Aliases for MAP3K7CL Gene

Aliases for MAP3K7CL Gene

  • MAP3K7 C-Terminal Like 2 3 5
  • MAP3K7 C-Terminal-Like Protein 3 4
  • C21orf7 3 4
  • TAK1L 3 4
  • Chromosome 21 Open Reading Frame 7 2
  • TGF-Beta Activated Kinase 3
  • TAK1-Like Protein 1 3
  • TAK1-Like Protein 2 3
  • TAK1-Like Protein 4 3
  • TAK1-Like Protein 4
  • HC21ORF7 3
  • TAKL-1 3
  • TAKL-2 3
  • TAKL-4 3
  • TAKL 3

External Ids for MAP3K7CL Gene

Previous HGNC Symbols for MAP3K7CL Gene

  • C21orf7

Previous GeneCards Identifiers for MAP3K7CL Gene

  • GC21P030450

Summaries for MAP3K7CL Gene

GeneCards Summary for MAP3K7CL Gene

MAP3K7CL (MAP3K7 C-Terminal Like) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. An important paralog of this gene is MAP3K7.

Gene Wiki entry for MAP3K7CL Gene

Additional gene information for MAP3K7CL Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP3K7CL Gene

Genomics for MAP3K7CL Gene

GeneHancer (GH) Regulatory Elements for MAP3K7CL Gene

Promoters and enhancers for MAP3K7CL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J029071 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 502.5 -1.2 -1155 10.6 ZBTB40 ZNF217 EP300 ZSCAN5C TCF12 SIN3A MYC NRF1 POLR2G SP1 CCT8 MAP3K7CL piR-40348-025 piR-36531-015 piR-58297-288 LTN1 RPL12P9 ENSG00000231125 RWDD2B GRIK1-AS1
GH21J029129 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 500.2 +53.8 53806 3.8 JUND FOS NR2F2 ZNF316 NCOR1 POLR2A NBN FOSL1 TAL1 MAFK MAP3K7CL RWDD2B GRIK1-AS1 RPL12P9 lnc-CCT8-3
GH21J029144 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 513.7 +69.4 69437 7.4 JUND FOS POLR2A OSR2 BCL11A ZBTB17 CEBPG FOSL2 JUN FOSL1 MAP3K7CL RWDD2B CCT8 BACH1 LTN1 ENSG00000201984 LOC105372767
GH21J029121 Promoter/Enhancer 0.9 EPDnew ENCODE 505.3 +44.7 44720 1.5 POLR2A RELA NBN POU2F2 TBP TAF1 SPI1 ZNF687 PKNOX1 PAX8 MAP3K7CL BACH1 lnc-CCT8-2
GH21J029194 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 +117.9 117901 5 CTCF TCF12 NRF1 SP1 GTF2E2 JUND FOS ZNF639 ZBTB10 AFF1 BACH1 GRIK1-AS2 RPL23P2 LINC00189 USP16 MAP3K7CL CCT8 ENSG00000232855 GAPDHP14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP3K7CL on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP3K7CL

Genomic Locations for MAP3K7CL Gene

Genomic Locations for MAP3K7CL Gene
chr21:29,077,471-29,175,889
(GRCh38/hg38)
Size:
98,419 bases
Orientation:
Plus strand
chr21:30,449,792-30,548,210
(GRCh37/hg19)
Size:
98,419 bases
Orientation:
Plus strand

Genomic View for MAP3K7CL Gene

Genes around MAP3K7CL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K7CL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K7CL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K7CL Gene

Proteins for MAP3K7CL Gene

  • Protein details for MAP3K7CL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57077-M3KCL_HUMAN
    Recommended name:
    MAP3K7 C-terminal-like protein
    Protein Accession:
    P57077
    Secondary Accessions:
    • D3DSE0
    • Q8TCL9

    Protein attributes for MAP3K7CL Gene

    Size:
    242 amino acids
    Molecular mass:
    27248 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform B]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform C]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    SequenceCaution:
    • Sequence=CAB90434.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP3K7CL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K7CL Gene

Post-translational modifications for MAP3K7CL Gene

No Post-translational modifications

No data available for DME Specific Peptides for MAP3K7CL Gene

Domains & Families for MAP3K7CL Gene

Gene Families for MAP3K7CL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAP3K7CL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP3K7CL Gene

GenScript: Design optimal peptide antigens:
  • TAK1-like protein 4 (B0EVZ6_HUMAN)
  • TAK1-like protein 2 (B0EVZ7_HUMAN)
  • cDNA FLJ31779 fis, clone NT2RI2008204, highly similar to TAK1-like protein (B0EVZ8_HUMAN)
  • cDNA FLJ60482, highly similar to TAK1-like protein (B4DFW0_HUMAN)
  • TAK1-like protein (TAK1L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P57077

UniProtKB/Swiss-Prot:

M3KCL_HUMAN :
  • Contains a C-terminal domain similar to that of the C-terminal section of MAP3K7.
Domain:
  • Contains a C-terminal domain similar to that of the C-terminal section of MAP3K7.
genes like me logo Genes that share domains with MAP3K7CL: view

Function for MAP3K7CL Gene

Phenotypes From GWAS Catalog for MAP3K7CL Gene

Gene Ontology (GO) - Molecular Function for MAP3K7CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MAP3K7CL: view
genes like me logo Genes that share phenotypes with MAP3K7CL: view

Animal Model Products

CRISPR Products

miRNA for MAP3K7CL Gene

miRTarBase miRNAs that target MAP3K7CL

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K7CL

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP3K7CL Gene

Localization for MAP3K7CL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K7CL gene
Compartment Confidence
cytosol 3
extracellular 1
nucleus 1
endoplasmic reticulum 1
plasma membrane 0
mitochondrion 0
lysosome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAP3K7CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 16780588
GO:0005829 cytosol HDA 16780588
genes like me logo Genes that share ontologies with MAP3K7CL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K7CL Gene

Pathways & Interactions for MAP3K7CL Gene

PathCards logo

SuperPathways for MAP3K7CL Gene

genes like me logo Genes that share pathways with MAP3K7CL: view

Pathways by source for MAP3K7CL Gene

1 BioSystems pathway for MAP3K7CL Gene

Gene Ontology (GO) - Biological Process for MAP3K7CL Gene

None

No data available for SIGNOR curated interactions for MAP3K7CL Gene

Drugs & Compounds for MAP3K7CL Gene

No Compound Related Data Available

Transcripts for MAP3K7CL Gene

mRNA/cDNA for MAP3K7CL Gene

16 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K7CL

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K7CL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - - - - -
SP8: - -
SP9:

Relevant External Links for MAP3K7CL Gene

GeneLoc Exon Structure for
MAP3K7CL

Expression for MAP3K7CL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP3K7CL Gene

mRNA differential expression in normal tissues according to GTEx for MAP3K7CL Gene

This gene is overexpressed in Artery - Coronary (x4.9), Muscle - Skeletal (x4.5), Artery - Tibial (x4.3), and Artery - Aorta (x4.0).

Protein differential expression in normal tissues from HIPED for MAP3K7CL Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP3K7CL Gene



Protein tissue co-expression partners for MAP3K7CL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP3K7CL

SOURCE GeneReport for Unigene cluster for MAP3K7CL Gene:

Hs.222802

mRNA Expression by UniProt/SwissProt for MAP3K7CL Gene:

P57077-M3KCL_HUMAN
Tissue specificity: Detected in lung and peripheral blood leukocytes. Expressed predominantly in peripheral blood leukocytes and ubiquitously in adult and fetal tissues. Also expressed strongly in breast carcinoma GI-101, colon adenocarcinoma GI-112, and prostatic adenocarcinoma PC3.

Evidence on tissue expression from TISSUES for MAP3K7CL Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with MAP3K7CL: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K7CL Gene

Orthologs for MAP3K7CL Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP3K7CL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C21H21orf7 30
  • 99.59 (n)
MAP3K7CL 31
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map3k7cl 31
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1H21ORF7 31
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP3K7CL 31
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP3K7CL 31
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP3K7CL 31
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii map3k7cl 31
  • 40 (a)
OneToOne
Species where no ortholog for MAP3K7CL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K7CL Gene

ENSEMBL:
Gene Tree for MAP3K7CL (if available)
TreeFam:
Gene Tree for MAP3K7CL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP3K7CL: view image

Paralogs for MAP3K7CL Gene

Paralogs for MAP3K7CL Gene

(2) SIMAP similar genes for MAP3K7CL Gene using alignment to 4 proteins:

  • M3KCL_HUMAN
  • B4DFW0_HUMAN
  • C9J990_HUMAN
  • C9JLK6_HUMAN
genes like me logo Genes that share paralogs with MAP3K7CL: view

Variants for MAP3K7CL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP3K7CL Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
rs3746843 - p.Ile112Val

Additional dbSNP identifiers (rs#s) for MAP3K7CL Gene

Structural Variations from Database of Genomic Variants (DGV) for MAP3K7CL Gene

Variant ID Type Subtype PubMed ID
esv2657269 CNV deletion 23128226
esv2762103 CNV loss 21179565
esv3646793 CNV loss 21293372
esv3646794 CNV loss 21293372
esv3646795 CNV loss 21293372
esv3893404 CNV loss 25118596
esv6197 CNV gain 19470904
nsv1109430 CNV deletion 24896259
nsv1141968 OTHER inversion 24896259
nsv187427 CNV deletion 16902084
nsv3485 CNV deletion 18451855
nsv3486 CNV insertion 18451855
nsv479449 CNV novel sequence insertion 20440878
nsv480671 CNV novel sequence insertion 20440878
nsv509792 CNV insertion 20534489
nsv516083 CNV loss 19592680
nsv521462 CNV gain 19592680

Variation tolerance for MAP3K7CL Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP3K7CL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K7CL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K7CL Gene

Disorders for MAP3K7CL Gene

Additional Disease Information for MAP3K7CL

No disorders were found for MAP3K7CL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K7CL Gene

Publications for MAP3K7CL Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman RT … Brenner SE (Genome biology 2004) 3 4 54
  3. Cloning and characterization of a novel human TGF-beta activated kinase-like gene. (PMID: 15168726) Li J … Mao Y (Biochemical genetics 2004) 3 4 54
  4. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A … Antonarakis SE (Genomics 2001) 3 4 54
  5. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 54

Products for MAP3K7CL Gene

Sources for MAP3K7CL Gene