The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubu... See more...

Aliases for MAP4 Gene

Aliases for MAP4 Gene

  • Microtubule Associated Protein 4 2 3 5
  • Microtubule-Associated Protein 4 3 4
  • MAP-4 3 4
  • MAP4 5

External Ids for MAP4 Gene

Previous GeneCards Identifiers for MAP4 Gene

  • GC03M047698
  • GC03M047175
  • GC03M047852
  • GC03M047853
  • GC03M047867
  • GC03M047892

Summaries for MAP4 Gene

Entrez Gene Summary for MAP4 Gene

  • The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for MAP4 Gene

MAP4 (Microtubule Associated Protein 4) is a Protein Coding gene. Diseases associated with MAP4 include Ovarian Clear Cell Adenocarcinoma and Dystonia 11, Myoclonic. Among its related pathways are Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics and Transcription_P53 signaling pathway. Gene Ontology (GO) annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot Summary for MAP4 Gene

  • Non-neuronal microtubule-associated protein. Promotes microtubule assembly.

Gene Wiki entry for MAP4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP4 Gene

Genomics for MAP4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MAP4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP4

Top Transcription factor binding sites by QIAGEN in the MAP4 gene promoter:
  • AML1a
  • E47
  • GATA-3
  • MAZR
  • Nkx2-5
  • Pax-4a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • RSRFC4

Genomic Locations for MAP4 Gene

Latest Assembly
chr3:47,850,690-48,089,272
(GRCh38/hg38)
Size:
238,583 bases
Orientation:
Minus strand

Previous Assembly
chr3:47,892,185-48,130,338
(GRCh37/hg19 by Entrez Gene)
Size:
238,154 bases
Orientation:
Minus strand

chr3:47,892,182-48,130,769
(GRCh37/hg19 by Ensembl)
Size:
238,588 bases
Orientation:
Minus strand

Genomic View for MAP4 Gene

Genes around MAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP4 Gene

Proteins for MAP4 Gene

  • Protein details for MAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27816-MAP4_HUMAN
    Recommended name:
    Microtubule-associated protein 4
    Protein Accession:
    P27816
    Secondary Accessions:
    • Q13082
    • Q59FT2
    • Q68D74
    • Q6ZUW9
    • Q86V26
    • Q96A76
    • Q96NS9

    Protein attributes for MAP4 Gene

    Size:
    1152 amino acids
    Molecular mass:
    121005 Da
    Quaternary structure:
    • Interacts with SEPTIN2; this interaction impedes tubulin-binding. Interacts with TRAF3IP1 (By similarity).
    SequenceCaution:
    • Sequence=BAD92614.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for MAP4 Gene

neXtProt entry for MAP4 Gene

Post-translational modifications for MAP4 Gene

  • Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.
  • Ubiquitination at Lys346, Lys498, and Lys946
  • Modification sites at PhosphoSitePlus

Other Protein References for MAP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP4 Gene

Domains & Families for MAP4 Gene

Gene Families for MAP4 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAP4 Gene

InterPro:
Blocks:
  • Tubulin-binding Tau protein

Suggested Antigen Peptide Sequences for MAP4 Gene

GenScript: Design optimal peptide antigens:
  • Microtubule-associated protein (B4DSQ1_HUMAN)
  • Microtubule-associated protein (B9ZVR1_HUMAN)
  • Microtubule-associated protein (E7EVA0_HUMAN)
  • Microtubule-associated protein (E9PGM5_HUMAN)
  • Microtubule-associated protein 4 (MAP4_HUMAN)
genes like me logo Genes that share domains with MAP4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MAP4 Gene

Function for MAP4 Gene

Molecular function for MAP4 Gene

UniProtKB/Swiss-Prot Function:
Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
GENATLAS Biochemistry:
microtubule-associated protein 4,non neuronal

Phenotypes From GWAS Catalog for MAP4 Gene

Gene Ontology (GO) - Molecular Function for MAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005198 structural molecule activity TAS 1905296
GO:0005515 protein binding IPI 17474147
GO:0008017 microtubule binding IEA,IBA 21873635
GO:0015631 tubulin binding IEA --
genes like me logo Genes that share ontologies with MAP4: view
genes like me logo Genes that share phenotypes with MAP4: view

miRNA for MAP4 Gene

miRTarBase miRNAs that target MAP4

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP4

Clone products for research

  • Addgene plasmids for MAP4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP4 Gene

Localization for MAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP4 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
nucleus 3
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Microtubules (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS 1905296
genes like me logo Genes that share ontologies with MAP4: view

Pathways & Interactions for MAP4 Gene

PathCards logo

SuperPathways for MAP4 Gene

SuperPathway Contained pathways
1 Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics
2 Transcription_P53 signaling pathway
-
genes like me logo Genes that share pathways with MAP4: view

Pathways by source for MAP4 Gene

1 PharmGKB pathway for MAP4 Gene
1 GeneGo (Thomson Reuters) pathway for MAP4 Gene
  • Transcription_P53 signaling pathway

SIGNOR curated interactions for MAP4 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA,ISS --
GO:0007052 mitotic spindle organization IMP 21822276
GO:0031175 neuron projection development IBA 21873635
GO:0051012 microtubule sliding IMP 21822276
GO:0051294 establishment of spindle orientation IMP 21822276
genes like me logo Genes that share ontologies with MAP4: view

Drugs & Compounds for MAP4 Gene

(8) Drugs for MAP4 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paclitaxel Approved, Vet_approved Pharma Target Tubulin and Bcl2 inhibitor, Taxanes 3989
Dihydroartemisinin Approved, Experimental, Investigational Pharma Target, ligand 123
Docetaxel Approved, Investigational Pharma Target Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2429

(1) Additional Compounds for MAP4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAP4: view

Transcripts for MAP4 Gene

mRNA/cDNA for MAP4 Gene

146 REFSEQ mRNAs :
30 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP4

Clone products for research

  • Addgene plasmids for MAP4

Alternative Splicing Database (ASD) splice patterns (SP) for MAP4 Gene

No ASD Table

Relevant External Links for MAP4 Gene

GeneLoc Exon Structure for
MAP4

Expression for MAP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP4 Gene

mRNA differential expression in normal tissues according to GTEx for MAP4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.2) and Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for MAP4 Gene

This gene is overexpressed in Bone marrow stromal cell (13.6) and Amniocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP4 Gene



Protein tissue co-expression partners for MAP4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP4

SOURCE GeneReport for Unigene cluster for MAP4 Gene:

Hs.517949

Evidence on tissue expression from TISSUES for MAP4 Gene

  • Nervous system(5)
  • Eye(4.8)
  • Muscle(4.7)
  • Heart(4.7)
  • Liver(4.6)
  • Blood(4.5)
  • Skin(3.8)
  • Intestine(3.6)
  • Kidney(3.5)
  • Lung(3.1)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with MAP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP4 Gene

Orthologs for MAP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MAP4 30
  • 91 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia MAP4 29 30
  • 83.29 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MAP4 29 30
  • 80.14 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Map4 29 16 30
  • 76.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Map4 29
  • 72.77 (n)
Oppossum
(Monodelphis domestica)
Mammalia MAP4 30
  • 38 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 35 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves MAP4 30
  • 24 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MAP4 30
  • 21 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1102 29
Zebrafish
(Danio rerio)
Actinopterygii MAP4 (2 of 3) 30
  • 71 (a)
OneToMany
MAP4 (1 of 3) 30
  • 24 (a)
OneToMany
MAP4 (3 of 3) 30
  • 18 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta tau 30
  • 17 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ptl-1 30
  • 17 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11294 30
  • 19 (a)
OneToOne
Species where no ortholog for MAP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for MAP4 Gene

ENSEMBL:
Gene Tree for MAP4 (if available)
TreeFam:
Gene Tree for MAP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP4: view image
Alliance of Genome Resources:
Additional Orthologs for MAP4

Paralogs for MAP4 Gene

(3) SIMAP similar genes for MAP4 Gene using alignment to 13 proteins:

  • MAP4_HUMAN
  • B4DSQ1_HUMAN
  • B5MEG9_HUMAN
  • B9ZVR1_HUMAN
  • E7EVA0_HUMAN
  • E9PGM5_HUMAN
  • F8W9U4_HUMAN
  • H0Y2V1_HUMAN
  • H7C456_HUMAN
  • H7C4C5_HUMAN
  • Q05D06_HUMAN
  • Q6NX68_HUMAN
  • Q86Y04_HUMAN
genes like me logo Genes that share paralogs with MAP4: view

No data available for Paralogs for MAP4 Gene

Variants for MAP4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP4 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs142463147 Likely Benign: not provided 47,916,279(-) C/T
NM_002375.5(MAP4):c.1548G>A (p.Leu516=)
SYNONYMOUS
rs148194575 Benign: not provided 47,998,750(-) A/G
NM_002375.5(MAP4):c.111T>C (p.Val37=)
SYNONYMOUS
rs182500657 Benign: not provided 47,977,856(-) A/C
NM_002375.5(MAP4):c.292+9T>G
INTRON
rs200339972 Uncertain Significance: not provided 47,916,656(-) C/T
NM_002375.5(MAP4):c.1171G>A (p.Ala391Thr)
MISSENSE
rs34711403 Benign: not provided 47,872,008(-) C/T
NM_002375.5(MAP4):c.2415G>A (p.Gln805=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MAP4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MAP4 Gene

Variant ID Type Subtype PubMed ID
dgv8314n54 CNV loss 21841781
esv24589 CNV loss 19812545
esv2660438 CNV deletion 23128226
esv2676938 CNV deletion 23128226
esv2725244 CNV deletion 23290073
esv2725245 CNV deletion 23290073
esv3561849 CNV deletion 23714750
esv3568737 CNV loss 25503493
esv3575568 CNV gain 25503493
esv3575569 CNV gain 25503493
esv3596095 CNV loss 21293372
esv3596096 CNV loss 21293372
esv3596097 CNV gain 21293372
esv3596098 CNV loss 21293372
esv3893693 CNV loss 25118596
nsv1000817 CNV gain 25217958
nsv1001056 CNV gain 25217958
nsv1006560 CNV gain 25217958
nsv1012024 CNV gain 25217958
nsv508916 CNV insertion 20534489
nsv590234 CNV loss 21841781
nsv590239 CNV loss 21841781
nsv834679 CNV loss 17160897
nsv834681 CNV loss 17160897

Variation tolerance for MAP4 Gene

Residual Variation Intolerance Score: 26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.28; 98.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP4 Gene

Human Gene Mutation Database (HGMD)
MAP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP4
Leiden Open Variation Database (LOVD)
MAP4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP4 Gene

Disorders for MAP4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAP4 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
ovarian clear cell adenocarcinoma
dystonia 11, myoclonic
  • dyt11
- elite association - COSMIC cancer census association via MalaCards
Search MAP4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAP4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MAP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP4 Gene

Publications for MAP4 Gene

  1. Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau. (PMID: 1905296) Chapin SJ … Bulinski JC (Journal of cell science 1991) 2 3 4 22
  2. Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. (PMID: 16093351) Kremer BE … Macara IG (Molecular biology of the cell 2005) 3 4 22
  3. Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains. (PMID: 7857940) Chapin SJ … Bulinski JC (Biochemistry 1995) 3 4 22
  4. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain LV … van Duijn CM (Nature genetics 2011) 3 40
  5. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PMID: 19367581) So HC … Sham PC (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 40

Products for MAP4 Gene

  • Addgene plasmids for MAP4

Sources for MAP4 Gene