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The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction ... See more...
Aliases for MAP2K7 Gene
Aliases for MAP2K7 Gene
- Mitogen-Activated Protein Kinase Kinase 7 2 3 5
- MKK7 2 3 4
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 7 3 4
- Stress-Activated Protein Kinase Kinase 4 3 4
- C-Jun N-Terminal Kinase Kinase 2 3 4
- JNK-Activating Kinase 2 3 4
- MAP Kinase Kinase 7 3 4
- MAPK/ERK Kinase 7 3 4
- SAPK Kinase 4 3 4
- EC 2.7.12.2 4 51
- SAPKK-4 3 4
- PRKMK7 3 4
External Ids for MAP2K7 Gene
- HGNC: 6847
- Entrez Gene: 5609
- Ensembl: ENSG00000076984
- OMIM: 603014
- UniProtKB: O14733
Previous HGNC Symbols for MAP2K7 Gene
- PRKMK7
Previous GeneCards Identifiers for MAP2K7 Gene
- GC19P007927
- GC19P008073
- GC19P007863
- GC19P007875
- GC19P007876
- GC19P007877
- GC19P007968
- GC19P007641
Summaries for MAP2K7 Gene
-
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for MAP2K7 Gene
MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7) is a Protein Coding gene. Diseases associated with MAP2K7 include Acneiform Dermatitis and Colorectal Adenocarcinoma. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K4.
UniProtKB/Swiss-Prot Summary for MAP2K7 Gene
-
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074).
Additional gene information for MAP2K7 Gene
- HGNC(6847)
- Entrez Gene(5609)
- Ensembl(ENSG00000076984)
- OMIM(603014)
- UniProtKB(O14733)
- Open Targets Platform(ENSG00000076984)
- Search for MAP2K7 at DataMed
- Search for MAP2K7 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP2K7 Gene
Genomics for MAP2K7 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MAP2K7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAP2K7 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP2K7
- Top Transcription factor binding sites by QIAGEN in the MAP2K7 gene promoter:
-
- AP-1
- ATF-2
- c-Fos
- c-Jun
- GR
- GR-alpha
Genomic Locations for MAP2K7 Gene
Genomic Locations for MAP2K7 Gene
- chr19:7,903,785-7,914,478
- (GRCh38/hg38)
- Size:
- 10,694 bases
- Orientation:
- Plus strand
- chr19:7,968,728-7,979,363
- (GRCh37/hg19)
- Size:
- 10,636 bases
- Orientation:
- Plus strand
Genomic View for MAP2K7 Gene
Genes around MAP2K7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
MAP2K7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAP2K7 Gene
Proteins for MAP2K7 Gene
-
Protein details for MAP2K7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14733-MP2K7_HUMAN
- Recommended name:
- Dual specificity mitogen-activated protein kinase kinase 7
- Protein Accession:
- O14733
- B2R9S5
- D6W659
- O14648
- O14816
- O60452
- O60453
- Q1PG43
- Q8IY10
Protein attributes for MAP2K7 Gene
- Size:
- 419 amino acids
- Molecular mass:
- 47485 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with isoform 1 of VRK2. Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and MAP3K1/MEKK1 (By similarity). Interacts with MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins. Interacts with RASSF7, the interaction promotes phosphorylation. Found in a complex with SH3RF1, RAC1, MAP3K11/MLK3, MAPK8IP1/JIP1 and MAPK8/JNK1. Found in a complex with SH3RF1, RAC2, MAP3K7/TAK1, MAPK8IP1/JIP1, MAPK8/JNK1 and MAPK9/JNK2 (By similarity).
- SequenceCaution:
-
- Sequence=AAB97813.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305}; Sequence=AAB97813.1; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 2]: May be due to intron retention.
Three dimensional structures from OCA and Proteopedia for MAP2K7 Gene
Protein Expression for MAP2K7 Gene
Selected DME Specific Peptides for MAP2K7 Gene
- O14733:
-
- YDIRADVWSLGI
- TDFEVLTKVL
- IKLCDFGISG
- TRSAGCAAYMAPERIDP
- EENKRILMDLDVVLKSHDC
Post-translational modifications for MAP2K7 Gene
- Activated by phosphorylation on Ser-271 and Thr-275 by MAP kinase kinase kinases (MAP3Ks).
-
Ubiquitination at Lys9
- NX_O14733 (NX_O14733-1)
- Modification sites at PhosphoSitePlus
Other Protein References for MAP2K7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents MEK7 Antibody / MAP2K7 / MKK7
-
Custom Antibody ServicesOriGene Antibodies for MAP2K7
- Novus Biologicals Antibodies for MAP2K7
-
Abcam antibodies for MAP2K7
- Invitrogen Antibodies for MAP2K7 (AFLGC-MAP2K7)
- antibodies-online: Show 52 available MAP2K7 Antibodies ranked by validation data
- Compare Top MAP2K7 Antibodies
-
Recommended
- 73 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 146 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 93 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
-
Boster Bio Antibodies for MAP2K7
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAP2K7
- Sino Biological Antibodies for MAP2K7
Protein Products
-
OriGene Purified Proteins for MAP2K7
- Search Origene for MassSpec and Protein Over-expression Lysates for MAP2K7
- Origene Custom Protein Services for MAP2K7
-
Signalway Proteins for MAP2K7
-
Abcam proteins for MAP2K7
Domains & Families for MAP2K7 Gene
Gene Families for MAP2K7 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MAP2K7 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAP2K7 Gene
- GenScript: Design optimal peptide antigens:
-
- Mitogen-activated protein kinase kinase 7, isoform CRA_b (D6W660_HUMAN)
- c-Jun N-terminal kinase kinase 2 (MP2K7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O14733UniProtKB/Swiss-Prot:
MP2K7_HUMAN :- The DVD domain (residues 377-400) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
- Domain:
-
- The DVD domain (residues 377-400) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.
- The D domain (residues 37-57) contains a conserved docking site and is required for the binding to MAPK substrates.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Function for MAP2K7 Gene
Molecular function for MAP2K7 Gene
- UniProtKB/Swiss-Prot Function:
- Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.
Enzyme Numbers (IUBMB) for MAP2K7 Gene
Phenotypes From GWAS Catalog for MAP2K7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | IDA | 9535930 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IBA | -- |
| GO:0004708 | MAP kinase kinase activity | IBA,IDA | 9535930 |
Phenotypes for MAP2K7 Gene
- MGI mutant phenotypes for MAP2K7:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for MAP2K7:
-
- no effect
- Decreased viability
- shRNA abundance <= 50%
- Dynamic nuclei (hole, folded or small irregular)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased endosome-nucleus distance (endosomes dispersed in the cell periphery)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased POU5F1-GFP protein expression
- Decreased Dengue Infection
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Decreased substrate adherent cell growth
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Synthetic lethal with gemcitabine
- Increased viability
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Fragmented cis-Golgi, fragmented trans-Golgi
- Increased viability after borna disease (rVSVΔG*/BDVG) virus infection
- Increased viability with 4OH tamoxifen
Animal Models for MAP2K7 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAP2K7 - Select products 50% OFF >
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-
OriGene CRISPR knockouts for MAP2K7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP2K7
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP2K7
miRNA for MAP2K7 Gene
- miRTarBase miRNAs that target MAP2K7
-
- mmu-miR-125b-5p (MIRT004799)
- hsa-miR-125a-5p (MIRT045769)
- hsa-miR-493-3p (MIRT054426)
- hsa-miR-218-5p (MIRT440290)
- hsa-miR-4732-5p (MIRT473817)
- hsa-miR-4451 (MIRT473818)
- hsa-miR-6722-3p (MIRT473819)
- hsa-miR-6077 (MIRT473820)
- hsa-miR-1909-3p (MIRT473821)
- hsa-miR-98-5p (MIRT473822)
- hsa-miR-4458 (MIRT473823)
- hsa-miR-4500 (MIRT473824)
- hsa-let-7i-5p (MIRT473825)
- hsa-let-7g-5p (MIRT473826)
- hsa-let-7f-5p (MIRT473827)
- hsa-let-7e-5p (MIRT473828)
- hsa-let-7d-5p (MIRT473829)
- hsa-let-7c-5p (MIRT473830)
- hsa-let-7b-5p (MIRT473831)
- hsa-let-7a-5p (MIRT473832)
- hsa-miR-3928-3p (MIRT473833)
- hsa-miR-6831-5p (MIRT473834)
- hsa-miR-3927-3p (MIRT473835)
- hsa-miR-6510-5p (MIRT473836)
- hsa-miR-6859-5p (MIRT473837)
- hsa-miR-3916 (MIRT473838)
- hsa-miR-3125 (MIRT473839)
- hsa-miR-2278 (MIRT473840)
- hsa-miR-6856-5p (MIRT473841)
- hsa-miR-6758-5p (MIRT473842)
- hsa-miR-8080 (MIRT473843)
- hsa-miR-4311 (MIRT502019)
- mmu-miR-1224-5p (MIRT598350)
- mmu-miR-1197-3p (MIRT598351)
- mmu-miR-362-3p (MIRT598352)
- mmu-miR-329-3p (MIRT598353)
- mmu-miR-338-5p (MIRT598354)
- hsa-miR-125b-1-3p (MIRT733561)
- hsa-miR-1182 (MIRT735879)
- hsa-miR-1207-5p (MIRT736034)
- hsa-miR-1321 (MIRT737341)
- hsa-miR-138-5p (MIRT737535)
- hsa-miR-149-3p (MIRT737748)
- hsa-miR-1827 (MIRT738117)
- hsa-miR-1972 (MIRT738677)
- hsa-miR-198 (MIRT738720)
- hsa-miR-24-3p (MIRT739228)
- hsa-miR-3155a (MIRT740434)
- hsa-miR-3155b (MIRT740445)
- hsa-miR-3178 (MIRT740715)
- hsa-miR-3652 (MIRT741895)
- hsa-miR-3934-3p (MIRT743087)
- hsa-miR-4270 (MIRT743576)
- hsa-miR-4299 (MIRT743820)
- hsa-miR-4430 (MIRT744333)
- hsa-miR-4441 (MIRT744543)
- hsa-miR-4505 (MIRT745529)
- hsa-miR-4524a-3p (MIRT745848)
- hsa-miR-4650-5p (MIRT746519)
- hsa-miR-4711-5p (MIRT747445)
- hsa-miR-4723-5p (MIRT747657)
- hsa-miR-4728-5p (MIRT747844)
- hsa-miR-4739 (MIRT748059)
- hsa-miR-4756-5p (MIRT748431)
- hsa-miR-4763-3p (MIRT748543)
- hsa-miR-484 (MIRT749049)
- hsa-miR-5197-3p (MIRT750086)
- hsa-miR-520a-5p (MIRT750193)
- hsa-miR-525-5p (MIRT750300)
- hsa-miR-5698 (MIRT751289)
- hsa-miR-5787 (MIRT751478)
- hsa-miR-635 (MIRT752675)
- hsa-miR-6499-5p (MIRT752869)
- hsa-miR-6731-5p (MIRT754015)
- hsa-miR-6746-5p (MIRT754491)
- hsa-miR-6754-5p (MIRT754718)
- hsa-miR-6757-5p (MIRT754845)
- hsa-miR-6774-5p (MIRT755345)
- hsa-miR-6785-5p (MIRT755839)
- hsa-miR-6795-5p (MIRT756133)
- hsa-miR-6799-5p (MIRT756310)
- hsa-miR-6804-5p (MIRT756432)
- hsa-miR-6808-5p (MIRT756573)
- hsa-miR-6825-5p (MIRT756992)
- hsa-miR-6842-3p (MIRT757345)
- hsa-miR-6853-5p (MIRT757660)
- hsa-miR-6870-5p (MIRT757990)
- hsa-miR-6873-5p (MIRT758073)
- hsa-miR-6883-5p (MIRT758424)
- hsa-miR-6887-5p (MIRT758592)
- hsa-miR-6893-5p (MIRT758717)
- hsa-miR-7111-5p (MIRT759047)
- hsa-miR-7152-3p (MIRT759192)
- hsa-miR-8085 (MIRT760219)
- hsa-miR-889-5p (MIRT760428)
- hsa-miR-940 (MIRT760814)
miRNA Products
Inhibitory RNA Products
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Clone Products
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-
- MG206931
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- MR216601
- MR216601L3
- MR216601L4
- MR218970
- MR218970L3
- MR218970L4
- MR229391
- MR229587
- MR229980
- RC213868
- RC213868L1
- RC213868L2
- RC213868L3
- RC213868L4
- RC238157
- RC238220
- RG213868
- RR208948
- RR208948L3
- RR208948L4
- MR206931L3V
- MR206931L4V
- MR216601L3V
- MR216601L4V
- MR218970L3V
- MR218970L4V
- RC213868L1V
- RC213868L2V
- RC213868L3V
- RC213868L4V
- RR208948L3V
- RR208948L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Addgene plasmids for MAP2K7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP2K7
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP2K7 Gene
Localization for MAP2K7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAP2K7 Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 3 |
| extracellular | 3 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| golgi apparatus | 3 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
- Cytosol (2)
- Golgi apparatus (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005737 | cytoplasm | IBA,ISS | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for MAP2K7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | TNFR1 Pathway |
Apoptosis and survival TNFR1 signaling pathway
.52
Apoptotic Pathways Triggered By HIV1
.42
|
Apoptosis through Death Receptors
.42
.34
|
| 3 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
|
|
| 4 | Toll-like Receptor Signaling Pathway |
.37
|
|
| 5 | 4-1BB Pathway |
4-1BB Pathway
.54
CD40 Signaling
.54
|
PKR Pathway
.36
SUMO Pathway
.30
|
Pathways by source for MAP2K7 Gene
3 Sino Biological pathways for MAP2K7 Gene
25 BioSystems pathways for MAP2K7 Gene
30 Reactome pathways for MAP2K7 Gene
3 PharmGKB pathways for MAP2K7 Gene
21 KEGG pathways for MAP2K7 Gene
15 GeneGo (Thomson Reuters) pathways for MAP2K7 Gene
- Apoptosis and survival Lymphotoxin-beta receptor signaling
- Apoptosis and survival TNFR1 signaling pathway
- Cytoskeleton remodeling FAK signaling
- Development A2A receptor signaling
- Development EGFR signaling pathway
5 R&D Systems pathways for MAP2K7 Gene
39 Qiagen pathways for MAP2K7 Gene
- 4-1BB Pathway
- Alpha-Adrenergic Signaling
- Apoptosis through Death Receptors
- Apoptotic Pathways Triggered By HIV1
- APRIL Pathway
1 Cell Signaling Technology pathway for MAP2K7 Gene
2 GeneTex pathways for MAP2K7 Gene
Interacting Proteins for MAP2K7 Gene
Selected Interacting proteins:
O14733-MP2K7_HUMAN
ENSP00000381070
for MAP2K7 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MAP2K7
SIGNOR curated interactions for MAP2K7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IBA | 21873635 |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006970 | response to osmotic stress | IDA | 9535930 |
| GO:0007165 | signal transduction | TAS | 9535930 |
Drugs & Compounds for MAP2K7 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dabrafenib | Approved, Investigational | Pharma | Inhibition, inhibitor | BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase | 116 | |
| Selumetinib | Approved, Investigational | Pharma | inhibitor, Biomarker | MEK inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors | 0 | |
| Trametinib | Approved | Pharma | inhibitor, Biomarker | MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors | 194 | |
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
| PD-0325901 | Investigational | Pharma | inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Transcripts for MAP2K7 Gene
mRNA/cDNA for MAP2K7 Gene
- 3 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000397979 3361 nts (view in UCSC)
- ENST00000397981 3430 nts (view in UCSC)
- ENST00000397983 3396 nts (view in UCSC)
- ENST00000465324 399 nts (view in UCSC)
- ENST00000468058 1589 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAP2K7 - Select products 50% OFF >
- * MAP2K7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAP2K7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAP2K7
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAP2K7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP2K7
- Browse OriGene Inhibitory RNA Products For MAP2K7
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Clone Products
- Applied Biological Materials (abm): Clones for MAP2K7 - Select products 50% OFF >
- * MAP2K7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
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- MG206931
- MG216601
- MG218970
- MR206931
- MR206931L3
- MR206931L4
- MR216601
- MR216601L3
- MR216601L4
- MR218970
- MR218970L3
- MR218970L4
- MR229391
- MR229587
- MR229980
- RC213868
- RC213868L1
- RC213868L2
- RC213868L3
- RC213868L4
- RC238157
- RC238220
- RG213868
- RR208948
- RR208948L3
- RR208948L4
- MR206931L3V
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- MR216601L3V
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Addgene plasmids for MAP2K7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAP2K7
Relevant External Links for MAP2K7 Gene
- GeneLoc Exon Structure for
- MAP2K7
Expression for MAP2K7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Intestine (Gastrointestinal Tract)
- Heart (Cardiovascular System)
- Blood (Hematopoietic System)
-
Testis (Reproductive System)
This gene is overexpressed in Urinary Bladder (12.0), Plasma (11.0), Prostate (9.1), and Retina (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP2K7 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP2K7
SOURCE GeneReport for Unigene cluster for MAP2K7 Gene:
Hs.531754mRNA Expression by UniProt/SwissProt for MAP2K7 Gene:
O14733-MP2K7_HUMAN
Tissue specificity:
Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
Evidence on tissue expression from TISSUES for MAP2K7 Gene
- Nervous system(4.7)
- Muscle(4.7)
- Heart(4.6)
- Intestine(3.4)
- Skin(3.4)
- Blood(3.4)
- Lung(3.2)
- Liver(3.2)
- Kidney(3.2)
- Lymph node(3.1)
- Bone marrow(3.1)
- Pancreas(3)
- Spleen(2.9)
- Thyroid gland(2.9)
- Adrenal gland(2.9)
- Stomach(2.8)
- Eye(2.7)
- Bone(2.4)
- Gall bladder(2.1)
Primer Products
-
OriGene qPCR primer pairs for MAP2K7
-
OriGene qPCR primer pairs and template standards for MAP2K7
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP2K7 Gene
Orthologs for MAP2K7 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MAP2K7 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MAP2K7 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MAP2K7 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MAP2K7 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Map2k7 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Map2k7 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MAP2K7 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MAP2K7 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | map2k7 30 |
|
||
| Str.69 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | map2k7-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | map2k7 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | hep 30 31 32 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | mek-1 30 31 32 |
|
OneToMany | |
| jkk-1 31 32 |
|
OneToMany | |||
| F35C8.1 32 |
|
|
|||
| sek-4 31 |
|
OneToMany | |||
| sek-5 31 |
|
OneToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PBS2 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4331 30 |
|
- Species where no ortholog for MAP2K7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MAP2K7 Gene
- ENSEMBL:
- Gene Tree for MAP2K7 (if available)
- TreeFam:
- Gene Tree for MAP2K7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAP2K7: view image
Paralogs for MAP2K7 Gene
Paralogs for MAP2K7 Gene
(26) SIMAP similar genes for MAP2K7 Gene using alignment to 3 proteins:
- MP2K7_HUMAN
- D6W660_HUMAN
- F6WCX7_HUMAN
Variants for MAP2K7 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP2K7 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710280 | Benign: not provided | 7,910,773(+) | C/A | SYNONYMOUS_VARIANT | |
| 710676 | Benign: not provided | 7,910,734(+) | C/T | SYNONYMOUS_VARIANT | |
| 715594 | Benign: not provided | 7,912,383(+) | G/T | SYNONYMOUS_VARIANT | |
| 717082 | Benign: not provided | 7,910,773(+) | C/T | SYNONYMOUS_VARIANT | |
| 717113 | Benign: not provided | 7,911,587(+) | C/T | INTRON_VARIANT |
Residual Variation Intolerance Score:
12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.83;
17.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAP2K7 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2K7 Gene
Disorders for MAP2K7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acneiform dermatitis |
|
|
| colorectal adenocarcinoma |
|
|
| gallbladder melanoma |
|
|
| skin carcinoma |
|
|
| vulvar melanoma |
|
|
Search MAP2K7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAP2K7
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MAP2K7 Gene
Publications for MAP2K7 Gene
- Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. (PMID: 9312068) Lu X … Lin A (The Journal of biological chemistry 1997) 2 3 4 23
- Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. (PMID: 18286207) Blanco S … Lazo PA (PloS one 2008) 3 4 23
- Cloning and expression of human mitogen-activated protein kinase kinase 7gamma1. (PMID: 16442502) Michael L … Robinson MJ (Biochemical and biophysical research communications 2006) 3 4 23
- The JIP group of mitogen-activated protein kinase scaffold proteins. (PMID: 10490659) Yasuda J … Davis RJ (Molecular and cellular biology 1999) 3 4 23
- Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli. (PMID: 9535930) Foltz IN … Schrader JW (The Journal of biological chemistry 1998) 3 4 23
ExternalLinks
Products for MAP2K7 Gene
- Custom Antibody ServicesOriGene Antibodies for MAP2K7
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- Custom Assay Services
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAP2K7
- Browse OriGene Inhibitory RNA Products For MAP2K7
- OriGene qPCR primer pairs for MAP2K7
- OriGene qPCR primer pairs and template standards for MAP2K7
- OriGene CRISPR knockouts for MAP2K7
- MG206931
- MG216601
- MG218970
- MR206931
- MR206931L3
- MR206931L4
- MR216601
- MR216601L3
- MR216601L4
- MR218970
- MR218970L3
- MR218970L4
- MR229391
- MR229587
- MR229980
- RC213868
- RC213868L1
- RC213868L2
- RC213868L3
- RC213868L4
- RC238157
- RC238220
- RG213868
- RR208948
- RR208948L3
- RR208948L4
- MR206931L3V
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