The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosi... See more...

Aliases for MAP3K10 Gene

Aliases for MAP3K10 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 10 2 3 4 5
  • Mixed Lineage Kinase 2 2 3 4
  • MST 2 3 4
  • MKN28 Derived Nonreceptor_type Serine/Threonine Kinase 2 3
  • Protein Kinase MST 3 4
  • MKN28 Kinase 2 3
  • EC 2.7.11.25 4 51
  • MEKK10 2 3
  • MLK2 3 4
  • EC 2.7.11 51
  • MAP3K10 5

External Ids for MAP3K10 Gene

Previous HGNC Symbols for MAP3K10 Gene

  • MLK2

Previous GeneCards Identifiers for MAP3K10 Gene

  • GC19P041337
  • GC19P041089
  • GC19P045373
  • GC19P045389
  • GC19P040697
  • GC19P037132

Summaries for MAP3K10 Gene

Entrez Gene Summary for MAP3K10 Gene

  • The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K10 Gene

MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10) is a Protein Coding gene. Diseases associated with MAP3K10 include Stress Polycythemia. Among its related pathways are Signal transduction_JNK pathway and IL-2 Pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot Summary for MAP3K10 Gene

Gene Wiki entry for MAP3K10 Gene

Additional gene information for MAP3K10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP3K10 Gene

Genomics for MAP3K10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MAP3K10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP3K10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP3K10

Top Transcription factor binding sites by QIAGEN in the MAP3K10 gene promoter:
  • AML1a
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • C/EBPalpha
  • CHOP-10
  • CUTL1
  • MIF-1
  • Spz1
  • ZIC2

Genomic Locations for MAP3K10 Gene

Genomic Locations for MAP3K10 Gene
chr19:40,191,426-40,215,575
(GRCh38/hg38)
Size:
24,150 bases
Orientation:
Plus strand
chr19:40,697,651-40,721,482
(GRCh37/hg19)
Size:
23,832 bases
Orientation:
Plus strand

Genomic View for MAP3K10 Gene

Genes around MAP3K10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K10 Gene

Proteins for MAP3K10 Gene

  • Protein details for MAP3K10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02779-M3K10_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 10
    Protein Accession:
    Q02779
    Secondary Accessions:
    • Q12761
    • Q14871

    Protein attributes for MAP3K10 Gene

    Size:
    954 amino acids
    Molecular mass:
    103694 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. Interacts with SH3RF2.

    Three dimensional structures from OCA and Proteopedia for MAP3K10 Gene

neXtProt entry for MAP3K10 Gene

Selected DME Specific Peptides for MAP3K10 Gene

Q02779:
  • LAVAYGVA
  • MSAAGTYAWM
  • KKKGRTWGP
  • KQWSSSAPNL
  • LRTKEKELRSREEEL
  • LWELLTGE
  • FPRLPDP
  • SGDEGWW
  • WMAPEVI
  • ELTLRRG
  • LAGRRVPPHVLVNWAVQ
  • EQLRRRE
  • QSLTPTHVT

Post-translational modifications for MAP3K10 Gene

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP3K10 Gene

Antibody Products

  • Abcam antibodies for MAP3K10
  • Santa Cruz Biotechnology (SCBT) Antibodies for MAP3K10

Domains & Families for MAP3K10 Gene

Gene Families for MAP3K10 Gene

Suggested Antigen Peptide Sequences for MAP3K10 Gene

GenScript: Design optimal peptide antigens:
  • Protein kinase MST (M3K10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q02779

UniProtKB/Swiss-Prot:

M3K10_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K10: view

Function for MAP3K10 Gene

Molecular function for MAP3K10 Gene

UniProtKB/Swiss-Prot Function:
Activates the JUN N-terminal pathway.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.
GENATLAS Biochemistry:
mitogen activated protein (MAP/ERK) kinase kinase kinase 10

Enzyme Numbers (IUBMB) for MAP3K10 Gene

Phenotypes From GWAS Catalog for MAP3K10 Gene

Gene Ontology (GO) - Molecular Function for MAP3K10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003714 transcription corepressor activity IEA,ISS --
GO:0004672 protein kinase activity IEA,TAS 8536694
GO:0004674 protein serine/threonine kinase activity IEA,IDA 19801649
GO:0004706 JUN kinase kinase kinase activity ISS --
genes like me logo Genes that share ontologies with MAP3K10: view
genes like me logo Genes that share phenotypes with MAP3K10: view

Animal Models for MAP3K10 Gene

MGI Knock Outs for MAP3K10:

Animal Model Products

CRISPR Products

miRNA for MAP3K10 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K10

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K10 Gene

Localization for MAP3K10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K10 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
extracellular 2
mitochondrion 2
nucleus 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP3K10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18455992
genes like me logo Genes that share ontologies with MAP3K10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K10 Gene

Pathways & Interactions for MAP3K10 Gene

PathCards logo

SuperPathways for MAP3K10 Gene

SuperPathway Contained pathways
1 Development EGFR signaling pathway
.51
.41
2 TGF-Beta Pathway
.60
.51
3 ERK Signaling
.61
.58
4 Development EGFR signaling via small GTPases
.40
.40
5 Angiopoietin Like Protein 8 Regulatory Pathway
genes like me logo Genes that share pathways with MAP3K10: view

Pathways by source for MAP3K10 Gene

1 Sino Biological pathway for MAP3K10 Gene
1 KEGG pathway for MAP3K10 Gene
4 GeneGo (Thomson Reuters) pathways for MAP3K10 Gene
  • Development EGFR signaling pathway
  • Development EGFR signaling via PIP3
  • Development EGFR signaling via small GTPases
  • Signal transduction_JNK pathway
11 Qiagen pathways for MAP3K10 Gene
  • EGF Pathway
  • JNK Pathway
  • MAPK Family Pathway
  • MAPK Signaling
  • NFAT and Cardiac Hypertrophy

SIGNOR curated interactions for MAP3K10 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAP3K10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000186 activation of MAPKK activity IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process TAS 10801775
GO:0007165 signal transduction TAS 10801775
genes like me logo Genes that share ontologies with MAP3K10: view

Drugs & Compounds for MAP3K10 Gene

(8) Drugs for MAP3K10 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
URMC-099 Pharma 0

(1) Additional Compounds for MAP3K10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0

(1) ApexBio Compounds for MAP3K10 Gene

Compound Action Cas Number
URMC-099 1229582-33-5
genes like me logo Genes that share compounds with MAP3K10: view

Drug Products

Transcripts for MAP3K10 Gene

mRNA/cDNA for MAP3K10 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP3K10

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K10 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2: - -
SP3: - - - - -
SP4: - -
SP5:

Relevant External Links for MAP3K10 Gene

GeneLoc Exon Structure for
MAP3K10

Expression for MAP3K10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP3K10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K10 Gene

This gene is overexpressed in Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for MAP3K10 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAP3K10 Gene



Protein tissue co-expression partners for MAP3K10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP3K10

SOURCE GeneReport for Unigene cluster for MAP3K10 Gene:

Hs.466743

mRNA Expression by UniProt/SwissProt for MAP3K10 Gene:

Q02779-M3K10_HUMAN
Tissue specificity: Expressed in brain and skeletal muscle.

Evidence on tissue expression from TISSUES for MAP3K10 Gene

  • Nervous system(4.5)
  • Intestine(4.4)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with MAP3K10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K10 Gene

Orthologs for MAP3K10 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP3K10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MAP3K10 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia MAP3K10 30 31
  • 90.85 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Map3k10 30
  • 87.69 (n)
Mouse
(Mus musculus)
Mammalia Map3k10 30 17 31
  • 87.54 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MAP3K10 31
  • 79 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia MAP3K10 31
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MAP3K10 31
  • 64 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MAP3K10 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia map3k10 30
  • 62.75 (n)
Str.11205 30
African clawed frog
(Xenopus laevis)
Amphibia mlk2 30
Zebrafish
(Danio rerio)
Actinopterygii map3k10 30 31
  • 66.59 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta slpr 32
  • 50 (a)
Worm
(Caenorhabditis elegans)
Secernentea K11D12.10b 32
  • 31 (a)
mlk-1 31
  • 19 (a)
OneToOne
Species where no ortholog for MAP3K10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MAP3K10 Gene

ENSEMBL:
Gene Tree for MAP3K10 (if available)
TreeFam:
Gene Tree for MAP3K10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP3K10: view image

Paralogs for MAP3K10 Gene

(15) SIMAP similar genes for MAP3K10 Gene using alignment to 4 proteins:

  • M3K10_HUMAN
  • M0R0A7_HUMAN
  • M0R1J8_HUMAN
  • M0R365_HUMAN
genes like me logo Genes that share paralogs with MAP3K10: view

Variants for MAP3K10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP3K10 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
737698 Likely Benign: not provided 40,198,439(+) C/T SYNONYMOUS_VARIANT
784393 Benign: not provided 40,205,303(+) G/A INTRON_VARIANT
VAR_040702 A metastatic melanoma sample p.Gly107Glu
rs36102209 - p.Pro168Gln

Additional dbSNP identifiers (rs#s) for MAP3K10 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAP3K10 Gene

Variant ID Type Subtype PubMed ID
esv2758761 CNV gain 17122850
esv3644344 CNV gain 21293372
esv3644345 CNV gain 21293372
nsv9727 CNV gain 18304495
nsv9728 CNV loss 18304495

Variation tolerance for MAP3K10 Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP3K10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K10 Gene

Disorders for MAP3K10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAP3K10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
stress polycythemia
  • gaisbock's syndrome
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MAP3K10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP3K10 Gene

Publications for MAP3K10 Gene

  1. Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain. (PMID: 7731697) Katoh M … Terada M (Oncogene 1995) 2 3 4 23
  2. Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2. (PMID: 8536694) Dorow DS … Simpson RJ (European journal of biochemistry 1995) 2 3 4 23
  3. Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease. (PMID: 19332348) Nagao M … Hayashi H (Journal of the neurological sciences 2009) 3 23
  4. Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways. (PMID: 19801649) Pedraza N … Gallego C (The Journal of biological chemistry 2009) 3 23
  5. Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release. (PMID: 17584736) Zhong J … Kyriakis JM (The Journal of biological chemistry 2007) 3 23

Products for MAP3K10 Gene

Sources for MAP3K10 Gene