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This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase... See more...
Aliases for MAP3K3 Gene
Aliases for MAP3K3 Gene
External Ids for MAP3K3 Gene
- HGNC: 6855
- NCBI Entrez Gene: 4215
- Ensembl: ENSG00000198909
- OMIM®: 602539
- UniProtKB/Swiss-Prot: Q99759
Previous HGNC Symbols for MAP3K3 Gene
- MEKK3
Previous GeneCards Identifiers for MAP3K3 Gene
- GC17P061350
- GC17P064126
- GC17P062040
- GC17P062173
- GC17P059053
- GC17P061699
- GC17P057077
Summaries for MAP3K3 Gene
-
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP3K3 Gene
MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3) is a Protein Coding gene. Diseases associated with MAP3K3 include Cerebral Cavernous Malformations and Cerebrocostomandibular Syndrome. Among its related pathways are Integrin Pathway and fMLP Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K2.
UniProtKB/Swiss-Prot Summary for MAP3K3 Gene
-
Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.
Additional gene information for MAP3K3 Gene
- HGNC (6855)
- NCBI Entrez Gene (4215)
- Ensembl (ENSG00000198909)
- OMIM® (602539)
- UniProtKB/Swiss-Prot (Q99759)
- Open Targets Platform(ENSG00000198909)
- Alliance of Genome Resources
- Search for MAP3K3 at DataMed
- Search for MAP3K3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP3K3 Gene
Genomics for MAP3K3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MAP3K3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAP3K3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP3K3
- Top Transcription factor binding sites by QIAGEN in the MAP3K3 gene promoter:
-
- AhR
- AP-1
- ATF-2
- c-Jun
- GATA-6
- POU2F1
- POU2F1a
Genomic Locations for MAP3K3 Gene
Latest Assembly
- chr17:63,622,209-63,696,305
- (GRCh38/hg38)
- Size:
- 74,097 bases
- Orientation:
- Plus strand
Previous Assembly
- chr17:61,699,777-61,773,665
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 73,889 bases
- Orientation:
- Plus strand
Genomic View for MAP3K3 Gene
Genes around MAP3K3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q23.3 by HGNC
- 17q23.3 by Entrez Gene
- 17q23.3 by Ensembl
MAP3K3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAP3K3 Gene
Proteins for MAP3K3 Gene
-
Protein details for MAP3K3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99759-M3K3_HUMAN
- Recommended name:
- Mitogen-activated protein kinase kinase kinase 3
- Protein Accession:
- Q99759
- B2RCW2
- D3DU15
- Q5BKZ6
- Q8N3I9
Protein attributes for MAP3K3 Gene
- Size:
- 626 amino acids
- Molecular mass:
- 70898 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a complex with MAP2K3, RAC1 and CCM2. Interacts with MAP2K5 and SPAG9.
Three dimensional structures from OCA and Proteopedia for MAP3K3 Gene
Protein Expression for MAP3K3 Gene
Post-translational modifications for MAP3K3 Gene
- Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MAP3K3 Gene
Antibodies for research
- Novus Biologicals Antibodies for MAP3K3
-
Abcam antibodies for MAP3K3
- Invitrogen Antibodies for MAP3K3 (AFLGC-Map3k3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAP3K3
Protein products for research
-
OriGene Purified Proteins for MAP3K3
- Search Origene for MassSpec and Protein Over-expression Lysates for MAP3K3
- Origene Custom Protein Services for MAP3K3
-
Abcam proteins for MAP3K3
Assay products for research
No data available for DME Specific Peptides for MAP3K3 Gene
Domains & Families for MAP3K3 Gene
Gene Families for MAP3K3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MAP3K3 Gene
- InterPro:
- Blocks:
-
- Octicosapeptide/Phox/Bem1p
Suggested Antigen Peptide Sequences for MAP3K3 Gene
- GenScript: Design optimal peptide antigens:
-
- MAPK/ERK kinase kinase 3 (M3K3_HUMAN)
- Mitogen-activated protein kinase kinase kinase 3 variant 2 (Q1PBM3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q99759UniProtKB/Swiss-Prot:
M3K3_HUMAN :- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Function for MAP3K3 Gene
Molecular function for MAP3K3 Gene
- UniProtKB/Swiss-Prot Function:
- Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by phosphorylation on Thr-530.
Enzyme Numbers (IUBMB) for MAP3K3 Gene
Phenotypes From GWAS Catalog for MAP3K3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA,IDA | 15001576 |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004709 | MAP kinase kinase kinase activity | TAS,IEA | -- |
| GO:0005515 | protein binding | IEA,IPI | 12392720 |
Phenotypes for MAP3K3 Gene
- MGI mutant phenotypes for MAP3K3:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for MAP3K3:
-
- Decreased viability
- no effect
- Decreased viability ratio
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased cell death HMECs cells
- Decreased substrate adherent cell growth
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased telomerase activity
- Decreased viability in pancreas lineage
- Increased cell death in DLD-1 cells
- Decreased mitotic index
- Decreased cell viability after pRB stimulation
- Decreased cell proliferation
Animal Models for MAP3K3 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for MAP3K3
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MAP3K3 - Starting at $85 >
- * MAP3K3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MAP3K3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K3
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K3
miRNA for MAP3K3 Gene
- miRTarBase miRNAs that target MAP3K3
-
- hsa-miR-145-5p (MIRT003519)
- mmu-miR-124-3p (MIRT015995)
- hsa-miR-9-5p (MIRT021476)
- hsa-miR-132-3p (MIRT021851)
- hsa-miR-124-3p (MIRT023113)
- hsa-miR-193b-3p (MIRT041562)
- hsa-miR-181a-5p (MIRT053682)
- hsa-miR-188-5p (MIRT053697)
- hsa-miR-19a-5p (MIRT078461)
- hsa-miR-19b-1-5p (MIRT078462)
- hsa-miR-19b-2-5p (MIRT078463)
- hsa-miR-96-5p (MIRT078464)
- hsa-miR-1271-5p (MIRT078466)
- hsa-miR-1178-5p (MIRT078467)
- hsa-miR-1182 (MIRT078468)
- hsa-miR-4328 (MIRT078470)
- hsa-miR-3613-3p (MIRT078471)
- hsa-miR-6753-3p (MIRT078474)
- hsa-miR-6885-3p (MIRT078475)
- hsa-miR-7107-3p (MIRT078476)
- hsa-miR-17-5p (MIRT147117)
- hsa-miR-20a-5p (MIRT147118)
- hsa-miR-93-5p (MIRT147119)
- hsa-miR-181b-5p (MIRT147121)
- hsa-miR-181c-5p (MIRT147122)
- hsa-miR-106b-5p (MIRT147124)
- hsa-miR-20b-5p (MIRT147128)
- hsa-miR-181d-5p (MIRT147129)
- hsa-miR-519d-3p (MIRT147133)
- hsa-miR-2052 (MIRT556298)
- hsa-miR-3140-3p (MIRT556299)
- hsa-miR-140-3p (MIRT556300)
- hsa-miR-182-5p (MIRT556301)
- hsa-miR-183-5p (MIRT556302)
- hsa-miR-193a-3p (MIRT727250)
- hsa-miR-328-5p (MIRT741291)
- hsa-miR-4459 (MIRT744813)
- hsa-miR-4754 (MIRT748355)
- hsa-miR-4779 (MIRT748742)
- hsa-miR-6774-5p (MIRT755346)
- hsa-miR-6804-5p (MIRT756433)
- hsa-miR-759 (MIRT759417)
- hsa-miR-3119 (MIRT784566)
- hsa-miR-892b (MIRT789923)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K3
- Browse OriGene Inhibitory RNA Products For MAP3K3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K3
Clone products for research
- Applied Biological Materials (abm): Clones for MAP3K3 - Starting at $45 >
- * MAP3K3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MAP3K3
- Addgene plasmids for MAP3K3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K3
Cell Lines for research
-
Horizon Cell Lines for MAP3K3
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K3 Gene
Localization for MAP3K3 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K3 Gene
Pathways & Interactions for MAP3K3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | TNFR1 Pathway |
TNF Signaling
.55
Apoptosis through Death Receptors
.42
|
|
| 2 | IL-1 signaling pathway | ||
| 3 | B Cell Receptor Signaling Pathway (sino) | ||
| 4 | 4-1BB Pathway |
CD27 Pathway
.48
|
TNFR2 Pathway
.37
|
| 5 | GPCR Pathway |
GPCR Pathway
.62
|
Estrogen Pathway
.55
|
Pathways by source for MAP3K3 Gene
5 Sino Biological pathways for MAP3K3 Gene
12 BioSystems pathways for MAP3K3 Gene
4 Reactome pathways for MAP3K3 Gene
3 GeneGo (Thomson Reuters) pathways for MAP3K3 Gene
- Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
- Immune response Function of MEF2 in T lymphocytes
- Signal transduction_JNK pathway
34 Qiagen pathways for MAP3K3 Gene
- Antioxidant Action of Vitamin-C
- Apoptosis through Death Receptors
- CD27 Pathway
- CRHR Pathway
- CXCR4 Pathway
1 Cell Signaling Technology pathway for MAP3K3 Gene
Interacting Proteins for MAP3K3 Gene
Selected Interacting proteins:
Q99759-M3K3_HUMAN
ENSP00000354927
for MAP3K3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MAP3K3
SIGNOR curated interactions for MAP3K3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | 9006902 |
| GO:0000186 | activation of MAPKK activity | IEA | -- |
| GO:0001568 | blood vessel development | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
Drugs & Compounds for MAP3K3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
58-64-0 |
|
Transcripts for MAP3K3 Gene
mRNA/cDNA for MAP3K3 Gene
- 4 REFSEQ mRNAs :
- 25 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000361357 4818 nts (view in UCSC)
- ENST00000361733 4752 nts (view in UCSC)
- ENST00000577395 2016 nts (view in UCSC)
- ENST00000577597 2024 nts (view in UCSC)
- ENST00000577784 565 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MAP3K3 - Starting at $85 >
- * MAP3K3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MAP3K3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K3
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K3
- Browse OriGene Inhibitory RNA Products For MAP3K3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K3
Clone products for research
- Applied Biological Materials (abm): Clones for MAP3K3 - Starting at $45 >
- * MAP3K3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MAP3K3
- Addgene plasmids for MAP3K3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K3
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for MAP3K3 Gene
- GeneLoc Exon Structure for
- MAP3K3
Expression for MAP3K3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
-
Lymph (Hematopoietic System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for MAP3K3 Gene
This gene is overexpressed in Whole Blood (x6.3).
This gene is overexpressed in Cervix (38.1) and Adipocyte (21.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP3K3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP3K3
SOURCE GeneReport for Unigene cluster for MAP3K3 Gene:
Hs.29282Evidence on tissue expression from TISSUES for MAP3K3 Gene
- Nervous system(4.7)
- Skin(2.9)
- Heart(2.5)
- Muscle(2.3)
- Blood(2.3)
- Intestine(2.2)
- Kidney(2.1)
- Lung(2.1)
- Spleen(2.1)
- Lymph node(2.1)
- Bone marrow(2)
Primer products for research
-
OriGene qPCR primer pairs for MAP3K3
-
OriGene qPCR primer pairs and template standards for MAP3K3
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K3 Gene
Orthologs for MAP3K3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MAP3K3 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MAP3K3 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MAP3K3 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MAP3K3 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Map3k3 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Map3k3 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MAP3K3 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MAP3K3 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MAP3K3 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | map3k3 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | map3k3 29 30 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | mtk-1 31 |
|
|
|
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STE11 30 32 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany |
- Species where no ortholog for MAP3K3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MAP3K3 Gene
- ENSEMBL:
- Gene Tree for MAP3K3 (if available)
- TreeFam:
- Gene Tree for MAP3K3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAP3K3: view image
- Alliance of Genome Resources:
- Additional Orthologs for MAP3K3
Paralogs for MAP3K3 Gene
Paralogs for MAP3K3 Gene
(46) SIMAP similar genes for MAP3K3 Gene using alignment to 7 proteins:
- M3K3_HUMAN
- J3KRN4_HUMAN
- J3KTC4_HUMAN
- J3QRB6_HUMAN
- J3QS19_HUMAN
- J3QS54_HUMAN
- Q1PBM3_HUMAN
Variants for MAP3K3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP3K3 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs115890040 | Benign: not provided | 63,692,327(+) |
G/A NM_002401.5(MAP3K3):c.1560G>A (p.Ser520=) |
SYNONYMOUS | |
| rs1598129104 | Likely Benign: not provided | 63,693,687(+) |
G/A NM_002401.5(MAP3K3):c.1791G>A (p.Arg597=) |
SYNONYMOUS | |
| rs2229673 | Benign: not provided | 63,693,594(+) |
G/A NM_002401.5(MAP3K3):c.1698G>A (p.Pro566=) |
SYNONYMOUS | |
| rs36109904 | Benign: not provided | 63,688,851(+) |
G/Ap.Val281Met NM_002401.5(MAP3K3):c.841G>A (p.Val281Met) |
MISSENSE | |
| rs77148458 | Benign: not provided | 63,689,605(+) |
C/T NM_002401.5(MAP3K3):c.933C>T (p.Ser311=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2510594 | CNV | insertion | 19546169 |
| esv2671505 | CNV | deletion | 23128226 |
| esv3379241 | CNV | insertion | 20981092 |
| esv3582854 | CNV | loss | 25503493 |
| esv3641003 | CNV | loss | 21293372 |
| esv3641004 | CNV | loss | 21293372 |
| nsv952356 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.06;
37.82% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAP3K3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K3 Gene
Disorders for MAP3K3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cerebral cavernous malformations |
|
|
| cerebrocostomandibular syndrome |
|
|
| cerebral cavernous malformations 2 |
|
|
| klippel-trenaunay-weber syndrome |
|
|
Search MAP3K3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAP3K3
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MAP3K3 Gene
Publications for MAP3K3 Gene
- Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. (PMID: 9006902) Ellinger-Ziegelbauer H ā¦ Siebenlist U (The Journal of biological chemistry 1997) 2 3 4 22
- Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. (PMID: 14661019) Huang Q ā¦ Su B (Nature immunology 2004) 3 4 22
- PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway. (PMID: 12912994) Nakamura K ā¦ Johnson GL (The Journal of biological chemistry 2003) 3 4 22
- Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe). (PMID: 22021425) Carty CL ā¦ Kooperberg C (Human molecular genetics 2012) 3 40
- Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A ā¦ Haiman CA (PLoS genetics 2011) 3 40
ExternalLinks
Products for MAP3K3 Gene
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- Novus Biologicals proteins and lysates for MAP3K3
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- antibodies-online: Show 23 available MAP3K3 Antibodies ranked by validation data
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Sources for MAP3K3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38)