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This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
MAP3K20 (Mitogen-Activated Protein Kinase Kinase Kinase 20) is a Protein Coding gene. Diseases associated with MAP3K20 include Split-Foot Malformation With Mesoaxial Polydactyly and Myopathy, Centronuclear, 6, With Fiber-Type Disproportion. Among its related pathways are MAPK signaling pathway and Signaling mediated by p38-gamma and p38-delta. An important paralog of this gene is MAP3K9.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | IDA | 11836244 |
GO:0003723 | RNA binding | HDA | 22681889 |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IEA,IDA | 11836244 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | ISS | -- |
GO:0005829 | cytosol | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MAPK signaling pathway | ||
2 | Sertoli-Sertoli Cell Junction Dynamics |
Sertoli-Sertoli Cell Junction Dynamics
.38
|
Epithelial Tight Junctions
.36
|
3 | G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins |
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
.40
|
|
4 | Signaling mediated by p38-gamma and p38-delta |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000077 | DNA damage checkpoint | IMP | 11836244 |
GO:0000165 | MAPK cascade | IEA | -- |
GO:0000186 | activation of MAPKK activity | TAS | 11836244 |
GO:0006468 | protein phosphorylation | IDA | 11836244 |
GO:0007010 | cytoskeleton organization | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Dasatinib | Approved, Investigational | Pharma | Target | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 324 | |
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC459745 30 |
|
||
ZAK 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToOne | |
ZAK 30 |
|
||||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToOne | |
ZAK 30 |
|
||||
Mouse (Mus musculus) |
Mammalia | Zak 30 31 |
|
OneToOne | |
Map3k20 17 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zak 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ZAK 30 |
|
||
-- 31 |
|
OneToOne | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100495797 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-15i8.3 30 |
|
||
zak 31 31 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709622 | Benign: not provided | 173,182,851(+) | T/C | INTRON_VARIANT | |
726848 | Benign: not provided | 173,266,394(+) | C/T | MISSENSE_VARIANT | |
734728 | Likely Benign: not provided | 173,239,483(+) | G/A | MISSENSE_VARIANT | |
736952 | Likely Benign: not provided | 173,217,160(+) | T/C | SYNONYMOUS_VARIANT | |
773489 | Benign: not provided | 173,209,827(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
split-foot malformation with mesoaxial polydactyly |
|
|
myopathy, centronuclear, 6, with fiber-type disproportion |
|
|
split-hand/foot malformation 1 |
|
|
congenital fiber-type disproportion |
|
|
hepatocellular carcinoma |
|