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This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8) is a Protein Coding gene. Diseases associated with MAP3K8 include Lung Cancer and Paronychia. Among its related pathways are Role of Calcineurin-dependent NFAT signaling in lymphocytes and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK24.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000287 | magnesium ion binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IBA,TAS | 21873635 |
GO:0004709 | MAP kinase kinase kinase activity | TAS | -- |
GO:0005515 | protein binding | IPI | 12832462 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | T cell receptor signaling pathway | ||
3 | Toll-like Receptor Signaling Pathway | ||
4 | CD28 co-stimulation | ||
5 | IL-1 signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000186 | activation of MAPKK activity | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0006468 | protein phosphorylation | TAS | 2072910 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007165 | signal transduction | IEA | -- |
Compound | Action | Cas Number |
---|---|---|
Cot inhibitor-1 | COT/Tpl2 inhibitor | 915365-57-0 |
Cot inhibitor-2 | COT/Tpl2 inhibitor | 915363-56-3 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP7: | - | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | MAP3K8 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | MAP3K8 33 32 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | MAP3K8 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | MAP3K8 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Map3k8 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Map3k8 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | MAP3K8 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | MAP3K8 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | MAP3K8 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | map3k8 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | map3k8 33 32 |
|
OneToOne | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BCK1 33 |
|
OneToMany |
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000244406 | -- | 30,436,871(+) | CCCC/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000316869 | -- | 30,453,217(+) | T/C | intron_variant | |
rs1000422699 | -- | 30,459,919(+) | T/G | intron_variant | |
rs1000475177 | -- | 30,459,615(+) | T/C | intron_variant | |
rs1000511223 | -- | 30,459,979(+) | A/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3303459 | CNV | mobile element insertion | 20981092 |
esv3377099 | CNV | insertion | 20981092 |
nsv1127096 | CNV | deletion | 24896259 |
nsv1129323 | OTHER | inversion | 24896259 |
nsv1161936 | CNV | duplication | 26073780 |
nsv831821 | CNV | loss | 17160897 |
nsv831822 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
lung cancer |
|
|
paronychia |
|
|