Aliases for MAP3K7CL Gene
Aliases for MAP3K7CL Gene
External Ids for MAP3K7CL Gene
- HGNC: 16457
- Entrez Gene: 56911
- Ensembl: ENSG00000156265
- OMIM: 611110
- UniProtKB: P57077
Previous HGNC Symbols for MAP3K7CL Gene
- C21orf7
Previous GeneCards Identifiers for MAP3K7CL Gene
- GC21P030450
Summaries for MAP3K7CL Gene
GeneCards Summary for MAP3K7CL Gene
MAP3K7CL (MAP3K7 C-Terminal Like) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway.
Additional gene information for MAP3K7CL Gene
- Monarch Initiative
- Search for MAP3K7CL at DataMed
- Search for MAP3K7CL at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K7CL Gene
Genomics for MAP3K7CL Gene
GeneHancer (GH) Regulatory Elements for MAP3K7CL Gene
Promoters and enhancers for MAP3K7CL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAP3K7CL on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MAP3K7CL Gene
Genomic Locations for MAP3K7CL Gene
- chr21:29,077,471-29,175,889
- (GRCh38/hg38)
- Size:
- 98,419 bases
- Orientation:
- Plus strand
- chr21:30,449,792-30,548,210
- (GRCh37/hg19)
- Size:
- 98,419 bases
- Orientation:
- Plus strand
Genomic View for MAP3K7CL Gene
Genes around MAP3K7CL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q21.3 by Entrez Gene
- 21q21.3 by HGNC
- 21q21.3 by Ensembl
MAP3K7CL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAP3K7CL Gene
Proteins for MAP3K7CL Gene
-
Protein details for MAP3K7CL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P57077-M3KCL_HUMAN
- Recommended name:
- MAP3K7 C-terminal-like protein
- Protein Accession:
- P57077
- D3DSE0
- Q8TCL9
Protein attributes for MAP3K7CL Gene
- Size:
- 242 amino acids
- Molecular mass:
- 27248 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=CAB90434.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for MAP3K7CL Gene
Post-translational modifications for MAP3K7CL Gene
No Post-translational modifications
Other Protein References for MAP3K7CL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MAP3K7CL
- Novus Biologicals Antibodies for MAP3K7CL
- Invitrogen Antibodies for MAP3K7CL (AFLGC-MAP3K7CL)
- GeneTex MAP3K7CL Antibody for MAP3K7CL
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAP3K7CL
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MAP3K7CL
- Origene Custom Protein Services for MAP3K7CL
- Search GeneTex for Proteins for MAP3K7CL
-
Abcam proteins for MAP3K7CL
Assay Products
No data available for DME Specific Peptides for MAP3K7CL Gene
Domains & Families for MAP3K7CL Gene
Gene Families for MAP3K7CL Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MAP3K7CL Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for MAP3K7CL Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P57077UniProtKB/Swiss-Prot:
M3KCL_HUMAN :- Contains a C-terminal domain similar to that of the C-terminal section of MAP3K7.
- Domain:
-
- Contains a C-terminal domain similar to that of the C-terminal section of MAP3K7.
Function for MAP3K7CL Gene
Phenotypes From GWAS Catalog for MAP3K7CL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004709 | MAP kinase kinase kinase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for MAP3K7CL Gene
- GenomeRNAi human phenotypes for MAP3K7CL:
-
- Increased HPV18 LCR reporter activity
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
- Decreased influenza A/WSN/33 replication
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAP3K7CL
-
CRISPR Products
-
OriGene CRISPR knockouts for MAP3K7CL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K7CL
- genomics-online: gRNA clones - Search results for available C21orf7 gene related products
- Applied Biological Materials CRISPR for MAP3K7CL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K7CL
- GenScript: Design CRISPR guide RNA sequences for MAP3K7CL
miRNA for MAP3K7CL Gene
- miRTarBase miRNAs that target MAP3K7CL
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K7CL
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K7CL
- genomics-online: shRNA clones - Search results for available C21orf7 gene related products
Clone Products
-
OriGene ORF clones in human for MAP3K7CL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAP3K7CL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K7CL
- genomics-online: cdna clones - Search results for available C21orf7 gene related products
- orf clones - Search results for available C21orf7 gene related products
- Applied Biological Materials Clones for MAP3K7CL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MAP3K7CL
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP3K7CL Gene
Localization for MAP3K7CL Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | HDA | 16780588 |
| GO:0005829 | cytosol | HDA | 16780588 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K7CL Gene
Pathways & Interactions for MAP3K7CL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Integrated Breast Cancer Pathway | ||
Pathways by source for MAP3K7CL Gene
1 BioSystems pathway for MAP3K7CL Gene
Interacting Proteins for MAP3K7CL Gene
Selected Interacting proteins:
P57077-M3KCL_HUMAN
ENSP00000343212
for MAP3K7CL Gene via
UniProtKB
IID
STRING
GPS-Prot Interaction Network for MAP3K7CL
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IEA | -- |
| GO:0000186 | activation of MAPKK activity | IBA | -- |
No data available for SIGNOR curated interactions for MAP3K7CL Gene
Transcripts for MAP3K7CL Gene
mRNA/cDNA for MAP3K7CL Gene
- (9) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (75) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000496779 1570 bps (uc032pxn.2)
- ENST00000419845 577 bps (uc061zkm.1)
- ENST00000492930 769 bps (uc061zkn.1)
- ENST00000341618 1855 bps (uc002yne.5)
- ENST00000399935 2093 bps (uc002ynd.5)
Unigene Clusters for MAP3K7CL Gene
- MAP3K7 C-terminal like:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MAP3K7CL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K7CL
- genomics-online: gRNA clones - Search results for available C21orf7 gene related products
- Applied Biological Materials CRISPR for MAP3K7CL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K7CL
- GenScript: Design CRISPR guide RNA sequences for MAP3K7CL
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K7CL
- Browse OriGene Inhibitory RNA Products For MAP3K7CL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K7CL
- genomics-online: shRNA clones - Search results for available C21orf7 gene related products
Clone Products
-
OriGene ORF clones in human for MAP3K7CL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAP3K7CL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K7CL
- genomics-online: cdna clones - Search results for available C21orf7 gene related products
- orf clones - Search results for available C21orf7 gene related products
- Applied Biological Materials Clones for MAP3K7CL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||
| SP9: |
Expression for MAP3K7CL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for MAP3K7CL Gene
This gene is overexpressed in Artery - Coronary (x4.9), Muscle - Skeletal (x4.5), Artery - Tibial (x4.3), and Artery - Aorta (x4.0).
This gene is overexpressed in Prostate (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP3K7CL Gene
NURSA nuclear receptor signaling pathways regulating expression of MAP3K7CL Gene:
MAP3K7CLSOURCE GeneReport for Unigene cluster for MAP3K7CL Gene:
Hs.222802mRNA Expression by UniProt/SwissProt for MAP3K7CL Gene:
P57077-M3KCL_HUMAN
Tissue specificity:
Detected in lung and peripheral blood leukocytes. Expressed predominantly in peripheral blood leukocytes and ubiquitously in adult and fetal tissues. Also expressed strongly in breast carcinoma GI-101, colon adenocarcinoma GI-112, and prostatic adenocarcinoma PC3.
Evidence on tissue expression from TISSUES for MAP3K7CL Gene
- Nervous system(4.6)
Primer Products
-
OriGene qPCR primer pairs for MAP3K7CL
- genomics-online: primer clones - Search results for available C21orf7 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K7CL Gene
Orthologs for MAP3K7CL Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C21H21orf7 33 |
|
||
| MAP3K7CL 34 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Map3k7cl 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | C1H21ORF7 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MAP3K7CL 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MAP3K7CL 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MAP3K7CL 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | map3k7cl 34 |
|
OneToOne |
- Species where no ortholog for MAP3K7CL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for MAP3K7CL Gene
- ENSEMBL:
- Gene Tree for MAP3K7CL (if available)
- TreeFam:
- Gene Tree for MAP3K7CL (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAP3K7CL: view image
Paralogs for MAP3K7CL Gene
(2) SIMAP similar genes for MAP3K7CL Gene using alignment to 4 proteins:
- M3KCL_HUMAN
- B4DFW0_HUMAN
- C9J990_HUMAN
- C9JLK6_HUMAN
No data available for Paralogs for MAP3K7CL Gene
Variants for MAP3K7CL Gene
| SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004672 | -- | 29,081,698(+) | C/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000024976 | -- | 29,124,973(+) | C/T | genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant | |
| rs1000099207 | -- | 29,138,112(+) | G/T | genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant | |
| rs1000108321 | -- | 29,096,514(+) | A/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000118299 | -- | 29,096,109(+) | T/A | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2657269 | CNV | deletion | 23128226 |
| esv2762103 | CNV | loss | 21179565 |
| esv3646793 | CNV | loss | 21293372 |
| esv3646794 | CNV | loss | 21293372 |
| esv3646795 | CNV | loss | 21293372 |
| esv3893404 | CNV | loss | 25118596 |
| esv6197 | CNV | gain | 19470904 |
| nsv1109430 | CNV | deletion | 24896259 |
| nsv1141968 | OTHER | inversion | 24896259 |
| nsv187427 | CNV | deletion | 16902084 |
| nsv3485 | CNV | deletion | 18451855 |
| nsv3486 | CNV | insertion | 18451855 |
| nsv479449 | CNV | novel sequence insertion | 20440878 |
| nsv480671 | CNV | novel sequence insertion | 20440878 |
| nsv509792 | CNV | insertion | 20534489 |
| nsv516083 | CNV | loss | 19592680 |
| nsv521462 | CNV | gain | 19592680 |
Residual Variation Intolerance Score:
65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.33;
41.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAP3K7CL Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MAP3K7CL
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K7CL Gene
Disorders for MAP3K7CL Gene
Additional Disease Information for MAP3K7CL
No disorders were found for MAP3K7CL Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K7CL Gene
Publications for MAP3K7CL Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Cloning and characterization of a novel human TGF-beta activated kinase-like gene. (PMID: 15168726) Li J … Mao Y (Biochemical genetics 2004) 3 4 58
- An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman RT … Brenner SE (Genome biology 2004) 3 4 58
- From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A … Antonarakis SE (Genomics 2001) 3 4 58
- The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 58
Products for MAP3K7CL Gene
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- Custom Antibody ServicesOriGene Antibodies for MAP3K7CL
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- Invitrogen Antibodies for MAP3K7CL (AFLGC-MAP3K7CL)
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- genomics-online: cdna clones - Search results for available C21orf7 gene related products
- orf clones - Search results for available C21orf7 gene related products
- genomics-online: gRNA clones - Search results for available C21orf7 gene related products
- genomics-online: primer clones - Search results for available C21orf7 gene related products
- genomics-online: shRNA clones - Search results for available C21orf7 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K7CL
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- GeneCopoeia miRNA 3'UTR Target clone products for MAP3K7CL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K7CL
Sources for MAP3K7CL Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
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