Aliases for MAP3K12 Gene
Aliases for MAP3K12 Gene
External Ids for MAP3K12 Gene
- HGNC: 6851
- Entrez Gene: 7786
- Ensembl: ENSG00000139625
- OMIM: 600447
- UniProtKB: Q12852
Previous HGNC Symbols for MAP3K12 Gene
- ZPK
Previous GeneCards Identifiers for MAP3K12 Gene
- GC12M053870
- GC12M053986
- GC12M053591
- GC12M052160
- GC12M050914
Summaries for MAP3K12 Gene
-
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
GeneCards Summary for MAP3K12 Gene
MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12) is a Protein Coding gene. Among its related pathways are Regulation of p38-alpha and p38-beta and Signal transduction_JNK pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is MAP3K13.
UniProtKB/Swiss-Prot for MAP3K12 Gene
-
May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
Additional gene information for MAP3K12 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K12 Gene
Genomics for MAP3K12 Gene
GeneHancer (GH) Regulatory Elements for MAP3K12 Gene
Promoters and enhancers for MAP3K12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAP3K12 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MAP3K12 gene promoter:
-
- AP-1
- Sp1
Regulatory Element Products
Genomic Locations for MAP3K12 Gene
Genomic Locations for MAP3K12 Gene
- chr12:53,479,669-53,500,136
- (GRCh38/hg38)
- Size:
- 20,468 bases
- Orientation:
- Minus strand
- chr12:53,874,274-53,893,847
- (GRCh37/hg19)
- Size:
- 19,574 bases
- Orientation:
- Minus strand
Genomic View for MAP3K12 Gene
Genes around MAP3K12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
- 12q13.13 by Ensembl
MAP3K12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAP3K12 Gene
Proteins for MAP3K12 Gene
-
Protein details for MAP3K12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q12852-M3K12_HUMAN
- Recommended name:
- Mitogen-activated protein kinase kinase kinase 12
- Protein Accession:
- Q12852
- B3KSS9
- G3V1Y2
- Q86VQ5
- Q8WY25
Protein attributes for MAP3K12 Gene
- Size:
- 859 amino acids
- Molecular mass:
- 93219 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with MBIP.
Three dimensional structures from OCA and Proteopedia for MAP3K12 Gene
Protein Expression for MAP3K12 Gene
Post-translational modifications for MAP3K12 Gene
- Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MAP3K12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MAP3K12
- Novus Biologicals Antibodies for MAP3K12
-
Abcam antibodies for MAP3K12
- Invitrogen Antibodies for MAP3K12
- GeneTex Map3k12 Antibody for MAP3K12
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAP3K12
Protein Products
-
OriGene Purified Proteins for MAP3K12
- Search Origene for MassSpec and Protein Over-expression Lysates for MAP3K12
- Origene Custom Protein Services for MAP3K12
- Search GeneTex for Proteins for MAP3K12
-
Abcam proteins for MAP3K12
Assay Products
No data available for DME Specific Peptides for MAP3K12 Gene
Domains & Families for MAP3K12 Gene
Gene Families for MAP3K12 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for MAP3K12 Gene
Suggested Antigen Peptide Sequences for MAP3K12 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q12852UniProtKB/Swiss-Prot:
M3K12_HUMAN :- Interacts with MBIP through the leucine-zipper motif.
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
- Domain:
-
- Interacts with MBIP through the leucine-zipper motif.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Function for MAP3K12 Gene
Molecular function for MAP3K12 Gene
- UniProtKB/Swiss-Prot Function:
- May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- GENATLAS Biochemistry:
- mitogen activated protein (MAP/ERK) kinase kinase kinase 12,expressed in brain,interacting with the GTP bound form of RAC and CDC42,regulators of JNK pathway
Enzyme Numbers (IUBMB) for MAP3K12 Gene
Phenotypes From GWAS Catalog for MAP3K12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | TAS,IEA | 8637721 |
| GO:0004674 | protein serine/threonine kinase activity | ISS,IBA | 9353328 |
| GO:0004709 | MAP kinase kinase kinase activity | IEA | -- |
| GO:0004871 | obsolete signal transducer activity | IBA | -- |
Phenotypes for MAP3K12 Gene
- MGI mutant phenotypes for MAP3K12:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for MAP3K12:
-
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Decreased substrate adherent cell growth
- Increased number of mitotic cells
- Increased G1 DNA content
- Increased cell size
- Increased viability after TNF/CHX stimulation
- Increased shRNA abundance (Z-score > 2)
- Increased cell death HMECs cells
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased viability in esophageal squamous lineage
- Increased cell viability after pRB stimulation
- Decreased viability
- no effect
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- shRNA abundance <= 50%
- Increased viability
- Increased transferrin (TF) endocytosis
- Decreased vesicular stomatitis virus (VSV) infection
Animal Models for MAP3K12 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAP3K12
-
CRISPR Products
-
OriGene CRISPR knockouts for MAP3K12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K12
- genomics-online: gRNA clones - Search results for 101 available MAP3K12 gene related products
- Overview of 101 available MAP3K12 gene related products
- Applied Biological Materials CRISPR for MAP3K12
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K12
- GenScript: Design CRISPR guide RNA sequences for MAP3K12
miRNA for MAP3K12 Gene
- miRTarBase miRNAs that target MAP3K12
-
- hsa-mir-20a-5p (MIRT003010)
- hsa-mir-17-5p (MIRT003013)
- hsa-mir-26b-5p (MIRT029590)
- hsa-mir-1277-5p (MIRT511191)
- hsa-mir-6083 (MIRT511192)
- hsa-mir-3924 (MIRT511193)
- hsa-mir-190a-3p (MIRT511194)
- hsa-mir-5011-5p (MIRT511195)
- hsa-mir-410-3p (MIRT511196)
- hsa-mir-32-3p (MIRT511197)
- hsa-mir-6722-5p (MIRT522632)
- hsa-mir-130a-3p (MIRT733110)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K12
- Browse OriGene Inhibitory RNA Products For MAP3K12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K12
- genomics-online: shRNA clones - Search results for 101 available MAP3K12 gene related products
- Overview of 101 available MAP3K12 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for MAP3K12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAP3K12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAP3K12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K12
- Applied Biological Materials Clones for MAP3K12
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K12 Gene
Localization for MAP3K12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAP3K12 Gene
- Cytoplasm. Membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 3 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Cell Junctions (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005737 | cytoplasm | TAS | 8663324 |
| GO:0005829 | cytosol | ISS,IEA | -- |
| GO:0005886 | plasma membrane | IEA,ISS | -- |
| GO:0016020 | membrane | ISS | 9353328 |
Pathways & Interactions for MAP3K12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MAPK signaling pathway | ||
| 2 | Angiopoietin Like Protein 8 Regulatory Pathway | ||
| 3 | TGF-Beta Pathway | ||
| 4 | NFAT and Cardiac Hypertrophy | ||
| 5 | IL-2 Pathway |
.37
|
|
Pathways by source for MAP3K12 Gene
5 BioSystems pathways for MAP3K12 Gene
1 KEGG pathway for MAP3K12 Gene
1 GeneGo (Thomson Reuters) pathway for MAP3K12 Gene
5 Qiagen pathways for MAP3K12 Gene
Interacting Proteins for MAP3K12 Gene
Selected Interacting proteins:
ENSP00000448689
Q12852-M3K12_HUMAN
for MAP3K12 Gene via
STRING
IID
MINT
UniProtKB
GPS-Prot Interaction Network for MAP3K12
SIGNOR curated interactions for MAP3K12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IBA | -- |
| GO:0000186 | activation of MAPKK activity | IEA | -- |
| GO:0006468 | protein phosphorylation | ISS,IEA | -- |
| GO:0007254 | JNK cascade | TAS,ISS | 9353328 |
| GO:0016310 | phosphorylation | IEA | -- |
Drugs & Compounds for MAP3K12 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Magnesium | Approved | Nutra | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker | 0 | ||
| URMC-099 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Drug Products
Transcripts for MAP3K12 Gene
mRNA/cDNA for MAP3K12 Gene
- (7) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (112) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000267079 4319 bps (uc001sdm.3)
- ENST00000547020 5627 bps (uc058oqz.1)
- ENST00000547488 2807 bps (uc001sdn.3)
- ENST00000551511 719 bps (uc058ora.1)
- ENST00000547035 2944 bps (uc058orb.1)
Unigene Clusters for MAP3K12 Gene
- Mitogen-activated protein kinase kinase kinase 12:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MAP3K12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K12
- genomics-online: gRNA clones - Search results for 101 available MAP3K12 gene related products
- Overview of 101 available MAP3K12 gene related products
- Applied Biological Materials CRISPR for MAP3K12
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K12
- GenScript: Design CRISPR guide RNA sequences for MAP3K12
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K12
- Browse OriGene Inhibitory RNA Products For MAP3K12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K12
- genomics-online: shRNA clones - Search results for 101 available MAP3K12 gene related products
- Overview of 101 available MAP3K12 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for MAP3K12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAP3K12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAP3K12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K12
- Applied Biological Materials Clones for MAP3K12
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for MAP3K12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Gut Tube (Gastrointestinal Tract)
-
Thyroid (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for MAP3K12 Gene
This gene is overexpressed in Brain - Cerebellum (x4.4).
This gene is overexpressed in Cervix (50.6) and Plasma (10.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAP3K12 Gene
NURSA nuclear receptor signaling pathways regulating expression of MAP3K12 Gene:
MAP3K12SOURCE GeneReport for Unigene cluster for MAP3K12 Gene:
Hs.713539mRNA Expression by UniProt/SwissProt for MAP3K12 Gene:
Q12852-M3K12_HUMAN
Tissue specificity:
Highly expressed in brain and kidney.
Evidence on tissue expression from TISSUES for MAP3K12 Gene
- Nervous system(2.8)
Primer Products
-
OriGene qPCR primer pairs for MAP3K12
- genomics-online: primer clones - Search results for 101 available MAP3K12 gene related products
- Overview of 101 available MAP3K12 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K12 Gene
Orthologs for MAP3K12 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAP3K12 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MAP3K12 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MAP3K12 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Map3k12 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Map3k12 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MAP3K12 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MAP3K12 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MAP3K12 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | map3k12 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | map3k12 33 |
|
||
| MAP3K12 34 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG8789 35 |
|
|
|
| wnd 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | dlk-1 34 |
|
OneToMany |
- Species where no ortholog for MAP3K12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MAP3K12 Gene
- ENSEMBL:
- Gene Tree for MAP3K12 (if available)
- TreeFam:
- Gene Tree for MAP3K12 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAP3K12: view image
Paralogs for MAP3K12 Gene
Paralogs for MAP3K12 Gene
(9) SIMAP similar genes for MAP3K12 Gene using alignment to 3 proteins:
- M3K12_HUMAN
- F8VUG4_HUMAN
- H3BMF0_HUMAN
Variants for MAP3K12 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_040705 | A breast pleomorphic lobular carcinoma sample | p.Glu409Lys | |||
| rs1000055065 | -- | 53,489,920(-) | G/A | intron_variant | |
| rs1000304068 | -- | 53,497,057(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000310038 | -- | 53,502,657(-) | C/A/G | upstream_transcript_variant | |
| rs1000619064 | -- | 53,488,714(-) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1293318 | CNV | deletion | 17803354 |
| esv2289574 | CNV | deletion | 18987734 |
| esv2745906 | CNV | deletion | 23290073 |
| esv2745908 | CNV | deletion | 23290073 |
| esv992595 | CNV | deletion | 20482838 |
| nsv714 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
6.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.70;
46.25% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAP3K12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MAP3K12
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K12 Gene
Disorders for MAP3K12 Gene
Additional Disease Information for MAP3K12
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MAP3K12 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K12 Gene
Publications for MAP3K12 Gene
- Cloning of a novel putative protein kinase having a leucine zipper domain from human brain. (PMID: 8037767) Reddy UR … Pleasure D (Biochemical and biophysical research communications 1994) 2 3 4 22 58
- SP3 acts as a positive regulator on the core promoter of human ZPK gene. (PMID: 14697235) Itoh A … Itoh T (Biochemical and biophysical research communications 2004) 3 4 22 58
- Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 44 58
- The small heat-shock protein Hsp27 undergoes ERK-dependent phosphorylation and redistribution to the cytoskeleton in response to dual leucine zipper-bearing kinase expression. (PMID: 19675578) Robitaille H … Germain L (The Journal of investigative dermatology 2010) 3 22 58
- The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PMID: 19730683) Landa I … Robledo M (PLoS genetics 2009) 3 44 58
Products for MAP3K12 Gene
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- Custom Antibody ServicesOriGene Antibodies for MAP3K12
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MAP3K12
- Search Origene for MassSpec and Protein Over-expression Lysates for MAP3K12
- Origene Custom Protein Services for MAP3K12
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K12
- Browse OriGene Inhibitory RNA Products For MAP3K12
- OriGene qPCR primer pairs for MAP3K12
- OriGene CRISPR knockouts for MAP3K12
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- GenScript: Next-day shipping of latest version cDNA ORF clones for MAP3K12 in any vector
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- GenScript: Design CRISPR guide RNA sequences for MAP3K12
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MAP3K12
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MAP3K12
- Novus Biologicals proteins and lysates for MAP3K12
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MAP3K12
- Abcam proteins for MAP3K12
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder custom plasmid, inducible vectors for MAP3K12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAP3K12
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAP3K12
- GeneTex Map3k12 Antibody for MAP3K12
- Search GeneTex for Proteins for MAP3K12
- Santa Cruz Biotechnology (SCBT) Antibodies for MAP3K12
- Search Santa Cruz Biotechnology (SCBT) for MAP3K12 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K12
- Horizon Cell Lines for MAP3K12
- genomics-online: cdna clones - Search results for 101 available MAP3K12 gene related products
- Overview of 101 available MAP3K12 gene related products
- orf clones - Search results for 101 available MAP3K12 gene related products
- Overview of 101 available MAP3K12 gene related products
- genomics-online: gRNA clones - Search results for 101 available MAP3K12 gene related products
- Overview of 101 available MAP3K12 gene related products
- genomics-online: primer clones - Search results for 101 available MAP3K12 gene related products
- Overview of 101 available MAP3K12 gene related products
- genomics-online: shRNA clones - Search results for 101 available MAP3K12 gene related products
- Overview of 101 available MAP3K12 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K12
- GeneCopoeia miRNA 3'UTR Target clone products for MAP3K12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K12
Sources for MAP3K12 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45)