Aliases for MAP3K20 Gene
- Mitogen-Activated Protein Kinase Kinase Kinase 20 2 3 4 5
- Mitogen-Activated Protein Kinase Kinase Kinase MLT 3 4
- MLK-Like Mitogen-Activated Protein Triple Kinase 3 4
- Human Cervical Cancer Suppressor Gene 4 Protein 3 4
- Mixed Lineage Kinase 7 2 3
- HCCS-4 3 4
- MLTK 3 4
- MRK 3 4
- ZAK 3 4
- ZAK1 Homolog, Leucine Zipper And Sterile-Alpha Motif Kinase (Dictyostelium) 2
- Mixed Lineage Kinase With A Leucine Zipper And A Sterile Alpha Motif 3
- Sterile Alpha Motif- And Leucine Zipper-Containing Kinase AZK 4
- Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK 3
- ZAK1 Homolog, Leucine Zipper And Sterile-Alpha Motif Kinase 3
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP3K20 Gene
MAP3K20 (Mitogen-Activated Protein Kinase Kinase Kinase 20) is a Protein Coding gene. Diseases associated with MAP3K20 include Split-Foot Malformation With Mesoaxial Polydactyly and Myopathy, Centronuclear, 6, With Fiber-Type Disproportion. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Signaling mediated by p38-gamma and p38-delta. An important paralog of this gene is MAP3K9.
UniProtKB/Swiss-Prot Summary for MAP3K20 Gene
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636).
[Isoform 1]: Phosphorylates histone H3 at 'Ser-28' (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189).