Aliases for MAP3K12 Gene
External Ids for MAP3K12 Gene
Previous HGNC Symbols for MAP3K12 Gene
Previous GeneCards Identifiers for MAP3K12 Gene
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
GeneCards Summary for MAP3K12 Gene
MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12) is a Protein Coding gene. Diseases associated with MAP3K12 include Vitreoretinal Degeneration, Snowflake Type and Hyperpigmentation With Or Without Hypopigmentation, Familial Progressive. Among its related pathways are Signal transduction_JNK pathway and IL-2 Pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is MAP3K13.
UniProtKB/Swiss-Prot Summary for MAP3K12 Gene
Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway.