Aliases for MAP3K20 Gene
Aliases for MAP3K20 Gene
- Mitogen-Activated Protein Kinase Kinase Kinase 20 2 3 3 5
- Mitogen-Activated Protein Kinase Kinase Kinase MLT 3 4
- MLK-Like Mitogen-Activated Protein Triple Kinase 3 4
- Human Cervical Cancer Suppressor Gene 4 Protein 3 4
- Mixed Lineage Kinase 7 2 3
- HCCS-4 3 4
- MLTK 3 4
- MRK 3 4
- ZAK 3 4
- ZAK1 Homolog, Leucine Zipper And Sterile-Alpha Motif Kinase (Dictyostelium) 2
- Mixed Lineage Kinase With A Leucine Zipper And A Sterile Alpha Motif 3
- Sterile Alpha Motif- And Leucine Zipper-Containing Kinase AZK 4
- Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK 3
- ZAK1 Homolog, Leucine Zipper And Sterile-Alpha Motif Kinase 3
- Leucine Zipper- And Sterile Alpha Motif-Containing Kinase 4
External Ids for MAP3K20 Gene
- HGNC: 17797
- Entrez Gene: 51776
- Ensembl: ENSG00000091436
- OMIM: 609479
- UniProtKB: Q9NYL2
Summaries for MAP3K20 Gene
-
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP3K20 Gene
MAP3K20 (Mitogen-Activated Protein Kinase Kinase Kinase 20) is a Protein Coding gene. Diseases associated with MAP3K20 include Split-Foot Malformation With Mesoaxial Polydactyly and Myopathy, Centronuclear, 6, With Fiber-Type Disproportion. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and MAPK signaling pathway. An important paralog of this gene is MAP3K21.
UniProtKB/Swiss-Prot for MAP3K20 Gene
-
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636).
-
Isoform 1: Phosphorylates histone H3 at Ser-28 (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189).
Additional gene information for MAP3K20 Gene
- Monarch Initiative
- Search for MAP3K20 at DataMed
- Search for MAP3K20 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K20 Gene
Genomics for MAP3K20 Gene
GeneHancer (GH) Regulatory Elements for MAP3K20 Gene
Promoters and enhancers for MAP3K20 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAP3K20 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MAP3K20 Gene
Genomic Locations for MAP3K20 Gene
- chr2:173,075,435-173,268,010
- (GRCh38/hg38)
- Size:
- 192,576 bases
- Orientation:
- Plus strand
- chr2:173,940,163-174,132,738
- (GRCh37/hg19)
- Size:
- 192,576 bases
- Orientation:
- Plus strand
Genomic View for MAP3K20 Gene
Genes around MAP3K20 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q31.1 by Entrez Gene
- 2q31.1 by HGNC
- 2q31.1 by Ensembl
MAP3K20 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAP3K20 Gene
Proteins for MAP3K20 Gene
-
Protein details for MAP3K20 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NYL2-M3K20_HUMAN
- Recommended name:
- Mitogen-activated protein kinase kinase kinase 20
- Protein Accession:
- Q9NYL2
- B3KPG2
- Q53SX1
- Q580W8
- Q59GY5
- Q86YW8
- Q9HCC4
- Q9HCC5
- Q9HDD2
- Q9NYE9
Protein attributes for MAP3K20 Gene
- Size:
- 800 amino acids
- Molecular mass:
- 91155 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Homodimer (PubMed:10924358, PubMed:26755636). Interacts with PKN1 and ZNF33A (PubMed:12535642, PubMed:12761180). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, MAP3K20 and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and MAP3K20 (PubMed:21224381).
- SequenceCaution:
-
- Sequence=BAD92211.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Post-translational modifications for MAP3K20 Gene
Other Protein References for MAP3K20 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MAP3K20
- Novus Biologicals Antibodies for MAP3K20
-
Abcam antibodies for MAP3K20
- Invitrogen Antibodies for MAP3K20 (AFLGC-MAP3K20)
- GeneTex MAP3K20 Antibody for MAP3K20
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MAP3K20
- Origene Custom Protein Services for MAP3K20
- Search GeneTex for Proteins for MAP3K20
-
Abcam proteins for MAP3K20
Assay Products
- antibodies-online: Search results for 3 available ZAK Elisa Kits ranked by validation data
- Compare Top ZAK Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MAP3K20 Gene
Domains & Families for MAP3K20 Gene
Gene Families for MAP3K20 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for MAP3K20 Gene
Suggested Antigen Peptide Sequences for MAP3K20 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NYL2UniProtKB/Swiss-Prot:
M3K20_HUMAN :- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Function for MAP3K20 Gene
Molecular function for MAP3K20 Gene
- UniProtKB/Swiss-Prot Function:
- Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636).
- UniProtKB/Swiss-Prot Function:
- Isoform 1: Phosphorylates histone H3 at Ser-28 (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189).
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by phosphorylation by PKN1 and autophosphorylation on Thr-161 and Ser-165.
Enzyme Numbers (IUBMB) for MAP3K20 Gene
Phenotypes From GWAS Catalog for MAP3K20 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | IDA | 11836244 |
| GO:0003723 | RNA binding | HDA | 22681889 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IDA,IEA | 11836244 |
Phenotypes for MAP3K20 Gene
- MGI mutant phenotypes for MAP3K20:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for MAP3K20:
-
- Increased mitotic index
- Decreased substrate adherent cell growth
- Moderately decreased NFAT1-GFP nuclear translocation
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased viability in esophageal squamous lineage
- Decreased Salmonella enterica Typhimurium invasion
- Reduced beta-catenin activity and colon cancer cell proliferation
- Decreased viability
- no effect
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- shRNA abundance <= 50%
- Decreased IL-8 secretion
- Increased transferrin (TF) endocytosis
- Increased simian virus 40 (SV40) infection
- Transferrin accumulation in the perinuclear area
- Decreased vesicular stomatitis virus (VSV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAP3K20
-
CRISPR Products
-
OriGene CRISPR knockouts for MAP3K20
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K20
- genomics-online: gRNA clones - Search results for 33 available ZAK gene related products
- Overview of 33 available ZAK gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- Applied Biological Materials CRISPR for MAP3K20
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for MAP3K20
miRNA for MAP3K20 Gene
- miRTarBase miRNAs that target MAP3K20
-
- hsa-mir-874-3p (MIRT522466)
- hsa-mir-6807-5p (MIRT522467)
- hsa-mir-146b-3p (MIRT522468)
- hsa-mir-6799-3p (MIRT522469)
- hsa-mir-3173-5p (MIRT522470)
- hsa-mir-7976 (MIRT522471)
- hsa-mir-4749-3p (MIRT522472)
- hsa-mir-210-5p (MIRT522473)
- hsa-mir-324-3p (MIRT522474)
- hsa-mir-1913 (MIRT522475)
- hsa-mir-6752-3p (MIRT522476)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K20
- Browse OriGene Inhibitory RNA Products For MAP3K20
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K20
- genomics-online: shRNA clones - Search results for 33 available ZAK gene related products
- Overview of 33 available ZAK gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
Clone Products
-
OriGene ORF clones in human for MAP3K20
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAP3K20
- Addgene plasmids for MAP3K20
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K20
- genomics-online: cdna clones - Search results for 33 available ZAK gene related products
- Overview of 33 available ZAK gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- orf clones - Search results for 33 available ZAK gene related products
- Overview of 33 available ZAK gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- Applied Biological Materials Clones for MAP3K20
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MAP3K20
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MAP3K20 Gene
Localization for MAP3K20 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAP3K20 Gene
- Cytoplasm. Nucleus. Note=Translocates to the nucleus upon ultraviolet B irradiation. {ECO:0000269 PubMed:15684425}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| extracellular | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | ISS,IBA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for MAP3K20 Gene
Pathways by source for MAP3K20 Gene
2 BioSystems pathways for MAP3K20 Gene
1 KEGG pathway for MAP3K20 Gene
1 GeneGo (Thomson Reuters) pathway for MAP3K20 Gene
2 Qiagen pathways for MAP3K20 Gene
Interacting Proteins for MAP3K20 Gene
Selected Interacting proteins:
Q9NYL2-M3K20_HUMAN
ENSP00000364361
for MAP3K20 Gene via
MINT
STRING
UniProtKB
IID
GPS-Prot Interaction Network for MAP3K20
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000077 | DNA damage checkpoint | IMP | 11836244 |
| GO:0000165 | MAPK cascade | IEA | -- |
| GO:0000186 | activation of MAPKK activity | TAS | 11836244 |
| GO:0006468 | protein phosphorylation | IDA | 11836244 |
| GO:0007010 | cytoskeleton organization | IEA | -- |
Drugs & Compounds for MAP3K20 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dasatinib | Approved, Investigational | Pharma | Target | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 295 | |
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Sprycel | Approved June 2006 | Pharma | 0 | |||
| Magnesium | Approved | Nutra | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Drug Products
Transcripts for MAP3K20 Gene
mRNA/cDNA for MAP3K20 Gene
- (5) REFSEQ mRNAs :
- (380) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000409176 2572 bps (uc061ptc.1)
- ENST00000468408 585 bps (uc061ptd.1)
- ENST00000338983 7179 bps (uc002uhy.4)
- ENST00000476618 4010 bps (uc061pte.1)
- ENST00000375213 3741 bps (uc002uhz.4)
CRISPR Products
-
OriGene CRISPR knockouts for MAP3K20
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K20
- genomics-online: gRNA clones - Search results for 33 available ZAK gene related products
- Overview of 33 available ZAK gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- Applied Biological Materials CRISPR for MAP3K20
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for MAP3K20
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K20
- Browse OriGene Inhibitory RNA Products For MAP3K20
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K20
- genomics-online: shRNA clones - Search results for 33 available ZAK gene related products
- Overview of 33 available ZAK gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
Clone Products
-
OriGene ORF clones in human for MAP3K20
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAP3K20
- Addgene plasmids for MAP3K20
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K20
- genomics-online: cdna clones - Search results for 33 available ZAK gene related products
- Overview of 33 available ZAK gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- orf clones - Search results for 33 available ZAK gene related products
- Overview of 33 available ZAK gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- Applied Biological Materials Clones for MAP3K20
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MAP3K20 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
mRNA Expression by UniProt/SwissProt for MAP3K20 Gene:
Q9NYL2-M3K20_HUMAN
Tissue specificity:
Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
Evidence on tissue expression from TISSUES for MAP3K20 Gene
- Heart(4.6)
- Nervous system(4.6)
- Liver(4.2)
- Muscle(2.7)
- Intestine(2.4)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for MAP3K20
-
OriGene qPCR primer pairs and template standards for MAP3K20
- genomics-online: primer clones - Search results for 33 available ZAK gene related products
- Overview of 33 available ZAK gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K20 Gene
Orthologs for MAP3K20 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC459745 33 |
|
||
| ZAK 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
OneToOne | |
| ZAK 33 |
|
||||
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToOne | |
| ZAK 33 |
|
||||
| mouse (Mus musculus) |
Mammalia | Zak 34 33 |
|
OneToOne | |
| Map3k20 16 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Zak 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZAK 33 |
|
||
| -- 34 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100495797 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-15i8.3 33 |
|
||
| zak 34 34 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for MAP3K20 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MAP3K20 Gene
Variants for MAP3K20 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs863225437 | pathogenic, Split-hand/foot malformation 1, Split-foot malformation with mesoaxial polydactyly, Split-foot malformation with mesoaxial polydactyly (SFMMP) [MIM:616890] | 173,232,359(+) | T/G | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| rs1000010561 | -- | 173,172,479(+) | C/T | intron_variant | |
| rs1000025659 | -- | 173,263,103(+) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000033607 | -- | 173,262,599(+) | AAAAAAGAAAAAAAAAAAGAAAA/AAAAAAGAAAA | genic_downstream_transcript_variant, intron_variant | |
| rs1000035538 | -- | 173,184,344(+) | C/T | intron_variant |
Residual Variation Intolerance Score:
17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.70;
78.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAP3K20 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K20 Gene
Disorders for MAP3K20 Gene
(6) MalaCards diseases for MAP3K20 Gene - From: HGMD, LncRNADisease, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| split-foot malformation with mesoaxial polydactyly |
|
|
| myopathy, centronuclear, 6, with fiber-type disproportion |
|
|
| split-hand/foot malformation 1 |
|
|
| congenital fiber-type disproportion |
|
|
| hepatocellular carcinoma |
|
Search MAP3K20 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
M3K20_HUMAN- Split-foot malformation with mesoaxial polydactyly (SFMMP) [MIM:616890]: An autosomal recessive disorder characterized by a split-foot defect, mesoaxial polydactyly, nail abnormalities of the hands, and sensorineural hearing loss. {ECO:0000269 PubMed:26755636}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MAP3K20
No data available for Genatlas for MAP3K20 Gene
Publications for MAP3K20 Gene
- Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. (PMID: 10924358) Liu TC … Yang JJ (Biochemical and biophysical research communications 2000) 2 3 4 22 58
- Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN. (PMID: 12761180) Takahashi M … Ono Y (Journal of biochemistry 2003) 3 4 22 58
- MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest. (PMID: 11836244) Gross EA … Ruggieri R (The Journal of biological chemistry 2002) 3 4 22 58
- Identification and characterization of a novel MAP kinase kinase kinase, MLTK. (PMID: 11042189) Gotoh I … Nishida E (The Journal of biological chemistry 2001) 3 4 22 58
- Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. (PMID: 11549352) Bloem LJ … Wang X (Journal of molecular and cellular cardiology 2001) 3 4 22 58
Products for MAP3K20 Gene
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- Invitrogen Antibodies for MAP3K20 (AFLGC-MAP3K20)
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- antibodies-online: Search results for 26 available ZAK Antibodies ranked by validation data
- Compare Top ZAK Antibodies
- antibodies-online: Search results for 3 available ZAK Elisa Kits ranked by validation data
- Compare Top ZAK Elisa Kits
- Quality Products:
- antibodies-online: Search results for 9 available ZAK Proteins ranked by validation data
- Compare Top ZAK Proteins
- GeneTex MAP3K20 Antibody for MAP3K20
- Search GeneTex for Proteins for MAP3K20
- Horizon Cell Lines for MAP3K20
- genomics-online: cdna clones - Search results for 33 available ZAK gene related products
- Overview of 33 available ZAK gene related products
- Recommended
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
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- orf clones - Search results for 33 available ZAK gene related products
- Overview of 33 available ZAK gene related products
- Recommended
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- genomics-online: gRNA clones - Search results for 33 available ZAK gene related products
- Overview of 33 available ZAK gene related products
- Recommended
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- genomics-online: primer clones - Search results for 33 available ZAK gene related products
- Overview of 33 available ZAK gene related products
- Recommended
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- genomics-online: shRNA clones - Search results for 33 available ZAK gene related products
- Overview of 33 available ZAK gene related products
- Recommended
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- pCMV6-XL5
- pCMV6-AC
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pRS
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pGEM-T
- pcDNA3.1+C-(K)-DYK
- pCLIP-dual-SFFV-ZsGreen
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K20
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K20
- GeneCopoeia miRNA 3'UTR Target clone products for MAP3K20
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K20
Sources for MAP3K20 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
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- (14) ProtoNet
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- (21) IntAct
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
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- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
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- (114) diseasecard
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- (146) TISSUES
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- (155) genomics-online
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- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt