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Aliases for MAP3K7CL Gene

Aliases for MAP3K7CL Gene

  • MAP3K7 C-Terminal Like 2 3 5
  • C21orf7 3 4
  • TAK1L 3 4
  • Chromosome 21 Open Reading Frame 7 2
  • MAP3K7 C-Terminal-Like Protein 3
  • TGF-Beta Activated Kinase 3
  • TAK1-Like Protein 1 3
  • TAK1-Like Protein 2 3
  • TAK1-Like Protein 4 3
  • TAK1-Like Protein 4
  • HC21ORF7 3
  • TAKL-1 3
  • TAKL-2 3
  • TAKL-4 3
  • TAKL 3

External Ids for MAP3K7CL Gene

Previous HGNC Symbols for MAP3K7CL Gene

  • C21orf7

Previous GeneCards Identifiers for MAP3K7CL Gene

  • GC21P030450

Summaries for MAP3K7CL Gene

GeneCards Summary for MAP3K7CL Gene

MAP3K7CL (MAP3K7 C-Terminal Like) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway.

Gene Wiki entry for MAP3K7CL Gene

Additional gene information for MAP3K7CL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K7CL Gene

Genomics for MAP3K7CL Gene

GeneHancer (GH) Regulatory Elements for MAP3K7CL Gene

Promoters and enhancers for MAP3K7CL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I029089 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 550.4 +14.1 14115 3.6 HDGF HDAC1 FOXA2 MZF1 NFXL1 YBX1 RAD21 YY1 ZNF366 ZSCAN5C MAP3K7CL N6AMT1 USP16 RPL23P2 RWDD2B CCT8 GRIK1-AS1 LTN1 GRIK1 GC21P029079
GH21I029075 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE 552.6 +1.1 1111 6.1 PKNOX1 SMAD1 ZNF133 SIN3A YY1 ZNF207 ZNF548 SP3 NFYC TSHZ1 MAP3K7CL GC21P029079 ENSG00000231125 LTN1 CCT8 RWDD2B RPL12P9 USP16 RPL23P2 GRIK1-AS1
GH21I029109 Promoter 0.5 EPDnew 550.3 +31.7 31713 0.1 MAP3K7CL GC21M029128 GC21P029079
GH21I029193 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +118.3 118305 4.2 PKNOX1 FOXA2 ARNT IRF4 YY1 ZNF766 CBX5 ZNF143 FOS KLF13 BACH1 GRIK1-AS2 RPL23P2 LINC00189 USP16 MAP3K7CL ENSG00000232855 GC21M029206
GH21I029161 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.7 +85.9 85901 3.4 RAD21 ZBTB40 RFX5 ZNF335 EGR1 ZNF366 FOS EGR2 ZNF654 ZNF362 BACH1 ENSG00000224649 MAP3K7CL CCT8 BACH1-IT2 BACH1-AS1 LINC00189 USP16 LOC105372767 ENSG00000201984
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAP3K7CL on UCSC Golden Path with GeneCards custom track

Genomic Locations for MAP3K7CL Gene

Genomic Locations for MAP3K7CL Gene
98,419 bases
Plus strand

Genomic View for MAP3K7CL Gene

Genes around MAP3K7CL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K7CL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K7CL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K7CL Gene

Proteins for MAP3K7CL Gene

  • Protein details for MAP3K7CL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MAP3K7 C-terminal-like protein
    Protein Accession:
    Secondary Accessions:
    • D3DSE0
    • Q8TCL9

    Protein attributes for MAP3K7CL Gene

    242 amino acids
    Molecular mass:
    27248 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB90434.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP3K7CL Gene


neXtProt entry for MAP3K7CL Gene

Post-translational modifications for MAP3K7CL Gene

No Post-translational modifications

Antibody Products

  • Cloud-Clone Corp. Antibodies for MAP3K7CL
  • Santa Cruz Biotechnology (SCBT) Antibodies for MAP3K7CL

No data available for DME Specific Peptides for MAP3K7CL Gene

Domains & Families for MAP3K7CL Gene

Gene Families for MAP3K7CL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAP3K7CL Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains a C-terminal domain similar to that of the C-terminal section of MAP3K7.
  • Contains a C-terminal domain similar to that of the C-terminal section of MAP3K7.
genes like me logo Genes that share domains with MAP3K7CL: view

Function for MAP3K7CL Gene

Phenotypes From GWAS Catalog for MAP3K7CL Gene

Gene Ontology (GO) - Molecular Function for MAP3K7CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004709 MAP kinase kinase kinase activity IBA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MAP3K7CL: view
genes like me logo Genes that share phenotypes with MAP3K7CL: view

Animal Model Products

CRISPR Products

miRNA for MAP3K7CL Gene

miRTarBase miRNAs that target MAP3K7CL

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP3K7CL Gene

Localization for MAP3K7CL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K7CL gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
mitochondrion 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAP3K7CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,HDA 16780588
GO:0005829 cytosol HDA,IDA 16780588
genes like me logo Genes that share ontologies with MAP3K7CL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K7CL Gene

Pathways & Interactions for MAP3K7CL Gene

genes like me logo Genes that share pathways with MAP3K7CL: view

Pathways by source for MAP3K7CL Gene

1 BioSystems pathway for MAP3K7CL Gene

Gene Ontology (GO) - Biological Process for MAP3K7CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000186 activation of MAPKK activity IBA --
genes like me logo Genes that share ontologies with MAP3K7CL: view

No data available for SIGNOR curated interactions for MAP3K7CL Gene

Drugs & Compounds for MAP3K7CL Gene

No Compound Related Data Available

Transcripts for MAP3K7CL Gene

Unigene Clusters for MAP3K7CL Gene

MAP3K7 C-terminal like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K7CL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - - - - -
SP8: - -

Relevant External Links for MAP3K7CL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP3K7CL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP3K7CL Gene

mRNA differential expression in normal tissues according to GTEx for MAP3K7CL Gene

This gene is overexpressed in Artery - Coronary (x4.9), Muscle - Skeletal (x4.5), Artery - Tibial (x4.3), and Artery - Aorta (x4.0).

Protein differential expression in normal tissues from HIPED for MAP3K7CL Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP3K7CL Gene

Protein tissue co-expression partners for MAP3K7CL Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP3K7CL Gene:


SOURCE GeneReport for Unigene cluster for MAP3K7CL Gene:


mRNA Expression by UniProt/SwissProt for MAP3K7CL Gene:

Tissue specificity: Detected in lung and peripheral blood leukocytes. Expressed predominantly in peripheral blood leukocytes and ubiquitously in adult and fetal tissues. Also expressed strongly in breast carcinoma GI-101, colon adenocarcinoma GI-112, and prostatic adenocarcinoma PC3.

Evidence on tissue expression from TISSUES for MAP3K7CL Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with MAP3K7CL: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K7CL Gene

Orthologs for MAP3K7CL Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP3K7CL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C21H21orf7 33
  • 99.59 (n)
  • 99 (a)
(Mus musculus)
Mammalia Map3k7cl 34
  • 77 (a)
(Bos Taurus)
Mammalia C1H21ORF7 34
  • 66 (a)
(Canis familiaris)
Mammalia MAP3K7CL 34
  • 59 (a)
(Gallus gallus)
Aves MAP3K7CL 34
  • 52 (a)
(Anolis carolinensis)
Reptilia MAP3K7CL 34
  • 69 (a)
(Danio rerio)
Actinopterygii map3k7cl 34
  • 40 (a)
Species where no ortholog for MAP3K7CL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K7CL Gene

Gene Tree for MAP3K7CL (if available)
Gene Tree for MAP3K7CL (if available)

Paralogs for MAP3K7CL Gene

(2) SIMAP similar genes for MAP3K7CL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MAP3K7CL: view

No data available for Paralogs for MAP3K7CL Gene

Variants for MAP3K7CL Gene

Sequence variations from dbSNP and Humsavar for MAP3K7CL Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000004672 -- 29,081,698(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000024976 -- 29,124,973(+) C/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000099207 -- 29,138,112(+) G/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000108321 -- 29,096,514(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000118299 -- 29,096,109(+) T/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K7CL Gene

Variant ID Type Subtype PubMed ID
esv2657269 CNV deletion 23128226
esv2762103 CNV loss 21179565
esv3646793 CNV loss 21293372
esv3646794 CNV loss 21293372
esv3646795 CNV loss 21293372
esv3893404 CNV loss 25118596
esv6197 CNV gain 19470904
nsv1109430 CNV deletion 24896259
nsv1141968 OTHER inversion 24896259
nsv187427 CNV deletion 16902084
nsv3485 CNV deletion 18451855
nsv3486 CNV insertion 18451855
nsv479449 CNV novel sequence insertion 20440878
nsv480671 CNV novel sequence insertion 20440878
nsv509792 CNV insertion 20534489
nsv516083 CNV loss 19592680
nsv521462 CNV gain 19592680

Variation tolerance for MAP3K7CL Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP3K7CL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K7CL Gene

Disorders for MAP3K7CL Gene

Additional Disease Information for MAP3K7CL

No disorders were found for MAP3K7CL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K7CL Gene

Publications for MAP3K7CL Gene

  1. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman RT … Brenner SE (Genome biology 2004) 3 4 58
  2. Cloning and characterization of a novel human TGF-beta activated kinase-like gene. (PMID: 15168726) Li J … Mao Y (Biochemical genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A … Antonarakis SE (Genomics 2001) 3 4 58
  5. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 58

Products for MAP3K7CL Gene

Sources for MAP3K7CL Gene

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