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The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic ... See more...
Aliases for MAP3K15 Gene
Aliases for MAP3K15 Gene
External Ids for MAP3K15 Gene
- HGNC: 31689
- Entrez Gene: 389840
- Ensembl: ENSG00000180815
- OMIM: 300820
- UniProtKB: Q6ZN16
Previous GeneCards Identifiers for MAP3K15 Gene
- GC0XM019138
- GC0XM019288
- GC0XM017127
Summaries for MAP3K15 Gene
-
The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]
GeneCards Summary for MAP3K15 Gene
MAP3K15 (Mitogen-Activated Protein Kinase Kinase Kinase 15) is a Protein Coding gene. Diseases associated with MAP3K15 include Pyruvate Dehydrogenase E1-Alpha Deficiency and Neuropathy, Hereditary Sensory And Autonomic, Type Iia. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K5.
UniProtKB/Swiss-Prot Summary for MAP3K15 Gene
-
May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.
Additional gene information for MAP3K15 Gene
- HGNC(31689)
- Entrez Gene(389840)
- Ensembl(ENSG00000180815)
- OMIM(300820)
- UniProtKB(Q6ZN16)
- Open Targets Platform(ENSG00000180815)
- Search for MAP3K15 at DataMed
- Search for MAP3K15 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP3K15 Gene
Genomics for MAP3K15 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MAP3K15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAP3K15 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP3K15
- Top Transcription factor binding sites by QIAGEN in the MAP3K15 gene promoter:
-
- AML1a
- HTF
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- PPAR-gamma1
- PPAR-gamma2
- RP58
- RSRFC4
- STAT3
Genomic Locations for MAP3K15 Gene
Genomic Locations for MAP3K15 Gene
- chrX:19,360,056-19,515,261
- (GRCh38/hg38)
- Size:
- 155,206 bases
- Orientation:
- Minus strand
- chrX:19,378,174-19,533,379
- (GRCh37/hg19)
- Size:
- 155,206 bases
- Orientation:
- Minus strand
Genomic View for MAP3K15 Gene
Genes around MAP3K15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.12 by HGNC
- Xp22.12 by Entrez Gene
- Xp22.12 by Ensembl
MAP3K15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAP3K15 Gene
Proteins for MAP3K15 Gene
-
Protein details for MAP3K15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZN16-M3K15_HUMAN
- Recommended name:
- Mitogen-activated protein kinase kinase kinase 15
- Protein Accession:
- Q6ZN16
- A2AI49
- A2AI50
- A6NJ61
- Q5JPR4
- Q6ZMV3
Protein attributes for MAP3K15 Gene
- Size:
- 1313 amino acids
- Molecular mass:
- 147437 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
- No Data Available
Protein Expression for MAP3K15 Gene
Selected DME Specific Peptides for MAP3K15 Gene
- Q6ZN16:
-
- LFGFQDAVN
- YGIVYAGRDLSNQVRIAIKEIPERD
- KISDFGTSK
- VPGGSLS
- NLLLSYRD
Post-translational modifications for MAP3K15 Gene
Other Protein References for MAP3K15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MAP3K15 Antibody
- Novus Biologicals Antibodies for MAP3K15
-
Abcam antibodies for MAP3K15
- Invitrogen Antibodies for MAP3K15 (AFLGC-MAP3K15)
-
Boster Bio Antibodies for MAP3K15
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAP3K15
Protein Products
-
OriGene Purified Proteins for MAP3K15
- Search Origene for MassSpec and Protein Over-expression Lysates for MAP3K15
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- Novus Biologicals proteins for MAP3K15
- antibodies-online: Show 5 available MAP3K15 Proteins ranked by validation data
- Compare Top MAP3K15 Proteins
-
Quality Products:
-
Abcam proteins for MAP3K15
Domains & Families for MAP3K15 Gene
Gene Families for MAP3K15 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for MAP3K15 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAP3K15 Gene
- GenScript: Design optimal peptide antigens:
-
- MAPK/ERK kinase kinase 15 (M3K15_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6ZN16UniProtKB/Swiss-Prot:
M3K15_HUMAN :- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Function for MAP3K15 Gene
Molecular function for MAP3K15 Gene
- UniProtKB/Swiss-Prot Function:
- May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence={ECO:0000269|PubMed:20362554};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence={ECO:0000269|PubMed:20362554};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-812, inhibited by phosphorylation at Ser-924 and Ser-994 (By similarity).
Enzyme Numbers (IUBMB) for MAP3K15 Gene
Phenotypes From GWAS Catalog for MAP3K15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IBA | 21873635 |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004709 | MAP kinase kinase kinase activity | IBA | 21873635 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for MAP3K15 Gene
- MGI mutant phenotypes for MAP3K15:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MAP3K15:
Animal Models for MAP3K15 Gene
- MGI Knock Outs for MAP3K15:
-
- Map3k15 Map3k15<tm1Hijo>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAP3K15 - Select products 50% OFF >
- * MAP3K15 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for MAP3K15 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for MAP3K15
- Addgene plasmids for MAP3K15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K15
Cell Line Products
-
Horizon Cell Lines for MAP3K15
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MAP3K15 Gene
Localization for MAP3K15 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Vesicles (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAP3K15 Gene
Pathways & Interactions for MAP3K15 Gene
Interacting Proteins for MAP3K15 Gene
GPS-Prot Interaction Network for MAP3K15
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IEA | -- |
| GO:0000186 | activation of MAPKK activity | IBA | 21873635 |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0033554 | cellular response to stress | IBA | 21873635 |
No data available for Pathways by source and SIGNOR curated interactions for MAP3K15 Gene
Transcripts for MAP3K15 Gene
mRNA/cDNA for MAP3K15 Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000338883 4012 nts (view in UCSC)
- ENST00000359173 3961 nts (view in UCSC)
- ENST00000470101 2049 nts (view in UCSC)
- ENST00000518578 4697 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAP3K15 - Select products 50% OFF >
- * MAP3K15 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAP3K15
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K15
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K15
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K15
- Browse OriGene Inhibitory RNA Products For MAP3K15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K15
Clone Products
- Applied Biological Materials (abm): Clones for MAP3K15 - Select products 50% OFF >
- * MAP3K15 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MAP3K15
- Addgene plasmids for MAP3K15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K15
Relevant External Links for MAP3K15 Gene
- GeneLoc Exon Structure for
- MAP3K15
Expression for MAP3K15 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Epithelial Cells
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Testis (Reproductive System)
- XY Germ Cells Testis Cord
-
Gonad
- XY Germ Cells Testis Cord
mRNA differential expression in normal tissues according to GTEx for MAP3K15 Gene
This gene is overexpressed in Adrenal Gland (x35.0).
This gene is overexpressed in Serum (35.8), Adrenal (23.9), and Peripheral blood mononuclear cells (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAP3K15 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP3K15
SOURCE GeneReport for Unigene cluster for MAP3K15 Gene:
Hs.713701mRNA Expression by UniProt/SwissProt for MAP3K15 Gene:
Q6ZN16-M3K15_HUMAN
Tissue specificity:
Isoform 2 and isoform 3 are widely expressed. Isoform 2 highest levels are observed in fetal brain, and isoform 3 highest levels in pancreas, peripheral blood leukocytes, fetal brain and spleen.
Evidence on tissue expression from TISSUES for MAP3K15 Gene
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs for MAP3K15
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K15 Gene
Orthologs for MAP3K15 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MAP3K15 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MAP3K15 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MAP3K15 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Map3k15 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Map3k15 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MAP3K15 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MAP3K15 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MAP3K15 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MAP3K15 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | MAP3K15 31 |
|
OneToOne | |
| map3k15 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000747 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Pk92B 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | nsy-1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STE11 31 |
|
OneToMany |
- Species where no ortholog for MAP3K15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for MAP3K15 Gene
- ENSEMBL:
- Gene Tree for MAP3K15 (if available)
- TreeFam:
- Gene Tree for MAP3K15 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAP3K15: view image
Paralogs for MAP3K15 Gene
(38) SIMAP similar genes for MAP3K15 Gene using alignment to 2 proteins:
- M3K15_HUMAN
- E7EWI5_HUMAN
Variants for MAP3K15 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP3K15 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 770825 | Benign: not provided | 19,464,336(-) | C/T | MISSENSE_VARIANT | |
| 788841 | Likely Benign: not provided | 19,425,607(-) | C/T | MISSENSE_VARIANT | |
| 913014 | Uncertain Significance: Pyruvate dehydrogenase E1-alpha deficiency | 19,361,029(-) | C/T | THREE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
| 913015 | Benign: Pyruvate dehydrogenase E1-alpha deficiency | 19,361,030(-) | G/A | THREE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
| 913016 | Benign: Pyruvate dehydrogenase E1-alpha deficiency | 19,361,047(-) | C/T | THREE_PRIME_UTR_VARIANT,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1395e199 | CNV | deletion | 23128226 |
| esv23814 | CNV | loss | 19812545 |
| esv2740000 | CNV | deletion | 23290073 |
| esv2740001 | CNV | deletion | 23290073 |
| esv3558663 | CNV | deletion | 23714750 |
| esv3558664 | CNV | deletion | 23714750 |
| esv3558667 | CNV | deletion | 23714750 |
| esv3573627 | CNV | loss | 25503493 |
| esv3573628 | CNV | loss | 25503493 |
| esv3573629 | CNV | loss | 25503493 |
| esv3573630 | CNV | loss | 25503493 |
| nsv1076247 | CNV | deletion | 25765185 |
| nsv1077221 | CNV | deletion | 25765185 |
| nsv1126943 | CNV | deletion | 24896259 |
| nsv1132237 | CNV | deletion | 24896259 |
| nsv1145286 | CNV | deletion | 24896259 |
| nsv425077 | CNV | insertion | 16902084 |
| nsv528469 | CNV | gain | 19592680 |
| nsv957810 | CNV | deletion | 24416366 |
Gene Damage Index Score:
3.96;
59.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAP3K15 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K15 Gene
Disorders for MAP3K15 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pyruvate dehydrogenase e1-alpha deficiency |
|
|
| neuropathy, hereditary sensory and autonomic, type iia |
|
|
| labyrinthitis |
|
|
Search MAP3K15 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAP3K15
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MAP3K15 Gene
Publications for MAP3K15 Gene
- ASK3, a novel member of the apoptosis signal-regulating kinase family, is essential for stress-induced cell death in HeLa cells. (PMID: 20362554) Kaji T … Kishimoto T (Biochemical and biophysical research communications 2010) 2 3 4
- ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney. (PMID: 23250415) Naguro I … Ichijo H (Nature communications 2012) 2 3
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress. (PMID: 29539411) Watanabe K … Ichijo H (Cell reports 2018) 3
ExternalLinks
Products for MAP3K15 Gene
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- antibodies-online: Show 11 available MAP3K15 Antibodies ranked by validation data
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- antibodies-online: Show 5 available MAP3K15 Proteins ranked by validation data
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- Quality Products:
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- Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K15
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- Boster Bio Antibodies for MAP3K15
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Sources for MAP3K15 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
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