MAP3K4 Gene (Protein Coding)

Mitogen-Activated Protein Kinase Kinase Kinase 4

GC06P160991
GIFtS:
44
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresse... See more...

Aliases for MAP3K4 Gene

Aliases for MAP3K4 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 4 2 3 4 5
  • MAPKKK4 2 3 4
  • MTK1 2 3 4
  • MAPK/ERK Kinase Kinase 4 3 4
  • MAP Three Kinase 1 3 4
  • MEK Kinase 4 3 4
  • KIAA0213 2 4
  • MEKK 4 3 4
  • MEKK4 3 4
  • DJ473J16.1 (Mitogen-Activated Protein Kinase Kinase Kinase 4) 3
  • SSK2/SSK22 MAP Kinase Kinase Kinase, Yeast, Homolog Of 3
  • Predicted Protein Of HQ0412 3
  • MAP/ERK Kinase Kinase 4 3
  • EC 2.7.11.25 4
  • PRO0412 3
  • MAP3K4 5

External Ids for MAP3K4 Gene

Previous HGNC Symbols for MAP3K4 Gene

  • MEKK4

Previous GeneCards Identifiers for MAP3K4 Gene

  • GC06P160766
  • GC06P161286
  • GC06P161322
  • GC06P161383
  • GC06P161332
  • GC06P161412
  • GC06P158868

Summaries for MAP3K4 Gene

Entrez Gene Summary for MAP3K4 Gene

  • The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]

GeneCards Summary for MAP3K4 Gene

MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K2.

UniProtKB/Swiss-Prot Summary for MAP3K4 Gene

  • Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.

Gene Wiki entry for MAP3K4 Gene

Additional gene information for MAP3K4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP3K4 Gene

Genomics for MAP3K4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAP3K4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J160990 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 277.2 +0.5 480 3.2 MYC IKZF1 ZNF600 ZNF592 KLF9 POLR2A ZIC2 YY1 MXD4 NONO MAP3K4 NONHSAG045334.2 MAP3K4-AS1 AGPAT4
GH06J161270 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 23.9 +281.8 281764 3.8 IKZF1 MYC SIX5 JUND ATF2 ZNF10 POLR2A NONO SMAD5 SIN3A AGPAT4 MAP3K4 HSALNG0054882
GH06J161226 Enhancer 0.8 ENCODE 41.5 +233.6 233563 0.2 ZNF223 ZNF148 TRIM25 NCOR1 ZBTB5 ZNF658 RELA JUND HLTF MLLT1 MAP3K4 AGPAT4 HSALNG0054882
GH06J160876 Enhancer 0.7 Ensembl ENCODE 38.3 -113.8 -113820 2.2 NFIC LCORL ZNF518A ZC3H11A ZNF140 ZNF202 ZBTB8A ZNF266 ZBTB11 MAP3K4 CHP1P2 ENSG00000233342 lnc-MAP3K4-5 HSALNG0054850 LOC112267969 lnc-PLG-4 HSALNG0054845 ENSG00000224371 LOC107986665
GH06J160949 Enhancer 0.8 Ensembl ENCODE 24.9 -41.1 -41118 2.4 MYC BHLHE40 MNT TAL1 MAFK TCF12 ZBTB21 L3MBTL2 DPF2 ARID1B MAP3K4 HSALNG0054860-001 ENSG00000231863 ENSG00000224371 ENSG00000233342 LOC102724087 HSALNG0054860-002 PLG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP3K4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP3K4

Top Transcription factor binding sites by QIAGEN in the MAP3K4 gene promoter:
  • aMEF-2
  • AP-4
  • Egr-3
  • MyoD
  • NRSF form 1
  • NRSF form 2
  • RSRFC4
  • Spz1

Genomic Locations for MAP3K4 Gene

Latest Assembly
chr6:160,991,521-161,117,385
(GRCh38/hg38)
Size:
125,865 bases
Orientation:
Plus strand

Previous Assembly
chr6:161,412,801-161,538,412
(GRCh37/hg19 by Entrez Gene)
Size:
125,612 bases
Orientation:
Plus strand

chr6:161,412,759-161,538,417
(GRCh37/hg19 by Ensembl)
Size:
125,659 bases
Orientation:
Plus strand

Genomic View for MAP3K4 Gene

Genes around MAP3K4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAP3K4 Gene

Proteins for MAP3K4 Gene

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  • Protein details for MAP3K4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6R4-M3K4_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 4
    Protein Accession:
    Q9Y6R4
    Secondary Accessions:
    • A6H8W0
    • B7ZLD3
    • B9EG75
    • Q5VTT8
    • Q5VTT9
    • Q92612
    • Q9H408

    Protein attributes for MAP3K4 Gene

    Size:
    1608 amino acids
    Molecular mass:
    181685 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer and homodimer. Homodimerization enhances kinase activity. Interacts with TRAF4; this promotes homodimerization (PubMed:16157600). Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with AXIN1 and DIXDC1; interaction with DIXDC1 prevents interaction with AXIN1 (PubMed:15262978). Interacts with GADD45 and MAP2K6 (PubMed:12052864). Interacts with ZFP36; this interaction enhances the association with SH3KBP1/CIN85 (PubMed:20221403). Interacts with SH3KBP1; this interaction enhances the association with ZFP36 (PubMed:20221403). Interacts with CDC42 (By similarity).
    SequenceCaution:
    • Sequence=BAA13204.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP3K4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K4 Gene

Protein Expression for MAP3K4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MAP3K4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP3K4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP3K4 Gene

Domains & Families for MAP3K4 Gene

Gene Families for MAP3K4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MAP3K4 Gene

InterPro:

Suggested Antigen Peptide Sequences for MAP3K4 Gene

GenScript: Design optimal peptide antigens:
  • MAPK/ERK kinase kinase 4 (M3K4_HUMAN)
  • Mitogen-activated protein kinase kinase kinase 4 (Q5JR42_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6R4

UniProtKB/Swiss-Prot:

M3K4_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K4: view

Function for MAP3K4 Gene

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  6. Cell Lines for research

Molecular function for MAP3K4 Gene

UniProtKB/Swiss-Prot Function:
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25;.
UniProtKB/Swiss-Prot EnzymeRegulation:
N-terminal autoinhibitory domain interacts with the C-terminal kinase domain, inhibiting kinase activity, and preventing interaction with its substrate, MAP2K6. The GADD45 proteins activate the kinase by binding to the N-terminal domain. Activated by phosphorylation on Thr-1505.
GENATLAS Biochemistry:
mitogen activated protein (MAP/ERK) kinase kinase kinase 4,major mediator of environnemtal stress,activating the MAPK and JNK signal transduction pathway (see MAP4K4)

Enzyme Numbers (IUBMB) for MAP3K4 Gene

Phenotypes From GWAS Catalog for MAP3K4 Gene

Gene Ontology (GO) - Molecular Function for MAP3K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004709 MAP kinase kinase kinase activity IEA,IDA 9305639
GO:0005515 protein binding IPI 12052864
genes like me logo Genes that share ontologies with MAP3K4: view
genes like me logo Genes that share phenotypes with MAP3K4: view

Animal Models for MAP3K4 Gene

MGI Knock Outs for MAP3K4:

Animal Models for research

  • Taconic Biosciences Mouse Models for MAP3K4

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K4 Gene

Localization for MAP3K4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K4 Gene

Cytoplasm, perinuclear region. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K4 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP3K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 9827804
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MAP3K4: view

Pathways & Interactions for MAP3K4 Gene

PathCards logo

SuperPathways for MAP3K4 Gene

SuperPathway Contained pathways
1 Development Endothelin-1/EDNRA signaling
Development Endothelin-1/EDNRA signaling
.41
GnRH signaling pathway
.38
2 MAPK signaling pathway
MAPK signaling pathway
.45
MAPK Signaling Pathway
.45
3 B Cell Receptor Signaling Pathway (sino)
B Cell Receptor Signaling Pathway
.38
T Cell Receptor Signaling Pathway
.38
4 TNFR1 Pathway
TNF Signaling
.55
Apoptosis through Death Receptors
.42
5 4-1BB Pathway
CD27 Pathway
.48
TNFR2 Pathway
.37
genes like me logo Genes that share pathways with MAP3K4: view

Pathways by source for MAP3K4 Gene

2 KEGG pathways for MAP3K4 Gene
13 GeneGo (Thomson Reuters) pathways for MAP3K4 Gene
  • Development A1 receptor signaling
  • Development A2A receptor signaling
  • Development A2B receptor- action via G-protein alpha s
  • Development Beta-adrenergic receptors signaling via cAMP
  • Development Endothelin-1/EDNRA signaling
33 Qiagen pathways for MAP3K4 Gene
  • Antioxidant Action of Vitamin-C
  • Apoptosis through Death Receptors
  • CD27 Pathway
  • CRHR Pathway
  • CXCR4 Pathway

SIGNOR curated interactions for MAP3K4 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAP3K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000186 activation of MAPKK activity IDA 9305639
GO:0006468 protein phosphorylation IEA --
GO:0010225 response to UV-C IMP 9305639
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with MAP3K4: view

Drugs & Compounds for MAP3K4 Gene

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(4) Drugs for MAP3K4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for MAP3K4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0
genes like me logo Genes that share compounds with MAP3K4: view

Transcripts for MAP3K4 Gene

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mRNA/cDNA for MAP3K4 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K4

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - -
SP2:
SP3: - - -
SP4: -
SP5: -
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11: - -

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for MAP3K4 Gene

GeneLoc Exon Structure for
MAP3K4

Expression for MAP3K4 Gene

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  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP3K4 Gene

mRNA expression in normal human tissues for MAP3K4 Gene
mRNA expression by GTEx for MAP3K4 GenemRNA expression by BioGPS for MAP3K4 Gene

Protein differential expression in normal tissues from HIPED for MAP3K4 Gene

This gene is overexpressed in Testis (13.1), Ovary (10.9), Breast (8.1), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP3K4 Gene



Protein tissue co-expression partners for MAP3K4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP3K4

SOURCE GeneReport for Unigene cluster for MAP3K4 Gene:

Hs.390428

mRNA Expression by UniProt/SwissProt for MAP3K4 Gene:

Q9Y6R4-M3K4_HUMAN
Tissue specificity: Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.

Evidence on tissue expression from TISSUES for MAP3K4 Gene

  • Nervous system(4.7)
  • Muscle(4.4)
  • Bone marrow(4.3)
  • Skin(2.2)
  • Kidney(2.1)
  • Heart(2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with MAP3K4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K4 Gene

Orthologs for MAP3K4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MAP3K4 29
  • 97.75 (n)
Dog
(Canis familiaris)
 Mammalia MAP3K4 29 30
  • 89.79 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia MAP3K4 30
  • 88 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MAP3K4 30
  • 87 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MAP3K4 29 30
  • 86.4 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Map3k4 29
  • 84.64 (n)
Mouse
(Mus musculus)
 Mammalia Map3k4 29 16 30
  • 83.67 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves MAP3K4 29 30
  • 80.69 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MAP3K4 30
  • 82 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia map3k4 29
  • 73.15 (n)
Str.625 29
African clawed frog
(Xenopus laevis)
 Amphibia Xl.15863 29
Zebrafish
(Danio rerio)
 Actinopterygii map3k4 29 30
  • 66.87 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002371 29
  • 48.44 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Mekk1 29 30 31
  • 45.83 (n)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea mtk-1 31
  • 36 (a)
F18F11.5 30
  • 24 (a)
 OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SSK22 30
  • 21 (a)
 OneToMany
SSK2 30 32
  • 18 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 58 (a)
 OneToOne
Species where no ortholog for MAP3K4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MAP3K4 Gene

ENSEMBL:
Gene Tree for MAP3K4 (if available)
TreeFam:
Gene Tree for MAP3K4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP3K4: view image
Alliance of Genome Resources:
Additional Orthologs for MAP3K4

Paralogs for MAP3K4 Gene

Paralogs for MAP3K4 Gene

(35) SIMAP similar genes for MAP3K4 Gene using alignment to 7 proteins:

  • M3K4_HUMAN
  • F5H1X6_HUMAN
  • F5H2S6_HUMAN
  • F5H4R1_HUMAN
  • F5H534_HUMAN
  • F5H538_HUMAN
  • J3KNB8_HUMAN
genes like me logo Genes that share paralogs with MAP3K4: view

Variants for MAP3K4 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP3K4 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs118042662 Benign: not provided 161,108,866(+) C/T
NM_005922.4(MAP3K4):c.4236+7C>T 		INTRON
rs376137087 Likely Benign: not provided 161,092,006(+) A/C
NM_005922.4(MAP3K4):c.3136-4A>C 		INTRON
rs55704622 Benign: not provided 161,091,414(+) T/A
NM_005922.4(MAP3K4):c.3009T>A (p.Asn1003Lys) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
VAR_040691 An ovarian serous carcinoma sample p.Glu1413Gln
rs34018542 -- p.Gln584His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MAP3K4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MAP3K4 Gene

Variant ID Type Subtype PubMed ID
esv1009798 CNV deletion 20482838
esv1022211 CNV deletion 17803354
esv2287098 CNV deletion 18987734
esv2422347 CNV duplication 17116639
esv2733067 CNV deletion 23290073
esv2733068 CNV deletion 23290073
esv2733069 CNV deletion 23290073
esv2733070 CNV deletion 23290073
esv2733071 CNV deletion 23290073
esv3576242 CNV gain 25503493
esv3611453 CNV gain 21293372
esv5229 CNV loss 18987735
nsv1026543 CNV gain 25217958
nsv1030045 CNV gain 25217958
nsv1030852 CNV gain 25217958
nsv1074442 CNV deletion 25765185
nsv1074443 CNV deletion 25765185
nsv1130850 CNV deletion 24896259
nsv1137172 CNV deletion 24896259
nsv1137559 CNV deletion 24896259
nsv1143327 CNV deletion 24896259
nsv1146290 CNV deletion 26484159
nsv1148627 CNV deletion 26484159
nsv949883 CNV duplication 24416366

Variation tolerance for MAP3K4 Gene

Residual Variation Intolerance Score: 3.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP3K4 Gene

Human Gene Mutation Database (HGMD)
MAP3K4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K4
Leiden Open Variation Database (LOVD)
MAP3K4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K4 Gene

Disorders for MAP3K4 Gene

Additional Disease Information for MAP3K4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MAP3K4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K4 Gene

Publications for MAP3K4 Gene

  1. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. (PMID: 9305639) Takekawa M … Saito H (The EMBO journal 1997) 2 3 4 22
  2. Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85. (PMID: 20221403) Kedar VP … Blackshear PJ (PloS one 2010) 3 4 22
  3. MEKK4 is an effector of the embryonic TRAF4 for JNK activation. (PMID: 16157600) Abell AN … Johnson GL (The Journal of biological chemistry 2005) 3 4 22
  4. The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. (PMID: 15262978) Wong CK … Lin SC (The Journal of biological chemistry 2004) 3 4 22
  5. Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. (PMID: 20624154) Grucza RA … Bierut LJ (Addiction biology 2010) 3 40

ExternalLinks

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Products for MAP3K4 Gene

Sources for MAP3K4 Gene