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Aliases for MAP3K10 Gene

Aliases for MAP3K10 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 10 2 3 3 5
  • Mixed Lineage Kinase 2 2 3 4
  • MKN28 Derived Nonreceptor_type Serine/Threonine Kinase 2 3
  • Protein Kinase MST 3 4
  • MKN28 Kinase 2 3
  • MLK2 3 4
  • MST 3 4
  • EC 4
  • MEKK10 3

External Ids for MAP3K10 Gene

Previous HGNC Symbols for MAP3K10 Gene

  • MLK2

Previous GeneCards Identifiers for MAP3K10 Gene

  • GC19P041337
  • GC19P041089
  • GC19P045373
  • GC19P045389
  • GC19P040697
  • GC19P037132

Summaries for MAP3K10 Gene

Entrez Gene Summary for MAP3K10 Gene

  • The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K10 Gene

MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10) is a Protein Coding gene. Among its related pathways are Development EGFR signaling via small GTPases and Signal transduction_JNK pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot for MAP3K10 Gene

  • Activates the JUN N-terminal pathway.

Gene Wiki entry for MAP3K10 Gene

Additional gene information for MAP3K10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K10 Gene

Genomics for MAP3K10 Gene

GeneHancer (GH) Regulatory Elements for MAP3K10 Gene

Promoters and enhancers for MAP3K10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J040190 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 659.2 -0.4 -412 2.3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF213 MAP3K10 ZNF780B NUMBL SNRPA ENSG00000269843 CYP2G1P FBL PSMC4 SUPT5H EID2B
GH19J040277 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 20 +90.9 90927 10.4 DMAP1 YY1 ZNF213 ZNF416 ZNF143 SP3 NFYC MEF2D ZNF610 ZNF585B AKT2 MIR641 ZNF780B SUPT5H COQ8B SNRPA NUMBL ZNF780A ENSG00000269843 MAP3K10
GH19J040273 Enhancer 1.3 Ensembl ENCODE dbSUPER 20.6 +82.7 82710 2.4 HDGF ATF1 ARNT TCF12 GLIS2 ATF7 NCOA1 ZNF623 ZNF592 ATF4 ENSG00000205041 MAP3K10 C19orf47 PLD3 SERTAD3 AKT2 PIR38327
GH19J040219 Enhancer 1.4 FANTOM5 Ensembl ENCODE 12.1 +28.4 28421 1.5 SIN3A ZNF2 GLIS2 ZFP91 FOS KLF13 SP3 YY2 REST ZNF518A TTC9B ENSG00000269843 SNRPA FBL ITPKC RPS16 ZNF780A ZNF780B LGALS14 ENSG00000269792
GH19J040360 Enhancer 1.1 Ensembl ENCODE 7.8 +169.3 169347 1.8 ZNF48 ZNF121 GLIS2 ELK1 KLF7 ATF7 SP3 TSHZ1 ZNF623 ZSCAN16 SNRPA ENSG00000269843 HNRNPUL1 EID2B AXL SPTBN4 RPS16 FBL ITPKC PSMC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP3K10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP3K10 gene promoter:
  • Spz1
  • CUTL1
  • ZIC2
  • CHOP-10
  • C/EBPalpha
  • MIF-1
  • AML1a
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta

Genomic Locations for MAP3K10 Gene

Genomic Locations for MAP3K10 Gene
23,931 bases
Plus strand
23,832 bases
Plus strand

Genomic View for MAP3K10 Gene

Genes around MAP3K10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K10 Gene

Proteins for MAP3K10 Gene

  • Protein details for MAP3K10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 10
    Protein Accession:
    Secondary Accessions:
    • Q12761
    • Q14871

    Protein attributes for MAP3K10 Gene

    954 amino acids
    Molecular mass:
    103694 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for MAP3K10 Gene

neXtProt entry for MAP3K10 Gene

Post-translational modifications for MAP3K10 Gene

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP3K10 Gene

No data available for DME Specific Peptides for MAP3K10 Gene

Domains & Families for MAP3K10 Gene

Gene Families for MAP3K10 Gene

Suggested Antigen Peptide Sequences for MAP3K10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K10: view

Function for MAP3K10 Gene

Molecular function for MAP3K10 Gene

UniProtKB/Swiss-Prot Function:
Activates the JUN N-terminal pathway.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.
GENATLAS Biochemistry:
mitogen activated protein (MAP/ERK) kinase kinase kinase 10

Enzyme Numbers (IUBMB) for MAP3K10 Gene

Phenotypes From GWAS Catalog for MAP3K10 Gene

Gene Ontology (GO) - Molecular Function for MAP3K10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003714 transcription corepressor activity ISS,IEA --
GO:0004672 protein kinase activity IEA,TAS 8536694
GO:0004674 protein serine/threonine kinase activity IEA,IDA 19801649
GO:0004706 JUN kinase kinase kinase activity ISS,IBA --
genes like me logo Genes that share ontologies with MAP3K10: view
genes like me logo Genes that share phenotypes with MAP3K10: view

Animal Models for MAP3K10 Gene

MGI Knock Outs for MAP3K10:

Animal Model Products

miRNA for MAP3K10 Gene

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K10 Gene

Localization for MAP3K10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K10 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP3K10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA 18455992
genes like me logo Genes that share ontologies with MAP3K10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K10 Gene

Pathways & Interactions for MAP3K10 Gene

genes like me logo Genes that share pathways with MAP3K10: view

SIGNOR curated interactions for MAP3K10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAP3K10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process TAS 10801775
GO:0007165 signal transduction TAS 10801775
GO:0007224 smoothened signaling pathway IMP 18455992
genes like me logo Genes that share ontologies with MAP3K10: view

Drugs & Compounds for MAP3K10 Gene

(8) Drugs for MAP3K10 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
URMC-099 Pharma 0

(1) Additional Compounds for MAP3K10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MAP3K10: view

Transcripts for MAP3K10 Gene

mRNA/cDNA for MAP3K10 Gene

Unigene Clusters for MAP3K10 Gene

Mitogen-activated protein kinase kinase kinase 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K10 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2: - -
SP3: - - - - -
SP4: - -

Relevant External Links for MAP3K10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP3K10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP3K10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K10 Gene

This gene is overexpressed in Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for MAP3K10 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAP3K10 Gene

Protein tissue co-expression partners for MAP3K10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP3K10 Gene:


SOURCE GeneReport for Unigene cluster for MAP3K10 Gene:


mRNA Expression by UniProt/SwissProt for MAP3K10 Gene:

Tissue specificity: Expressed in brain and skeletal muscle.

Evidence on tissue expression from TISSUES for MAP3K10 Gene

  • Nervous system(4.4)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with MAP3K10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K10 Gene

Orthologs for MAP3K10 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP3K10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP3K10 34
  • 100 (a)
(Canis familiaris)
Mammalia MAP3K10 34 33
  • 90.85 (n)
(Rattus norvegicus)
Mammalia Map3k10 33
  • 87.69 (n)
(Mus musculus)
Mammalia Map3k10 16 34 33
  • 87.54 (n)
(Monodelphis domestica)
Mammalia MAP3K10 34
  • 79 (a)
(Bos Taurus)
Mammalia MAP3K10 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia MAP3K10 34
  • 64 (a)
(Anolis carolinensis)
Reptilia MAP3K10 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia map3k10 33
  • 62.75 (n)
Str.11205 33
African clawed frog
(Xenopus laevis)
Amphibia mlk2 33
(Danio rerio)
Actinopterygii map3k10 34 33
  • 66.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta slpr 35
  • 50 (a)
(Caenorhabditis elegans)
Secernentea K11D12.10b 35
  • 31 (a)
mlk-1 34
  • 19 (a)
Species where no ortholog for MAP3K10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP3K10 Gene

Gene Tree for MAP3K10 (if available)
Gene Tree for MAP3K10 (if available)
Evolutionary constrained regions (ECRs) for MAP3K10: view image

Paralogs for MAP3K10 Gene

(15) SIMAP similar genes for MAP3K10 Gene using alignment to 4 proteins:

  • M3K10_HUMAN
  • M0R0A7_HUMAN
  • M0R1J8_HUMAN
  • M0R365_HUMAN
genes like me logo Genes that share paralogs with MAP3K10: view

Variants for MAP3K10 Gene

Sequence variations from dbSNP and Humsavar for MAP3K10 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
VAR_040702 A metastatic melanoma sample p.Gly107Glu
rs1000070474 -- 40,193,149(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000142053 -- 40,190,820(+) G/C upstream_transcript_variant
rs1000168896 -- 40,208,319(+) C/A intron_variant
rs1000511419 -- 40,214,258(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K10 Gene

Variant ID Type Subtype PubMed ID
esv2758761 CNV gain 17122850
esv3644344 CNV gain 21293372
esv3644345 CNV gain 21293372
nsv9727 CNV gain 18304495
nsv9728 CNV loss 18304495

Variation tolerance for MAP3K10 Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP3K10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K10 Gene

Disorders for MAP3K10 Gene

Additional Disease Information for MAP3K10

No disorders were found for MAP3K10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K10 Gene

Publications for MAP3K10 Gene

  1. Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2. (PMID: 8536694) Dorow DS … Simpson RJ (European journal of biochemistry 1995) 2 3 4 22 58
  2. Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain. (PMID: 7731697) Katoh M … Terada M (Oncogene 1995) 2 3 4 22 58
  3. Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways. (PMID: 19801649) Pedraza N … Gallego C (The Journal of biological chemistry 2009) 3 22 58
  4. Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease. (PMID: 19332348) Nagao M … Hayashi H (Journal of the neurological sciences 2009) 3 22 58
  5. Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release. (PMID: 17584736) Zhong J … Kyriakis JM (The Journal of biological chemistry 2007) 3 22 58

Products for MAP3K10 Gene

Sources for MAP3K10 Gene

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