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This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
MAP3K6 (Mitogen-Activated Protein Kinase Kinase Kinase 6) is a Protein Coding gene. Diseases associated with MAP3K6 include Gastric Cancer, Hereditary Diffuse and Familial Adenomatous Polyposis 2. Among its related pathways are TCR Signaling (Qiagen) and IL-2 Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K5.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | IDA | 9875215 |
GO:0004672 | protein kinase activity | IBA | 21873635 |
GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
GO:0004709 | MAP kinase kinase kinase activity | TAS,IDA | 9875215 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MAPK signaling pathway | ||
2 | TCR Signaling (Qiagen) |
PKC-Theta Pathway
.68
|
TCR Signaling
.68
|
3 | Angiopoietin Like Protein 8 Regulatory Pathway | ||
4 | P38 MAPK Signaling Pathway (sino) | ||
5 | G-Beta Gamma Signaling |
CRHR Pathway
.44
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000186 | activation of MAPKK activity | IBA | 21873635 |
GO:0006468 | protein phosphorylation | IDA | 9875215 |
GO:0007165 | signal transduction | TAS | 9875215 |
GO:0007257 | activation of JUN kinase activity | TAS | 9875215 |
GO:0016310 | phosphorylation | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: |
ExUns: | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||
SP2: | |||||||||||
SP3: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MAP3K6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MAP3K6 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MAP3K6 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Map3k6 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Map3k6 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | MAP3K6 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MAP3K6 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MAP3K6 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MAP3K6 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | MAP3K6 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Pk92B 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | nsy-1 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STE11 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
718391 | Benign: not provided | 27,358,172(-) | T/A | INTRON_VARIANT | |
718416 | Benign: not provided | 27,358,309(-) | A/G | SYNONYMOUS_VARIANT | |
718726 | Benign: not provided | 27,362,681(-) | G/A | SYNONYMOUS_VARIANT | |
718894 | Likely Benign: not provided | 27,362,252(-) | T/C | SPLICE_ACCEPTOR_VARIANT | |
733210 | Likely Benign: not provided | 27,362,714(-) | T/C | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1006916 | CNV | deletion | 20482838 |
nsv1075766 | CNV | deletion | 25765185 |
nsv516766 | CNV | loss | 19592680 |
nsv526051 | CNV | gain | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
gastric cancer, hereditary diffuse |
|
|
familial adenomatous polyposis 2 |
|
|
periampullary adenoma |
|
|