Aliases for MAP3K10 Gene
External Ids for MAP3K10 Gene
Previous HGNC Symbols for MAP3K10 Gene
Previous GeneCards Identifiers for MAP3K10 Gene
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP3K10 Gene
MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10) is a Protein Coding gene. Among its related pathways are Development EGFR signaling via small GTPases and Pathways of neurodegeneration - multiple diseases. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is MAP3K9.
UniProtKB/Swiss-Prot Summary for MAP3K10 Gene
Activates the JUN N-terminal pathway.