Aliases for MAP3K6 Gene
External Ids for MAP3K6 Gene
Previous GeneCards Identifiers for MAP3K6 Gene
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for MAP3K6 Gene
MAP3K6 (Mitogen-Activated Protein Kinase Kinase Kinase 6) is a Protein Coding gene. Diseases associated with MAP3K6 include Gastric Cancer, Hereditary Diffuse and Familial Adenomatous Polyposis 2. Among its related pathways are TCR Signaling (Qiagen) and IL-2 Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K5.
UniProtKB/Swiss-Prot Summary for MAP3K6 Gene
Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.