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This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription fa... See more...
Aliases for MAP3K12 Gene
Aliases for MAP3K12 Gene
External Ids for MAP3K12 Gene
- HGNC: 6851
- Entrez Gene: 7786
- Ensembl: ENSG00000139625
- OMIM: 600447
- UniProtKB: Q12852
Previous HGNC Symbols for MAP3K12 Gene
- ZPK
Previous GeneCards Identifiers for MAP3K12 Gene
- GC12M053870
- GC12M053986
- GC12M053591
- GC12M052160
- GC12M050914
Summaries for MAP3K12 Gene
-
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
GeneCards Summary for MAP3K12 Gene
MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12) is a Protein Coding gene. Diseases associated with MAP3K12 include Vitreoretinal Degeneration, Snowflake Type and Hyperpigmentation With Or Without Hypopigmentation, Familial Progressive. Among its related pathways are Signal transduction_JNK pathway and IL-2 Pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is MAP3K13.
UniProtKB/Swiss-Prot Summary for MAP3K12 Gene
-
Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway.
Additional gene information for MAP3K12 Gene
- HGNC(6851)
- Entrez Gene(7786)
- Ensembl(ENSG00000139625)
- OMIM(600447)
- UniProtKB(Q12852)
- Open Targets Platform(ENSG00000139625)
- Search for MAP3K12 at DataMed
- Search for MAP3K12 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP3K12 Gene
Genomics for MAP3K12 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MAP3K12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAP3K12 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP3K12
- Top Transcription factor binding sites by QIAGEN in the MAP3K12 gene promoter:
-
- AP-1
- Sp1
Genomic Locations for MAP3K12 Gene
Genomic Locations for MAP3K12 Gene
- chr12:53,479,669-53,501,205
- (GRCh38/hg38)
- Size:
- 21,537 bases
- Orientation:
- Minus strand
- chr12:53,874,274-53,893,847
- (GRCh37/hg19)
- Size:
- 19,574 bases
- Orientation:
- Minus strand
Genomic View for MAP3K12 Gene
Genes around MAP3K12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by HGNC
- 12q13.13 by Entrez Gene
- 12q13.13 by Ensembl
MAP3K12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAP3K12 Gene
Proteins for MAP3K12 Gene
-
Protein details for MAP3K12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q12852-M3K12_HUMAN
- Recommended name:
- Mitogen-activated protein kinase kinase kinase 12
- Protein Accession:
- Q12852
- B3KSS9
- G3V1Y2
- Q86VQ5
- Q8WY25
Protein attributes for MAP3K12 Gene
- Size:
- 859 amino acids
- Molecular mass:
- 93219 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Homodimer (By similarity). Interacts with MBIP (PubMed:10801814).
Three dimensional structures from OCA and Proteopedia for MAP3K12 Gene
Protein Expression for MAP3K12 Gene
Selected DME Specific Peptides for MAP3K12 Gene
- Q12852:
-
- RRREELRHALDIREHYERKLERANNLYMEL
- HLDIASADVL
- GMNYLHLHKIIHRDLKSPN
- HRDLKSPN
- KISDFGTSK
- RNRPSFRQ
- STFSSEN
- LWELLTGE
- GQLYEVLRAGR
- TPQETYFKSQAEWREEVK
- WMAPEVI
- CPDGFKIL
- IGKAYST
- GFLEGLFGCLRPVW
- VKISDFGTSKELSDKSTKMSFAGTVAW
- GSGAQGAVFLG
- WEVPFEEI
- HFEKIKSEGTC
- ETDIKHLRKLKHPNII
Post-translational modifications for MAP3K12 Gene
- Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated (By similarity).
- The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MAP3K12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MAP3K12 Antibody
- Novus Biologicals Antibodies for MAP3K12
-
Abcam antibodies for MAP3K12
- Invitrogen Antibodies for MAP3K12 (AFLGC-MAP3K12)
-
Biorbyt antibodies for MAP3K12
-
Boster Bio Antibodies for MAP3K12
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAP3K12
Protein Products
-
OriGene Purified Proteins for MAP3K12
- Search Origene for MassSpec and Protein Over-expression Lysates for MAP3K12
- Origene Custom Protein Services for MAP3K12
- Novus Biologicals proteins for MAP3K12
-
Signalway Proteins for MAP3K12
-
Abcam proteins for MAP3K12
Domains & Families for MAP3K12 Gene
Gene Families for MAP3K12 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for MAP3K12 Gene
Suggested Antigen Peptide Sequences for MAP3K12 Gene
- GenScript: Design optimal peptide antigens:
-
- Mixed lineage kinase (M3K12_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q12852UniProtKB/Swiss-Prot:
M3K12_HUMAN :- Interacts with MBIP through the leucine-zipper motif.
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
- Domain:
-
- Interacts with MBIP through the leucine-zipper motif.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Function for MAP3K12 Gene
Molecular function for MAP3K12 Gene
- UniProtKB/Swiss-Prot Function:
- Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence={ECO:0000250|UniProtKB:Q60700};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence={ECO:0000250|UniProtKB:Q60700};.
- GENATLAS Biochemistry:
- mitogen activated protein (MAP/ERK) kinase kinase kinase 12,expressed in brain,interacting with the GTP bound form of RAC and CDC42,regulators of JNK pathway
Enzyme Numbers (IUBMB) for MAP3K12 Gene
Phenotypes From GWAS Catalog for MAP3K12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA,TAS | 8637721 |
| GO:0004674 | protein serine/threonine kinase activity | ISS | 9353328 |
| GO:0004706 | JUN kinase kinase kinase activity | IBA,ISS | -- |
| GO:0004709 | MAP kinase kinase kinase activity | IEA | -- |
Phenotypes for MAP3K12 Gene
- MGI mutant phenotypes for MAP3K12:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for MAP3K12:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- shRNA abundance <= 50%
- Decreased viability ratio
- Decreased viability
- Increased cell size
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- shRNA abundance <= 25%
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased viability in glioblastoma multiforme (GBM) lineage
- Decreased transferrin (TF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Increased viability
- Increased shRNA abundance (Z-score > 2)
- Increased S DNA content
- Decreased shRNA abundance (Z-score < -2)
- Increased number of mitotic cells
- Increased cell death in DLD-1 cells
- Decreased viability after TNF/CHX stimulation
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Decreased substrate adherent cell growth
- Decreased cell viability after pRB stimulation
- Increased vesicular stomatitis virus (VSV) infection
Animal Models for MAP3K12 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAP3K12 - Select products 50% OFF >
- * MAP3K12 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAP3K12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K12
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K12
miRNA for MAP3K12 Gene
- miRTarBase miRNAs that target MAP3K12
-
- hsa-miR-20a-5p (MIRT003010)
- hsa-miR-17-5p (MIRT003013)
- hsa-miR-26b-5p (MIRT029590)
- hsa-miR-1277-5p (MIRT511191)
- hsa-miR-6083 (MIRT511192)
- hsa-miR-3924 (MIRT511193)
- hsa-miR-190a-3p (MIRT511194)
- hsa-miR-5011-5p (MIRT511195)
- hsa-miR-410-3p (MIRT511196)
- hsa-miR-32-3p (MIRT511197)
- hsa-miR-6722-5p (MIRT522632)
- mmu-miR-5127 (MIRT604870)
- mmu-miR-150-5p (MIRT604871)
- mmu-miR-105 (MIRT604872)
- mmu-miR-291b-3p (MIRT604873)
- mmu-miR-301a-3p (MIRT604874)
- mmu-miR-130a-3p (MIRT604875)
- mmu-miR-130b-3p (MIRT604876)
- mmu-miR-301b-3p (MIRT604877)
- mmu-miR-721 (MIRT604878)
- mmu-miR-19b-3p (MIRT604879)
- mmu-miR-19a-3p (MIRT604880)
- hsa-miR-130a-3p (MIRT733110)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K12
- Browse OriGene Inhibitory RNA Products For MAP3K12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K12
Clone Products
- Applied Biological Materials (abm): Clones for MAP3K12 - Select products 50% OFF >
- * MAP3K12 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211069
- MG217856
- MR211069
- MR211069L3
- MR211069L4
- MR217856
- MR217856L3
- MR217856L4
- RC216463
- RC216463L1
- RC216463L2
- RC216463L3
- RC216463L4
- RC231434
- RC231434L3
- RC231434L4
- RG216463
- RG231434
- RR200674
- RR200674L3
- RR200674L4
- MR211069L3V
- MR211069L4V
- MR217856L3V
- MR217856L4V
- RC216463L1V
- RC216463L2V
- RC216463L3V
- RC216463L4V
- RC231434L3V
- RC231434L4V
- RR200674L3V
- RR200674L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAP3K12
- Addgene plasmids for MAP3K12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K12
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K12 Gene
Localization for MAP3K12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAP3K12 Gene
- Cytoplasm. Cell membrane. Note=Behaves essentially as an integral membrane protein. {ECO:0000250 UniProtKB:Q60700}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cell Junctions (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | TAS | 8663324 |
| GO:0005829 | cytosol | ISS | -- |
| GO:0005886 | plasma membrane | TAS,ISS | -- |
| GO:0016020 | membrane | ISS | 9353328 |
| GO:0030424 | axon | IEA | -- |
Pathways & Interactions for MAP3K12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MAPK signaling pathway | ||
| 2 | Angiopoietin Like Protein 8 Regulatory Pathway | ||
| 3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
|
|
| 4 | NFAT and Cardiac Hypertrophy |
NFAT and Cardiac Hypertrophy
.42
|
|
| 5 | IL-2 Pathway |
PACAP Signaling
.37
|
|
Pathways by source for MAP3K12 Gene
5 BioSystems pathways for MAP3K12 Gene
1 KEGG pathway for MAP3K12 Gene
1 GeneGo (Thomson Reuters) pathway for MAP3K12 Gene
- Signal transduction_JNK pathway
5 Qiagen pathways for MAP3K12 Gene
- MAPK Family Pathway
- NFAT and Cardiac Hypertrophy
- PACAP Signaling
- TNFR2 Pathway
- WNT Signaling
Interacting Proteins for MAP3K12 Gene
Selected Interacting proteins:
Q12852-M3K12_HUMAN
ENSP00000448689
for MAP3K12 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MAP3K12
SIGNOR curated interactions for MAP3K12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000186 | activation of MAPKK activity | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA,ISS | -- |
| GO:0007254 | JNK cascade | TAS,ISS | 9353328 |
| GO:0007256 | activation of JNKK activity | ISS | -- |
| GO:0007257 | activation of JUN kinase activity | ISS | -- |
Drugs & Compounds for MAP3K12 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
| URMC-099 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
(1) ApexBio Compounds for MAP3K12 Gene
| Compound | Action | Cas Number |
|---|---|---|
| URMC-099 | 1229582-33-5 |
Transcripts for MAP3K12 Gene
mRNA/cDNA for MAP3K12 Gene
- 2 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000267079 4319 nts (view in UCSC)
- ENST00000547020 5627 nts (view in UCSC)
- ENST00000547035 2944 nts (view in UCSC)
- ENST00000547151 584 nts (view in UCSC)
- ENST00000547488 4261 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAP3K12 - Select products 50% OFF >
- * MAP3K12 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAP3K12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP3K12
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP3K12
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K12
- Browse OriGene Inhibitory RNA Products For MAP3K12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K12
Clone Products
- Applied Biological Materials (abm): Clones for MAP3K12 - Select products 50% OFF >
- * MAP3K12 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211069
- MG217856
- MR211069
- MR211069L3
- MR211069L4
- MR217856
- MR217856L3
- MR217856L4
- RC216463
- RC216463L1
- RC216463L2
- RC216463L3
- RC216463L4
- RC231434
- RC231434L3
- RC231434L4
- RG216463
- RG231434
- RR200674
- RR200674L3
- RR200674L4
- MR211069L3V
- MR211069L4V
- MR217856L3V
- MR217856L4V
- RC216463L1V
- RC216463L2V
- RC216463L3V
- RC216463L4V
- RC231434L3V
- RC231434L4V
- RR200674L3V
- RR200674L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAP3K12
- Addgene plasmids for MAP3K12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP3K12
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
Relevant External Links for MAP3K12 Gene
- GeneLoc Exon Structure for
- MAP3K12
Expression for MAP3K12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Gut Tube (Gastrointestinal Tract)
-
Thyroid (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for MAP3K12 Gene
This gene is overexpressed in Brain - Cerebellum (x4.4).
This gene is overexpressed in Cervix (50.6) and Plasma (10.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAP3K12 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP3K12
SOURCE GeneReport for Unigene cluster for MAP3K12 Gene:
Hs.713539mRNA Expression by UniProt/SwissProt for MAP3K12 Gene:
Q12852-M3K12_HUMAN
Tissue specificity:
Highly expressed in brain and kidney.
Evidence on tissue expression from TISSUES for MAP3K12 Gene
- Nervous system(3.2)
- Skin(2.9)
- Blood(2.3)
- Intestine(2.2)
- Heart(2.1)
- Kidney(2.1)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for MAP3K12
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K12 Gene
Orthologs for MAP3K12 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MAP3K12 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MAP3K12 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MAP3K12 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Map3k12 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Map3k12 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MAP3K12 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MAP3K12 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MAP3K12 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | map3k12 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | map3k12 30 |
|
||
| MAP3K12 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG8789 32 |
|
|
|
| wnd 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | dlk-1 31 |
|
OneToMany |
- Species where no ortholog for MAP3K12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MAP3K12 Gene
- ENSEMBL:
- Gene Tree for MAP3K12 (if available)
- TreeFam:
- Gene Tree for MAP3K12 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAP3K12: view image
Paralogs for MAP3K12 Gene
Paralogs for MAP3K12 Gene
(9) SIMAP similar genes for MAP3K12 Gene using alignment to 3 proteins:
- M3K12_HUMAN
- F8VUG4_HUMAN
- H3BMF0_HUMAN
Variants for MAP3K12 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP3K12 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 716174 | Benign: not provided | 53,482,786(-) | C/T | MISSENSE_VARIANT | |
| VAR_040705 | A breast pleomorphic lobular carcinoma sample | p.Glu409Lys | |||
| rs34366500 | - | p.Gly628Arg | |||
| rs55794887 | - | p.Gly640Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1293318 | CNV | deletion | 17803354 |
| esv2289574 | CNV | deletion | 18987734 |
| esv2745906 | CNV | deletion | 23290073 |
| esv2745908 | CNV | deletion | 23290073 |
| esv992595 | CNV | deletion | 20482838 |
| nsv714 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
6.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.70;
46.25% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAP3K12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MAP3K12
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K12 Gene
Disorders for MAP3K12 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| vitreoretinal degeneration, snowflake type |
|
|
| hyperpigmentation with or without hypopigmentation, familial progressive |
|
|
| noonan syndrome 1 |
|
|
Search MAP3K12 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAP3K12
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MAP3K12 Gene
Publications for MAP3K12 Gene
- Cloning of a novel putative protein kinase having a leucine zipper domain from human brain. (PMID: 8037767) Reddy UR … Pleasure D (Biochemical and biophysical research communications 1994) 2 3 4 23
- SP3 acts as a positive regulator on the core promoter of human ZPK gene. (PMID: 14697235) Itoh A … Itoh T (Biochemical and biophysical research communications 2004) 3 4 23
- ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion. (PMID: 28111074) Huang YA … Südhof TC (Cell 2017) 3 4
- The small heat-shock protein Hsp27 undergoes ERK-dependent phosphorylation and redistribution to the cytoskeleton in response to dual leucine zipper-bearing kinase expression. (PMID: 19675578) Robitaille H … Germain L (The Journal of investigative dermatology 2010) 3 23
- Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 41
ExternalLinks
Products for MAP3K12 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MAP3K12
- Search Origene for MassSpec and Protein Over-expression Lysates for MAP3K12
- Origene Custom Protein Services for MAP3K12
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP3K12
- Browse OriGene Inhibitory RNA Products For MAP3K12
- OriGene qPCR primer pairs for MAP3K12
- OriGene CRISPR knockouts for MAP3K12
- MG211069
- MG217856
- MR211069
- MR211069L3
- MR211069L4
- MR217856
- MR217856L3
- MR217856L4
- RC216463
- RC216463L1
- RC216463L2
- RC216463L3
- RC216463L4
- RC231434
- RC231434L3
- RC231434L4
- RG216463
- RG231434
- RR200674
- RR200674L3
- RR200674L4
- MR211069L3V
- MR211069L4V
- MR217856L3V
- MR217856L4V
- RC216463L1V
- RC216463L2V
- RC216463L3V
- RC216463L4V
- RC231434L3V
- RC231434L4V
- RR200674L3V
- RR200674L4V
- Custom cloning services - gene synthesis, subclonin