Aliases for MAP4K3 Gene
External Ids for MAP4K3 Gene
Previous HGNC Symbols for MAP4K3 Gene
Previous GeneCards Identifiers for MAP4K3 Gene
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for MAP4K3 Gene
MAP4K3 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3) is a Protein Coding gene. Diseases associated with MAP4K3 include Adult-Onset Still's Disease. Among its related pathways are PI3K / Akt Signaling and Angiopoietin Like Protein 8 Regulatory Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K5.
UniProtKB/Swiss-Prot Summary for MAP4K3 Gene
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.