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Aliases for MAP4 Gene

Aliases for MAP4 Gene

  • Microtubule Associated Protein 4 2 3 5
  • MAP-4 3 4
  • Microtubule-Associated Protein 4 3

External Ids for MAP4 Gene

Previous GeneCards Identifiers for MAP4 Gene

  • GC03M047698
  • GC03M047175
  • GC03M047852
  • GC03M047853
  • GC03M047867

Summaries for MAP4 Gene

Entrez Gene Summary for MAP4 Gene

  • The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for MAP4 Gene

MAP4 (Microtubule Associated Protein 4) is a Protein Coding gene. Diseases associated with MAP4 include Ovarian Clear Cell Adenocarcinoma and Deafness, Autosomal Recessive 6. Among its related pathways are Taxane Pathway, Pharmacokinetics and Transcription_P53 signaling pathway. Gene Ontology (GO) annotations related to this gene include microtubule binding. An important paralog of this gene is MAP2.

UniProtKB/Swiss-Prot for MAP4 Gene

  • Non-neuronal microtubule-associated protein. Promotes microtubule assembly.

Gene Wiki entry for MAP4 Gene

Additional gene information for MAP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP4 Gene

Genomics for MAP4 Gene

GeneHancer (GH) Regulatory Elements for MAP4 Gene

Promoters and enhancers for MAP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I048085 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +1.4 1378 5.3 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZNF263 MAP4 ATRIP DHX30 ZNF589 ENSG00000235236 SETD2 PTPN23 TMEM89 KLHL18 ENSG00000260236
GH03I048012 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.2 +74.2 74156 5 HDGF ATF1 FOXA2 ARNT TCF12 FOS ATF7 SP5 ZNF592 NFIL3 MAP4 ZNF589 NDUFB1P1 RNU7-128P CDC25A IP6K2 NME6 ENSG00000270285 VPS26BP1
GH03I047778 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 11.6 +308.5 308479 5.2 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 SMARCC1 ZNF589 DHX30 MAP4 SCAP SLC26A6 ENSG00000235695
GH03I047824 Promoter/Enhancer 1.5 Ensembl ENCODE 12.9 +264.0 264000 2.3 HDGF ARNT ARID4B SIN3A DMAP1 YY1 POLR2B CBX5 ZNF207 ZNF143 DHX30 ZNF589 MIR1226 MAP4 FCF1P2 ELP6 ENSG00000260236 CDC25A ENSG00000274420 PIR41733
GH03I047474 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 4.4 +613.5 613491 2.8 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 SCAP LOC105377073 GC03P047477 TREX1 ZNF589 NBEAL2 MAP4 ENSG00000276925
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP4 gene promoter:

Genomic Locations for MAP4 Gene

Genomic Locations for MAP4 Gene
chr3:47,850,690-48,089,279
(GRCh38/hg38)
Size:
238,590 bases
Orientation:
Minus strand
chr3:47,892,180-48,130,769
(GRCh37/hg19)

Genomic View for MAP4 Gene

Genes around MAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP4 Gene

Proteins for MAP4 Gene

  • Protein details for MAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27816-MAP4_HUMAN
    Recommended name:
    Microtubule-associated protein 4
    Protein Accession:
    P27816
    Secondary Accessions:
    • Q13082
    • Q59FT2
    • Q68D74
    • Q6ZUW9
    • Q86V26
    • Q96A76
    • Q96NS9

    Protein attributes for MAP4 Gene

    Size:
    1152 amino acids
    Molecular mass:
    121005 Da
    Quaternary structure:
    • Interacts with SEPT2; this interaction impedes tubulin-binding. Interacts with TRAF3IP1 (By similarity).
    SequenceCaution:
    • Sequence=BAD92614.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP4 Gene

neXtProt entry for MAP4 Gene

Post-translational modifications for MAP4 Gene

  • Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.
  • Ubiquitination at isoforms=2, 6346
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MAP4 Gene

Domains & Families for MAP4 Gene

Gene Families for MAP4 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAP4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAP4: view

No data available for UniProtKB/Swiss-Prot for MAP4 Gene

Function for MAP4 Gene

Molecular function for MAP4 Gene

GENATLAS Biochemistry:
microtubule-associated protein 4,non neuronal
UniProtKB/Swiss-Prot Function:
Non-neuronal microtubule-associated protein. Promotes microtubule assembly.

Phenotypes From GWAS Catalog for MAP4 Gene

Gene Ontology (GO) - Molecular Function for MAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005198 structural molecule activity TAS 1905296
GO:0005515 protein binding IPI 17474147
GO:0008017 microtubule binding IBA --
GO:0015631 tubulin binding IEA --
genes like me logo Genes that share ontologies with MAP4: view
genes like me logo Genes that share phenotypes with MAP4: view

Animal Model Products

Clone Products

  • Addgene plasmids for MAP4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP4 Gene

Localization for MAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP4 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP4 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 4
plasma membrane 3
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Microtubules (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS 1905296
genes like me logo Genes that share ontologies with MAP4: view

Pathways & Interactions for MAP4 Gene

genes like me logo Genes that share pathways with MAP4: view

Pathways by source for MAP4 Gene

1 PharmGKB pathway for MAP4 Gene
1 GeneGo (Thomson Reuters) pathway for MAP4 Gene

SIGNOR curated interactions for MAP4 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007052 mitotic spindle organization IMP 21822276
GO:0031175 neuron projection development IBA --
GO:0051012 microtubule sliding IMP 21822276
GO:0051294 establishment of spindle orientation IMP 21822276
GO:0051301 cell division IMP 21822276
genes like me logo Genes that share ontologies with MAP4: view

Drugs & Compounds for MAP4 Gene

(9) Drugs for MAP4 Gene - From: DrugBank, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Target Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2040
Paclitaxel Approved, Vet_approved Pharma Target Tubulin and Bcl2 inhibitor, Taxanes 3027
Abraxane Approved October 2012 Pharma Taxanes 0
taxol Approved August 1997 Pharma Agonist 0

(1) Additional Compounds for MAP4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAP4: view

Transcripts for MAP4 Gene

Unigene Clusters for MAP4 Gene

Microtubule-associated protein 4:
Representative Sequences:

Clone Products

  • Addgene plasmids for MAP4

Alternative Splicing Database (ASD) splice patterns (SP) for MAP4 Gene

No ASD Table

Relevant External Links for MAP4 Gene

GeneLoc Exon Structure for
MAP4
ECgene alternative splicing isoforms for
MAP4

Expression for MAP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP4 Gene

mRNA differential expression in normal tissues according to GTEx for MAP4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.2) and Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for MAP4 Gene

This gene is overexpressed in Bone marrow stromal cell (13.6) and Amniocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP4 Gene



Protein tissue co-expression partners for MAP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP4 Gene:

MAP4

SOURCE GeneReport for Unigene cluster for MAP4 Gene:

Hs.517949

Evidence on tissue expression from TISSUES for MAP4 Gene

  • Nervous system(5)
  • Eye(4.8)
  • Muscle(4.7)
  • Heart(4.6)
  • Liver(4.5)
  • Blood(4.4)
  • Skin(3.5)
  • Intestine(3.3)
  • Kidney(3.2)
  • Lung(2.7)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with MAP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP4 Gene

Orthologs for MAP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP4 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP4 33 34
  • 83.29 (n)
cow
(Bos Taurus)
Mammalia MAP4 34 33
  • 80.14 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Map4 34 16 33
  • 76.54 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map4 33
  • 72.77 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP4 34
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 35 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MAP4 34
  • 24 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP4 34
  • 21 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1102 33
zebrafish
(Danio rerio)
Actinopterygii MAP4 (2 of 3) 34
  • 71 (a)
OneToMany
MAP4 (1 of 3) 34
  • 24 (a)
OneToMany
MAP4 (3 of 3) 34
  • 18 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta tau 34
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ptl-1 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11294 34
  • 19 (a)
OneToOne
Species where no ortholog for MAP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAP4 Gene

ENSEMBL:
Gene Tree for MAP4 (if available)
TreeFam:
Gene Tree for MAP4 (if available)

Paralogs for MAP4 Gene

Paralogs for MAP4 Gene

genes like me logo Genes that share paralogs with MAP4: view

Variants for MAP4 Gene

Sequence variations from dbSNP and Humsavar for MAP4 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs200339972 uncertain-significance, not provided 47,916,656(-) C/T coding_sequence_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, missense_variant
rs1000017073 -- 47,878,823(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000017921 -- 47,954,886(-) G/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000023716 -- 47,972,201(-) T/C/G genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000044246 -- 47,942,136(-) C/G genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP4 Gene

Variant ID Type Subtype PubMed ID
dgv8314n54 CNV loss 21841781
esv24589 CNV loss 19812545
esv2660438 CNV deletion 23128226
esv2676938 CNV deletion 23128226
esv2725244 CNV deletion 23290073
esv2725245 CNV deletion 23290073
esv3561849 CNV deletion 23714750
esv3568737 CNV loss 25503493
esv3575568 CNV gain 25503493
esv3575569 CNV gain 25503493
esv3596095 CNV loss 21293372
esv3596096 CNV loss 21293372
esv3596097 CNV gain 21293372
esv3596098 CNV loss 21293372
esv3893693 CNV loss 25118596
nsv1000817 CNV gain 25217958
nsv1001056 CNV gain 25217958
nsv1006560 CNV gain 25217958
nsv1012024 CNV gain 25217958
nsv508916 CNV insertion 20534489
nsv590234 CNV loss 21841781
nsv590239 CNV loss 21841781
nsv834679 CNV loss 17160897
nsv834681 CNV loss 17160897

Variation tolerance for MAP4 Gene

Residual Variation Intolerance Score: 26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.28; 98.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP4 Gene

Human Gene Mutation Database (HGMD)
MAP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP4 Gene

Disorders for MAP4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MAP4 Gene - From: HGMD, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MAP4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAP4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP4 Gene

Publications for MAP4 Gene

  1. Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau. (PMID: 1905296) Chapin SJ … Bulinski JC (Journal of cell science 1991) 2 3 4 22 58
  2. Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. (PMID: 16093351) Kremer BE … Macara IG (Molecular biology of the cell 2005) 3 4 22 58
  3. Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains. (PMID: 7857940) Chapin SJ … Bulinski JC (Biochemistry 1995) 3 4 22 58
  4. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain LV … van Duijn CM (Nature genetics 2011) 3 44 58
  5. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PMID: 19367581) So HC … Sham PC (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58

Products for MAP4 Gene

  • Addgene plasmids for MAP4

Sources for MAP4 Gene

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