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Aliases for MAP4K3 Gene

Aliases for MAP4K3 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 2 3 3 5
  • Germinal Center Kinase-Related Protein Kinase 3 4
  • MAPK/ERK Kinase Kinase Kinase 3 3 4
  • MEK Kinase Kinase 3 3 4
  • RAB8IPL1 3 4
  • MEKKK 3 3 4
  • GLK 3 4
  • Germinal Center Kinase-Like Kinase 3
  • EC 4
  • MAPKKKK3 3
  • MEKKK3 3

External Ids for MAP4K3 Gene

Previous HGNC Symbols for MAP4K3 Gene

  • RAB8IPL1

Previous GeneCards Identifiers for MAP4K3 Gene

  • GC02M039440
  • GC02M039623
  • GC02M039450
  • GC02M039388
  • GC02M039329
  • GC02M039476

Summaries for MAP4K3 Gene

Entrez Gene Summary for MAP4K3 Gene

  • This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for MAP4K3 Gene

MAP4K3 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3) is a Protein Coding gene. Among its related pathways are Signal transduction_JNK pathway and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K5.

UniProtKB/Swiss-Prot for MAP4K3 Gene

  • May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Additional gene information for MAP4K3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP4K3 Gene

Genomics for MAP4K3 Gene

GeneHancer (GH) Regulatory Elements for MAP4K3 Gene

Promoters and enhancers for MAP4K3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J039434 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 650.7 -0.3 -300 5.6 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ENSG00000231312 MAP4K3 LOC728730 SRSF7 DHX57 THUMPD2 HNRNPLL SOS1 PIR40288
GH02J039229 Enhancer 1.1 Ensembl ENCODE 15.6 +207.4 207417 0.9 FOXA2 ARNT ARID4B ARID2 ZNF143 RXRA NFYC MXD4 REST MIER2 THUMPD2 MAP4K3 SOS1 HNRNPLL CDKL4 GC02M039185
GH02J038540 Enhancer 1.5 FANTOM5 Ensembl ENCODE 10.6 +894.9 894872 3.4 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B FEZF1 DMAP1 CBX5 E2F8 DHX57 HNRNPLL SRSF7 SOS1 ENSG00000235586 ENSG00000232518 GALM MAP4K3 ENSG00000252473 CYP1B1
GH02J039467 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.9 -31.9 -31861 3.9 PKNOX1 FOXA2 MLX ARID4B DMAP1 IRF4 ZNF766 FOS JUNB ZNF592 SRSF7 THUMPD2 SOS1 MAP4K3 ENSG00000252473 ENSG00000231312 TMEM178A LOC728730 PIR40288
GH02J039150 Enhancer 1 dbSUPER 10.7 +280.8 280802 13 FOXA2 MLX ARNT ARID4B YY1 SLC30A9 ZNF766 SP5 ZHX2 ZNF592 SOS1 SRSF7 THUMPD2 ENSG00000202309 MAP4K3 ENSG00000252473 GC02M039185 GC02M039129 GC02P039110
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP4K3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP4K3 gene promoter:
  • HTF
  • Msx-1
  • SRF (504 AA)
  • SRF
  • RORalpha1
  • AML1a
  • HSF2
  • PPAR-alpha
  • NF-AT1
  • CUTL1

Genomic Locations for MAP4K3 Gene

Genomic Locations for MAP4K3 Gene
188,047 bases
Minus strand
188,047 bases
Minus strand

Genomic View for MAP4K3 Gene

Genes around MAP4K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP4K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP4K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP4K3 Gene

Proteins for MAP4K3 Gene

  • Protein details for MAP4K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase kinase kinase kinase 3
    Protein Accession:
    Secondary Accessions:
    • Q6IQ39
    • Q8IVH7
    • Q9UDM5
    • Q9Y6R5

    Protein attributes for MAP4K3 Gene

    894 amino acids
    Molecular mass:
    101316 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation (By similarity).

    Three dimensional structures from OCA and Proteopedia for MAP4K3 Gene

    Alternative splice isoforms for MAP4K3 Gene


neXtProt entry for MAP4K3 Gene

Post-translational modifications for MAP4K3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAP4K3 Gene

Domains & Families for MAP4K3 Gene

Gene Families for MAP4K3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAP4K3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MAP4K3: view

Function for MAP4K3 Gene

Molecular function for MAP4K3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for MAP4K3 Gene

Gene Ontology (GO) - Molecular Function for MAP4K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity TAS,IEA 9275185
GO:0004674 protein serine/threonine kinase activity IDA,IEA 9275185
GO:0005515 protein binding IPI 17474147
GO:0005524 ATP binding IDA,IEA 9275185
genes like me logo Genes that share ontologies with MAP4K3: view
genes like me logo Genes that share phenotypes with MAP4K3: view

Animal Model Products

miRNA for MAP4K3 Gene

miRTarBase miRNAs that target MAP4K3

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP4K3 Gene

Localization for MAP4K3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP4K3 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAP4K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with MAP4K3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP4K3 Gene

Pathways & Interactions for MAP4K3 Gene

genes like me logo Genes that share pathways with MAP4K3: view

Pathways by source for MAP4K3 Gene

1 KEGG pathway for MAP4K3 Gene
1 GeneGo (Thomson Reuters) pathway for MAP4K3 Gene
2 Qiagen pathways for MAP4K3 Gene
1 Cell Signaling Technology pathway for MAP4K3 Gene

SIGNOR curated interactions for MAP4K3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAP4K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IBA --
GO:0000185 activation of MAPKKK activity IEA --
GO:0006468 protein phosphorylation IDA,IEA 9275185
GO:0007254 JNK cascade TAS 9275185
GO:0007346 regulation of mitotic cell cycle IBA --
genes like me logo Genes that share ontologies with MAP4K3: view

Drugs & Compounds for MAP4K3 Gene

(5) Drugs for MAP4K3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for MAP4K3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MAP4K3: view

Transcripts for MAP4K3 Gene

mRNA/cDNA for MAP4K3 Gene

Unigene Clusters for MAP4K3 Gene

Mitogen-activated protein kinase kinase kinase kinase 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP2: -
SP3: - - - -

ExUns: 26a · 26b ^ 27a · 27b ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
SP1: - - -
SP2: - - -
SP4: -

Relevant External Links for MAP4K3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP4K3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP4K3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP4K3 Gene

This gene is overexpressed in Placenta (19.7), Testis (10.6), Frontal cortex (10.5), and Pancreas (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP4K3 Gene

Protein tissue co-expression partners for MAP4K3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP4K3 Gene:


SOURCE GeneReport for Unigene cluster for MAP4K3 Gene:


mRNA Expression by UniProt/SwissProt for MAP4K3 Gene:

Tissue specificity: Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.

Evidence on tissue expression from TISSUES for MAP4K3 Gene

  • Muscle(4.4)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with MAP4K3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP4K3 Gene

Orthologs for MAP4K3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP4K3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP4K3 34 33
  • 99.66 (n)
(Ornithorhynchus anatinus)
Mammalia MAP4K3 34
  • 98 (a)
(Monodelphis domestica)
Mammalia MAP4K3 34
  • 95 (a)
(Canis familiaris)
Mammalia MAP4K3 34 33
  • 94.89 (n)
(Bos Taurus)
Mammalia MAP4K3 34 33
  • 94.15 (n)
(Mus musculus)
Mammalia Map4k3 16 34 33
  • 88.96 (n)
(Rattus norvegicus)
Mammalia Map4k3 33
  • 87.78 (n)
(Gallus gallus)
Aves MAP4K3 34 33
  • 83.77 (n)
(Anolis carolinensis)
Reptilia MAP4K3 34
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia map4k3 33
  • 79.61 (n)
(Danio rerio)
Actinopterygii MAP4K3 (2 of 2) 34
  • 80 (a)
map4k3b 34 33
  • 71.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7097 35
  • 75 (a)
hppy 34 33
  • 58.74 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010837 33
  • 42.51 (n)
(Caenorhabditis elegans)
Secernentea gck-2 34 33
  • 54.92 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIC1 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
Cin.2532 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2532 33
Species where no ortholog for MAP4K3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP4K3 Gene

Gene Tree for MAP4K3 (if available)
Gene Tree for MAP4K3 (if available)
Evolutionary constrained regions (ECRs) for MAP4K3: view image

Paralogs for MAP4K3 Gene

Paralogs for MAP4K3 Gene

(47) SIMAP similar genes for MAP4K3 Gene using alignment to 8 proteins:

  • M4K3_HUMAN
  • F5H5A3_HUMAN
  • H7C1A4_HUMAN
  • Q53RV1_HUMAN
  • V9GY95_HUMAN
genes like me logo Genes that share paralogs with MAP4K3: view

Variants for MAP4K3 Gene

Sequence variations from dbSNP and Humsavar for MAP4K3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
VAR_040745 A lung squamous cell carcinoma sample p.Thr669Ser
rs1000000766 -- 39,432,850(-) A/G intron_variant
rs1000006435 -- 39,304,621(-) G/A intron_variant
rs1000025140 -- 39,320,533(-) T/A intron_variant
rs1000037020 -- 39,391,577(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP4K3 Gene

Variant ID Type Subtype PubMed ID
dgv6792n54 CNV gain 21841781
esv2442819 CNV deletion 19546169
esv2582384 CNV deletion 19546169
esv2677029 CNV deletion 23128226
esv2762497 CNV loss 21179565
esv3590429 CNV loss 21293372
esv6749 CNV gain 19470904
nsv2693 CNV deletion 18451855
nsv2694 CNV insertion 18451855
nsv2695 CNV deletion 18451855
nsv833847 CNV loss 17160897
nsv997934 CNV gain 25217958

Variation tolerance for MAP4K3 Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP4K3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP4K3 Gene

Disorders for MAP4K3 Gene

Additional Disease Information for MAP4K3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MAP4K3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP4K3 Gene

Publications for MAP4K3 Gene

  1. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. (PMID: 9275185) Diener K … Yao Z (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. (PMID: 29507340) Hsu CL … La Spada AR (Nature communications 2018) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for MAP4K3 Gene

Sources for MAP4K3 Gene

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