Aliases for MAP4K1 Gene
External Ids for MAP4K1 Gene
Previous GeneCards Identifiers for MAP4K1 Gene
GeneCards Summary for MAP4K1 Gene
MAP4K1 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1) is a Protein Coding gene. Among its related pathways are Signal transduction_JNK pathway and B cell receptor signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K3.
UniProtKB/Swiss-Prot Summary for MAP4K1 Gene
Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026). Able to autophosphorylate (PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity).