K5 Gene

Genomic Locations for MAP4K5 Gene
142,647 bases
Minus strand
142,634 bases
Minus strand

Genomic View for MAP4K5 Gene

Genes around MAP4K5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP4K5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP4K5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP4K5 Gene

Proteins for MAP4K5 Gene

  • Protein details for MAP4K5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase kinase kinase kinase 5
    Protein Accession:
    Secondary Accessions:
    • A0A0A0MQR1
    • Q8IYF6

    Protein attributes for MAP4K5 Gene

    846 amino acids
    Molecular mass:
    95024 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with both SH3 domains of the adapter proteins CRK and CRKL.

neXtProt entry for MAP4K5 Gene

Post-translational modifications for MAP4K5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for MAP4K5
  • Boster Bio Antibodies for MAP4K5

No data available for DME Specific Peptides for MAP4K5 Gene

Domains & Families for MAP4K5 Gene

Protein Domains for MAP4K5 Gene

Suggested Antigen Peptide Sequences for MAP4K5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MAP4K5: view

Function for MAP4K5 Gene

Molecular function for MAP4K5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
GENATLAS Biochemistry:
mitogen-activated kinase kinase kinase kinase 5,widely expressed,S cerevisiae STE20 family homolog,activating in N terminal kinase,potentially involved in the stress response of fibroblast

Enzyme Numbers (IUBMB) for MAP4K5 Gene

Phenotypes From GWAS Catalog for MAP4K5 Gene

Gene Ontology (GO) - Molecular Function for MAP4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9038372
GO:0004674 protein serine/threonine kinase activity IDA 9038372
GO:0005515 protein binding IPI 9788432
GO:0005524 ATP binding IDA,IEA 9038372
GO:0008349 MAP kinase kinase kinase kinase activity IEA,IBA --
genes like me logo Genes that share ontologies with MAP4K5: view
genes like me logo Genes that share phenotypes with MAP4K5: view

Animal Models for MAP4K5 Gene

MGI Knock Outs for MAP4K5:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAP4K5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP4K5

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP4K5 Gene

Localization for MAP4K5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP4K5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP4K5 gene
Compartment Confidence
cytosol 4
plasma membrane 2
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 9038372
genes like me logo Genes that share ontologies with MAP4K5: view

Pathways & Interactions for MAP4K5 Gene

genes like me logo Genes that share pathways with MAP4K5: view

Pathways by source for MAP4K5 Gene

1 GeneGo (Thomson Reuters) pathway for MAP4K5 Gene
3 Qiagen pathways for MAP4K5 Gene

SIGNOR curated interactions for MAP4K5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAP4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IBA --
GO:0000185 activation of MAPKKK activity IEA --
GO:0006468 protein phosphorylation IEA,IDA 9038372
GO:0007257 activation of JUN kinase activity TAS 9038372
GO:0007346 regulation of mitotic cell cycle IBA --
genes like me logo Genes that share ontologies with MAP4K5: view

Drugs & Compounds for MAP4K5 Gene

(5) Drugs for MAP4K5 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for MAP4K5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MAP4K5: view

Transcripts for MAP4K5 Gene

Unigene Clusters for MAP4K5 Gene

Mitogen-activated protein kinase kinase kinase kinase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP4K5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - -
SP2: - - -
SP5: -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b · 34c · 34d
SP4: -

Relevant External Links for MAP4K5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP4K5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP4K5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP4K5 Gene

This gene is overexpressed in Breast (36.4) and Peripheral blood mononuclear cells (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP4K5 Gene

Protein tissue co-expression partners for MAP4K5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP4K5 Gene:


SOURCE GeneReport for Unigene cluster for MAP4K5 Gene:


mRNA Expression by UniProt/SwissProt for MAP4K5 Gene:

Tissue specificity: Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate.

Evidence on tissue expression from TISSUES for MAP4K5 Gene

  • Blood(4.2)
  • Liver(4.1)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with MAP4K5: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP4K5 Gene

Orthologs for MAP4K5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP4K5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP4K5 34 33
  • 99.65 (n)
(Canis familiaris)
Mammalia MAP4K5 34 33
  • 95.11 (n)
(Bos Taurus)
Mammalia MAP4K5 34 33
  • 94.17 (n)
(Mus musculus)
Mammalia Map4k5 16 34 33
  • 89.36 (n)
(Rattus norvegicus)
Mammalia Map4k5 33
  • 88.57 (n)
(Monodelphis domestica)
Mammalia MAP4K5 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia MAP4K5 34
  • 22 (a)
(Gallus gallus)
Aves MAP4K5 34 33
  • 80.22 (n)
(Anolis carolinensis)
Reptilia MAP4K5 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia map4k5 33
  • 74.48 (n)
Str.195 33
(Danio rerio)
Actinopterygii map4k5 34 33
  • 70.08 (n)
zgc55719 33
fruit fly
(Drosophila melanogaster)
Insecta CG7097 35
  • 73 (a)
hppy 34
  • 38 (a)
(Caenorhabditis elegans)
Secernentea gck-2 34
  • 42 (a)
ZC404.9 35
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIC1 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
Species where no ortholog for MAP4K5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP4K5 Gene

Gene Tree for MAP4K5 (if available)
Gene Tree for MAP4K5 (if available)
Evolutionary constrained regions (ECRs) for MAP4K5: view image

Paralogs for MAP4K5 Gene

Paralogs for MAP4K5 Gene

genes like me logo Genes that share paralogs with MAP4K5: view

Variants for MAP4K5 Gene

Sequence variations from dbSNP and Humsavar for MAP4K5 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs146613929 benign, Spastic paraplegia 3 50,560,295(-) T/C genic_upstream_transcript_variant, intron_variant
rs886050530 uncertain-significance, Spastic Paraplegia, Dominant 50,560,111(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000002134 -- 50,530,761(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000024860 -- 50,436,437(-) G/A intron_variant
rs1000025602 -- 50,541,258(-) T/ genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP4K5 Gene

Variant ID Type Subtype PubMed ID
esv2674140 CNV deletion 23128226
esv28926 CNV gain+loss 19812545
esv3634480 CNV loss 21293372
nsv1039493 CNV gain 25217958
nsv1054247 CNV loss 25217958
nsv1131138 CNV deletion 24896259
nsv564835 CNV gain 21841781
nsv832793 CNV loss 17160897

Variation tolerance for MAP4K5 Gene

Gene Damage Index Score: 5.97; 74.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP4K5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP4K5 Gene

Disorders for MAP4K5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MAP4K5 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • agraphia
spastic paraplegia 3
  • spastic paraplegia 3, autosomal dominant
writing disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAP4K5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAP4K5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP4K5 Gene

Publications for MAP4K5 Gene

  1. A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase. (PMID: 9038372) Tung RM … Blenis J (Oncogene 1997) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). (PMID: 12591926) Shi CS … Kehrl JH (The Journal of biological chemistry 2003) 3 22 58
  4. Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation. (PMID: 10648385) Shi CS … Kehrl JH (Blood 2000) 3 22 58
  5. GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway. (PMID: 9949177) Shi CS … Kehrl JH (Blood 1999) 3 22 58

Products for MAP4K5 Gene

Sources for MAP4K5 Gene

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