MAP2K7 Gene (Protein Coding)

Mitogen-Activated Protein Kinase Kinase 7

GC19P007903
GIFtS:
46
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction ... See more...

Aliases for MAP2K7 Gene

Aliases for MAP2K7 Gene

  • Mitogen-Activated Protein Kinase Kinase 7 2 3 5
  • Dual Specificity Mitogen-Activated Protein Kinase Kinase 7 3 4
  • Stress-Activated Protein Kinase Kinase 4 3 4
  • C-Jun N-Terminal Kinase Kinase 2 3 4
  • JNK-Activating Kinase 2 3 4
  • MAP Kinase Kinase 7 3 4
  • MAPK/ERK Kinase 7 3 4
  • SAPK Kinase 4 3 4
  • EC 2.7.12.2 4 52
  • SAPKK-4 3 4
  • PRKMK7 3 4
  • SAPKK4 3 4
  • JNKK2 3 4
  • MEK 7 3 4
  • MKK7 3 4
  • JNK Kinase 2 4
  • MAPKK 7 4
  • MAPKK7 3
  • JNKK 2 4
  • MEK7 4
  • SKK4 4
  • MEK 3

External Ids for MAP2K7 Gene

Previous HGNC Symbols for MAP2K7 Gene

  • PRKMK7

Previous GeneCards Identifiers for MAP2K7 Gene

  • GC19P007927
  • GC19P008073
  • GC19P007863
  • GC19P007875
  • GC19P007876
  • GC19P007877
  • GC19P007968
  • GC19P007641

Summaries for MAP2K7 Gene

Entrez Gene Summary for MAP2K7 Gene

  • The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

CIViC Summary for MAP2K7 Gene

GeneCards Summary for MAP2K7 Gene

MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7) is a Protein Coding gene. Diseases associated with MAP2K7 include Acneiform Dermatitis and Colorectal Adenocarcinoma. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and RET signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K4.

UniProtKB/Swiss-Prot Summary for MAP2K7 Gene

  • Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074).

Gene Wiki entry for MAP2K7 Gene

Additional gene information for MAP2K7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP2K7 Gene

Genomics for MAP2K7 Gene

GeneHancer (GH) Regulatory Elements for MAP2K7 Gene

Promoters and enhancers for MAP2K7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP2K7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP2K7

Top Transcription factor binding sites by QIAGEN in the MAP2K7 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • GR
  • GR-alpha

Genomic Locations for MAP2K7 Gene

Genomic Locations for MAP2K7 Gene
chr19:7,903,780-7,914,483
(GRCh38/hg38)
Size:
10,704 bases
Orientation:
Plus strand
chr19:7,968,728-7,979,363
(GRCh37/hg19)
Size:
10,636 bases
Orientation:
Plus strand

Genomic View for MAP2K7 Gene

Genes around MAP2K7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2K7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2K7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAP2K7 Gene

Proteins for MAP2K7 Gene

Products:

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  • Protein details for MAP2K7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14733-MP2K7_HUMAN
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 7
    Protein Accession:
    O14733
    Secondary Accessions:
    • B2R9S5
    • D6W659
    • O14648
    • O14816
    • O60452
    • O60453
    • Q1PG43
    • Q8IY10

    Protein attributes for MAP2K7 Gene

    Size:
    419 amino acids
    Molecular mass:
    47485 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with isoform 1 of VRK2. Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and MAP3K1/MEKK1 (By similarity). Interacts with MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins. Interacts with RASSF7, the interaction promotes phosphorylation. Found in a complex with SH3RF1, RAC1, MAP3K11/MLK3, MAPK8IP1/JIP1 and MAPK8/JNK1. Found in a complex with SH3RF1, RAC2, MAP3K7/TAK1, MAPK8IP1/JIP1, MAPK8/JNK1 and MAPK9/JNK2 (By similarity).
    Miscellaneous:
    • [Isoform 2]: May be due to intron retention.
    SequenceCaution:
    • Sequence=AAB97813.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305}; Sequence=AAB97813.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAP2K7 Gene

    Alternative splice isoforms for MAP2K7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2K7 Gene

Protein Expression for MAP2K7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MAP2K7 Gene

O14733:
  • YDIRADVWSLGI
  • TDFEVLTKVL
  • IKLCDFGISG
  • TRSAGCAAYMAPERIDP
  • EENKRILMDLDVVLKSHDC

Post-translational modifications for MAP2K7 Gene

  • Activated by phosphorylation on Ser-271 and Thr-275 by MAP kinase kinase kinases (MAP3Ks).
  • Ubiquitination at Lys9
  • Modification sites at PhosphoSitePlus

Other Protein References for MAP2K7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MAP2K7
  • Santa Cruz Biotechnology (SCBT) Antibodies for MAP2K7

Domains & Families for MAP2K7 Gene

Gene Families for MAP2K7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAP2K7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP2K7 Gene

GenScript: Design optimal peptide antigens:
  • Mitogen-activated protein kinase kinase 7, isoform CRA_b (D6W660_HUMAN)
  • c-Jun N-terminal kinase kinase 2 (MP2K7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14733

UniProtKB/Swiss-Prot:

MP2K7_HUMAN :
  • The DVD domain (residues 377-400) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Domain:
  • The DVD domain (residues 377-400) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.
  • The D domain (residues 37-57) contains a conserved docking site and is required for the binding to MAPK substrates.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
genes like me logo Genes that share domains with MAP2K7: view

Function for MAP2K7 Gene

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  2. CRISPR
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Molecular function for MAP2K7 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.

Enzyme Numbers (IUBMB) for MAP2K7 Gene

Phenotypes From GWAS Catalog for MAP2K7 Gene

Gene Ontology (GO) - Molecular Function for MAP2K7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 9535930
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0004708 MAP kinase kinase activity IDA 9535930
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with MAP2K7: view
genes like me logo Genes that share phenotypes with MAP2K7: view

Animal Models for MAP2K7 Gene

MGI Knock Outs for MAP2K7:

Animal Model Products

CRISPR Products

miRNA for MAP2K7 Gene

miRTarBase miRNAs that target MAP2K7

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP2K7 Gene

Localization for MAP2K7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP2K7 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP2K7 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 3
cytoskeleton 3
mitochondrion 3
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP2K7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IBA,ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAP2K7: view

Pathways & Interactions for MAP2K7 Gene

PathCards logo

SuperPathways for MAP2K7 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
.01
2 Toll-like Receptor Signaling Pathway
Toll-like receptor signaling pathway
.92
Toll-like Receptor Signaling Pathway
.92
Regulation of toll-like receptor signaling pathway
.71
NOD-like Receptor Signaling Pathways
.39
Hepatitis B
.37
3 TNFR1 Pathway
Apoptosis and survival TNFR1 signaling pathway
.52
HIV-1 Nef- Negative effector of Fas and TNF-alpha
.46
Apoptotic Pathways Triggered By HIV1
.42
Apoptosis through Death Receptors
.42
TNF alpha Signaling Pathway
.30
4 4-1BB Pathway
4-1BB Pathway
.54
CD40 Signaling
.54
PKR Pathway
.36
SUMO Pathway
.30
5 RANK Signaling in Osteoclasts
APRIL Pathway
.92
BAFF in B-Cell Signaling
.92
RANK Signaling in Osteoclasts
.45
RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
.31
genes like me logo Genes that share pathways with MAP2K7: view

Pathways by source for MAP2K7 Gene

15 GeneGo (Thomson Reuters) pathways for MAP2K7 Gene
  • Apoptosis and survival Lymphotoxin-beta receptor signaling
  • Apoptosis and survival TNFR1 signaling pathway
  • Cytoskeleton remodeling FAK signaling
  • Development A2A receptor signaling
  • Development EGFR signaling pathway
39 Qiagen pathways for MAP2K7 Gene
  • 4-1BB Pathway
  • Alpha-Adrenergic Signaling
  • Apoptosis through Death Receptors
  • Apoptotic Pathways Triggered By HIV1
  • APRIL Pathway
1 Cell Signaling Technology pathway for MAP2K7 Gene
2 GeneTex pathways for MAP2K7 Gene

SIGNOR curated interactions for MAP2K7 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAP2K7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IBA 21873635
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process IEA --
GO:0006970 response to osmotic stress IDA 9535930
GO:0007165 signal transduction TAS 9535930
genes like me logo Genes that share ontologies with MAP2K7: view

Drugs & Compounds for MAP2K7 Gene

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  1. Drug

(22) Drugs for MAP2K7 Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dabrafenib Approved, Investigational Pharma Inhibition, inhibitor BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 109
Trametinib Approved Pharma inhibitor, Biomarker MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 181
Magnesium Approved, Experimental, Investigational Pharma 0
PD-0325901 Investigational Pharma inhibitor 0
Selumetinib Investigational Pharma inhibitor, Biomarker MEK inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 0

(3) Additional Compounds for MAP2K7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MAP2K7: view

Transcripts for MAP2K7 Gene

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  1. CRISPR
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  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MAP2K7 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K7 Gene

No ASD Table

Relevant External Links for MAP2K7 Gene

GeneLoc Exon Structure for
MAP2K7

Expression for MAP2K7 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP2K7 Gene

mRNA expression in normal human tissues for MAP2K7 Gene
mRNA expression by BioGPS for MAP2K7 GenemRNA expression by GTEx for MAP2K7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP2K7 Gene

This gene is overexpressed in Urinary Bladder (12.0), Plasma (11.0), Prostate (9.1), and Retina (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP2K7 Gene



Protein tissue co-expression partners for MAP2K7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP2K7

SOURCE GeneReport for Unigene cluster for MAP2K7 Gene:

Hs.531754

mRNA Expression by UniProt/SwissProt for MAP2K7 Gene:

O14733-MP2K7_HUMAN
Tissue specificity: Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.

Evidence on tissue expression from TISSUES for MAP2K7 Gene

  • Muscle(4.6)
  • Nervous system(4.6)
  • Heart(4.5)
  • Lung(2.9)
  • Skin(2.9)
  • Blood(2.8)
  • Intestine(2.8)
  • Adrenal gland(2.6)
  • Kidney(2.6)
  • Liver(2.6)
  • Bone marrow(2.5)
  • Pancreas(2.3)
  • Thyroid gland(2.3)
  • Eye(2.2)
  • Lymph node(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with MAP2K7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP2K7 Gene

Orthologs for MAP2K7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP2K7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MAP2K7 31 30
  • 99.44 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia MAP2K7 31 30
  • 93.67 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia MAP2K7 31 30
  • 93.24 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia MAP2K7 31
  • 91 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Map2k7 17 31 30
  • 90.27 (n)
rat
(Rattus norvegicus)
 Mammalia Map2k7 30
  • 90.14 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia MAP2K7 31
  • 82 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MAP2K7 31
  • 74 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia map2k7 30
  • 75.54 (n)
Str.69 30
African clawed frog
(Xenopus laevis)
 Amphibia map2k7-A 30
zebrafish
(Danio rerio)
 Actinopterygii map2k7 31 30
  • 73.54 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta hep 31 32 30
  • 65 (n)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea mek-1 31 32 30
  • 58.91 (n)
 OneToMany
jkk-1 31 32
  • 36 (a)
 OneToMany
F35C8.1 32
  • 32 (a)
sek-4 31
  • 30 (a)
 OneToMany
sek-5 31
  • 29 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PBS2 31
  • 20 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 51 (a)
 OneToOne
Cin.4331 30
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.4331 30
Species where no ortholog for MAP2K7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP2K7 Gene

ENSEMBL:
Gene Tree for MAP2K7 (if available)
TreeFam:
Gene Tree for MAP2K7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP2K7: view image

Paralogs for MAP2K7 Gene

Paralogs for MAP2K7 Gene

(26) SIMAP similar genes for MAP2K7 Gene using alignment to 3 proteins:

  • MP2K7_HUMAN
  • D6W660_HUMAN
  • F6WCX7_HUMAN
genes like me logo Genes that share paralogs with MAP2K7: view

Variants for MAP2K7 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP2K7 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1555701191 Other: Neuroblastoma 7,911,056(+) T/C MISSENSE_VARIANT
VAR_040827 A colorectal adenocarcinoma sample p.Arg162Cys
VAR_040828 A colorectal adenocarcinoma sample p.Arg162His
rs1053566 - p.Leu259Phe
rs55800262 - p.Ala195Thr

Additional dbSNP identifiers (rs#s) for MAP2K7 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAP2K7 Gene

Variant ID Type Subtype PubMed ID
nsv828421 CNV gain 20364138
nsv833733 CNV gain 17160897
nsv953961 CNV deletion 24416366

Variation tolerance for MAP2K7 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP2K7 Gene

Human Gene Mutation Database (HGMD)
MAP2K7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP2K7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2K7 Gene

Disorders for MAP2K7 Gene

MalaCards: The human disease database

(28) MalaCards diseases for MAP2K7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acneiform dermatitis
  • dermatitis acneiform
colorectal adenocarcinoma
  • adenocarcinoma of large intestine
gallbladder melanoma
  • malignant melanoma of gallbladder
skin carcinoma
  • carcinoma of skin
cardiofaciocutaneous syndrome 1
  • cfc1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAP2K7

Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAP2K7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP2K7 Gene

Publications for MAP2K7 Gene

  1. Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. (PMID: 9312068) Lu X … Lin A (The Journal of biological chemistry 1997) 2 3 4 23 54
  2. Cloning and expression of human mitogen-activated protein kinase kinase 7gamma1. (PMID: 16442502) Michael L … Robinson MJ (Biochemical and biophysical research communications 2006) 3 4 23 54
  3. The JIP group of mitogen-activated protein kinase scaffold proteins. (PMID: 10490659) Yasuda J … Davis RJ (Molecular and cellular biology 1999) 3 4 23 54
  4. Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli. (PMID: 9535930) Foltz IN … Schrader JW (The Journal of biological chemistry 1998) 3 4 23 54
  5. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. (PMID: 9207092) Tournier C … Davis RJ (Proceedings of the National Academy of Sciences of the United States of America 1997) 3 4 23 54

ExternalLinks

View latest publications for MAP2K7 gene in Mastermind

Products for MAP2K7 Gene