The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kina... See more...

Aliases for MAP4K4 Gene

Aliases for MAP4K4 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 2 3 4 5
  • Hepatocyte Progenitor Kinase-Like/Germinal Center Kinase-Like Kinase 2 3
  • MAPK/ERK Kinase Kinase Kinase 4 3 4
  • HPK/GCK-Like Kinase HGK 3 4
  • Nck-Interacting Kinase 3 4
  • MEK Kinase Kinase 4 3 4
  • EC 2.7.11.1 4 52
  • HGK 3 4
  • NIK 3 4
  • Epididymis Secretory Protein Li 31 3
  • Ste20 Group Protein Kinase HGK 3
  • HPK/GCK-Like Kinase 2
  • EC 2.7.11 52
  • FLH21957 3
  • HEL-S-31 3
  • KIAA0687 4
  • MEKKK 4 4
  • MEKKK4 3

External Ids for MAP4K4 Gene

Previous GeneCards Identifiers for MAP4K4 Gene

  • GC02P100178
  • GC02P100767
  • GC02P101919
  • GC02P101935
  • GC02P102313
  • GC02P096078

Summaries for MAP4K4 Gene

Entrez Gene Summary for MAP4K4 Gene

  • The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP4K4 Gene

MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4) is a Protein Coding gene. Diseases associated with MAP4K4 include Theileriasis. Among its related pathways are Direct p53 effectors and Ceramide signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TNIK.

UniProtKB/Swiss-Prot Summary for MAP4K4 Gene

  • Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.

Tocris Summary for MAP4K4 Gene

Gene Wiki entry for MAP4K4 Gene

Additional gene information for MAP4K4 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP4K4 Gene

Genomics for MAP4K4 Gene

GeneHancer (GH) Regulatory Elements for MAP4K4 Gene

Promoters and enhancers for MAP4K4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J101696 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +2.1 2051 5.8 HNRNPK EP300 CTCF SIN3A NRF1 POLR2G NCOR1 PHF8 ZFX REST MAP4K4 IL1R2 lnc-RFX8-3
GH02J101745 Promoter/Enhancer 0.6 EPDnew dbSUPER 500.3 +48.5 48455 0.1 HNRNPK MAP4K4 lnc-RFX8-3 piR-38051-158
GH02J102060 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 +367.1 367121 6.2 EP300 TCF12 NRF1 POLR2G NCOR1 NONO JUND FOS KDM6A POLR2A IL1R1 HSALNG0017398 MAP4K4 IL1R1-AS1 IL1R2 IL18R1
GH02J101732 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 16 +39.2 39183 6.3 POLR2G NCOR1 FOS KDM6A TCF7 TGIF2 SKI TEAD1 TBX3 SIN3A MAP4K4 IL1R2 IL1R1 RNF149 lnc-RFX8-3 piR-38051-158
GH02J102069 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 11.2 +373.3 373322 2 TCF12 NRF1 POLR2G PHF8 PHB2 ZBTB11 AFF1 TARDBP REST DNMT1 IL1R1 MAP4K4 RF00994-505
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP4K4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP4K4

Top Transcription factor binding sites by QIAGEN in the MAP4K4 gene promoter:
  • AML1a
  • C/EBPalpha
  • C/EBPbeta
  • FOXL1
  • HSF2
  • Msx-1
  • Pbx1a

Genomic Locations for MAP4K4 Gene

Genomic Locations for MAP4K4 Gene
chr2:101,696,850-101,894,690
(GRCh38/hg38)
Size:
197,841 bases
Orientation:
Plus strand
chr2:102,313,312-102,511,152
(GRCh37/hg19)
Size:
197,841 bases
Orientation:
Plus strand

Genomic View for MAP4K4 Gene

Genes around MAP4K4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP4K4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP4K4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP4K4 Gene

Proteins for MAP4K4 Gene

  • Protein details for MAP4K4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95819-M4K4_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase kinase 4
    Protein Accession:
    O95819
    Secondary Accessions:
    • E7ESS2
    • O75172
    • Q9NST7

    Protein attributes for MAP4K4 Gene

    Size:
    1239 amino acids
    Molecular mass:
    142101 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with the SH3 domain of the adapter proteins Nck (By similarity). Interacts (via its CNH regulatory domain) with ATL1 (via the N-terminal region). Interacts with RAP2A (GTP-bound form preferentially).

    Three dimensional structures from OCA and Proteopedia for MAP4K4 Gene

    Alternative splice isoforms for MAP4K4 Gene

neXtProt entry for MAP4K4 Gene

Selected DME Specific Peptides for MAP4K4 Gene

O95819:
  • FIGTPYWMAPEV
  • ILHNDPEVEKKQGW
  • PRLKSKKWSKKF
  • ERQVRIQLKDHIDR
  • GITAIEMAEGAPPLC
  • PFIRDQP
  • EGVYVNTYGR
  • RVYYLSWLR
  • GLMLLDRSGQGKVY
  • ETEYEYSGSEEE
  • YAWAPKPYHKFM
  • WMAPEVI
  • VKLVDFGVSAQL
  • VVLQWGEMP
  • TGHLDGVFMHK
  • RRRFQQMDVLEGLN
  • VIHRDIKGQNVLLT
  • SVVNVNPTN
  • ATYYGAFIKK
  • MEFCGAGS
  • EILCAALWGVNLL
  • LRDPAGIFEL
  • RNDKVFF
  • GTPYWMAPE
  • DQLWLVMEFCG
  • KAIEIRSV
  • AAIKVMDVTEDEEEEI
  • YERIKFLV
  • PEIRKYKK
  • VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
  • DYSSSSEE

Post-translational modifications for MAP4K4 Gene

  • Ubiquitination at Lys1179
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for MAP4K4
  • Boster Bio Antibodies for MAP4K4
  • Santa Cruz Biotechnology (SCBT) Antibodies for MAP4K4

Domains & Families for MAP4K4 Gene

Gene Families for MAP4K4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAP4K4 Gene

Suggested Antigen Peptide Sequences for MAP4K4 Gene

GenScript: Design optimal peptide antigens:
  • Nck-interacting kinase (M4K4_HUMAN)
  • Mitogen-activated protein kinase kinase kinase kinase 4 isoform (Q5MD60_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95819

UniProtKB/Swiss-Prot:

M4K4_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MAP4K4: view

Function for MAP4K4 Gene

Molecular function for MAP4K4 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
GENATLAS Biochemistry:
mitogen-activated kinase kinase kinase kinase 4,S cerevisiae STE20 family homolog,specifically activating the JNK signaling through the pathway TAK1

Enzyme Numbers (IUBMB) for MAP4K4 Gene

Phenotypes From GWAS Catalog for MAP4K4 Gene

Gene Ontology (GO) - Molecular Function for MAP4K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004111 creatine kinase activity IDA 23207904
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,IDA 9890973
GO:0005515 protein binding IPI 12387898
GO:0005524 ATP binding IDA,IEA 9890973
genes like me logo Genes that share ontologies with MAP4K4: view
genes like me logo Genes that share phenotypes with MAP4K4: view

Animal Models for MAP4K4 Gene

MGI Knock Outs for MAP4K4:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAP4K4

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP4K4 Gene

Localization for MAP4K4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP4K4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP4K4 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MAP4K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IBA 14966141
GO:0005925 focal adhesion IDA 25490267
genes like me logo Genes that share ontologies with MAP4K4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAP4K4 Gene

Pathways & Interactions for MAP4K4 Gene

genes like me logo Genes that share pathways with MAP4K4: view

Pathways by source for MAP4K4 Gene

2 GeneGo (Thomson Reuters) pathways for MAP4K4 Gene
  • Cell adhesion Ephrins signaling
  • Signal transduction_JNK pathway
2 Qiagen pathways for MAP4K4 Gene
  • JNK Pathway
  • MAPK Family Pathway
1 Cell Signaling Technology pathway for MAP4K4 Gene

SIGNOR curated interactions for MAP4K4 Gene

Activates:

Gene Ontology (GO) - Biological Process for MAP4K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001953 negative regulation of cell-matrix adhesion NAS 25490267
GO:0006468 protein phosphorylation IDA,IEA 9890973
GO:0010977 negative regulation of neuron projection development IMP --
GO:0016310 phosphorylation IEA --
GO:0023014 signal transduction by protein phosphorylation IBA 21873635
genes like me logo Genes that share ontologies with MAP4K4: view

Drugs & Compounds for MAP4K4 Gene

(10) Drugs for MAP4K4 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Anastrozole Approved, Investigational Pharma Aromatase inhibitor, Potent aromatase (CYP19) inhibitor, Aromatase Inhibitors, Hormone therapy 325
Exemestane Approved, Investigational Pharma Steroidal aromatase inhibitor,selective and irreversible, Steroidal aromatase (CYP19) inhibitor 255
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for MAP4K4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MAP4K4: view

Transcripts for MAP4K4 Gene

mRNA/cDNA for MAP4K4 Gene

5 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K4 Gene

No ASD Table

Relevant External Links for MAP4K4 Gene

GeneLoc Exon Structure for
MAP4K4

Expression for MAP4K4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP4K4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP4K4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.7).

Protein differential expression in normal tissues from HIPED for MAP4K4 Gene

This gene is overexpressed in Lung (12.5), Breast (11.3), Peripheral blood mononuclear cells (11.2), and Fetal Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP4K4 Gene



Protein tissue co-expression partners for MAP4K4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP4K4

SOURCE GeneReport for Unigene cluster for MAP4K4 Gene:

Hs.701013

mRNA Expression by UniProt/SwissProt for MAP4K4 Gene:

O95819-M4K4_HUMAN
Tissue specificity: Widely expressed. Isoform 5 is abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta.

Evidence on tissue expression from TISSUES for MAP4K4 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Lung(3.6)
  • Blood(2.5)
  • Kidney(2.4)
  • Heart(2.3)
  • Pancreas(2.3)
  • Lymph node(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with MAP4K4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP4K4 Gene

Orthologs for MAP4K4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP4K4 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 98 (a)
OneToMany
-- 31
  • 79 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MAP4K4 31 30
  • 95.31 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP4K4 31
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP4K4 31 30
  • 88.95 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map4k4 30
  • 86.32 (n)
mouse
(Mus musculus)
Mammalia Map4k4 17 31 30
  • 86.18 (n)
cow
(Bos Taurus)
Mammalia MAP4K4 31 30
  • 85.28 (n)
OneToOne
chicken
(Gallus gallus)
Aves MAP4K4 31 30
  • 84.39 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP4K4 31
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map4k4 30
  • 81.14 (n)
zebrafish
(Danio rerio)
Actinopterygii wu:fa03e11 30
  • 73.38 (n)
MAP4K4 31
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta msn 31 32
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC504.4c 32
  • 67 (a)
ZC504.4b 32
  • 67 (a)
mig-15 31 32
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3520 31
  • 47 (a)
OneToMany
Species where no ortholog for MAP4K4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP4K4 Gene

ENSEMBL:
Gene Tree for MAP4K4 (if available)
TreeFam:
Gene Tree for MAP4K4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP4K4: view image

Paralogs for MAP4K4 Gene

(49) SIMAP similar genes for MAP4K4 Gene using alignment to 15 proteins:

  • M4K4_HUMAN
  • C9J840_HUMAN
  • E7EN19_HUMAN
  • E7ENQ1_HUMAN
  • E7ESS2_HUMAN
  • E7ETN6_HUMAN
  • E7EX83_HUMAN
  • G3XAA2_HUMAN
  • G5E948_HUMAN
  • H7C0P6_HUMAN
  • H7C360_HUMAN
  • H7C3Z6_HUMAN
  • Q53TW0_HUMAN
  • Q53TX8_HUMAN
  • Q5MD60_HUMAN
genes like me logo Genes that share paralogs with MAP4K4: view

Variants for MAP4K4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP4K4 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs373459163 Likely Benign: not specified 101,790,717(+) C/T INTRON_VARIANT
rs781410462 Likely Pathogenic: Cerebral arteriovenous malformation 101,859,854(+) G/A MISSENSE_VARIANT
VAR_040746 - p.Ser712Thr

Additional dbSNP identifiers (rs#s) for MAP4K4 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAP4K4 Gene

Variant ID Type Subtype PubMed ID
dgv1981n106 CNV deletion 24896259
dgv1982n106 CNV deletion 24896259
esv1631190 CNV deletion 17803354
esv2061482 CNV deletion 18987734
esv2109649 CNV deletion 18987734
esv2484314 CNV deletion 19546169
esv2632369 CNV deletion 19546169
esv2661163 CNV deletion 23128226
esv2663691 CNV deletion 23128226
esv2669350 CNV deletion 23128226
esv2720452 CNV deletion 23290073
esv2720453 CNV deletion 23290073
esv2720454 CNV deletion 23290073
esv2720455 CNV deletion 23290073
esv2762747 CNV gain 21179565
esv2829 CNV loss 18987735
esv3559862 CNV deletion 23714750
esv3559863 CNV deletion 23714750
esv3591775 CNV loss 21293372
nsv1072012 CNV deletion 25765185
nsv1072429 CNV deletion 25765185
nsv1072431 CNV deletion 25765185
nsv1136302 CNV deletion 24896259
nsv1143949 CNV deletion 24896259
nsv213949 CNV deletion 16902084
nsv213987 CNV deletion 16902084
nsv2851 CNV insertion 18451855
nsv441771 CNV loss 18776908
nsv475255 CNV novel sequence insertion 20440878
nsv834318 CNV loss 17160897
nsv954785 CNV deletion 24416366

Variation tolerance for MAP4K4 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP4K4 Gene

Human Gene Mutation Database (HGMD)
MAP4K4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP4K4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP4K4 Gene

Disorders for MAP4K4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAP4K4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
theileriasis
  • infection by theileria
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAP4K4

genes like me logo Genes that share disorders with MAP4K4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP4K4 Gene

Publications for MAP4K4 Gene

  1. A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. (PMID: 9890973) Yao Z … Tan TH (The Journal of biological chemistry 1999) 2 3 4 23 54
  2. Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. (PMID: 14966141) Machida N … Kariya K (The Journal of biological chemistry 2004) 3 4 23 54
  3. The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. (PMID: 12612079) Wright JH … Jallal B (Molecular and cellular biology 2003) 3 4 23 54
  4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 54
  5. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. (PMID: 9135144) Su YC … Skolnik EY (The EMBO journal 1997) 2 3 23 54

Products for MAP4K4 Gene

Sources for MAP4K4 Gene