This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or envi... See more...

Aliases for MAP2K6 Gene

Aliases for MAP2K6 Gene

  • Mitogen-Activated Protein Kinase Kinase 6 2 3 5
  • Protein Kinase, Mitogen-Activated, Kinase 6 (MAP Kinase Kinase 6) 2 3
  • Dual Specificity Mitogen-Activated Protein Kinase Kinase 6 3 4
  • Stress-Activated Protein Kinase Kinase 3 3 4
  • MAPK/ERK Kinase 6 3 4
  • SAPK Kinase 3 3 4
  • EC 2.7.12.2 4 52
  • MAPKK 6 3 4
  • SAPKK-3 3 4
  • PRKMK6 3 4
  • SAPKK3 3 4
  • MEK 6 3 4
  • MEK6 3 4
  • MKK6 3 4
  • MAP Kinase Kinase 6 4
  • MAPKK6 3
  • SKK3 4

External Ids for MAP2K6 Gene

Previous HGNC Symbols for MAP2K6 Gene

  • PRKMK6

Previous GeneCards Identifiers for MAP2K6 Gene

  • GC17P067254
  • GC17P070371
  • GC17P067875
  • GC17P068007
  • GC17P064922
  • GC17P067410
  • GC17P062796

Summaries for MAP2K6 Gene

Entrez Gene Summary for MAP2K6 Gene

  • This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP2K6 Gene

MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6) is a Protein Coding gene. Diseases associated with MAP2K6 include Ischemia. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Amyotrophic lateral sclerosis (ALS). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K3.

UniProtKB/Swiss-Prot Summary for MAP2K6 Gene

  • Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.

Gene Wiki entry for MAP2K6 Gene

Additional gene information for MAP2K6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP2K6 Gene

Genomics for MAP2K6 Gene

GeneHancer (GH) Regulatory Elements for MAP2K6 Gene

Promoters and enhancers for MAP2K6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J069414 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.7 1690 4.8 EP300 ZBTB40 ZNF217 TCF12 NRF1 POLR2G NCOR1 PHF8 SIX5 ZBTB10 MAP2K6 ENSG00000278972
GH17J069500 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 511.7 +87.2 87226 2.6 TCF12 ZIC2 ZBTB25 POLR2A ATF2 CEBPB ZBTB17 ZNF384 CEBPG SAP130 MAP2K6 ENSG00000267653 RF00017-2522
GH17J069479 Enhancer 0.5 Ensembl dbSUPER 4.7 +65.8 65803 0.6 NR3C1 MYC ENSG00000267653 MAP2K6 LOC105371880 piR-43166-011
GH17J069427 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 +16.9 16904 9.2 USF1 JUND POLR2A ATF2 OSR2 NFIC ZBTB17 FOS TCF12 CBLL2 ENSG00000278972 ABCA5 MAP2K6
GH17J069450 Enhancer 1 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 +37.3 37304 3.6 GATA3 FOS STAT3 POU2F2 ZBTB40 JUN CHD2 GATA2 NANOG ABCA5 piR-43166-011 ENSG00000278972 MAP2K6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP2K6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP2K6

Top Transcription factor binding sites by QIAGEN in the MAP2K6 gene promoter:
  • ATF-2
  • ATF6
  • CREB
  • deltaCREB
  • HSF2
  • ISGF-3
  • Nkx2-5
  • STAT1

Genomic Locations for MAP2K6 Gene

Genomic Locations for MAP2K6 Gene
chr17:69,414,697-69,553,865
(GRCh38/hg38)
Size:
139,169 bases
Orientation:
Plus strand
chr17:67,410,838-67,539,472
(GRCh37/hg19)
Size:
128,635 bases
Orientation:
Plus strand

Genomic View for MAP2K6 Gene

Genes around MAP2K6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2K6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2K6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2K6 Gene

Proteins for MAP2K6 Gene

  • Protein details for MAP2K6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52564-MP2K6_HUMAN
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 6
    Protein Accession:
    P52564

    Protein attributes for MAP2K6 Gene

    Size:
    334 amino acids
    Molecular mass:
    37492 Da
    Quaternary structure:
    • Dimer. Interacts with Yersinia yopJ. Interacts (via its D domain) with its substrates MAPK11, MAPK12, MAPK13 and MAPK14 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2 (By similarity). Interacts with DCTN1. Interacts with EIF2AK2/PKR.

    Three dimensional structures from OCA and Proteopedia for MAP2K6 Gene

    Alternative splice isoforms for MAP2K6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2K6 Gene

Selected DME Specific Peptides for MAP2K6 Gene

P52564:
  • SWGTPFQQLKQVVEEPSPQLPAD
  • IMAVKRIRATVN
  • FYGALFREGD
  • DAGCKPYMAPERINPELNQKGY
  • TPPRDLDSKA
  • VSIVKALEHLHS
  • WICMELM
  • AILRFPY
  • LSVIHRDVKPSNVLIN

Post-translational modifications for MAP2K6 Gene

  • Weakly autophosphorylated. Phosphorylated at Ser-207 and Thr-211 by the majority of M3Ks, such as MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2.
  • Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for MAP2K6 Gene

Gene Families for MAP2K6 Gene

Protein Domains for MAP2K6 Gene

Suggested Antigen Peptide Sequences for MAP2K6 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75671, highly similar to Homo sapiens mitogen-activated protein kinase kinase 6 (MAP2K6), transcript variant 1, mRNA (A8K3Y2_HUMAN)
  • Mitogen-activated protein kinase kinase 6 (B5BU16_HUMAN)
  • SAPKK3 (MP2K6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P52564

UniProtKB/Swiss-Prot:

MP2K6_HUMAN :
  • The DVD domain (residues 311-334) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Domain:
  • The DVD domain (residues 311-334) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.
  • The D domain (residues 4-19) contains a conserved docking site and is required for the binding to MAPK substrates.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
genes like me logo Genes that share domains with MAP2K6: view

Function for MAP2K6 Gene

Molecular function for MAP2K6 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by dual phosphorylation on Ser-207 and Thr-211 in response to a variety of cellular stresses, including UV radiation, osmotic shock, hypoxia, inflammatory cytokines, interferon gamma (IFNG), and less often by growth factors. MAP2K6/MKK6 is activated by the majority of M3Ks, such as MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2.
UniProtKB/Swiss-Prot Induction:
Strongly activated by UV, anisomycin, and osmotic shock but not by phorbol esters, NGF or EGF.
GENATLAS Biochemistry:
mitogen-activated protein kinase kinase 6,activated by TNFA,involved in TNFA mediated endothelial SCYA2 (MCP1) expression,activating PRKMK8 and p38 kinase (MAPK) and required for ABL1 induced apoptosis

Enzyme Numbers (IUBMB) for MAP2K6 Gene

Phenotypes From GWAS Catalog for MAP2K6 Gene

Gene Ontology (GO) - Molecular Function for MAP2K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004708 MAP kinase kinase activity TAS --
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with MAP2K6: view
genes like me logo Genes that share phenotypes with MAP2K6: view

Animal Models for MAP2K6 Gene

MGI Knock Outs for MAP2K6:

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP2K6 Gene

Localization for MAP2K6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP2K6 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Binds to microtubules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP2K6 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP2K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with MAP2K6: view

Pathways & Interactions for MAP2K6 Gene

PathCards logo

SuperPathways for MAP2K6 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 IL-2 Pathway
.59
.59
.54
.51
.49
.48
.47
.43
.37
.36
.34
3 4-1BB Pathway
.54
.54
.48
.46
.42
.36
.30
4 Toll-like Receptor Signaling Pathway
5 CNTF Signaling
.50
.50
.46
.46
.45
genes like me logo Genes that share pathways with MAP2K6: view

Pathways by source for MAP2K6 Gene

19 GeneGo (Thomson Reuters) pathways for MAP2K6 Gene
  • Cell adhesion_Plasmin signaling
  • Development A2A receptor signaling
  • Development Beta-adrenergic receptors signaling via cAMP
  • Development Endothelin-1/EDNRA signaling
  • Development FGF-family signaling
79 Qiagen pathways for MAP2K6 Gene
  • 14-3-3 Induced Intracellular Signaling
  • 4-1BB Pathway
  • Aldosterone Signaling in Epithelial Cells
  • Alpha-Adrenergic Signaling
  • APRIL Pathway
1 Cell Signaling Technology pathway for MAP2K6 Gene
1 GeneTex pathway for MAP2K6 Gene

SIGNOR curated interactions for MAP2K6 Gene

Gene Ontology (GO) - Biological Process for MAP2K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity TAS --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002931 response to ischemia IEA --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with MAP2K6: view

Drugs & Compounds for MAP2K6 Gene

(19) Drugs for MAP2K6 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Dabrafenib Approved, Investigational Pharma Inhibition, inhibitor BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 109
Trametinib Approved Pharma inhibitor, Biomarker MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 181
PD-0325901 Investigational Pharma inhibitor 0
Selumetinib Investigational Pharma inhibitor, Biomarker MEK inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 0

(3) Additional Compounds for MAP2K6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAP2K6: view

Transcripts for MAP2K6 Gene

mRNA/cDNA for MAP2K6 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: -
SP3:

Relevant External Links for MAP2K6 Gene

GeneLoc Exon Structure for
MAP2K6

Expression for MAP2K6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP2K6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP2K6 Gene

This gene is overexpressed in Whole Blood (x11.0) and Muscle - Skeletal (x7.3).

Protein differential expression in normal tissues from HIPED for MAP2K6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.0), Tonsil (8.2), and CD8 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP2K6 Gene



Protein tissue co-expression partners for MAP2K6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP2K6

SOURCE GeneReport for Unigene cluster for MAP2K6 Gene:

Hs.463978

mRNA Expression by UniProt/SwissProt for MAP2K6 Gene:

P52564-MP2K6_HUMAN
Tissue specificity: Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas.

Evidence on tissue expression from TISSUES for MAP2K6 Gene

  • Muscle(4.5)
  • Blood(4.4)
  • Intestine(2.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with MAP2K6: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP2K6 Gene

Orthologs for MAP2K6 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP2K6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP2K6 31 30
  • 99.9 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP2K6 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP2K6 31 30
  • 91.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Map2k6 17 31 30
  • 91.02 (n)
rat
(Rattus norvegicus)
Mammalia Map2k6 30
  • 90.32 (n)
cow
(Bos Taurus)
Mammalia MAP2K6 31 30
  • 89.62 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP2K6 31
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP2K6 31 30
  • 84.63 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP2K6 31
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map2k6 30
  • 78.64 (n)
Str.6414 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.717 30
zebrafish
(Danio rerio)
Actinopterygii map2k6 31 30
  • 75.25 (n)
OneToOne
map2k3 30
fruit fly
(Drosophila melanogaster)
Insecta lic 31 32
  • 57 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sek-1 31 32 30
  • 56.28 (n)
OneToMany
VZC374L.1 32
  • 45 (a)
jkk-1 32
  • 39 (a)
F35C8.1 32
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3213 31
  • 61 (a)
OneToMany
Cin.2206 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2206 30
Species where no ortholog for MAP2K6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP2K6 Gene

ENSEMBL:
Gene Tree for MAP2K6 (if available)
TreeFam:
Gene Tree for MAP2K6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP2K6: view image

Paralogs for MAP2K6 Gene

(22) SIMAP similar genes for MAP2K6 Gene using alignment to 5 proteins:

  • MP2K6_HUMAN
  • A8K3Y2_HUMAN
  • B5BU16_HUMAN
  • K7EIW3_HUMAN
  • K7ELM6_HUMAN
genes like me logo Genes that share paralogs with MAP2K6: view

Variants for MAP2K6 Gene

Additional dbSNP identifiers (rs#s) for MAP2K6 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAP2K6 Gene

Variant ID Type Subtype PubMed ID
esv2716154 CNV deletion 23290073
nsv2130 CNV insertion 18451855
nsv520649 CNV loss 19592680

Variation tolerance for MAP2K6 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP2K6 Gene

Human Gene Mutation Database (HGMD)
MAP2K6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP2K6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP2K6 Gene

Disorders for MAP2K6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAP2K6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ischemia
  • acute coronary syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAP2K6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAP2K6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP2K6 Gene

Publications for MAP2K6 Gene

  1. Characterization of the structure and function of a novel MAP kinase kinase (MKK6). (PMID: 8621675) Han J … Ulevitch RJ (The Journal of biological chemistry 1996) 2 3 4 23 54
  2. Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation. (PMID: 20364819) Sturchler E … Duckett D (Biochemistry 2010) 3 4 23 54
  3. Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase. (PMID: 15550393) Kaur R … Lu ML (The Journal of biological chemistry 2005) 3 4 23 54
  4. Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation. (PMID: 15229216) Silva AM … Williams BR (The Journal of biological chemistry 2004) 3 4 23 54
  5. The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription. (PMID: 11727828) Bode JG … Häussinger D (Biological chemistry 2001) 3 4 23 54

Products for MAP2K6 Gene

Sources for MAP2K6 Gene