Aliases for MAP3K3 Gene
External Ids for MAP3K3 Gene
Previous HGNC Symbols for MAP3K3 Gene
Previous GeneCards Identifiers for MAP3K3 Gene
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP3K3 Gene
MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3) is a Protein Coding gene. Diseases associated with MAP3K3 include Cerebral Cavernous Malformations and Cerebrocostomandibular Syndrome. Among its related pathways are Integrin Pathway and fMLP Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K2.
UniProtKB/Swiss-Prot Summary for MAP3K3 Gene
Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.