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Aliases for MAP3K2 Gene

Aliases for MAP3K2 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 2 2 3 5
  • MAPK/ERK Kinase Kinase 2 3 4
  • MAP/ERK Kinase Kinase 2 2 3
  • MEK Kinase 2 3 4
  • MEKK 2 3 4
  • MEKK2 3 4
  • EC 4
  • MAPKKK2 4
  • MEKK2B 3

External Ids for MAP3K2 Gene

Previous HGNC Symbols for MAP3K2 Gene

  • MEKK2

Previous GeneCards Identifiers for MAP3K2 Gene

  • GC02M125364
  • GC02M125990
  • GC02M127968
  • GC02M128157
  • GC02M128156
  • GC02M127780
  • GC02M120369
  • GC02M128057

Summaries for MAP3K2 Gene

Entrez Gene Summary for MAP3K2 Gene

  • The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K2 Gene

MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2) is a Protein Coding gene. Among its related pathways are NFAT and Cardiac Hypertrophy and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K3.

UniProtKB/Swiss-Prot for MAP3K2 Gene

  • Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.

Gene Wiki entry for MAP3K2 Gene

Additional gene information for MAP3K2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K2 Gene

Genomics for MAP3K2 Gene

GeneHancer (GH) Regulatory Elements for MAP3K2 Gene

Promoters and enhancers for MAP3K2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I127385 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 583.1 +0.0 38 5.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ENSG00000236682 MAP3K2 ERCC3 AMMECR1L GPR17 WDR33 ENSG00000231731 SFT2D3 GC02P127390 GC02P127379
GH02I127343 Promoter 0.5 EPDnew 562 +45.3 45272 0.1 MAP3K2 ENSG00000236682 PROC ERCC3 RNU4-48P LOC105373606 LOC100506922
GH02I127525 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.3 -138.7 -138665 4 HDGF PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IWS1 MAP3K2 AMMECR1L WDR33 ENSG00000236682 UGGT1 ENSG00000272789 ENSG00000231731 SFT2D3 GC02P127529
GH02I127413 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 32.6 -26.8 -26779 4.3 HDGF CLOCK FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS ERCC3 MAP3K2 SFT2D3 ENSG00000236682 AMMECR1L IWS1 PROC GC02P127390 GC02P127379
GH02I128090 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.9 -702.9 -702936 2.4 HDGF FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 UGGT1 AMMECR1L WDR33 SAP130 ERCC3 MAP3K2 GC02P128122 GC02P127983
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAP3K2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP3K2 gene promoter:

Genomic Locations for MAP3K2 Gene

Genomic Locations for MAP3K2 Gene
89,797 bases
Minus strand

Genomic View for MAP3K2 Gene

Genes around MAP3K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K2 Gene

Proteins for MAP3K2 Gene

  • Protein details for MAP3K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 2
    Protein Accession:
    Secondary Accessions:
    • B9EG87
    • Q53QL9
    • Q53S75
    • Q59GZ6
    • Q8NC32
    • Q9NYK3

    Protein attributes for MAP3K2 Gene

    619 amino acids
    Molecular mass:
    69741 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PKN2; the interaction activates PKN2 kinase activity in a MAP3K2-independent kinase activity (By similarity). Self-associates. Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts (via the kinase catalytic domain) with STK38. Interacts with XIAP/BIRC4.
    • Sequence=BAC11348.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAP3K2 Gene

neXtProt entry for MAP3K2 Gene

Post-translational modifications for MAP3K2 Gene

Other Protein References for MAP3K2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP3K2 (MEKK2)
  • Abcam antibodies for MAP3K2

No data available for DME Specific Peptides for MAP3K2 Gene

Domains & Families for MAP3K2 Gene

Gene Families for MAP3K2 Gene

Suggested Antigen Peptide Sequences for MAP3K2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K2: view

Function for MAP3K2 Gene

Molecular function for MAP3K2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-524.
UniProtKB/Swiss-Prot Function:
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.

Enzyme Numbers (IUBMB) for MAP3K2 Gene

Phenotypes From GWAS Catalog for MAP3K2 Gene

Gene Ontology (GO) - Molecular Function for MAP3K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IDA 15001576
GO:0004674 protein serine/threonine kinase activity TAS 8621389
GO:0004709 MAP kinase kinase kinase activity IEA --
GO:0005515 protein binding IPI 15778465
genes like me logo Genes that share ontologies with MAP3K2: view
genes like me logo Genes that share phenotypes with MAP3K2: view

Animal Models for MAP3K2 Gene

MGI Knock Outs for MAP3K2:

miRNA for MAP3K2 Gene

miRTarBase miRNAs that target MAP3K2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K2 Gene

Localization for MAP3K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K2 Gene

Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K2 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP3K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MAP3K2: view

Pathways & Interactions for MAP3K2 Gene

genes like me logo Genes that share pathways with MAP3K2: view

SIGNOR curated interactions for MAP3K2 Gene


Gene Ontology (GO) - Biological Process for MAP3K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0000187 activation of MAPK activity TAS 8621389
GO:0006468 protein phosphorylation TAS 8621389
GO:0007257 activation of JUN kinase activity TAS 8621389
GO:0007346 regulation of mitotic cell cycle IBA --
genes like me logo Genes that share ontologies with MAP3K2: view

Drugs & Compounds for MAP3K2 Gene

(17) Drugs for MAP3K2 Gene - From: DrugBank, ApexBio, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
bosutinib Approved Pharma Target, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
Bosulif Approved September 2012 Pharma 0
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist 0
AZD6244 (Selumetinib) Pharma MEK inhibitor 0

(1) Additional Compounds for MAP3K2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(9) ApexBio Compounds for MAP3K2 Gene

Compound Action Cas Number
AZD6244 (Selumetinib) MEK inhibitor 606143-52-6
PD0325901 MEK inhibitor 391210-10-9
PD98059 MEK inhibitor,selective and reversible 167869-21-8
Pimasertib (AS-703026) MEK1/2 inhibitor 1236699-92-5
SCH772984 ERK1 and ERK2 inhibitor 942183-80-4
SL-327 Selective MEK1/2 inhibitor 305350-87-2
Trametinib (GSK1120212) MEK1 and MEK2 inhibitor, potent and selective 871700-17-3
U0126-EtOH MEK1/2 inhibitor 1173097-76-1
Vemurafenib (PLX4032, RG7204) BRAF kinase inhibitor 918504-65-1
genes like me logo Genes that share compounds with MAP3K2: view

Drug Products

Transcripts for MAP3K2 Gene

mRNA/cDNA for MAP3K2 Gene

Unigene Clusters for MAP3K2 Gene

Mitogen-activated protein kinase kinase kinase 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K2 Gene

No ASD Table

Relevant External Links for MAP3K2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP3K2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP3K2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K2 Gene

This gene is overexpressed in Whole Blood (x4.0).

Protein differential expression in normal tissues from HIPED for MAP3K2 Gene

This gene is overexpressed in Plasma (29.5), Peripheral blood mononuclear cells (8.8), and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP3K2 Gene

Protein tissue co-expression partners for MAP3K2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP3K2 Gene:


SOURCE GeneReport for Unigene cluster for MAP3K2 Gene:


Evidence on tissue expression from TISSUES for MAP3K2 Gene

  • Nervous system(4.5)
  • Blood(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with MAP3K2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K2 Gene

Orthologs for MAP3K2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP3K2 33 34
  • 99.78 (n)
(Canis familiaris)
Mammalia MAP3K2 33 34
  • 95.42 (n)
(Monodelphis domestica)
Mammalia MAP3K2 34
  • 94 (a)
(Bos Taurus)
Mammalia MAP3K2 33 34
  • 93.91 (n)
(Mus musculus)
Mammalia Map3k2 33 16 34
  • 91.98 (n)
(Rattus norvegicus)
Mammalia Map3k2 33
  • 90.74 (n)
(Ornithorhynchus anatinus)
Mammalia MAP3K2 34
  • 87 (a)
(Gallus gallus)
Aves MAP3K2 33 34
  • 82.59 (n)
(Anolis carolinensis)
Reptilia MAP3K2 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia map3k2 33
  • 77.74 (n)
Str.7239 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15388 33
(Danio rerio)
Actinopterygii MAP3K2 34
  • 82 (a)
map3k2 33
  • 72.73 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE11 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
Species where no ortholog for MAP3K2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K2 Gene

Gene Tree for MAP3K2 (if available)
Gene Tree for MAP3K2 (if available)

Paralogs for MAP3K2 Gene

Variants for MAP3K2 Gene

Sequence variations from dbSNP and Humsavar for MAP3K2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
VAR_040683 A lung large cell carcinoma sample p.Met112Ile
rs1000010255 -- 127,325,146(-) G/C intron_variant
rs1000062610 -- 127,324,769(-) A/G intron_variant
rs1000124559 -- 127,342,588(-) T/C intron_variant
rs1000294881 -- 127,323,172(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K2 Gene

Variant ID Type Subtype PubMed ID
esv3584056 CNV loss 25503493

Variation tolerance for MAP3K2 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP3K2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K2 Gene

Disorders for MAP3K2 Gene

Additional Disease Information for MAP3K2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MAP3K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K2 Gene

Publications for MAP3K2 Gene

  1. Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PMID: 17906693) Enomoto A … Miyagawa K (Oncogene 2008) 3 4 22 58
  2. XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2. (PMID: 18761086) Winsauer G … de Martin R (Cellular signalling 2008) 3 4 22 58
  3. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. (PMID: 15075238) Raviv Z … Seger R (Journal of cell science 2004) 3 4 22 58
  4. Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. (PMID: 10713157) Cheng J … Su B (Molecular and cellular biology 2000) 3 4 22 58
  5. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta. (PMID: 10085062) Zhao Q … Lee FS (The Journal of biological chemistry 1999) 2 3 22 58

Products for MAP3K2 Gene

Sources for MAP3K2 Gene

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