Aliases for MAP3K9 Gene
External Ids for MAP3K9 Gene
Previous HGNC Symbols for MAP3K9 Gene
Previous GeneCards Identifiers for MAP3K9 Gene
GeneCards Summary for MAP3K9 Gene
MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9) is a Protein Coding gene. Diseases associated with MAP3K9 include Retroperitoneal Neuroblastoma and Esophagus Squamous Cell Carcinoma. Among its related pathways are PEDF Induced Signaling and Angiopoietin Like Protein 8 Regulatory Pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is MAP3K10.
UniProtKB/Swiss-Prot Summary for MAP3K9 Gene
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.