The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be invol... See more...

Aliases for MAP3K11 Gene

Aliases for MAP3K11 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 11 2 3 4 5
  • Src-Homology 3 Domain-Containing Proline-Rich Kinase 3 4
  • Mixed Lineage Kinase 3 3 4
  • EC 2.7.11.25 4 52
  • MLK3 3 4
  • PTK1 3 4
  • SPRK 3 4
  • SH3 Domain-Containing Proline-Rich Kinase 3
  • Protein-Tyrosine Kinase PTK1 3
  • EC 2.7.11 52
  • MEKK11 3
  • MLK-3 3

External Ids for MAP3K11 Gene

Previous HGNC Symbols for MAP3K11 Gene

  • MLK3
  • PTK1

Previous GeneCards Identifiers for MAP3K11 Gene

  • GC11M067881
  • GC11M067046
  • GC11M065615
  • GC11M065140
  • GC11M065121
  • GC11M065365
  • GC11M061692

Summaries for MAP3K11 Gene

Entrez Gene Summary for MAP3K11 Gene

  • The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K11 Gene

MAP3K11 (Mitogen-Activated Protein Kinase Kinase Kinase 11) is a Protein Coding gene. Diseases associated with MAP3K11 include Parkinson Disease, Late-Onset. Among its related pathways are RET signaling and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot Summary for MAP3K11 Gene

  • Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.

Gene Wiki entry for MAP3K11 Gene

Additional gene information for MAP3K11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP3K11 Gene

Genomics for MAP3K11 Gene

GeneHancer (GH) Regulatory Elements for MAP3K11 Gene

Promoters and enhancers for MAP3K11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP3K11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP3K11

Top Transcription factor binding sites by QIAGEN in the MAP3K11 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • NF-1
  • NF-1/L

Genomic Locations for MAP3K11 Gene

Genomic Locations for MAP3K11 Gene
chr11:65,597,755-65,615,382
(GRCh38/hg38)
Size:
17,628 bases
Orientation:
Minus strand
chr11:65,365,226-65,382,853
(GRCh37/hg19)
Size:
17,628 bases
Orientation:
Minus strand

Genomic View for MAP3K11 Gene

Genes around MAP3K11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K11 Gene

Proteins for MAP3K11 Gene

  • Protein details for MAP3K11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16584-M3K11_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 11
    Protein Accession:
    Q16584
    Secondary Accessions:
    • B4DS76
    • Q53H00
    • Q59F06
    • Q6P2G4

    Protein attributes for MAP3K11 Gene

    Size:
    847 amino acids
    Molecular mass:
    92688 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer; undergoes dimerization during activation (PubMed:9829970). Interacts with MAP2K4/MKK4 (By similarity). Interacts with MAP2K7/MKK7 (PubMed:9003778). Found in a complex with SH3RF1, RAC1, MAP2K7/MKK7, MAPK8IP1/JIP1 and MAPK8/JNK1 (By similarity).
    SequenceCaution:
    • Sequence=BAD92892.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAP3K11 Gene

    Alternative splice isoforms for MAP3K11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K11 Gene

Selected DME Specific Peptides for MAP3K11 Gene

Q16584:
  • LAVAYGVA
  • MSAAGTYAWM
  • LWELLTGE
  • LRAKEKEL
  • EARLFAML
  • SGDEGWW
  • WMAPEVI
  • LAGRRVPPHVLVNWAVQ
  • VIHRDLK
  • EQLRRRE

Post-translational modifications for MAP3K11 Gene

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by CDC42.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP3K11 Gene

Domains & Families for MAP3K11 Gene

Gene Families for MAP3K11 Gene

Suggested Antigen Peptide Sequences for MAP3K11 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ78931, highly similar to Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (B4DS76_HUMAN)
  • Src-homology 3 domain-containing proline-rich kinase (M3K11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16584

UniProtKB/Swiss-Prot:

M3K11_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K11: view

Function for MAP3K11 Gene

Molecular function for MAP3K11 Gene

UniProtKB/Swiss-Prot Function:
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.
GENATLAS Biochemistry:
mitogen activated protein (MAP/ERK) kinase kinase kinase 11,interacting specifically with the GTP bound form of RAC and CDC42,regulators of JNK pathway

Enzyme Numbers (IUBMB) for MAP3K11 Gene

Phenotypes From GWAS Catalog for MAP3K11 Gene

Gene Ontology (GO) - Molecular Function for MAP3K11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS,IEA 8183572
GO:0004674 protein serine/threonine kinase activity IDA,TAS 8195146
GO:0004706 JUN kinase kinase kinase activity ISS --
GO:0004709 MAP kinase kinase kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with MAP3K11: view
genes like me logo Genes that share phenotypes with MAP3K11: view

Animal Models for MAP3K11 Gene

MGI Knock Outs for MAP3K11:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAP3K11

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K11 Gene

Localization for MAP3K11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K11 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Location is cell cycle dependent.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K11 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 2
extracellular 2
mitochondrion 2
nucleus 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP3K11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IBA,IDA 12529434
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IDA 12529434
genes like me logo Genes that share ontologies with MAP3K11: view

Pathways & Interactions for MAP3K11 Gene

PathCards logo

SuperPathways for MAP3K11 Gene

SuperPathway Contained pathways
1 RET signaling
2 G-protein signaling RAC1 in cellular process
.37
.37
3 Paradoxical activation of RAF signaling by kinase inactive BRAF
4 MAPK signaling pathway
5 TGF-Beta Pathway
.60
.51
genes like me logo Genes that share pathways with MAP3K11: view

Pathways by source for MAP3K11 Gene

7 GeneGo (Thomson Reuters) pathways for MAP3K11 Gene
  • Cytoskeleton remodeling CDC42 in cellular processes
  • Development FGF-family signaling
  • Development FGFR signaling pathway
  • G-protein signaling RAC1 in cellular process
  • Signal transduction_JNK pathway
13 Qiagen pathways for MAP3K11 Gene
  • CDC42 Pathway
  • JNK Pathway
  • MAPK Family Pathway
  • MAPK Signaling
  • NFAT and Cardiac Hypertrophy
1 Cell Signaling Technology pathway for MAP3K11 Gene

SIGNOR curated interactions for MAP3K11 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAP3K11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IMP 15258589
GO:0006468 protein phosphorylation IEA,IDA 11053428
GO:0007017 microtubule-based process IMP 12529434
GO:0007254 JNK cascade TAS 10799501
GO:0007256 activation of JNKK activity IEA --
genes like me logo Genes that share ontologies with MAP3K11: view

Drugs & Compounds for MAP3K11 Gene

(13) Drugs for MAP3K11 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
URMC-099 Pharma 0

(5) Additional Compounds for MAP3K11 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(1) ApexBio Compounds for MAP3K11 Gene

Compound Action Cas Number
URMC-099 1229582-33-5
genes like me logo Genes that share compounds with MAP3K11: view

Drug Products

Transcripts for MAP3K11 Gene

mRNA/cDNA for MAP3K11 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ·
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: -
SP8: -
SP9: - -
SP10: - - -
SP11: -
SP12:
SP13:
SP14:

ExUns: 12c ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for MAP3K11 Gene

GeneLoc Exon Structure for
MAP3K11

Expression for MAP3K11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP3K11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K11 Gene

This gene is overexpressed in Whole Blood (x5.8).

Protein differential expression in normal tissues from HIPED for MAP3K11 Gene

This gene is overexpressed in Plasma (31.1), Lung (29.7), and Pancreatic juice (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP3K11 Gene



Protein tissue co-expression partners for MAP3K11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP3K11

SOURCE GeneReport for Unigene cluster for MAP3K11 Gene:

Hs.502872

mRNA Expression by UniProt/SwissProt for MAP3K11 Gene:

Q16584-M3K11_HUMAN
Tissue specificity: Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.

Evidence on tissue expression from TISSUES for MAP3K11 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Blood(4.3)
  • Spleen(4.3)
genes like me logo Genes that share expression patterns with MAP3K11: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K11 Gene

Orthologs for MAP3K11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAP3K11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP3K11 31 30
  • 99.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MAP3K11 31 30
  • 89.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MAP3K11 31 30
  • 89.3 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map3k11 30
  • 86.25 (n)
mouse
(Mus musculus)
Mammalia Map3k11 17 31 30
  • 86.17 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP3K11 31
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP3K11 31
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MAP3K11 31
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta slpr 31 32
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K11D12.10b 32
  • 28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons HT1 30
  • 46.32 (n)
rice
(Oryza sativa)
Liliopsida Os06g0636600 30
  • 50.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8999 31
  • 29 (a)
OneToMany
Species where no ortholog for MAP3K11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)