Aliases for MAP4K4 Gene
External Ids for MAP4K4 Gene
Previous GeneCards Identifiers for MAP4K4 Gene
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP4K4 Gene
MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4) is a Protein Coding gene. Diseases associated with MAP4K4 include Arteriovenous Malformations Of The Brain and Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1. Among its related pathways are MAPK signaling pathway and EPH-Ephrin signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TNIK.
UniProtKB/Swiss-Prot Summary for MAP4K4 Gene
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.