Aliases for MAP3K19 Gene

Aliases for MAP3K19 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 19 2 3 4 5
  • Yeast Sps1/Ste20-Related Kinase 4 (S. Cerevisiae) 2 2
  • SPS1/STE20-Related Protein Kinase YSK4 3 4
  • Regulated In COPD, Protein Kinase 3 4
  • YSK4 3 4
  • RCK 3 4
  • YSK4 Sps1/Ste20-Related Kinase Homolog (S. Cerevisiae) 2
  • YSK4 Sps1/Ste20-Related Kinase Homolog 3
  • Yeast Sps1/Ste20-Related Kinase 4 3
  • Regulated In COPD Kinase 3
  • HSALNG0019044 167
  • Lnc-ZRANB3-1 168
  • EC 4

External Ids for MAP3K19 Gene

Previous HGNC Symbols for MAP3K19 Gene

  • YSK4

Previous GeneCards Identifiers for MAP3K19 Gene

  • GC02M135723

Summaries for MAP3K19 Gene

GeneCards Summary for MAP3K19 Gene

MAP3K19 (Mitogen-Activated Protein Kinase Kinase Kinase 19) is a Protein Coding gene. Diseases associated with MAP3K19 include Optic Disk Drusen. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PAK5.

Additional gene information for MAP3K19 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP3K19 Gene

Genomics for MAP3K19 Gene

GeneHancer (GH) Regulatory Elements for MAP3K19 Gene

Promoters and enhancers for MAP3K19 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J135047 Promoter 0.6 EPDnew 500.7 +0.0 1 0.1 RFX1 SIN3A ZBTB17 SREBF1 RFX3 MAP3K19 RF00017-3317
GH02J135048 Enhancer 0.4 Ensembl 500.7 -0.3 -332 0.4 RFX1 SIN3A ZBTB17 SREBF1 ZNF7 MAP3K19 RAB3GAP1
GH02J135049 Enhancer 0.4 Ensembl 500.7 +0.2 167 0.2 RFX1 SIN3A RFX3 MAP3K19 RF00017-3317
GH02J135050 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 18.4 -5.6 -5644 4.8 ZNF217 SIN3A POLR2G SP1 GTF2E2 PHF8 ZNF639 EP300 ZBTB10 POLR2A RAB3GAP1 MAP3K19 DARS1 ZRANB3 RF01210-215
GH02J135529 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 15.1 -484.0 -484038 5 ZBTB40 ZNF217 EP300 TCF12 SIN3A MYC NRF1 USF1 POLR2G SP1 R3HDM1 ZRANB3 MAP3K19 UBXN4 MCM6 CCNT2 lnc-UBXN4-11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP3K19 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP3K19

Genomic Locations for MAP3K19 Gene

Genomic Locations for MAP3K19 Gene
83,179 bases
Minus strand
82,978 bases
Minus strand

Genomic View for MAP3K19 Gene

Genes around MAP3K19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K19 Gene

Proteins for MAP3K19 Gene

  • Protein details for MAP3K19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 19
    Protein Accession:
    Secondary Accessions:
    • B2RP57
    • B7ZMH9
    • E2QRE3
    • Q56UN1
    • Q56UN2
    • Q56UN3
    • Q56UN4
    • Q8N4E9
    • Q9H5T2

    Protein attributes for MAP3K19 Gene

    1328 amino acids
    Molecular mass:
    150537 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAT81412.1; Type=Miscellaneous discrepancy; Note=Non-canonical splice intron-exon junction.; Evidence={ECO:0000305}; Sequence=BAB15538.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP3K19 Gene


neXtProt entry for MAP3K19 Gene

Post-translational modifications for MAP3K19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAP3K19 Gene

Domains & Families for MAP3K19 Gene

Gene Families for MAP3K19 Gene

Protein Domains for MAP3K19 Gene

Suggested Antigen Peptide Sequences for MAP3K19 Gene

GenScript: Design optimal peptide antigens:
  • YSK4 protein (B7ZMH9_HUMAN)
  • Regulated in COPD, protein kinase (YSK4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MAP3K19: view

Function for MAP3K19 Gene

Molecular function for MAP3K19 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=;.

Enzyme Numbers (IUBMB) for MAP3K19 Gene

Phenotypes From GWAS Catalog for MAP3K19 Gene

Gene Ontology (GO) - Molecular Function for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with MAP3K19: view
genes like me logo Genes that share phenotypes with MAP3K19: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAP3K19 Gene

Localization for MAP3K19 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K19 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with MAP3K19: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K19 Gene

Pathways & Interactions for MAP3K19 Gene

PathCards logo

SuperPathways for MAP3K19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0023014 signal transduction by protein phosphorylation IBA 21873635
GO:0032147 activation of protein kinase activity IBA 21873635
genes like me logo Genes that share ontologies with MAP3K19: view

No data available for Pathways by source and SIGNOR curated interactions for MAP3K19 Gene

Drugs & Compounds for MAP3K19 Gene

(1) Drugs for MAP3K19 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
genes like me logo Genes that share compounds with MAP3K19: view

Transcripts for MAP3K19 Gene

mRNA/cDNA for MAP3K19 Gene

17 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
7 RNACentral transcripts :
1 LncBook transcripts :
1 LNCipedia transcripts :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K19 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e
SP1: -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - -

Relevant External Links for MAP3K19 Gene

GeneLoc Exon Structure for

Expression for MAP3K19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP3K19 Gene

mRNA differential expression in normal tissues according to GTEx for MAP3K19 Gene

This gene is overexpressed in Testis (x18.6), Brain - Hypothalamus (x6.5), Brain - Caudate (basal ganglia) (x4.6), and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for MAP3K19 Gene

This gene is overexpressed in Heart (54.3) and Brain (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAP3K19 Gene

Protein tissue co-expression partners for MAP3K19 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP3K19

SOURCE GeneReport for Unigene cluster for MAP3K19 Gene:


Evidence on tissue expression from TISSUES for MAP3K19 Gene

  • Lung(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MAP3K19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K19 Gene

Orthologs for MAP3K19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia YSK4 30
  • 99.02 (n)
MAP3K19 31
  • 98 (a)
(Canis familiaris)
Mammalia MAP3K19 31 30
  • 84.63 (n)
(Bos Taurus)
Mammalia YSK4 30
  • 83.79 (n)
MAP3K19 31
  • 73 (a)
(Mus musculus)
Mammalia Map3k19 17 31 30
  • 73.8 (n)
(Rattus norvegicus)
Mammalia Map3k19 30
  • 71.86 (n)
(Ornithorhynchus anatinus)
Mammalia MAP3K19 31
  • 61 (a)
(Monodelphis domestica)
Mammalia MAP3K19 31
  • 47 (a)
(Gallus gallus)
Aves YSK4 30
  • 59.97 (n)
MAP3K19 31
  • 41 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 27 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15442 30
(Danio rerio)
Actinopterygii map3k19 31
  • 67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE11 31
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
Species where no ortholog for MAP3K19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K19 Gene

Gene Tree for MAP3K19 (if available)
Gene Tree for MAP3K19 (if available)
Evolutionary constrained regions (ECRs) for MAP3K19: view image

Paralogs for MAP3K19 Gene

(20) SIMAP similar genes for MAP3K19 Gene using alignment to 5 proteins:

  • M3K19_HUMAN
  • H7C041_HUMAN
genes like me logo Genes that share paralogs with MAP3K19: view

Variants for MAP3K19 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP3K19 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
VAR_041334 A breast pleomorphic lobular carcinoma sample p.Ile500Met
rs1112542 - p.Glu676Gln
rs16831235 - p.Thr438Ile
rs3905317 - p.Glu812Gly

Additional dbSNP identifiers (rs#s) for MAP3K19 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAP3K19 Gene

Variant ID Type Subtype PubMed ID
esv3560186 CNV deletion 23714750
esv3592568 CNV loss 21293372
nsv961516 CNV duplication 23825009

Variation tolerance for MAP3K19 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.94; 91.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP3K19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K19 Gene

Disorders for MAP3K19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAP3K19 Gene - From: DISEASES

Disorder Aliases PubMed IDs
optic disk drusen
  • drusen of optic disc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAP3K19

genes like me logo Genes that share disorders with MAP3K19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP3K19 Gene

Publications for MAP3K19 Gene

  1. MAP3K19 Is a Novel Regulator of TGF-β Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis. (PMID: 27144281) Boehme SA … Bacon KB (PloS one 2016) 2 3 54
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. MAP3K19 Is Overexpressed in COPD and Is a Central Mediator of Cigarette Smoke-Induced Pulmonary Inflammation and Lower Airway Destruction. (PMID: 27935962) Boehme SA … Bacon KB (PloS one 2016) 3 54

Products for MAP3K19 Gene

Sources for MAP3K19 Gene