Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7) is a Protein Coding gene. Diseases associated with MAP2K7 include Acneiform Dermatitis and Colorectal Adenocarcinoma. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | IDA | 9535930 |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IBA | -- |
GO:0004708 | MAP kinase kinase activity | IBA,IDA | 9535930 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | ISS | -- |
GO:0005737 | cytoplasm | IBA,ISS | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | TNFR1 Pathway |
Apoptosis and survival TNFR1 signaling pathway
.52
Apoptotic Pathways Triggered By HIV1
.42
|
Apoptosis through Death Receptors
.42
.34
|
3 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
|
|
4 | Toll-like Receptor Signaling Pathway |
.37
|
|
5 | 4-1BB Pathway |
4-1BB Pathway
.54
CD40 Signaling
.54
|
PKR Pathway
.36
SUMO Pathway
.30
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000187 | activation of MAPK activity | IBA | 21873635 |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0006970 | response to osmotic stress | IDA | 9535930 |
GO:0007165 | signal transduction | TAS | 9535930 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Dabrafenib | Approved, Investigational | Pharma | Inhibition, inhibitor | BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase | 116 | |
Selumetinib | Approved, Investigational | Pharma | inhibitor, Biomarker | MEK inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors | 0 | |
Trametinib | Approved | Pharma | inhibitor, Biomarker | MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors | 194 | |
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
PD-0325901 | Investigational | Pharma | inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MAP2K7 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MAP2K7 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MAP2K7 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MAP2K7 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Map2k7 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Map2k7 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | MAP2K7 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MAP2K7 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | map2k7 30 |
|
||
Str.69 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | map2k7-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | map2k7 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | hep 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | mek-1 30 31 32 |
|
OneToMany | |
jkk-1 31 32 |
|
OneToMany | |||
F35C8.1 32 |
|
|
|||
sek-4 31 |
|
OneToMany | |||
sek-5 31 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PBS2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4331 30 |
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710280 | Benign: not provided | 7,910,773(+) | C/A | SYNONYMOUS_VARIANT | |
710676 | Benign: not provided | 7,910,734(+) | C/T | SYNONYMOUS_VARIANT | |
715594 | Benign: not provided | 7,912,383(+) | G/T | SYNONYMOUS_VARIANT | |
717082 | Benign: not provided | 7,910,773(+) | C/T | SYNONYMOUS_VARIANT | |
717113 | Benign: not provided | 7,911,587(+) | C/T | INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
acneiform dermatitis |
|
|
colorectal adenocarcinoma |
|
|
gallbladder melanoma |
|
|
skin carcinoma |
|
|
vulvar melanoma |
|
|