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The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresse... See more...
Aliases for MAP3K4 Gene
Aliases for MAP3K4 Gene
External Ids for MAP3K4 Gene
- HGNC: 6856
- Entrez Gene: 4216
- Ensembl: ENSG00000085511
- OMIM: 602425
- UniProtKB: Q9Y6R4
Previous HGNC Symbols for MAP3K4 Gene
- MEKK4
Previous GeneCards Identifiers for MAP3K4 Gene
- GC06P160766
- GC06P161286
- GC06P161322
- GC06P161383
- GC06P161332
- GC06P161412
- GC06P158868
Summaries for MAP3K4 Gene
-
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]
GeneCards Summary for MAP3K4 Gene
MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4) is a Protein Coding gene. Among its related pathways are NGF Pathway and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K2.
UniProtKB/Swiss-Prot Summary for MAP3K4 Gene
-
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
Additional gene information for MAP3K4 Gene
- HGNC(6856)
- Entrez Gene(4216)
- Ensembl(ENSG00000085511)
- OMIM(602425)
- UniProtKB(Q9Y6R4)
- Open Targets Platform(ENSG00000085511)
- Monarch Initiative
- Search for MAP3K4 at DataMed
- Search for MAP3K4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP3K4 Gene
Genomics for MAP3K4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MAP3K4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAP3K4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP3K4
- Top Transcription factor binding sites by QIAGEN in the MAP3K4 gene promoter:
-
- aMEF-2
- AP-4
- Egr-3
- MyoD
- NRSF form 1
- NRSF form 2
- RSRFC4
- Spz1
Genomic Locations for MAP3K4 Gene
Genomic Locations for MAP3K4 Gene
- chr6:160,991,521-161,117,385
- (GRCh38/hg38)
- Size:
- 125,865 bases
- Orientation:
- Plus strand
- chr6:161,412,759-161,538,417
- (GRCh37/hg19)
- Size:
- 125,659 bases
- Orientation:
- Plus strand
Genomic View for MAP3K4 Gene
Genes around MAP3K4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q26 by HGNC
- 6q26 by Entrez Gene
- 6q26 by Ensembl
MAP3K4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAP3K4 Gene
Proteins for MAP3K4 Gene
-
Protein details for MAP3K4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6R4-M3K4_HUMAN
- Recommended name:
- Mitogen-activated protein kinase kinase kinase 4
- Protein Accession:
- Q9Y6R4
- A6H8W0
- B7ZLD3
- B9EG75
- Q5VTT8
- Q5VTT9
- Q92612
- Q9H408
Protein attributes for MAP3K4 Gene
- Size:
- 1608 amino acids
- Molecular mass:
- 181685 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Monomer and homodimer. Homodimerization enhances kinase activity. Interacts with TRAF4; this promotes homodimerization (PubMed:16157600). Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with AXIN1 and DIXDC1; interaction with DIXDC1 prevents interaction with AXIN1 (PubMed:15262978). Interacts with GADD45 and MAP2K6 (PubMed:12052864). Interacts with ZFP36; this interaction enhances the association with SH3KBP1/CIN85 (PubMed:20221403). Interacts with SH3KBP1; this interaction enhances the association with ZFP36 (PubMed:20221403). Interacts with CDC42 (By similarity).
- SequenceCaution:
-
- Sequence=BAA13204.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for MAP3K4 Gene
Post-translational modifications for MAP3K4 Gene
Other Protein References for MAP3K4 Gene
Antibody Products
- G Biosciences Immunotag™ MAP3K4 Antibody
-
Custom Antibody ServicesOriGene Antibodies for MAP3K4
- Novus Biologicals Antibodies for MAP3K4
-
Abcam antibodies for MAP3K4
- Invitrogen Antibodies for MAP3K4 (AFLGC-MAP3K4)
- antibodies-online: Show 17 available MAP3K4 Antibodies ranked by validation data
- Compare Top MAP3K4 Antibodies
-
Recommended
- 12 IF (p) Antibodies (anti-rat)
- 11 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 48 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 14 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAP3K4
Protein Products
-
OriGene Purified Proteins for MAP3K4
- Search Origene for MassSpec and Protein Over-expression Lysates for MAP3K4
- Origene Custom Protein Services for MAP3K4
- Novus Biologicals proteins for MAP3K4
-
Abcam proteins for MAP3K4
No data available for DME Specific Peptides for MAP3K4 Gene
Domains & Families for MAP3K4 Gene
Gene Families for MAP3K4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for MAP3K4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAP3K4 Gene
- GenScript: Design optimal peptide antigens:
-
- MAPK/ERK kinase kinase 4 (M3K4_HUMAN)
- Mitogen-activated protein kinase kinase kinase 4 (Q5JR42_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y6R4UniProtKB/Swiss-Prot:
M3K4_HUMAN :- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Function for MAP3K4 Gene
Molecular function for MAP3K4 Gene
- UniProtKB/Swiss-Prot Function:
- Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- N-terminal autoinhibitory domain interacts with the C-terminal kinase domain, inhibiting kinase activity, and preventing interaction with its substrate, MAP2K6. The GADD45 proteins activate the kinase by binding to the N-terminal domain. Activated by phosphorylation on Thr-1505.
- GENATLAS Biochemistry:
- mitogen activated protein (MAP/ERK) kinase kinase kinase 4,major mediator of environnemtal stress,activating the MAPK and JNK signal transduction pathway (see MAP4K4)
Enzyme Numbers (IUBMB) for MAP3K4 Gene
Phenotypes From GWAS Catalog for MAP3K4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IBA | -- |
| GO:0004709 | MAP kinase kinase kinase activity | IEA,IDA | 9305639 |
| GO:0005515 | protein binding | IPI | 12052864 |
Phenotypes for MAP3K4 Gene
- MGI mutant phenotypes for MAP3K4:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for MAP3K4:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Increased cell death HMECs cells
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased shRNA abundance (Z-score < -2)
- Reduced mammosphere formation
- Increased apoptosis
- Decreased telomerase activity
- Increased shRNA abundance (Z-score > 2)
- Decreased ionizing radiation sensitivity
- Increased cell death in DLD-1 cells
- Decreased cell proliferation
Animal Models for MAP3K4 Gene
- MGI Knock Outs for MAP3K4:
-
- Map3k4 Map3k4<tm1Flv>
Animal Model Products
-
Taconic Biosciences Mouse Models for MAP3K4
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAP3K4 - Select products 50% OFF >
- * MAP3K4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAP3K4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K4
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K4
miRNA for MAP3K4 Gene
- miRTarBase miRNAs that target MAP3K4
-
- hsa-miR-124-3p (MIRT022893)
- hsa-miR-148a-3p (MIRT048040)
- hsa-miR-93-5p (MIRT048846)
- hsa-miR-92a-3p (MIRT049769)
- hsa-miR-199a-3p (MIRT099168)
- hsa-miR-199b-3p (MIRT099169)
- hsa-miR-1245a (MIRT099172)
- hsa-miR-3123 (MIRT099173)
- hsa-miR-3129-5p (MIRT099174)
- hsa-miR-3691-3p (MIRT099176)
- hsa-miR-6073 (MIRT099178)
- hsa-miR-8062 (MIRT099180)
- hsa-miR-8079 (MIRT099181)
- hsa-miR-144-3p (MIRT493268)
- hsa-miR-101-3p (MIRT493269)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K4
- Browse OriGene Inhibitory RNA Products For MAP3K4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K4
Clone Products
- Applied Biological Materials (abm): Clones for MAP3K4 - Select products 50% OFF >
- * MAP3K4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MAP3K4
- Addgene plasmids for MAP3K4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K4
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K4 Gene
Localization for MAP3K4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAP3K4 Gene
- Cytoplasm, perinuclear region. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| nucleus | 3 |
| extracellular | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA,IDA | 9827804 |
| GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
Pathways & Interactions for MAP3K4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Development Endothelin-1/EDNRA signaling |
Development Endothelin-1/EDNRA signaling
.41
|
|
| 2 | MAPK signaling pathway | ||
| 3 | B Cell Receptor Signaling Pathway (sino) | ||
| 4 | TNFR1 Pathway |
TNF Signaling
.55
|
Apoptosis through Death Receptors
.42
|
| 5 | 4-1BB Pathway |
CD27 Pathway
.48
|
TNFR2 Pathway
.37
|
Pathways by source for MAP3K4 Gene
4 Sino Biological pathways for MAP3K4 Gene
7 BioSystems pathways for MAP3K4 Gene
2 KEGG pathways for MAP3K4 Gene
13 GeneGo (Thomson Reuters) pathways for MAP3K4 Gene
- Development A1 receptor signaling
- Development A2A receptor signaling
- Development A2B receptor- action via G-protein alpha s
- Development Beta-adrenergic receptors signaling via cAMP
- Development Endothelin-1/EDNRA signaling
33 Qiagen pathways for MAP3K4 Gene
- Antioxidant Action of Vitamin-C
- Apoptosis through Death Receptors
- CD27 Pathway
- CRHR Pathway
- CXCR4 Pathway
Interacting Proteins for MAP3K4 Gene
Selected Interacting proteins:
Q9Y6R4-M3K4_HUMAN
ENSP00000375986
for MAP3K4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MAP3K4
SIGNOR curated interactions for MAP3K4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IEA | -- |
| GO:0000186 | activation of MAPKK activity | IDA | 9305639 |
| GO:0001890 | placenta development | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007346 | regulation of mitotic cell cycle | IBA | -- |
Drugs & Compounds for MAP3K4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Transcripts for MAP3K4 Gene
mRNA/cDNA for MAP3K4 Gene
- 5 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000348824 5295 nts (view in UCSC)
- ENST00000366919 5397 nts (view in UCSC)
- ENST00000366920 5445 nts (view in UCSC)
- ENST00000392142 5500 nts (view in UCSC)
- ENST00000446500 326 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAP3K4 - Select products 50% OFF >
- * MAP3K4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAP3K4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K4
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K4
- Browse OriGene Inhibitory RNA Products For MAP3K4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K4
Clone Products
- Applied Biological Materials (abm): Clones for MAP3K4 - Select products 50% OFF >
- * MAP3K4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MAP3K4
- Addgene plasmids for MAP3K4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K4
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - |
| ExUns: | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||
| SP2: | - | - | |||||||||||||
| SP3: | |||||||||||||||
| SP4: | |||||||||||||||
| SP5: | |||||||||||||||
| SP6: | - | ||||||||||||||
| SP7: | |||||||||||||||
| SP8: | |||||||||||||||
| SP9: | |||||||||||||||
| SP10: | |||||||||||||||
| SP11: |
Relevant External Links for MAP3K4 Gene
- GeneLoc Exon Structure for
- MAP3K4
Expression for MAP3K4 Gene
This gene is overexpressed in Testis (13.1), Ovary (10.9), Breast (8.1), and Lymph node (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP3K4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP3K4
SOURCE GeneReport for Unigene cluster for MAP3K4 Gene:
Hs.390428mRNA Expression by UniProt/SwissProt for MAP3K4 Gene:
Q9Y6R4-M3K4_HUMAN
Tissue specificity:
Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.
Evidence on tissue expression from TISSUES for MAP3K4 Gene
- Nervous system(4.7)
- Muscle(4.4)
- Bone marrow(4.3)
- Skin(2.3)
- Heart(2.2)
- Kidney(2.2)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs for MAP3K4
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K4 Gene
Orthologs for MAP3K4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MAP3K4 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | MAP3K4 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MAP3K4 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MAP3K4 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MAP3K4 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Map3k4 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Map3k4 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MAP3K4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MAP3K4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | map3k4 30 |
|
||
| Str.625 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15863 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | map3k4 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002371 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Mekk1 30 31 32 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | mtk-1 32 |
|
|
|
| F18F11.5 31 |
|
OneToOne | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSK22 31 |
|
OneToMany | |
| SSK2 31 33 |
|
OneToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for MAP3K4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MAP3K4 Gene
- ENSEMBL:
- Gene Tree for MAP3K4 (if available)
- TreeFam:
- Gene Tree for MAP3K4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAP3K4: view image
Paralogs for MAP3K4 Gene
Paralogs for MAP3K4 Gene
(35) SIMAP similar genes for MAP3K4 Gene using alignment to 7 proteins:
- M3K4_HUMAN
- F5H1X6_HUMAN
- F5H2S6_HUMAN
- F5H4R1_HUMAN
- F5H534_HUMAN
- F5H538_HUMAN
- J3KNB8_HUMAN
Variants for MAP3K4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP3K4 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 713468 | Benign: not provided | 161,108,866(+) | C/T | INTRON_VARIANT | |
| 759692 | Likely Benign: not provided | 161,092,006(+) | A/C | INTRON_VARIANT | |
| 790732 | Benign: not provided | 161,091,414(+) | T/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| VAR_040691 | An ovarian serous carcinoma sample | p.Glu1413Gln | |||
| rs34018542 | - | p.Gln584His |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1009798 | CNV | deletion | 20482838 |
| esv1022211 | CNV | deletion | 17803354 |
| esv2287098 | CNV | deletion | 18987734 |
| esv2422347 | CNV | duplication | 17116639 |
| esv2733067 | CNV | deletion | 23290073 |
| esv2733068 | CNV | deletion | 23290073 |
| esv2733069 | CNV | deletion | 23290073 |
| esv2733070 | CNV | deletion | 23290073 |
| esv2733071 | CNV | deletion | 23290073 |
| esv3576242 | CNV | gain | 25503493 |
| esv3611453 | CNV | gain | 21293372 |
| esv5229 | CNV | loss | 18987735 |
| nsv1026543 | CNV | gain | 25217958 |
| nsv1030045 | CNV | gain | 25217958 |
| nsv1030852 | CNV | gain | 25217958 |
| nsv1074442 | CNV | deletion | 25765185 |
| nsv1074443 | CNV | deletion | 25765185 |
| nsv1130850 | CNV | deletion | 24896259 |
| nsv1137172 | CNV | deletion | 24896259 |
| nsv1137559 | CNV | deletion | 24896259 |
| nsv1143327 | CNV | deletion | 24896259 |
| nsv1146290 | CNV | deletion | 26484159 |
| nsv1148627 | CNV | deletion | 26484159 |
| nsv949883 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
3.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.58;
65.17% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAP3K4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K4 Gene
Disorders for MAP3K4 Gene
Additional Disease Information for MAP3K4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for MAP3K4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K4 Gene
Publications for MAP3K4 Gene
- A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. (PMID: 9305639) Takekawa M … Saito H (The EMBO journal 1997) 2 3 4 23
- Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85. (PMID: 20221403) Kedar VP … Blackshear PJ (PloS one 2010) 3 4 23
- MEKK4 is an effector of the embryonic TRAF4 for JNK activation. (PMID: 16157600) Abell AN … Johnson GL (The Journal of biological chemistry 2005) 3 4 23
- The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. (PMID: 15262978) Wong CK … Lin SC (The Journal of biological chemistry 2004) 3 4 23
- Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. (PMID: 20624154) Grucza RA … Bierut LJ (Addiction biology 2010) 3 41
ExternalLinks
Products for MAP3K4 Gene
- Custom Antibody ServicesOriGene Antibodies for MAP3K4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MAP3K4
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K4
- Browse OriGene Inhibitory RNA Products For MAP3K4
- OriGene qPCR primer pairs for MAP3K4
- OriGene CRISPR knockouts for MAP3K4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MAP3K4
- Sino Biological Human cDNA Clone for MAP3K4
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- High-throughput Antibody Production Service
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- Novus Biologicals proteins for MAP3K4
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- Taconic Biosciences Mouse Models for MAP3K4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MAP3K4 (AFLGC-MAP3K4)
- VectorBuilder Custom and pre-made DNA vectors for MAP3K4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MAP3K4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MAP3K4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MAP3K4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MAP3K4
- Addgene plasmids for MAP3K4
- antibodies-online: Show 17 available MAP3K4 Antibodies ranked by validation data
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- Recommended
- 12 IF (p) Antibodies (anti-rat)
- 11 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 48 WB Antibodies (anti-human)
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- 8 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 14 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- antibodies-online: Search results for available MAP3K4 related products ranked by validation data
- antibodies-online: Show 5 available MAP3K4 Proteins ranked by validation data
- Compare Top MAP3K4 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for MAP3K4
- Search Santa Cruz Biotechnology (SCBT) for MAP3K4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K4
- Horizon Cell Lines for MAP3K4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MAP3K4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K4
Sources for MAP3K4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
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- (48) IMGT
- (49) Leiden
- (50) miRBase
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- (53) PubMed
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- (55) TGDB
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- (57) Abcam
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
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- (84) COMPARTMENTS
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