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Aliases for MAP3K13 Gene

Aliases for MAP3K13 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 13 2 3 5
  • Leucine Zipper-Bearing Kinase 2 3 4
  • Mixed Lineage Kinase 3 4
  • EC 4 56
  • LZK 3 4
  • MLK 3 4
  • EC 2.7.11 56
  • MEKK13 3

External Ids for MAP3K13 Gene

Previous GeneCards Identifiers for MAP3K13 Gene

  • GC03P181938
  • GC03P186229
  • GC03P186482
  • GC03P186401
  • GC03P186563
  • GC03P185000
  • GC03P182490

Summaries for MAP3K13 Gene

Entrez Gene Summary for MAP3K13 Gene

  • The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K13 Gene

MAP3K13 (Mitogen-Activated Protein Kinase Kinase Kinase 13) is a Protein Coding gene. Among its related pathways are NFAT and Cardiac Hypertrophy and Angiopoietin Like Protein 8 Regulatory Pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is MAP3K12.

UniProtKB/Swiss-Prot for MAP3K13 Gene

  • Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.

Gene Wiki entry for MAP3K13 Gene

Additional gene information for MAP3K13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K13 Gene

Genomics for MAP3K13 Gene

GeneHancer (GH) Regulatory Elements for MAP3K13 Gene

Promoters and enhancers for MAP3K13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I185282 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 577 +0.1 107 1.7 HDGF PKNOX1 ARID4B SIN3A DMAP1 BRCA1 ZNF48 YY1 ETS1 GLIS2 MAP3K13 EHHADH C3orf70 RPL4P4
GH03I185361 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 557.4 +80.2 80248 3 PKNOX1 ATF1 FOXA2 SIN3A YY1 ATF7 RUNX3 MCM3 SP3 REST MAP3K13 TRA2B RPL4P4
GH03I185325 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 38.4 +46.5 46523 7.6 PKNOX1 FOXA2 ARID4B DMAP1 YY1 TCF12 ATF7 RXRA SP5 REST MAP3K13 EHHADH RPL4P4
GH03I185316 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 39 +34.5 34508 2.3 HDAC1 FOXA2 ZBTB40 RARA YY1 CHAMP1 ATF7 RXRA CEBPB REST MAP3K13 EHHADH C3orf70 RPL4P4
GH03I185335 Enhancer 1.3 Ensembl ENCODE dbSUPER 26.4 +54.3 54290 3.3 ELF3 PKNOX1 FOXA2 THRB RARA RFX5 ZEB1 ZSCAN5C RCOR1 FOS MAP3K13 VPS8 RPL4P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAP3K13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP3K13 gene promoter:

Genomic Locations for MAP3K13 Gene

Genomic Locations for MAP3K13 Gene
206,157 bases
Plus strand

Genomic View for MAP3K13 Gene

Genes around MAP3K13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K13 Gene

Proteins for MAP3K13 Gene

  • Protein details for MAP3K13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 13
    Protein Accession:
    Secondary Accessions:
    • B2R6U2
    • B4DLE3
    • B4DMV2
    • B4DZJ4
    • D3DNU1
    • Q05BY6
    • Q15450
    • Q2NKN3

    Protein attributes for MAP3K13 Gene

    966 amino acids
    Molecular mass:
    108296 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP1 through the kinase catalytic domain. Binds PRDX3. Associates with the IKK complex through the kinase domain.
    • Sequence=AAI11727.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG59505.1; Type=Erroneous termination; Positions=740; Note=Translated as Tyr.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP3K13 Gene


neXtProt entry for MAP3K13 Gene

Selected DME Specific Peptides for MAP3K13 Gene


Post-translational modifications for MAP3K13 Gene

Domains & Families for MAP3K13 Gene

Gene Families for MAP3K13 Gene

Suggested Antigen Peptide Sequences for MAP3K13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K13: view

Function for MAP3K13 Gene

Molecular function for MAP3K13 Gene

GENATLAS Biochemistry:
mitogen activated protein (MAP/ERK) kinase kinase kinase 13,mixed lineage kinase family,most strongly expressed in pancreas
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by autophosphorylation and homodimerization.
UniProtKB/Swiss-Prot Function:
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.

Enzyme Numbers (IUBMB) for MAP3K13 Gene

Phenotypes From GWAS Catalog for MAP3K13 Gene

Gene Ontology (GO) - Molecular Function for MAP3K13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 9353328
GO:0004709 MAP kinase kinase kinase activity IDA 11726277
GO:0005515 protein binding IPI 11726277
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MAP3K13: view
genes like me logo Genes that share phenotypes with MAP3K13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP3K13 Gene

Localization for MAP3K13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K13 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K13 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubule organizing center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP3K13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0008385 colocalizes_with IkappaB kinase complex IDA 12492477
GO:0016020 membrane IEA,IDA 9353328
genes like me logo Genes that share ontologies with MAP3K13: view

Pathways & Interactions for MAP3K13 Gene

genes like me logo Genes that share pathways with MAP3K13: view

Pathways by source for MAP3K13 Gene

SIGNOR curated interactions for MAP3K13 Gene


Gene Ontology (GO) - Biological Process for MAP3K13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IDA 11726277
GO:0006468 protein phosphorylation IDA,IEA 9353328
GO:0007254 JNK cascade IDA 9353328
GO:0016310 phosphorylation IEA --
GO:0046777 protein autophosphorylation IDA 9353328
genes like me logo Genes that share ontologies with MAP3K13: view

Drugs & Compounds for MAP3K13 Gene

(8) Drugs for MAP3K13 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist 0

(2) Additional Compounds for MAP3K13 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAP3K13: view

Transcripts for MAP3K13 Gene

Unigene Clusters for MAP3K13 Gene

Mitogen-activated protein kinase kinase kinase 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K13 Gene

No ASD Table

Relevant External Links for MAP3K13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP3K13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP3K13 Gene

Protein differential expression in normal tissues from HIPED for MAP3K13 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAP3K13 Gene

Protein tissue co-expression partners for MAP3K13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP3K13 Gene:


SOURCE GeneReport for Unigene cluster for MAP3K13 Gene:


mRNA Expression by UniProt/SwissProt for MAP3K13 Gene:

Tissue specificity: Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas.

Evidence on tissue expression from TISSUES for MAP3K13 Gene

  • Nervous system(4.8)
  • Kidney(2.6)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with MAP3K13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K13 Gene

Orthologs for MAP3K13 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP3K13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP3K13 33 34
  • 99.14 (n)
(Bos Taurus)
Mammalia MAP3K13 33 34
  • 91.37 (n)
(Canis familiaris)
Mammalia MAP3K13 33 34
  • 91.34 (n)
(Ornithorhynchus anatinus)
Mammalia MAP3K13 34
  • 87 (a)
(Mus musculus)
Mammalia Map3k13 33 16 34
  • 84.78 (n)
(Rattus norvegicus)
Mammalia Map3k13 33
  • 84.36 (n)
(Monodelphis domestica)
Mammalia MAP3K13 34
  • 84 (a)
(Gallus gallus)
Aves MAP3K13 33 34
  • 76.41 (n)
(Anolis carolinensis)
Reptilia MAP3K13 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493878 33
  • 69.4 (n)
(Danio rerio)
Actinopterygii si:ch211-45c16.2 33
  • 67.94 (n)
MAP3K13 34
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8789 35
  • 62 (a)
wnd 34
  • 36 (a)
(Caenorhabditis elegans)
Secernentea dlk-1 34
  • 31 (a)
Species where no ortholog for MAP3K13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP3K13 Gene

Gene Tree for MAP3K13 (if available)
Gene Tree for MAP3K13 (if available)

Paralogs for MAP3K13 Gene

(11) SIMAP similar genes for MAP3K13 Gene using alignment to 6 proteins: Pseudogenes for MAP3K13 Gene

genes like me logo Genes that share paralogs with MAP3K13: view

Variants for MAP3K13 Gene

Sequence variations from dbSNP and Humsavar for MAP3K13 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
VAR_040710 A metastatic melanoma sample p.Pro746Leu
rs1000010127 -- 185,363,242(+) C/T 5_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000019374 -- 185,360,639(+) C/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000032558 -- 185,311,871(+) A/G genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000038867 -- 185,405,996(+) T/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K13 Gene

Variant ID Type Subtype PubMed ID
nsv967100 CNV duplication 23825009
nsv955530 CNV deletion 24416366
nsv829818 CNV loss 17160897
nsv829817 CNV gain 17160897
nsv822366 CNV loss 20364138
nsv441852 CNV loss 18776908
nsv237556 CNV deletion 16902084
nsv1152810 CNV insertion 26484159
nsv1146973 CNV duplication 26484159
nsv1140347 OTHER inversion 24896259
nsv1139185 CNV deletion 24896259
nsv1139184 CNV deletion 24896259
nsv1133332 CNV tandem duplication 24896259
nsv1133331 CNV tandem duplication 24896259
nsv1129705 CNV tandem duplication 24896259
nsv1120466 CNV tandem duplication 24896259
nsv1117357 CNV tandem duplication 24896259
nsv1074114 CNV deletion 25765185
nsv1074113 CNV deletion 25765185
esv7825 CNV loss 19470904
esv3893837 CNV gain 25118596
esv3598968 CNV loss 21293372
esv3598967 CNV loss 21293372
esv3598966 CNV gain 21293372
esv3563020 CNV deletion 23714750
esv3258 CNV loss 18987735
esv2832347 CNV deletion 24192839
esv2726325 CNV deletion 23290073
esv2659506 CNV deletion 23128226
esv2545135 CNV deletion 19546169
esv2339714 CNV deletion 18987734
esv1742989 CNV deletion 17803354
esv1687636 CNV insertion 17803354
dgv5002n100 CNV gain 25217958
dgv2653n106 CNV duplication 24896259
dgv2652n106 CNV deletion 24896259
dgv183n111 CNV deletion 26073780

Variation tolerance for MAP3K13 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP3K13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K13 Gene

Disorders for MAP3K13 Gene

Additional Disease Information for MAP3K13

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MAP3K13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K13 Gene

Publications for MAP3K13 Gene

  1. Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain. (PMID: 9353328) Sakuma H … Kawasaki T (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. (PMID: 11726277) Ikeda A … Kawasaki T (Journal of biochemistry 2001) 3 4 22 58
  3. Identification and characterization of functional domains in a mixed lineage kinase LZK. (PMID: 11163770) Ikeda A … Kawasaki T (FEBS letters 2001) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for MAP3K13 Gene

Sources for MAP3K13 Gene

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