Aliases for MAP3K21 Gene

Aliases for MAP3K21 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 21 2 3 4 5
  • Mixed Lineage Kinase 4 2 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase MLK4 3 4
  • EC 2.7.11.25 4 54
  • MLK4 3 4
  • DJ862P8.3 3
  • EC 2.7.11 54
  • KIAA1804 4

External Ids for MAP3K21 Gene

Summaries for MAP3K21 Gene

GeneCards Summary for MAP3K21 Gene

MAP3K21 (Mitogen-Activated Protein Kinase Kinase Kinase 21) is a Protein Coding gene. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot Summary for MAP3K21 Gene

  • Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

Additional gene information for MAP3K21 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP3K21 Gene

Genomics for MAP3K21 Gene

GeneHancer (GH) Regulatory Elements for MAP3K21 Gene

Promoters and enhancers for MAP3K21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J233326 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 790.8 +1.0 977 4.2 ZBTB6 POLR2A CTBP1 ZNF133 ZNF362 L3MBTL2 ZNF121 ZNF148 SP1 ZNF384 MAP3K21 RF00017-513
GH01J233355 Enhancer 0.6 Ensembl 35.6 +28.8 28777 1.4 ZNF148 ZNF629 ATF7 NFE2 ZBTB17 JUNB ZNF18 CEBPG CEBPB BATF MAP3K21 RF00017-513
GH01J233288 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 12.5 -35.3 -35287 7.9 ZBTB6 POLR2A CTBP1 HDAC2 ZNF362 SREBF1 ZNF280D ZNF384 MAFK SP7 MAP3K21 PCNX2 RPS7P3 ENSG00000251508 lnc-PCNX2-2
GH01J233332 Enhancer 0.5 Ensembl 40.9 +5.0 4977 1.8 PRDM1 ZBTB20 SCRT2 SCRT1 ZNF335 MAP3K21 ENSG00000251508 PCNX2 RF00017-513
GH01J233338 Enhancer 0.5 Ensembl 39.2 +11.4 11377 1.4 SCRT2 SCRT1 ZNF366 ZNF513 FEZF1 MAP3K21 PCNX2 ENSG00000251508 RF00017-513
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP3K21 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MAP3K21 Gene

Genomic Locations for MAP3K21 Gene
chr1:233,327,724-233,385,148
(GRCh38/hg38)
Size:
57,425 bases
Orientation:
Plus strand
chr1:233,463,514-233,520,894
(GRCh37/hg19)
Size:
57,381 bases
Orientation:
Plus strand

Genomic View for MAP3K21 Gene

Genes around MAP3K21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K21 Gene

Proteins for MAP3K21 Gene

  • Protein details for MAP3K21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TCX8-M3K21_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 21
    Protein Accession:
    Q5TCX8
    Secondary Accessions:
    • A0A1W2PKR9
    • B2RN34
    • Q5TCX7
    • Q5TCX9
    • Q8WWN1
    • Q8WWN2
    • Q96JM1
    • X6R610

    Protein attributes for MAP3K21 Gene

    Size:
    1036 amino acids
    Molecular mass:
    113957 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer (By similarity). Interacts with TLR4.
    SequenceCaution:
    • Sequence=BAB47433.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAP3K21 Gene

    Alternative splice isoforms for MAP3K21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K21 Gene

Selected DME Specific Peptides for MAP3K21 Gene

Q5TCX8:
  • ILHRDLK
  • HRDLKSSN
  • LAVAYGVA
  • LRTKEKELRSREEEL
  • LWELLTGE
  • EARLFAML
  • SGDEGWW
  • WMAPEVI

Post-translational modifications for MAP3K21 Gene

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP3K21 Gene

Domains & Families for MAP3K21 Gene

Gene Families for MAP3K21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for MAP3K21 Gene

GenScript: Design optimal peptide antigens:
  • Mixed lineage kinase 4 (M3KL4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5TCX8

UniProtKB/Swiss-Prot:

M3K21_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K21: view

Function for MAP3K21 Gene

Molecular function for MAP3K21 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.

Enzyme Numbers (IUBMB) for MAP3K21 Gene

Phenotypes From GWAS Catalog for MAP3K21 Gene

Gene Ontology (GO) - Molecular Function for MAP3K21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004709 MAP kinase kinase kinase activity IEA --
GO:0005515 protein binding IPI 26859459
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MAP3K21: view
genes like me logo Genes that share phenotypes with MAP3K21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K21

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP3K21 Gene

Localization for MAP3K21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K21 gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP3K21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MAP3K21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K21 Gene

Pathways & Interactions for MAP3K21 Gene

PathCards logo

SuperPathways for MAP3K21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP3K21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0006468 protein phosphorylation ISS --
GO:0007257 activation of JUN kinase activity ISS --
GO:0016310 phosphorylation IEA --
GO:0046777 protein autophosphorylation ISS --
genes like me logo Genes that share ontologies with MAP3K21: view

No data available for Pathways by source and SIGNOR curated interactions for MAP3K21 Gene

Drugs & Compounds for MAP3K21 Gene

(1) Drugs for MAP3K21 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
genes like me logo Genes that share compounds with MAP3K21: view

Transcripts for MAP3K21 Gene

mRNA/cDNA for MAP3K21 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(55) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K21

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K21 Gene

No ASD Table

Relevant External Links for MAP3K21 Gene

GeneLoc Exon Structure for
MAP3K21
ECgene alternative splicing isoforms for
MAP3K21

Expression for MAP3K21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Evidence on tissue expression from TISSUES for MAP3K21 Gene

  • Lung(2.3)
genes like me logo Genes that share expression patterns with MAP3K21: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K21 Gene

Orthologs for MAP3K21 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP3K21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 33
  • 99 (a)
OneToOne
LOC469711 32
  • 99 (n)
dog
(Canis familiaris)
Mammalia -- 33
  • 84 (a)
OneToOne
KIAA1804 32
  • 83.32 (n)
cow
(Bos Taurus)
Mammalia LOC616014 32
  • 82.92 (n)
-- 33
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC021891 33 32
  • 73.98 (n)
OneToOne
Map3k21 17
rat
(Rattus norvegicus)
Mammalia RGD1306091 32
  • 73.75 (n)
chicken
(Gallus gallus)
Aves LOC428586 32
  • 71.43 (n)
-- 33
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-120p12.3 33 32
  • 63.99 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta slpr 33
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8999 33
  • 34 (a)
OneToMany
Species where no ortholog for MAP3K21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K21 Gene

ENSEMBL:
Gene Tree for MAP3K21 (if available)
TreeFam:
Gene Tree for MAP3K21 (if available)

Paralogs for MAP3K21 Gene

genes like me logo Genes that share paralogs with MAP3K21: view

Variants for MAP3K21 Gene

Sequence variations from dbSNP and Humsavar for MAP3K21 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000020006 -- 233,330,027(+) G/A intron_variant
rs1000034979 -- 233,378,147(+) A/G intron_variant
rs1000089489 -- 233,336,303(+) G/A intron_variant
rs1000141181 -- 233,327,798(+) C/A/T 5_prime_UTR_variant
rs1000189097 -- 233,385,354(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K21 Gene

Variant ID Type Subtype PubMed ID
esv22442 CNV gain 19812545
esv2431778 CNV insertion 19546169
esv3305388 CNV mobile element insertion 20981092
esv3309615 CNV mobile element insertion 20981092
esv3325227 CNV insertion 20981092
esv3325872 CNV insertion 20981092
esv3354604 CNV insertion 20981092
nsv1069391 CNV deletion 25765185
nsv1112566 CNV deletion 24896259
nsv1118149 CNV deletion 24896259

Variation tolerance for MAP3K21 Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.70; 93.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP3K21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K21 Gene

Disorders for MAP3K21 Gene

Additional Disease Information for MAP3K21

No disorders were found for MAP3K21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K21 Gene

Publications for MAP3K21 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 56
  2. MLK4 has negative effect on TLR4 signaling. (PMID: 21602844) Seit-Nebi A … Han J (Cellular & molecular immunology 2012) 3 4 56
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  4. Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells. (PMID: 30552384) Marusiak AA … Nowis D (Oncogene 2019) 3 56
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56

Products for MAP3K21 Gene

Sources for MAP3K21 Gene