Aliases for MAP4K5 Gene
External Ids for MAP4K5 Gene
Previous GeneCards Identifiers for MAP4K5 Gene
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP4K5 Gene
MAP4K5 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5) is a Protein Coding gene. Diseases associated with MAP4K5 include Spastic Paraplegia 3A and Septal Myocardial Infarction. Among its related pathways are Signal transduction_JNK pathway and TRAF Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K3.
UniProtKB/Swiss-Prot Summary for MAP4K5 Gene
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.