Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kina... See more...
Aliases for MAP4K4 Gene
Aliases for MAP4K4 Gene
External Ids for MAP4K4 Gene
- HGNC: 6866
- NCBI Entrez Gene: 9448
- Ensembl: ENSG00000071054
- OMIM®: 604666
- UniProtKB/Swiss-Prot: O95819
Previous GeneCards Identifiers for MAP4K4 Gene
- GC02P100178
- GC02P100767
- GC02P101919
- GC02P101935
- GC02P102313
- GC02P096078
Summaries for MAP4K4 Gene
-
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP4K4 Gene
MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4) is a Protein Coding gene. Diseases associated with MAP4K4 include Arteriovenous Malformations Of The Brain and Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1. Among its related pathways are MAPK signaling pathway and EPH-Ephrin signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TNIK.
UniProtKB/Swiss-Prot Summary for MAP4K4 Gene
-
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.
Additional gene information for MAP4K4 Gene
- HGNC (6866)
- NCBI Entrez Gene (9448)
- Ensembl (ENSG00000071054)
- OMIM® (604666)
- UniProtKB/Swiss-Prot (O95819)
- Open Targets Platform(ENSG00000071054)
- Monarch Initiative
- Search for MAP4K4 at DataMed
- Search for MAP4K4 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP4K4 Gene
Genomics for MAP4K4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MAP4K4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAP4K4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP4K4
- Top Transcription factor binding sites by QIAGEN in the MAP4K4 gene promoter:
-
- AML1a
- C/EBPalpha
- C/EBPbeta
- FOXL1
- HSF2
- Msx-1
- Pbx1a
Genomic Locations for MAP4K4 Gene
Latest Assembly
- chr2:101,696,850-101,894,690
- (GRCh38/hg38)
- Size:
- 197,841 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:102,314,169-102,511,152
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 196,984 bases
- Orientation:
- Plus strand
- chr2:102,313,312-102,511,149
- (GRCh37/hg19 by Ensembl)
- Size:
- 197,838 bases
- Orientation:
- Plus strand
Genomic View for MAP4K4 Gene
Genes around MAP4K4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q11.2 by HGNC
- 2q11.2 by Entrez Gene
- 2q11.2 by Ensembl
MAP4K4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAP4K4 Gene
Proteins for MAP4K4 Gene
-
Protein details for MAP4K4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95819-M4K4_HUMAN
- Recommended name:
- Mitogen-activated protein kinase kinase kinase kinase 4
- Protein Accession:
- O95819
- E7ESS2
- O75172
- Q9NST7
Protein attributes for MAP4K4 Gene
- Size:
- 1239 amino acids
- Molecular mass:
- 142101 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with the SH3 domain of the adapter proteins Nck (By similarity). Interacts (via its CNH regulatory domain) with ATL1 (via the N-terminal region). Interacts with RAP2A (GTP-bound form preferentially).
Three dimensional structures from OCA and Proteopedia for MAP4K4 Gene
Protein Expression for MAP4K4 Gene
Selected DME Specific Peptides for MAP4K4 Gene
- O95819:
-
- FIGTPYWMAPEV
- ILHNDPEVEKKQGW
- PRLKSKKWSKKF
- ERQVRIQLKDHIDR
- GITAIEMAEGAPPLC
- PFIRDQP
- EGVYVNTYGR
- RVYYLSWLR
- GLMLLDRSGQGKVY
- ETEYEYSGSEEE
- YAWAPKPYHKFM
- WMAPEVI
- VKLVDFGVSAQL
- VVLQWGEMP
- TGHLDGVFMHK
- RRRFQQMDVLEGLN
- VIHRDIKGQNVLLT
- SVVNVNPTN
- ATYYGAFIKK
- MEFCGAGS
- EILCAALWGVNLL
- LRDPAGIFEL
- RNDKVFF
- GTPYWMAPE
- DQLWLVMEFCG
- KAIEIRSV
- AAIKVMDVTEDEEEEI
- YERIKFLV
- PEIRKYKK
- VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
- DYSSSSEE
Post-translational modifications for MAP4K4 Gene
Other Protein References for MAP4K4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005264105.1
- XP_005264107.1
- XP_005264109.1
- XP_005264114.1
- XP_005264116.1
- XP_005264117.1
- XP_005264119.1
- XP_005264120.1
- XP_005264122.1
- XP_005264123.1
- XP_005264125.1
- XP_005264126.1
- XP_005264128.1
- XP_006712928.1
- XP_016860840.1
- XP_016860843.1
- XP_016860845.1
- XP_016860846.1
- XP_016860847.1
- XP_016860849.1
- XP_016860852.1
- XP_016860855.1
- XP_016860857.1
- XP_016860858.1
- XP_016860860.1
- XP_016860861.1
- XP_016860862.1
- NP_001229488.1
- NP_001229489.1
- NP_001371405.1
- NP_001371406.1
- NP_001371407.1
- NP_001371410.1
- NP_001371411.1
- NP_001371412.1
- NP_001371413.1
- NP_001371414.1
- NP_001371415.1
- NP_001371416.1
- NP_001371417.1
- NP_001371419.1
- NP_001371420.1
- NP_001371421.1
- NP_001371422.1
- NP_001371423.1
- NP_001371424.1
- NP_001371425.1
- NP_001371426.1
- NP_001371435.1
- NP_001371436.1
- NP_001371437.1
- NP_001371438.1
- NP_001371449.1
- NP_001371472.1
- NP_001371477.1
- NP_001371478.1
- NP_001371479.1
- NP_001371480.1
- NP_001371481.1
- NP_001371482.1
- NP_001371483.1
- NP_001371484.1
- NP_001371485.1
- NP_001371486.1
- NP_001371487.1
- NP_001371488.1
- NP_001371489.1
- NP_001371490.1
- NP_001371491.1
- NP_001371492.1
- NP_001371493.1
- NP_001371496.1
- NP_001371501.1
- NP_001371508.1
- NP_004825.3
- NP_663719.2
- NP_663720.1
Antibodies for research
- LifeSpan BioSciences MAP4K4 Antibody (LS-B712) and MAP4K4 Antibody (LS-B5815)
- GeneTex Anti-MAP4K4 antibody
-
Custom Antibody ServicesOriGene Antibodies for MAP4K4
- Novus Biologicals Antibodies for MAP4K4
-
Abcam antibodies for MAP4K4
- Invitrogen Antibodies for MAP4K4 (AFLGC-MAP4K4)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAP4K4
Protein products for research
-
OriGene Purified Proteins for MAP4K4
- Search Origene for MassSpec and Protein Over-expression Lysates for MAP4K4
- Origene Custom Protein Services for MAP4K4
- antibodies-online: Show 6 available MAP4K4 Proteins ranked by validation data
- Compare Top MAP4K4 Proteins
-
Quality Products:
-
Abcam proteins for MAP4K4
Assay products for research
- antibodies-online: Show 2 available MAP4K4 Elisa Kits ranked by validation data
- Compare Top MAP4K4 Elisa Kits
-
Quality Products:
Domains & Families for MAP4K4 Gene
Gene Families for MAP4K4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MAP4K4 Gene
- InterPro:
- Blocks:
-
- Citron-like
- ProtoNet:
Suggested Antigen Peptide Sequences for MAP4K4 Gene
- GenScript: Design optimal peptide antigens:
-
- Nck-interacting kinase (M4K4_HUMAN)
- Mitogen-activated protein kinase kinase kinase kinase 4 isoform (Q5MD60_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O95819UniProtKB/Swiss-Prot:
M4K4_HUMAN :- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Function for MAP4K4 Gene
Molecular function for MAP4K4 Gene
- UniProtKB/Swiss-Prot Function:
- Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:9890973};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:9890973};.
- GENATLAS Biochemistry:
- mitogen-activated kinase kinase kinase kinase 4,S cerevisiae STE20 family homolog,specifically activating the JNK signaling through the pathway TAK1
Enzyme Numbers (IUBMB) for MAP4K4 Gene
Phenotypes From GWAS Catalog for MAP4K4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004111 | creatine kinase activity | IDA | 23207904 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IBA,IDA | 9890973 |
| GO:0005515 | protein binding | IPI | 12387898 |
Phenotypes for MAP4K4 Gene
- MGI mutant phenotypes for MAP4K4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MAP4K4:
Animal Models for MAP4K4 Gene
- MGI Knock Outs for MAP4K4:
-
- Map4k4 Map4k4<tm1Eys>
Animal Models for research
-
Taconic Biosciences Mouse Models for MAP4K4
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MAP4K4 - Starting at $85 >
- * MAP4K4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MAP4K4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP4K4
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP4K4
miRNA for MAP4K4 Gene
- miRTarBase miRNAs that target MAP4K4
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP4K4
- Browse OriGene Inhibitory RNA Products For MAP4K4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP4K4
Clone products for research
- Applied Biological Materials (abm): Clones for MAP4K4 - Starting at $45 >
- * MAP4K4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG226085
- MR226085
- MR226085L3
- MR226085L4
- MR231685
- MR231695
- MR231754
- RC215163
- RC215163L1
- RC215163L2
- RC215163L3
- RC215163L4
- RC219540
- RC219540L3
- RC219540L4
- RC219603
- RC219603L3
- RC219603L4
- RC235232
- RC235235
- RG215163
- RG219540
- RG219603
- RG235232
- RG235235
- RR201398
- MR226085L3V
- MR226085L4V
- RC215163L1V
- RC215163L2V
- RC215163L3V
- RC215163L4V
- RC219540L3V
- RC219540L4V
- RC219603L3V
- RC219603L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAP4K4
- Addgene plasmids for MAP4K4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP4K4
Cell Lines for research
-
Horizon Cell Lines for MAP4K4
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP4K4 Gene
Localization for MAP4K4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAP4K4 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA,IDA | 14966141 |
| GO:0005925 | focal adhesion | IDA | 25490267 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAP4K4 Gene
Pathways & Interactions for MAP4K4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence (REACTOME) | ||
| 2 | MAPK signaling pathway | ||
| 3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
|
JNK Pathway
.51
|
| 4 | EPH-Ephrin signaling |
Cell adhesion Ephrins signaling
.35
|
|
| 5 | Angiopoietin Like Protein 8 Regulatory Pathway | ||
Pathways by source for MAP4K4 Gene
7 BioSystems pathways for MAP4K4 Gene
3 Reactome pathways for MAP4K4 Gene
1 KEGG pathway for MAP4K4 Gene
2 GeneGo (Thomson Reuters) pathways for MAP4K4 Gene
- Cell adhesion Ephrins signaling
- Signal transduction_JNK pathway
2 Qiagen pathways for MAP4K4 Gene
- JNK Pathway
- MAPK Family Pathway
1 Cell Signaling Technology pathway for MAP4K4 Gene
Interacting Proteins for MAP4K4 Gene
Selected Interacting proteins:
O95819-M4K4_HUMAN
ENSP00000343658
for MAP4K4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MAP4K4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IBA | 21873635 |
| GO:0001953 | negative regulation of cell-matrix adhesion | NAS | 25490267 |
| GO:0006468 | protein phosphorylation | IEA,IDA | 9890973 |
| GO:0007165 | signal transduction | IBA | -- |
| GO:0010977 | negative regulation of neuron projection development | IEA | -- |
Drugs & Compounds for MAP4K4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Anastrozole | Approved, Investigational | Pharma | Aromatase inhibitor, Potent aromatase (CYP19) inhibitor, Aromatase Inhibitors, Hormone therapy | 353 | ||
| Exemestane | Approved, Investigational | Pharma | Steroidal aromatase inhibitor,selective and irreversible, Steroidal aromatase (CYP19) inhibitor | 270 | ||
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
| ATP | Investigational | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
58-64-0 |
|
Transcripts for MAP4K4 Gene
mRNA/cDNA for MAP4K4 Gene
- 50 REFSEQ mRNAs :
- 27 NCBI additional mRNA sequence :
- 21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000302217 6624 nts (view in UCSC)
- ENST00000324219 7526 nts (view in UCSC)
- ENST00000347699 3792 nts (view in UCSC)
- ENST00000350198 7316 nts (view in UCSC)
- ENST00000350878 7640 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MAP4K4 - Starting at $85 >
- * MAP4K4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MAP4K4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP4K4
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP4K4
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP4K4
- Browse OriGene Inhibitory RNA Products For MAP4K4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP4K4
Clone products for research
- Applied Biological Materials (abm): Clones for MAP4K4 - Starting at $45 >
- * MAP4K4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG226085
- MR226085
- MR226085L3
- MR226085L4
- MR231685
- MR231695
- MR231754
- RC215163
- RC215163L1
- RC215163L2
- RC215163L3
- RC215163L4
- RC219540
- RC219540L3
- RC219540L4
- RC219603
- RC219603L3
- RC219603L4
- RC235232
- RC235235
- RG215163
- RG219540
- RG219603
- RG235232
- RG235235
- RR201398
- MR226085L3V
- MR226085L4V
- RC215163L1V
- RC215163L2V
- RC215163L3V
- RC215163L4V
- RC219540L3V
- RC219540L4V
- RC219603L3V
- RC219603L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAP4K4
- Addgene plasmids for MAP4K4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP4K4
Relevant External Links for MAP4K4 Gene
- GeneLoc Exon Structure for
- MAP4K4
Expression for MAP4K4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for MAP4K4 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.7).
This gene is overexpressed in Lung (12.5), Breast (11.3), Peripheral blood mononuclear cells (11.2), and Fetal Brain (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP4K4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP4K4
SOURCE GeneReport for Unigene cluster for MAP4K4 Gene:
Hs.701013mRNA Expression by UniProt/SwissProt for MAP4K4 Gene:
O95819-M4K4_HUMAN
Tissue specificity:
Widely expressed. Isoform 5 is abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta.
Evidence on tissue expression from TISSUES for MAP4K4 Gene
- Nervous system(4.9)
- Liver(4.5)
- Lung(3.6)
- Skin(2.9)
- Heart(2.8)
- Kidney(2.8)
- Pancreas(2.7)
- Blood(2.7)
- Muscle(2.6)
- Lymph node(2.5)
- Intestine(2.5)
- Spleen(2.4)
- Bone(2.3)
- Bone marrow(2.1)
Primer products for research
-
OriGene qPCR primer pairs for MAP4K4
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP4K4 Gene
Orthologs for MAP4K4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chimpanzee (Pan troglodytes) |
Mammalia | MAP4K4 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MAP4K4 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MAP4K4 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Map4k4 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Map4k4 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MAP4K4 30 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MAP4K4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MAP4K4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | map4k4 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | wu:fa03e11 30 |
|
||
| MAP4K4 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | msn 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | ZC504.4b 32 |
|
|
|
| ZC504.4c 32 |
|
|
|||
| mig-15 31 32 |
|
OneToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3520 31 |
|
OneToMany |
- Species where no ortholog for MAP4K4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MAP4K4 Gene
- ENSEMBL:
- Gene Tree for MAP4K4 (if available)
- TreeFam:
- Gene Tree for MAP4K4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAP4K4: view image
Paralogs for MAP4K4 Gene
Paralogs for MAP4K4 Gene
(49) SIMAP similar genes for MAP4K4 Gene using alignment to 15 proteins:
- M4K4_HUMAN
- C9J840_HUMAN
- E7EN19_HUMAN
- E7ENQ1_HUMAN
- E7ESS2_HUMAN
- E7ETN6_HUMAN
- E7EX83_HUMAN
- G3XAA2_HUMAN
- G5E948_HUMAN
- H7C0P6_HUMAN
- H7C360_HUMAN
- H7C3Z6_HUMAN
- Q53TW0_HUMAN
- Q53TX8_HUMAN
- Q5MD60_HUMAN
- MINK1
- TNIK
- MYO3A
- MAP4K2
- MAP4K5
- MYO3B
- MAP4K3
- CDKL3
- STK3
- MAP4K1
- PAK4
- STK4/SLC36AL fusion
- STK25
- STK24
- TBK1
- MST4
- STK4
- CDK1
- PAK1
- DKFZp686J1430
- TAOK3
- PAK2
- NRK
- NEK9
- DKFZp564L2416
- MAPK8
- MAP3K2
- RPS6KA2
- OXSR1
- CHEK1
- BRAF
- ZAK
- ULK1
- STK11
- MST094
- MAP2K7
- FGFR1
- MAP2K6
- MARK4
- MARK2
- CDK4
- PHKG1
- PRKAA1
- MAPK14
- BRSK2
- RPS6KA1
- NUAK1
- MAP2K5
- DKFZp686A2068
Variants for MAP4K4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP4K4 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs371995247 | Benign: not provided | 101,887,813(+) |
C/T NM_145686.3(MAP4K4):c.3474C>T (p.Ile1158=) |
SYNONYMOUS | |
| rs373459163 | Likely Benign: not specified | 101,790,717(+) |
C/T NM_145686.3(MAP4K4):c.124-3C>T |
INTRON | |
| rs374842800 | Benign: not provided | 101,834,405(+) |
G/A NM_145686.3(MAP4K4):c.640-4G>A |
INTRON | |
| rs55844421 | Benign: not provided | 101,859,759(+) |
G/A NM_145686.3(MAP4K4):c.1506G>A (p.Pro502=) |
SYNONYMOUS | |
| rs55856263 | Likely Benign: not provided | 101,824,002(+) |
T/C NM_145686.3(MAP4K4):c.255T>C (p.Tyr85=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.78;
33.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAP4K4 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP4K4 Gene
Disorders for MAP4K4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| arteriovenous malformations of the brain |
|
|
| spinal muscular atrophy, distal, autosomal recessive, 1 |
|
|
| theileriasis |
|
|
| autosomal recessive distal hereditary motor neuronopathy |
|
|
Search MAP4K4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAP4K4
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MAP4K4 Gene
Publications for MAP4K4 Gene
- A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. (PMID: 9890973) Yao Z … Tan TH (The Journal of biological chemistry 1999) 2 3 4 23
- Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. (PMID: 14966141) Machida N … Kariya K (The Journal of biological chemistry 2004) 3 4 23
- The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. (PMID: 12612079) Wright JH … Jallal B (Molecular and cellular biology 2003) 3 4 23
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
- NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. (PMID: 9135144) Su YC … Skolnik EY (The EMBO journal 1997) 2 3 23
ExternalLinks
Products for MAP4K4 Gene
- Custom Antibody ServicesOriGene Antibodies for MAP4K4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MAP4K4
- Search Origene for MassSpec and Protein Over-expression Lysates for MAP4K4
- Origene Custom Protein Services for MAP4K4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP4K4
- Browse OriGene Inhibitory RNA Products For MAP4K4
- OriGene qPCR primer pairs for MAP4K4
- OriGene CRISPR knockouts for MAP4K4
- MG226085
- MR226085
- MR226085L3
- MR226085L4
- MR231685
- MR231695
- MR231754
- RC215163
- RC215163L1
- RC215163L2
- RC215163L3
- RC215163L4
- RC219540
- RC219540L3
- RC219540L4
- RC219603
- RC219603L3
- RC219603L4
- RC235232
- RC235235
- RG215163
- RG219540
- RG219603
- RG235232
- RG235235
- RR201398
- MR226085L3V
- MR226085L4V
- RC215163L1V
- RC215163L2V
- RC215163L3V
- RC215163L4V
- RC219540L3V
- RC219540L4V
- RC219603L3V
- RC219603L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MAP4K4
- Sino Biological Human cDNA Clone for MAP4K4
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MAP4K4
- Novus Biologicals proteins and lysates for MAP4K4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MAP4K4
- Abcam proteins for MAP4K4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for MAP4K4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MAP4K4 (AFLGC-MAP4K4)
- VectorBuilder Custom and pre-made DNA vectors for MAP4K4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MAP4K4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MAP4K4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MAP4K4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MAP4K4
- Addgene plasmids for MAP4K4
- antibodies-online: Show 55 available MAP4K4 Antibodies ranked by validation data
- Compare Top MAP4K4 Antibodies
- antibodies-online: Show 2 available MAP4K4 Elisa Kits ranked by validation data
- Compare Top MAP4K4 Elisa Kits
- Quality Products:
- antibodies-online: Show 6 available MAP4K4 Proteins ranked by validation data
- Compare Top MAP4K4 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for MAP4K4
- Search Santa Cruz Biotechnology (SCBT) for MAP4K4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MAP4K4
- Horizon Cell Lines for MAP4K4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP4K4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP4K4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MAP4K4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP4K4
Sources for MAP4K4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB