Aliases for MAP3K6 Gene
Aliases for MAP3K6 Gene
External Ids for MAP3K6 Gene
- HGNC: 6858
- Entrez Gene: 9064
- Ensembl: ENSG00000142733
- OMIM: 604468
- UniProtKB: O95382
Previous GeneCards Identifiers for MAP3K6 Gene
- GC01P027901
- GC01M026713
- GC01M026914
- GC01M027286
- GC01M027554
- GC01M027681
- GC01M025937
Summaries for MAP3K6 Gene
-
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for MAP3K6 Gene
MAP3K6 (Mitogen-Activated Protein Kinase Kinase Kinase 6) is a Protein Coding gene. Diseases associated with MAP3K6 include Gastric Cancer, Hereditary Diffuse. Among its related pathways are G-Beta Gamma Signaling and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K5.
UniProtKB/Swiss-Prot for MAP3K6 Gene
-
Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.
Additional gene information for MAP3K6 Gene
- Monarch Initiative
- Search for MAP3K6 at DataMed
- Search for MAP3K6 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K6 Gene
Genomics for MAP3K6 Gene
GeneHancer (GH) Regulatory Elements for MAP3K6 Gene
Promoters and enhancers for MAP3K6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAP3K6 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MAP3K6 gene promoter:
-
- NF-kappaB1
- Elk-1
- YY1
- MZF-1
- AREB6
- STAT5A
- Tal-1beta
- ITF-2
- SEF-1 (1)
- p53
Regulatory Element Products
Genomic Locations for MAP3K6 Gene
Genomic Locations for MAP3K6 Gene
- chr1:27,355,179-27,368,014
- (GRCh38/hg38)
- Size:
- 12,836 bases
- Orientation:
- Minus strand
- chr1:27,681,670-27,693,383
- (GRCh37/hg19)
- Size:
- 11,714 bases
- Orientation:
- Minus strand
Genomic View for MAP3K6 Gene
Genes around MAP3K6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.11 by Entrez Gene
- 1p36.11 by HGNC
- 1p36.11 by Ensembl
MAP3K6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAP3K6 Gene
Proteins for MAP3K6 Gene
-
Protein details for MAP3K6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95382-M3K6_HUMAN
- Recommended name:
- Mitogen-activated protein kinase kinase kinase 6
- Protein Accession:
- O95382
- A2ACE8
- A2VDG4
- A2VDG5
- Q59HF4
- Q5SSD4
- Q75PK3
- Q96B75
Protein attributes for MAP3K6 Gene
- Size:
- 1288 amino acids
- Molecular mass:
- 142596 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Binds both upstream activators and downstream substrates in multimolecular complexes.
- SequenceCaution:
-
- Sequence=AAD05304.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MAP3K6 Gene
Post-translational modifications for MAP3K6 Gene
Other Protein References for MAP3K6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MAP3K6
-
Abcam antibodies for MAP3K6
- Invitrogen Antibodies for MAP3K6
- GeneTex MAP3K6 Antibody for MAP3K6
Protein Products
-
OriGene Purified Proteins for MAP3K6
- Search Origene for MassSpec and Protein Over-expression Lysates for MAP3K6
- Origene Custom Protein Services for MAP3K6
- antibodies-online: Search results for 7 available MAP3K6 Proteins ranked by validation data
- Compare Top MAP3K6 Proteins
-
Quality Products:
- Search GeneTex for Proteins for MAP3K6
-
Abcam proteins for MAP3K6
Assay Products
- antibodies-online: Search results for 4 available MAP3K6 Elisa Kits ranked by validation data
- Compare Top MAP3K6 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MAP3K6 Gene
Domains & Families for MAP3K6 Gene
Gene Families for MAP3K6 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MAP3K6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAP3K6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O95382UniProtKB/Swiss-Prot:
M3K6_HUMAN :- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Function for MAP3K6 Gene
Molecular function for MAP3K6 Gene
- UniProtKB/Swiss-Prot Function:
- Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.
Enzyme Numbers (IUBMB) for MAP3K6 Gene
Phenotypes From GWAS Catalog for MAP3K6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 9875215 |
| GO:0004672 | protein kinase activity | IEA,IBA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004709 | MAP kinase kinase kinase activity | TAS,IDA | 9875215 |
| GO:0005515 | protein binding | IEA | -- |
Phenotypes for MAP3K6 Gene
- MGI mutant phenotypes for MAP3K6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MAP3K6:
-
- Decreased substrate adherent cell growth
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased cell viability after pRB stimulation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased viability after Maraba virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased IL-8 secretion
- Increased simian virus 40 (SV40) infection
- Transferrin accumulation in the perinuclear area
Animal Models for MAP3K6 Gene
- MGI Knock Outs for MAP3K6:
-
- Map3k6 Map3k6<tm1Hijo>
Animal Model Products
-
Taconic Biosciences Mouse Models for MAP3K6
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAP3K6
-
CRISPR Products
-
OriGene CRISPR knockouts for MAP3K6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K6
- genomics-online: gRNA clones - Search results for available MAP3K6 gene related products
- Applied Biological Materials CRISPR for MAP3K6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K6
- GenScript: Design CRISPR guide RNA sequences for MAP3K6
miRNA for MAP3K6 Gene
- miRTarBase miRNAs that target MAP3K6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K6
- Browse OriGene Inhibitory RNA Products For MAP3K6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K6
- genomics-online: shRNA clones - Search results for available MAP3K6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MAP3K6
- VectorBuilder custom plasmid, inducible vectors for MAP3K6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAP3K6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAP3K6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K6
- genomics-online: cdna clones - Search results for available MAP3K6 gene related products
- orf clones - Search results for available MAP3K6 gene related products
- Applied Biological Materials Clones for MAP3K6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MAP3K6
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K6 Gene
Localization for MAP3K6 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 2 |
| mitochondrion | 1 |
- Actin filaments (2)
- Cytosol (2)
- Nucleus (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K6 Gene
Pathways & Interactions for MAP3K6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MAPK signaling pathway | ||
| 2 | TCR Signaling (Qiagen) |
.68
|
|
| 3 | Angiopoietin Like Protein 8 Regulatory Pathway | ||
| 4 | G-Beta Gamma Signaling |
.44
|
|
| 5 | Type I Interferon Signaling Pathways | ||
Pathways by source for MAP3K6 Gene
4 BioSystems pathways for MAP3K6 Gene
1 KEGG pathway for MAP3K6 Gene
9 Qiagen pathways for MAP3K6 Gene
Interacting Proteins for MAP3K6 Gene
Selected Interacting proteins:
ENSP00000350195
O95382-M3K6_HUMAN
for MAP3K6 Gene via
STRING
MINT
IID
GPS-Prot Interaction Network for MAP3K6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000186 | activation of MAPKK activity | IEA | -- |
| GO:0006468 | protein phosphorylation | IDA | 9875215 |
| GO:0007165 | signal transduction | TAS | 9875215 |
| GO:0007257 | activation of JUN kinase activity | TAS | 9875215 |
| GO:0016310 | phosphorylation | IEA | -- |
No data available for SIGNOR curated interactions for MAP3K6 Gene
Drugs & Compounds for MAP3K6 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Drug Products
Transcripts for MAP3K6 Gene
mRNA/cDNA for MAP3K6 Gene
- (4) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (121) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000486046 444 bps (uc057dvg.1)
- ENST00000472410 2530 bps (uc057dvh.1)
- ENST00000374040 4309 bps (uc009vsw.2)
- ENST00000493901 4309 bps (uc057dvi.1)
- ENST00000470890 956 bps (uc057dvj.1)
Unigene Clusters for MAP3K6 Gene
- Mitogen-activated protein kinase kinase kinase 6:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MAP3K6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K6
- genomics-online: gRNA clones - Search results for available MAP3K6 gene related products
- Applied Biological Materials CRISPR for MAP3K6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K6
- GenScript: Design CRISPR guide RNA sequences for MAP3K6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K6
- Browse OriGene Inhibitory RNA Products For MAP3K6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K6
- genomics-online: shRNA clones - Search results for available MAP3K6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MAP3K6
- VectorBuilder custom plasmid, inducible vectors for MAP3K6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAP3K6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAP3K6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K6
- genomics-online: cdna clones - Search results for available MAP3K6 gene related products
- orf clones - Search results for available MAP3K6 gene related products
- Applied Biological Materials Clones for MAP3K6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: |
| ExUns: | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: |
Expression for MAP3K6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- Ovary (Reproductive System)
This gene is overexpressed in Breast (19.6), Neutrophil (14.4), Plasma (13.4), and Heart (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP3K6 Gene
NURSA nuclear receptor signaling pathways regulating expression of MAP3K6 Gene:
MAP3K6SOURCE GeneReport for Unigene cluster for MAP3K6 Gene:
Hs.194694Evidence on tissue expression from TISSUES for MAP3K6 Gene
- Skin(4.3)
- Nervous system(4.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K6 Gene
Germ Layers:
- endoderm
- mesoderm
Systems:
- digestive
- immune
Regions:
Abdomen:
- stomach
Primer Products
-
OriGene qPCR primer pairs for MAP3K6
- genomics-online: primer clones - Search results for available MAP3K6 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MAP3K6 Gene
Orthologs for MAP3K6 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAP3K6 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MAP3K6 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MAP3K6 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Map3k6 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Map3k6 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MAP3K6 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MAP3K6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MAP3K6 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MAP3K6 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | MAP3K6 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Pk92B 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | nsy-1 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STE11 34 |
|
OneToMany |
- Species where no ortholog for MAP3K6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for MAP3K6 Gene
- ENSEMBL:
- Gene Tree for MAP3K6 (if available)
- TreeFam:
- Gene Tree for MAP3K6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAP3K6: view image
Paralogs for MAP3K6 Gene
(28) SIMAP similar genes for MAP3K6 Gene using alignment to 5 proteins:
- M3K6_HUMAN
- H0Y894_HUMAN
- H0Y8A3_HUMAN
- L8ECB4_HUMAN
- Q32MQ5_HUMAN
Variants for MAP3K6 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035629 | A breast cancer sample | p.Pro869Thr | |||
| VAR_046054 | A breast pleomorphic lobular carcinoma sample | p.Ser925Leu | |||
| VAR_046055 | An ovarian endometrioid cancer sample | p.Thr968Ile | |||
| rs35659744 | benign, not specified | 27,360,975(-) | G/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000284785 | -- | 27,356,168(-) | T/C | downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1006916 | CNV | deletion | 20482838 |
| nsv1075766 | CNV | deletion | 25765185 |
| nsv516766 | CNV | loss | 19592680 |
| nsv526051 | CNV | gain | 19592680 |
Residual Variation Intolerance Score:
36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.35;
92.67% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAP3K6 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K6 Gene
Disorders for MAP3K6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastric cancer, hereditary diffuse |
|
|
Search MAP3K6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAP3K6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MAP3K6 Gene
Publications for MAP3K6 Gene
- Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. (PMID: 17210579) Takeda K … Ichijo H (The Journal of biological chemistry 2007) 3 4 22 58
- MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5. (PMID: 9875215) Wang XS … Yao Z (Biochemical and biophysical research communications 1998) 2 3 4 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression. (PMID: 19246638) Eto N … Nangaku M (The American journal of pathology 2009) 3 22 58
- ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease. (PMID: 18327563) Arning L … Epplen JT (Journal of molecular medicine (Berlin, Germany) 2008) 3 44 58
Products for MAP3K6 Gene
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- Taconic Biosciences Mouse Models for MAP3K6
- Find your next knockout model in the Taconic Knockout Repository
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAP3K6
- antibodies-online: Search results for 62 available MAP3K6 Antibodies ranked by validation data
- Compare Top MAP3K6 Antibodies
- antibodies-online: Search results for 4 available MAP3K6 Elisa Kits ranked by validation data
- Compare Top MAP3K6 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 7 available MAP3K6 Proteins ranked by validation data
- Compare Top MAP3K6 Proteins
- Quality Products:
- GeneTex MAP3K6 Antibody for MAP3K6
- Search GeneTex for Proteins for MAP3K6
- Horizon Cell Lines for MAP3K6
- genomics-online: cdna clones - Search results for available MAP3K6 gene related products
- orf clones - Search results for available MAP3K6 gene related products
- genomics-online: gRNA clones - Search results for available MAP3K6 gene related products
- genomics-online: primer clones - Search results for available MAP3K6 gene related products
- genomics-online: shRNA clones - Search results for available MAP3K6 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K6
- GeneCopoeia miRNA 3'UTR Target clone products for MAP3K6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K6
Sources for MAP3K6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt