Aliases for MAP3K13 Gene
External Ids for MAP3K13 Gene
Previous GeneCards Identifiers for MAP3K13 Gene
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP3K13 Gene
MAP3K13 (Mitogen-Activated Protein Kinase Kinase Kinase 13) is a Protein Coding gene. Diseases associated with MAP3K13 include Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease and Parkinson Disease, Late-Onset. Among its related pathways are Signal transduction_JNK pathway and Signaling events mediated by VEGFR1 and VEGFR2. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is MAP3K12.
UniProtKB/Swiss-Prot Summary for MAP3K13 Gene
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.