Aliases for MAP3K4 Gene
Aliases for MAP3K4 Gene
External Ids for MAP3K4 Gene
- HGNC: 6856
- Entrez Gene: 4216
- Ensembl: ENSG00000085511
- OMIM: 602425
- UniProtKB: Q9Y6R4
Previous HGNC Symbols for MAP3K4 Gene
- MEKK4
Previous GeneCards Identifiers for MAP3K4 Gene
- GC06P160766
- GC06P161286
- GC06P161322
- GC06P161383
- GC06P161332
- GC06P161412
- GC06P158868
Summaries for MAP3K4 Gene
-
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]
GeneCards Summary for MAP3K4 Gene
MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4) is a Protein Coding gene. Among its related pathways are EGF/EGFR Signaling Pathway and 4-1BB Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
UniProtKB/Swiss-Prot for MAP3K4 Gene
-
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
Additional gene information for MAP3K4 Gene
- Monarch Initiative
- Search for MAP3K4 at DataMed
- Search for MAP3K4 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K4 Gene
Genomics for MAP3K4 Gene
GeneHancer (GH) Regulatory Elements for MAP3K4 Gene
Promoters and enhancers for MAP3K4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAP3K4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MAP3K4 gene promoter:
-
- NRSF form 2
- NRSF form 1
- Egr-3
- RSRFC4
- MyoD
- AP-4
- Spz1
- aMEF-2
Regulatory Element Products
Genomic Locations for MAP3K4 Gene
Genomic Locations for MAP3K4 Gene
- chr6:160,991,727-161,117,385
- (GRCh38/hg38)
- Size:
- 125,659 bases
- Orientation:
- Plus strand
- chr6:161,412,759-161,538,417
- (GRCh37/hg19)
- Size:
- 125,659 bases
- Orientation:
- Plus strand
Genomic View for MAP3K4 Gene
Genes around MAP3K4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q26 by Entrez Gene
- 6q26 by HGNC
- 6q26 by Ensembl
MAP3K4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAP3K4 Gene
Proteins for MAP3K4 Gene
-
Protein details for MAP3K4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6R4-M3K4_HUMAN
- Recommended name:
- Mitogen-activated protein kinase kinase kinase 4
- Protein Accession:
- Q9Y6R4
- A6H8W0
- B7ZLD3
- B9EG75
- Q5VTT8
- Q5VTT9
- Q92612
- Q9H408
Protein attributes for MAP3K4 Gene
- Size:
- 1608 amino acids
- Molecular mass:
- 181685 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Monomer and homodimer. Homodimerization enhances kinase activity. Interacts with TRAF4; this promotes homodimerization (PubMed:16157600). Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with AXIN1 and DIXDC1; interaction with DIXDC1 prevents interaction with AXIN1 (PubMed:15262978). Interacts with GADD45 and MAP2K6 (PubMed:12052864). Interacts with ZFP36; this interaction enhances the association with SH3KBP1/CIN85 (PubMed:20221403). Interacts with SH3KBP1; this interaction enhances the association with ZFP36 (PubMed:20221403). Interacts with CDC42 (By similarity).
- SequenceCaution:
-
- Sequence=BAA13204.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAC12766.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH70639.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH70640.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI20815.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI20816.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21477.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41309.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41310.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for MAP3K4 Gene
Post-translational modifications for MAP3K4 Gene
Other Protein References for MAP3K4 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MAP3K4
- Novus Biologicals Antibodies for MAP3K4
-
Abcam antibodies for MAP3K4
- Invitrogen Antibodies for MAP3K4 (AFLGC-MAP3K4)
- antibodies-online: Search results for 81 available MAP3K4 Antibodies ranked by validation data
- Compare Top MAP3K4 Antibodies
-
Recommended
- 12 IF (p) Antibodies (anti-rat)
- 9 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 53 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 12 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- GeneTex MAP3K4 Antibody for MAP3K4
-
Boster Bio Antibodies for MAP3K4
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAP3K4
Protein Products
-
OriGene Purified Proteins for MAP3K4
- Search Origene for MassSpec and Protein Over-expression Lysates for MAP3K4
- Origene Custom Protein Services for MAP3K4
- Novus Biologicals proteins for MAP3K4
- Search GeneTex for Proteins for MAP3K4
-
Abcam proteins for MAP3K4
Assay Products
No data available for DME Specific Peptides for MAP3K4 Gene
Domains & Families for MAP3K4 Gene
Gene Families for MAP3K4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for MAP3K4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAP3K4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y6R4UniProtKB/Swiss-Prot:
M3K4_HUMAN :- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Function for MAP3K4 Gene
Molecular function for MAP3K4 Gene
- UniProtKB/Swiss-Prot Function:
- Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- N-terminal autoinhibitory domain interacts with the C-terminal kinase domain, inhibiting kinase activity, and preventing interaction with its substrate, MAP2K6. The GADD45 proteins activate the kinase by binding to the N-terminal domain. Activated by phosphorylation on Thr-1505.
- GENATLAS Biochemistry:
- mitogen activated protein (MAP/ERK) kinase kinase kinase 4,major mediator of environnemtal stress,activating the MAPK and JNK signal transduction pathway (see MAP4K4)
Enzyme Numbers (IUBMB) for MAP3K4 Gene
Phenotypes From GWAS Catalog for MAP3K4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA,IBA | -- |
| GO:0004709 | MAP kinase kinase kinase activity | IEA,IDA | 9305639 |
| GO:0005515 | protein binding | IPI | 12052864 |
Phenotypes for MAP3K4 Gene
- MGI mutant phenotypes for MAP3K4:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for MAP3K4:
-
- Decreased viability
- Decreased cell proliferation
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased telomerase activity
- Increased cell death HMECs cells
- Reduced mammosphere formation
- Decreased ionizing radiation sensitivity
- no effect
- Increased vaccinia virus (VACV) infection
- Apoptosis resistance
- Increased transferrin (TF) endocytosis
Animal Models for MAP3K4 Gene
- MGI Knock Outs for MAP3K4:
-
- Map3k4 Map3k4<tm1Flv>
Animal Model Products
-
Taconic Biosciences Mouse Models for MAP3K4
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAP3K4
-
CRISPR Products
-
OriGene CRISPR knockouts for MAP3K4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K4
- genomics-online: gRNA clones - Search results for 90 available MAP3K4 gene related products
- Overview of 90 available MAP3K4 gene related products
- Applied Biological Materials CRISPR for MAP3K4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K4
- GenScript: Design CRISPR guide RNA sequences for MAP3K4
miRNA for MAP3K4 Gene
- miRTarBase miRNAs that target MAP3K4
-
- hsa-mir-124-3p (MIRT022893)
- hsa-mir-148a-3p (MIRT048040)
- hsa-mir-93-5p (MIRT048846)
- hsa-mir-92a-3p (MIRT049769)
- hsa-mir-199a-3p (MIRT099168)
- hsa-mir-199b-3p (MIRT099169)
- hsa-mir-1245a (MIRT099172)
- hsa-mir-3123 (MIRT099173)
- hsa-mir-3129-5p (MIRT099174)
- hsa-mir-3691-3p (MIRT099176)
- hsa-mir-6073 (MIRT099178)
- hsa-mir-8062 (MIRT099180)
- hsa-mir-8079 (MIRT099181)
- hsa-mir-144-3p (MIRT493268)
- hsa-mir-101-3p (MIRT493269)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K4
- Browse OriGene Inhibitory RNA Products For MAP3K4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K4
- genomics-online: shRNA clones - Search results for 90 available MAP3K4 gene related products
- Overview of 90 available MAP3K4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MAP3K4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K4
- Applied Biological Materials Clones for MAP3K4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K4 Gene
Localization for MAP3K4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAP3K4 Gene
- Cytoplasm, perinuclear region. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| nucleus | 2 |
| extracellular | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 9827804 |
| GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
Pathways & Interactions for MAP3K4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Development Endothelin-1/EDNRA signaling | ||
| 2 | MAPK signaling pathway | ||
| 3 | TNFR1 Pathway |
.55
|
|
| 4 | 4-1BB Pathway |
.48
|
.37
|
| 5 | GPCR Pathway |
.62
|
.55
|
Pathways by source for MAP3K4 Gene
7 BioSystems pathways for MAP3K4 Gene
2 KEGG pathways for MAP3K4 Gene
13 GeneGo (Thomson Reuters) pathways for MAP3K4 Gene
33 Qiagen pathways for MAP3K4 Gene
Interacting Proteins for MAP3K4 Gene
Selected Interacting proteins:
ENSP00000375986
Q9Y6R4-M3K4_HUMAN
for MAP3K4 Gene via
STRING
MINT
UniProtKB
IID
GPS-Prot Interaction Network for MAP3K4
SIGNOR curated interactions for MAP3K4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IEA | -- |
| GO:0000186 | activation of MAPKK activity | IDA | 9305639 |
| GO:0001890 | placenta development | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007346 | regulation of mitotic cell cycle | IBA | -- |
Drugs & Compounds for MAP3K4 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Drug Products
Transcripts for MAP3K4 Gene
mRNA/cDNA for MAP3K4 Gene
- (6) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (125) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000539610 295 bps (uc063ssh.1)
- ENST00000536852 2526 bps (uc063ssg.1)
- ENST00000544733 645 bps (uc063ssf.1)
- ENST00000541901 797 bps (uc063sse.1)
- ENST00000543421 581 bps (uc063ssd.1)
Unigene Clusters for MAP3K4 Gene
- Mitogen-activated protein kinase kinase kinase 4:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MAP3K4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K4
- genomics-online: gRNA clones - Search results for 90 available MAP3K4 gene related products
- Overview of 90 available MAP3K4 gene related products
- Applied Biological Materials CRISPR for MAP3K4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K4
- GenScript: Design CRISPR guide RNA sequences for MAP3K4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K4
- Browse OriGene Inhibitory RNA Products For MAP3K4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K4
- genomics-online: shRNA clones - Search results for 90 available MAP3K4 gene related products
- Overview of 90 available MAP3K4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MAP3K4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K4
- Applied Biological Materials Clones for MAP3K4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - |
| ExUns: | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||
| SP2: | - | - | |||||||||||||
| SP3: | |||||||||||||||
| SP4: | |||||||||||||||
| SP5: | |||||||||||||||
| SP6: | - | ||||||||||||||
| SP7: | |||||||||||||||
| SP8: | |||||||||||||||
| SP9: | |||||||||||||||
| SP10: | |||||||||||||||
| SP11: |
Expression for MAP3K4 Gene
This gene is overexpressed in Testis (13.1), Ovary (10.9), Breast (8.1), and Lymph node (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP3K4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MAP3K4 Gene:
MAP3K4SOURCE GeneReport for Unigene cluster for MAP3K4 Gene:
Hs.390428mRNA Expression by UniProt/SwissProt for MAP3K4 Gene:
Q9Y6R4-M3K4_HUMAN
Tissue specificity:
Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.
Evidence on tissue expression from TISSUES for MAP3K4 Gene
- Nervous system(4.6)
- Bone marrow(4.2)
- Muscle(4.2)
Primer Products
-
OriGene qPCR primer pairs for MAP3K4
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K4 Gene
Orthologs for MAP3K4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAP3K4 33 |
|
||
| dog (Canis familiaris) |
Mammalia | MAP3K4 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MAP3K4 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MAP3K4 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MAP3K4 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Map3k4 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Map3k4 16 34 33 |
|
||
| chicken (Gallus gallus) |
Aves | MAP3K4 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MAP3K4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | map3k4 33 |
|
||
| Str.625 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15863 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | map3k4 34 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002371 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Mekk1 34 35 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | mtk-1 35 |
|
|
|
| F18F11.5 34 |
|
OneToOne | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSK22 34 |
|
OneToMany | |
| SSK2 36 34 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for MAP3K4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MAP3K4 Gene
- ENSEMBL:
- Gene Tree for MAP3K4 (if available)
- TreeFam:
- Gene Tree for MAP3K4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAP3K4: view image
Paralogs for MAP3K4 Gene
(35) SIMAP similar genes for MAP3K4 Gene using alignment to 7 proteins:
- M3K4_HUMAN
- F5H1X6_HUMAN
- F5H2S6_HUMAN
- F5H4R1_HUMAN
- F5H534_HUMAN
- F5H538_HUMAN
- J3KNB8_HUMAN
No data available for Paralogs for MAP3K4 Gene
Variants for MAP3K4 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_040691 | An ovarian serous carcinoma sample | p.Glu1413Gln | |||
| rs1000004389 | -- | 161,111,196(+) | G/A | intron_variant | |
| rs1000016481 | -- | 161,069,883(+) | G/A | intron_variant | |
| rs1000021181 | -- | 161,012,068(+) | G/A | intron_variant | |
| rs1000044829 | -- | 161,026,846(+) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1009798 | CNV | deletion | 20482838 |
| esv1022211 | CNV | deletion | 17803354 |
| esv2287098 | CNV | deletion | 18987734 |
| esv2422347 | CNV | duplication | 17116639 |
| esv2733067 | CNV | deletion | 23290073 |
| esv2733068 | CNV | deletion | 23290073 |
| esv2733069 | CNV | deletion | 23290073 |
| esv2733070 | CNV | deletion | 23290073 |
| esv2733071 | CNV | deletion | 23290073 |
| esv3576242 | CNV | gain | 25503493 |
| esv3611453 | CNV | gain | 21293372 |
| esv5229 | CNV | loss | 18987735 |
| nsv1026543 | CNV | gain | 25217958 |
| nsv1030045 | CNV | gain | 25217958 |
| nsv1030852 | CNV | gain | 25217958 |
| nsv1074442 | CNV | deletion | 25765185 |
| nsv1074443 | CNV | deletion | 25765185 |
| nsv1130850 | CNV | deletion | 24896259 |
| nsv1137172 | CNV | deletion | 24896259 |
| nsv1137559 | CNV | deletion | 24896259 |
| nsv1143327 | CNV | deletion | 24896259 |
| nsv1146290 | CNV | deletion | 26484159 |
| nsv1148627 | CNV | deletion | 26484159 |
| nsv949883 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
3.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.58;
65.17% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAP3K4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K4 Gene
Disorders for MAP3K4 Gene
Additional Disease Information for MAP3K4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MAP3K4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K4 Gene
Publications for MAP3K4 Gene
- A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. (PMID: 9305639) Takekawa M … Saito H (The EMBO journal 1997) 2 3 4 22 58
- Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85. (PMID: 20221403) Kedar VP … Blackshear PJ (PloS one 2010) 3 4 22 58
- MEKK4 is an effector of the embryonic TRAF4 for JNK activation. (PMID: 16157600) Abell AN … Johnson GL (The Journal of biological chemistry 2005) 3 4 22 58
- The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. (PMID: 15262978) Wong CK … Lin SC (The Journal of biological chemistry 2004) 3 4 22 58
- Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. (PMID: 20624154) Grucza RA … Bierut LJ (Addiction biology 2010) 3 44 58
Products for MAP3K4 Gene
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- Custom Antibody ServicesOriGene Antibodies for MAP3K4
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- antibodies-online: Search results for 81 available MAP3K4 Antibodies ranked by validation data
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- Recommended
- 12 IF (p) Antibodies (anti-rat)
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- 53 WB Antibodies (anti-human)
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- 12 IF (p) Antibodies (anti-mouse)
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- 3 IHC Antibodies (anti-mouse)
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- antibodies-online: Search results for available MAP3K4 related products ranked by validation data
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- GeneTex MAP3K4 Antibody for MAP3K4
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- genomics-online: cdna clones - Search results for 90 available MAP3K4 gene related products
- Overview of 90 available MAP3K4 gene related products
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- Overview of 90 available MAP3K4 gene related products
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- Boster Bio Antibodies for MAP3K4
- Browse Boster Bio ELISA Kits
Sources for MAP3K4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt