Aliases for MAP3K2 Gene
External Ids for MAP3K2 Gene
Previous HGNC Symbols for MAP3K2 Gene
Previous GeneCards Identifiers for MAP3K2 Gene
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP3K2 Gene
MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2) is a Protein Coding gene. Diseases associated with MAP3K2 include Lung Cancer and Neurofibromatosis, Type I. Among its related pathways are G-Beta Gamma Signaling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K3.
UniProtKB/Swiss-Prot Summary for MAP3K2 Gene
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.