Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and ho... See more...

Aliases for MAP3K5 Gene

Aliases for MAP3K5 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 5 2 3 4 5
  • MAPKKK5 2 3 4
  • ASK1 2 3 4
  • Apoptosis Signal-Regulating Kinase 1 3 4
  • MAPK/ERK Kinase Kinase 5 3 4
  • MEK Kinase 5 3 4
  • EC 2.7.11.25 4 50
  • MEKK 5 3 4
  • MEKK5 3 4
  • ASK-1 3 4
  • Apoptosis Signal Regulating Kinase 1 2
  • MAP/ERK Kinase Kinase 5 3
  • EC 2.7.11 50
  • MAP3K5 5

External Ids for MAP3K5 Gene

Previous HGNC Symbols for MAP3K5 Gene

  • MEKK5

Previous GeneCards Identifiers for MAP3K5 Gene

  • GC06M136500
  • GC06M136725
  • GC06M136858
  • GC06M136919
  • GC06M134442
  • GC06M136878

Summaries for MAP3K5 Gene

Entrez Gene Summary for MAP3K5 Gene

  • Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K5 Gene

MAP3K5 (Mitogen-Activated Protein Kinase Kinase Kinase 5) is a Protein Coding gene. Diseases associated with MAP3K5 include Non-Alcoholic Fatty Liver Disease and Fatty Liver Disease. Among its related pathways are Apoptosis Modulation and Signaling and Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is MAP3K15.

UniProtKB/Swiss-Prot Summary for MAP3K5 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).

Tocris Summary for MAP3K5 Gene

  • Apoptosis signal-regulated kinase 1 (ASK1) is a serine/threonine kinase, MAP3K family member, which induces apoptosis through the activation of JNK and p38. ASK1 has been implicated in the pathology of neurodegenerative and oxidative stress-related diseases.

Gene Wiki entry for MAP3K5 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP3K5 Gene

Genomics for MAP3K5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MAP3K5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J136782 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 256.7 +5.2 5216 12.2 BCLAF1 ZNF207 MYC IKZF1 ZNF654 ZNF600 JUND ZNF580 ZNF592 POLR2A MAP3K5 BCLAF1 PEX7 MTFR2 IFNGR1 ENSG00000286646 LOC101928429 MK280510 MAP7
GH06J136760 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 14.8 +28.5 28482 9.2 BCLAF1 IKZF1 ZNF592 YY1 BCL11A CEBPB TRIM22 ZNF341 RXRA IRF4 piR-35672-048 BCLAF1 PEX7 MAP3K5 RNA5SP219 MAP3K5-AS1 piR-32286-006 HSALNG0053718 MAP7
GH06J137222 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -430.7 -430676 3.5 BCLAF1 MYC ZNF592 CEBPA NFIC YY1 CTCF REST TRIM22 HOMEZ IFNGR1 MAP3K5 piR-46847-233 OLIG3
GH06J136606 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.9 +183.8 183756 5.7 ZNF654 NCOR1 IKZF1 JUND CEBPA ZNF217 CTCF REST CEBPB TRIM22 RF00017-5287 BCLAF1 RNA5SP219 MAP3K5 PEX7 MAP7 MAP3K5-AS1
GH06J136590 Enhancer 1.2 FANTOM5 Ensembl ENCODE 12 +199.5 199465 5.5 JUND BCL11A SIN3A TRIM22 MAFF IRF4 ELF1 ZNF316 EBF1 CBFB MAP3K5-AS1 MAP3K5 RNA5SP219 piR-60146-164 MAP7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP3K5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP3K5

Top Transcription factor binding sites by QIAGEN in the MAP3K5 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • p53
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for MAP3K5 Gene

Latest Assembly
chr6:136,557,046-136,793,098
(GRCh38/hg38)
Size:
236,053 bases
Orientation:
Minus strand

Previous Assembly
chr6:136,878,184-137,113,615
(GRCh37/hg19 by Entrez Gene)
Size:
235,432 bases
Orientation:
Minus strand

chr6:136,878,185-137,113,656
(GRCh37/hg19 by Ensembl)
Size:
235,472 bases
Orientation:
Minus strand

Genomic View for MAP3K5 Gene

Genes around MAP3K5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K5 Gene

Proteins for MAP3K5 Gene

  • Protein details for MAP3K5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99683-M3K5_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 5
    Protein Accession:
    Q99683
    Secondary Accessions:
    • A6NIA0
    • B4DGB2
    • Q5THN3
    • Q99461

    Protein attributes for MAP3K5 Gene

    Size:
    1374 amino acids
    Molecular mass:
    154537 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF (PubMed:15310755, PubMed:15701637, PubMed:17210579, PubMed:17389591). This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis. Interacts with SOCS1 which recognizes phosphorylation of Tyr-718 and induces MAP3K5/ASK1 degradation in endothelial cells. Interacts with the 14-3-3 family proteins such as YWHAB, YWHAE, YWHAQ, YWHAH, YWHAZ and SFN (PubMed:10411906, PubMed:15023544, PubMed:15094778). Interacts with ARRB2, BIRC2, DAB2IP, IGF1R, MAP3K6/ASK2, PGAM5, PIM1, PPP5C, SOCS1, STUB1, TRAF2, TRAF6 and TXN (PubMed:9564042,PubMed:9774977, PubMed:10688666, PubMed:11090355, PubMed:11689443, PubMed:12556535, PubMed:12813029, PubMed:15310755, PubMed:16038411, PubMed:16129676, PubMed:16407264, PubMed:17220297, PubMed:17724081, PubMed:18408005, PubMed:19590015, PubMed:19749799). Interacts with ERN1 in a TRAF2-dependent manner (PubMed:14749717). Interacts with calcineurin subunit PPP3R1 (By similarity). and with PPM1L (PubMed:17456047). Interacts (via N-terminus) with RAF1 and this interaction inhibits the proapoptotic function of MAP3K5 (PubMed:11427728). Interacts with DAB2IP (via N-terminus C2 domain); the interaction occurs in a TNF-alpha-dependent manner (PubMed:15310755). Interacts with DUSP13/DUSP13A; may positively regulate apoptosis (PubMed:20358250). Interacts with DAXX (PubMed:9743501). Interacts with RC3H2 (PubMed:24448648). Interacts with PPIA/CYPA (PubMed:26095851).
    • (Microbial infection) Interacts with HIV-1 Nef; this interaction inhibits MAP3K5 signaling.

    Three dimensional structures from OCA and Proteopedia for MAP3K5 Gene

    Alternative splice isoforms for MAP3K5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K5 Gene

Selected DME Specific Peptides for MAP3K5 Gene

Q99683:
  • LGKKGNL
  • LFGFQDAVN
  • YGIVYAGRDLSNQVRIAIKEIPERD
  • KISDFGTSK
  • VPGGSLS
  • NLLLSYRD

Post-translational modifications for MAP3K5 Gene

  • Phosphorylated at Thr-838 through autophosphorylation and by MAP3K6/ASK2 which leads to activation. Thr-838 is dephosphorylated by PPP5C. Ser-83 and Ser-1033 are inactivating phosphorylation sites, the former of which is phosphorylated by AKT1 and AKT2. Phosphorylated at Ser-966 which induces association of MAP3K5/ASK1 with the 14-3-3 family proteins and suppresses MAP3K5/ASK1 activity. Calcineurin (CN) dephosphorylates this site. Also dephosphorylated and activated by PGAM5. Phosphorylation at Ser-966 in response to oxidative stress is negatively regulated by PPIA/CYPA (PubMed:26095851).
  • Ubiquitinated. Tumor necrosis factor (TNF) induces TNFR2-dependent ubiquitination leading to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for MAP3K5

Domains & Families for MAP3K5 Gene

Gene Families for MAP3K5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for MAP3K5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50139, highly similar to Mitogen-activated protein kinase kinase kinase 5(EC 2.7.11.25) (A6NIA0_HUMAN)
  • MAPK/ERK kinase kinase 5 (M3K5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99683

UniProtKB/Swiss-Prot:

M3K5_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K5: view

Function for MAP3K5 Gene

Molecular function for MAP3K5 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence={ECO:0000269|PubMed:26095851};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence={ECO:0000269|PubMed:26095851};.
UniProtKB/Swiss-Prot Induction:
By TNF. Inhibited by HIV-1 Nef.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by various stressors, including oxidative stress, endoplasmic reticulum stress, and calcium overload, as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) and lipopolysaccharide (LPS). Homophilic association of MAP3K5/ASK1 through the C-terminal coiled-coil domains and the heteromeric complex formation of MAP3K5/ASK1 with the reduced form of thioredoxin (TXN), constitutes an inactive form of the kinase (PubMed:17210579, PubMed:9564042). Upon ROS-induced dissociation of TXN from MAP3K5/ASK1, TRAF2 and TRAF6 are reciprocally recruited to MAP3K5/ASK1 and form the active MAP3K5/ASK1 signalosome, in which TRAF2 and TRAF6 appear to facilitate the active configuration of MAP3K5/ASK1 (PubMed:9774977, PubMed:10688666, PubMed:11920685). MAP3K5/ASK1 activity is also regulated through several phosphorylation and dephosphorylation events. Thr-838 is an activating phosphorylation site that is autophosphorylated and phosphorylated by MAP3K6/ASK2 and dephosphorylated by PPP5C (PubMed:11689443). Ser-83 and Ser-1033 are inactivating phosphorylation sites, the former of which is phosphorylated by AKT1 and AKT2 (PubMed:11154276, PubMed:12697749, PubMed:15094778). Phosphorylation of Ser-966 induces association of MAP3K5/ASK1 with the 14-3-3 family proteins, which suppresses MAP3K5/ASK1 activity (PubMed:10411906, PubMed:14688258). Calcium/calmodulin-activated protein phosphatase calcineurin (PPP3CA) has been shown to directly dephosphorylate this site (PubMed:14749717). SOCS1 binds to ASK1 by recognizing phosphorylation of Tyr-718 and induces MAP3K5/ASK1 degradation in endothelial cells (PubMed:16407264). Also dephosphorylated and activated by PGAM5. Contains an N-terminal autoinhibitory domain. Once activated targeted for proteosomal degradation by RC3H2-mediated ubiquitination (PubMed:24448648).
GENATLAS Biochemistry:
mitogen activated protein (MAP/ERK) kinase kinase kinase 5

Enzyme Numbers (IUBMB) for MAP3K5 Gene

Phenotypes From GWAS Catalog for MAP3K5 Gene

Gene Ontology (GO) - Molecular Function for MAP3K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 17210579
GO:0004672 protein kinase activity IBA,IDA 11096076
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004709 MAP kinase kinase kinase activity TAS,IDA 17210579
genes like me logo Genes that share ontologies with MAP3K5: view
genes like me logo Genes that share phenotypes with MAP3K5: view

Animal Models for MAP3K5 Gene

MGI Knock Outs for MAP3K5:

Animal Models for research

  • Taconic Biosciences Mouse Models for MAP3K5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K5 Gene

Localization for MAP3K5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K5 Gene

Cytoplasm. Endoplasmic reticulum. Note=Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K5 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
plasma membrane 3
mitochondrion 3
nucleus 3
extracellular 2
cytoskeleton 2
peroxisome 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAP3K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 26095851
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol IEA,TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0032991 protein-containing complex IMP 11096076
genes like me logo Genes that share ontologies with MAP3K5: view

Pathways & Interactions for MAP3K5 Gene

genes like me logo Genes that share pathways with MAP3K5: view

Pathways by source for MAP3K5 Gene

7 GeneGo (Thomson Reuters) pathways for MAP3K5 Gene
  • Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
  • Apoptosis and survival FAS signaling cascades
  • Apoptosis and survival Lymphotoxin-beta receptor signaling
  • Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2
  • Development Angiotensin signaling via beta-Arrestin
1 R&D Systems pathway for MAP3K5 Gene
43 Qiagen pathways for MAP3K5 Gene
  • 14-3-3 and Regulation of BAD Activity
  • 14-3-3 Induced Apoptosis
  • 14-3-3 Induced Intracellular Signaling
  • 4-1BB Pathway
  • Akt Signaling
2 Cell Signaling Technology pathways for MAP3K5 Gene
3 GeneTex pathways for MAP3K5 Gene

SIGNOR curated interactions for MAP3K5 Gene

Gene Ontology (GO) - Biological Process for MAP3K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS,IDA 17210579
GO:0000186 activation of MAPKK activity IDA 11959862
GO:0000187 activation of MAPK activity IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with MAP3K5: view

Drugs & Compounds for MAP3K5 Gene

(25) Drugs for MAP3K5 Gene - From: PharmGKB, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydroxyurea Approved Pharma 276
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra 0
NQDI 1 Pharma ASK1, MAP3K5 inhibitor, ASK1 inhibitor 0
TC ASK 10 Pharma Potent and selective ASK1 inhibitor; orally bioavailable 0

(11) Additional Compounds for MAP3K5 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
MSC 2032964A
1124381-43-6

(3) Tocris Compounds for MAP3K5 Gene

Compound Action Cas Number
MSC 2032964A Potent and selective ASK1 inhibitor; orally bioavailable 1124381-43-6
NQDI 1 ASK1 inhibitor 175026-96-7
TC ASK 10 Potent and selective ASK1 inhibitor; orally bioavailable 1005775-56-3

(2) ApexBio Compounds for MAP3K5 Gene

Compound Action Cas Number
NQDI 1 ASK1, MAP3K5 inhibitor 175026-96-7
TC ASK 10 1005775-56-3
genes like me logo Genes that share compounds with MAP3K5: view

Drug products for research

Transcripts for MAP3K5 Gene

mRNA/cDNA for MAP3K5 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K5

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K5 Gene

No ASD Table

Relevant External Links for MAP3K5 Gene

GeneLoc Exon Structure for
MAP3K5

Expression for MAP3K5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP3K5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K5 Gene

This gene is overexpressed in Adrenal Gland (x5.6).

Protein differential expression in normal tissues from HIPED for MAP3K5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP3K5 Gene



Protein tissue co-expression partners for MAP3K5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP3K5

SOURCE GeneReport for Unigene cluster for MAP3K5 Gene:

Hs.186486

mRNA Expression by UniProt/SwissProt for MAP3K5 Gene:

Q99683-M3K5_HUMAN
Tissue specificity: Abundantly expressed in heart and pancreas.

Evidence on tissue expression from TISSUES for MAP3K5 Gene

  • Nervous system(4.7)
  • Liver(4.5)
  • Blood(4.5)
  • Lung(4.5)
  • Eye(4.4)
  • Heart(3)
  • Adrenal gland(2.8)
  • Kidney(2.7)
  • Muscle(2.6)
  • Spleen(2.6)
  • Pancreas(2.5)
  • Intestine(2.5)
  • Skin(2.4)
  • Lymph node(2.2)
  • Stomach(2.2)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with MAP3K5: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K5 Gene

Orthologs for MAP3K5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MAP3K5 29 30
  • 99.61 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MAP3K5 30
  • 93 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia MAP3K5 29 30
  • 92.43 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MAP3K5 29 30
  • 92.26 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Map3k5 29 16 30
  • 86.78 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Map3k5 29
  • 85.59 (n)
Oppossum
(Monodelphis domestica)
Mammalia MAP3K5 30
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MAP3K5 29 30
  • 81.29 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MAP3K5 30
  • 87 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100497692 29
  • 72.03 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30542 29
Zebrafish
(Danio rerio)
Actinopterygii map3k5 29 30
  • 68.35 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Pk92B 30 31
  • 39 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea nsy-1 30 31
  • 33 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE11 30
  • 22 (a)
OneToMany
Species where no ortholog for MAP3K5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MAP3K5 Gene

ENSEMBL:
Gene Tree for MAP3K5 (if available)
TreeFam:
Gene Tree for MAP3K5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP3K5: view image
Alliance of Genome Resources:
Additional Orthologs for MAP3K5

Paralogs for MAP3K5 Gene

Paralogs for MAP3K5 Gene

(12) SIMAP similar genes for MAP3K5 Gene using alignment to 2 proteins:

  • M3K5_HUMAN
  • A6NIA0_HUMAN
genes like me logo Genes that share paralogs with MAP3K5: view

Variants for MAP3K5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP3K5 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs114824668 Benign: not provided 136,614,151(-) T/C
NM_005923.4(MAP3K5):c.2278+8A>G
INTRON
rs142989545 Benign: not provided 136,792,134(-) G/A
NM_005923.4(MAP3K5):c.24C>T (p.Gly8=)
SYNONYMOUS
rs150394997 Benign: not provided 136,592,478(-) G/A
NM_005923.4(MAP3K5):c.3015C>T (p.Cys1005=)
SYNONYMOUS
rs35551087 Benign: not provided 136,567,644(-) T/Cp.Ile1250Val
NM_005923.4(MAP3K5):c.3748A>G (p.Ile1250Val)
MISSENSE
rs41288961 Benign: not provided 136,622,838(-) A/G
NM_005923.4(MAP3K5):c.2150+10T>C
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MAP3K5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MAP3K5 Gene

Variant ID Type Subtype PubMed ID
dgv404e215 CNV deletion 23714750
dgv6149n100 CNV gain 25217958
esv3610929 CNV loss 21293372
nsv1140697 CNV deletion 24896259
nsv1140698 CNV deletion 24896259
nsv464064 CNV loss 19166990
nsv475107 CNV novel sequence insertion 20440878
nsv604725 CNV loss 21841781
nsv604733 CNV gain 21841781

Variation tolerance for MAP3K5 Gene

Residual Variation Intolerance Score: 2.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP3K5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K5
Leiden Open Variation Database (LOVD)
MAP3K5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K5 Gene

Disorders for MAP3K5 Gene

MalaCards: The human disease database

(9) MalaCards diseases for MAP3K5 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
non-alcoholic fatty liver disease
  • nafld
fatty liver disease
  • alcoholic fatty liver
liver disease
  • disorder of liver
glottis squamous cell carcinoma
  • epidermoid carcinoma of the glottis
pyriform sinus cancer
  • malignant neoplasm of pyriform fossa
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAP3K5

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MAP3K5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP3K5 Gene

Publications for MAP3K5 Gene

  1. Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians. (PMID: 20185809) Bian L … Bogardus C (Diabetes 2010) 3 22 40
  2. Apoptosis signal-regulating kinase 1 in stress and immune response. (PMID: 17883330) Takeda K … Ichijo H (Annual review of pharmacology and toxicology 2008) 3 4 22
  3. Tumor necrosis factor receptor 2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling. (PMID: 17220297) Zhao Y … Ashwell JD (The Journal of biological chemistry 2007) 3 4 22
  4. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. (PMID: 17210579) Takeda K … Ichijo H (The Journal of biological chemistry 2007) 3 4 22
  5. RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation. (PMID: 17389591) Zhang H … Min W (The Journal of biological chemistry 2007) 3 4 22

Products for MAP3K5 Gene

Sources for MAP3K5 Gene