MAP3K19 Gene (Protein Coding)

Mitogen-Activated Protein Kinase Kinase Kinase 19

GC02M134964
GIFtS:
32
See more...

Aliases for MAP3K19 Gene

Aliases for MAP3K19 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 19 2 3 4 5
  • RCK 2 3 4
  • Yeast Sps1/Ste20-Related Kinase 4 (S. Cerevisiae) 2 2
  • SPS1/STE20-Related Protein Kinase YSK4 3 4
  • Regulated In COPD, Protein Kinase 3 4
  • YSK4 3 4
  • YSK4 Sps1/Ste20-Related Kinase Homolog (S. Cerevisiae) 2
  • YSK4 Sps1/Ste20-Related Kinase Homolog 3
  • Yeast Sps1/Ste20-Related Kinase 4 3
  • Regulated In COPD Kinase 3
  • EC 2.7.11.1 4
  • FLJ23074 2
  • MAP3K19 5

External Ids for MAP3K19 Gene

Previous HGNC Symbols for MAP3K19 Gene

  • YSK4

Previous GeneCards Identifiers for MAP3K19 Gene

  • GC02M135723

Summaries for MAP3K19 Gene

GeneCards Summary for MAP3K19 Gene

MAP3K19 (Mitogen-Activated Protein Kinase Kinase Kinase 19) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PAK5.

Additional gene information for MAP3K19 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP3K19 Gene

Genomics for MAP3K19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAP3K19 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J135049 Promoter/Enhancer 0.8 EPDnew Ensembl 250.7 -0.1 -133 0.8 RFX1 ZBTB17 ZNF7 RFX3 SREBF1 MAP3K19 lnc-ZRANB3-1 RAB3GAP1
GH02J135051 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 18.4 -6.1 -6092 3.9 TBP ZBTB10 SP1 MXD4 MNT SMAD5 HES1 MBD2 ZNF217 POLR2A HSALNG0019045 RAB3GAP1 CCNT2 UBXN4 MAP3K19 MCM6 DARS1 ZRANB3 HSALNG0019046
GH02J135529 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 15.1 -484.0 -484038 5 CHD2 TBP MXD4 SP1 FEZF1 CEBPA SIX5 NR2C1 MNT BRCA1 R3HDM1 ZRANB3 CCNT2 UBXN4 MCM6 MAP3K19 lnc-UBXN4-11
GH02J135149 Enhancer 1 Ensembl ENCODE 29 -104.0 -104018 3 CEBPA FOXA1 ZNF217 HOMEZ KDM6A THAP11 FOXA2 SAP130 MIER3 ZSCAN9 MAP3K19 RAB3GAP1 HSALNG0019048 SNORA40B ZRANB3
GH02J135164 Enhancer 0.7 Ensembl ENCODE 28.7 -117.2 -117191 1.1 MBD2 CUX1 CTBP1 RAD21 PKNOX1 FOSL2 MNT FOS MAP3K19 SNORA40B RAB3GAP1 HSALNG0019048 HSALNG0019049 ZRANB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP3K19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP3K19

Genomic Locations for MAP3K19 Gene

Latest Assembly
chr2:134,963,875-135,047,468
(GRCh38/hg38)
Size:
83,594 bases
Orientation:
Minus strand

Previous Assembly
chr2:135,722,061-135,805,017
(GRCh37/hg19 by Entrez Gene)
Size:
82,957 bases
Orientation:
Minus strand

chr2:135,722,061-135,805,038
(GRCh37/hg19 by Ensembl)
Size:
82,978 bases
Orientation:
Minus strand

Genomic View for MAP3K19 Gene

Genes around MAP3K19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K19 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAP3K19 Gene

Proteins for MAP3K19 Gene

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  • Protein details for MAP3K19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q56UN5-M3K19_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 19
    Protein Accession:
    Q56UN5
    Secondary Accessions:
    • B2RP57
    • B7ZMH9
    • E2QRE3
    • Q56UN1
    • Q56UN2
    • Q56UN3
    • Q56UN4
    • Q8N4E9
    • Q9H5T2

    Protein attributes for MAP3K19 Gene

    Size:
    1328 amino acids
    Molecular mass:
    150537 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAT81412.1; Type=Miscellaneous discrepancy; Note=Non-canonical splice intron-exon junction.; Evidence={ECO:0000305}; Sequence=BAB15538.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP3K19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K19 Gene

Protein Expression for MAP3K19 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MAP3K19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP3K19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP3K19 Gene

Domains & Families for MAP3K19 Gene

Gene Families for MAP3K19 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MAP3K19 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP3K19 Gene

GenScript: Design optimal peptide antigens:
  • YSK4 protein (B7ZMH9_HUMAN)
  • Regulated in COPD, protein kinase (YSK4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q56UN5

UniProtKB/Swiss-Prot:

M3K19_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MAP3K19: view

Function for MAP3K19 Gene

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  6. Cell Lines for research

Molecular function for MAP3K19 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for MAP3K19 Gene

Phenotypes From GWAS Catalog for MAP3K19 Gene

Gene Ontology (GO) - Molecular Function for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with MAP3K19: view
genes like me logo Genes that share phenotypes with MAP3K19: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K19

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAP3K19 Gene

Localization for MAP3K19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K19 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAP3K19 Gene

Pathways & Interactions for MAP3K19 Gene

PathCards logo

SuperPathways for MAP3K19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with MAP3K19: view

No data available for Pathways by source and SIGNOR curated interactions for MAP3K19 Gene

Drugs & Compounds for MAP3K19 Gene

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  1. Drug products for research

(1) Drugs for MAP3K19 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
genes like me logo Genes that share compounds with MAP3K19: view

Transcripts for MAP3K19 Gene

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mRNA/cDNA for MAP3K19 Gene

7 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K19

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K19 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e
SP1: -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - -
SP6:

Relevant External Links for MAP3K19 Gene

GeneLoc Exon Structure for
MAP3K19

Expression for MAP3K19 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP3K19 Gene

mRNA expression in normal human tissues for MAP3K19 Gene
mRNA expression by GTEx for MAP3K19 GenemRNA expression by BioGPS for MAP3K19 Gene

mRNA differential expression in normal tissues according to GTEx for MAP3K19 Gene

This gene is overexpressed in Testis (x18.6), Brain - Hypothalamus (x6.5), Brain - Caudate (basal ganglia) (x4.6), and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for MAP3K19 Gene

This gene is overexpressed in Heart (54.3) and Brain (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAP3K19 Gene



Protein tissue co-expression partners for MAP3K19 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP3K19

SOURCE GeneReport for Unigene cluster for MAP3K19 Gene:

Hs.659395

Evidence on tissue expression from TISSUES for MAP3K19 Gene

  • Lung(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MAP3K19: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K19 Gene

Orthologs for MAP3K19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K19 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia YSK4 30
  • 99.02 (n)
MAP3K19 31
  • 98 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MAP3K19 30 31
  • 84.63 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia YSK4 30
  • 83.79 (n)
MAP3K19 31
  • 73 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Map3k19 30 17 31
  • 73.8 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Map3k19 30
  • 71.86 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia MAP3K19 31
  • 61 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MAP3K19 31
  • 47 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves YSK4 30
  • 59.97 (n)
MAP3K19 31
  • 41 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 27 (a)
 ManyToMany
African clawed frog
(Xenopus laevis)
 Amphibia Xl.15442 30
Zebrafish
(Danio rerio)
 Actinopterygii map3k19 31
  • 67 (a)
 OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes STE11 31
  • 22 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 50 (a)
 OneToOne
Species where no ortholog for MAP3K19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MAP3K19 Gene

ENSEMBL:
Gene Tree for MAP3K19 (if available)
TreeFam:
Gene Tree for MAP3K19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP3K19: view image

Paralogs for MAP3K19 Gene

Paralogs for MAP3K19 Gene

(20) SIMAP similar genes for MAP3K19 Gene using alignment to 5 proteins:

  • M3K19_HUMAN
  • A8MWG7_HUMAN
  • C9JEJ9_HUMAN
  • C9JGQ2_HUMAN
  • H7C041_HUMAN
genes like me logo Genes that share paralogs with MAP3K19: view

Variants for MAP3K19 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP3K19 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
VAR_041334 A breast pleomorphic lobular carcinoma sample p.Ile500Met
rs1112542 - p.Glu676Gln
rs16831235 - p.Thr438Ile
rs3905317 - p.Glu812Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MAP3K19 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MAP3K19 Gene

Variant ID Type Subtype PubMed ID
esv3560186 CNV deletion 23714750
esv3592568 CNV loss 21293372
nsv961516 CNV duplication 23825009

Variation tolerance for MAP3K19 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.94; 91.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP3K19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K19

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K19 Gene

Disorders for MAP3K19 Gene

Additional Disease Information for MAP3K19

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MAP3K19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K19 Gene

Publications for MAP3K19 Gene

  1. MAP3K19 Is a Novel Regulator of TGF-β Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis. (PMID: 27144281) Boehme SA … Bacon KB (PloS one 2016) 2 3
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells. (PMID: 32358059) Hoang VT … Brognard J (The Journal of biological chemistry 2020) 3

ExternalLinks

View latest publications for MAP3K19 gene in Mastermind

Products for MAP3K19 Gene

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