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This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3) is a Protein Coding gene. Diseases associated with MAP3K3 include Cerebral Cavernous Malformations and Cerebrocostomandibular Syndrome. Among its related pathways are Nur77 Signaling in T-Cell and NGF Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA,IDA | 15001576 |
GO:0004674 | protein serine/threonine kinase activity | IBA | -- |
GO:0004709 | MAP kinase kinase kinase activity | TAS,IEA | -- |
GO:0005515 | protein binding | IEA,IPI | 12392720 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | TNFR1 Pathway |
TNF Signaling
.55
Apoptosis through Death Receptors
.42
|
|
2 | IL-1 signaling pathway | ||
3 | B Cell Receptor Signaling Pathway (sino) | ||
4 | 4-1BB Pathway |
CD27 Pathway
.48
|
TNFR2 Pathway
.37
|
5 | GPCR Pathway |
GPCR Pathway
.62
|
Estrogen Pathway
.55
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | 9006902 |
GO:0000186 | activation of MAPKK activity | IEA | -- |
GO:0001568 | blood vessel development | IEA | -- |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0007346 | regulation of mitotic cell cycle | IBA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MAP3K3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MAP3K3 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MAP3K3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MAP3K3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Map3k3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Map3k3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | MAP3K3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MAP3K3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MAP3K3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | map3k3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | map3k3 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | mtk-1 32 |
|
|
|
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STE11 31 33 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
713294 | Benign: not provided | 63,688,851(+) | G/A | MISSENSE_VARIANT | |
717040 | Benign: not provided | 63,689,605(+) | C/T | SYNONYMOUS_VARIANT | |
757648 | Likely Benign: not provided | 63,693,687(+) | G/A | SYNONYMOUS_VARIANT | |
768907 | Benign: not provided | 63,693,594(+) | G/A | SYNONYMOUS_VARIANT | |
780446 | Benign: not provided | 63,692,327(+) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2510594 | CNV | insertion | 19546169 |
esv2671505 | CNV | deletion | 23128226 |
esv3379241 | CNV | insertion | 20981092 |
esv3582854 | CNV | loss | 25503493 |
esv3641003 | CNV | loss | 21293372 |
esv3641004 | CNV | loss | 21293372 |
nsv952356 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cerebral cavernous malformations |
|
|
cerebrocostomandibular syndrome |
|
|
cerebral cavernous malformations 2 |
|
|