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Aliases for MAP2K5 Gene

Aliases for MAP2K5 Gene

  • Mitogen-Activated Protein Kinase Kinase 5 2 3 5
  • MAP Kinase Kinase 5 3 4
  • MAPK/ERK Kinase 5 3 4
  • MAPKK 5 3 4
  • PRKMK5 3 4
  • MEK 5 3 4
  • MEK5 3 4
  • Dual Specificity Mitogen-Activated Protein Kinase Kinase 5 3
  • MAP Kinase Kinase MEK5b 3
  • EC 4
  • HsT17454 3
  • MAPKK5 3
  • MKK5 4

External Ids for MAP2K5 Gene

Previous HGNC Symbols for MAP2K5 Gene

  • PRKMK5

Previous GeneCards Identifiers for MAP2K5 Gene

  • GC15P063628
  • GC15P060933
  • GC15P065413
  • GC15P065550
  • GC15P065622
  • GC15P067835
  • GC15P044669
  • GC15P067543
  • GC15P067681
  • GC15P067682
  • GC15P067932
  • GC15P068415

Summaries for MAP2K5 Gene

Entrez Gene Summary for MAP2K5 Gene

  • The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

GeneCards Summary for MAP2K5 Gene

MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5) is a Protein Coding gene. Diseases associated with MAP2K5 include Caroli Disease and Restless Legs Syndrome. Among its related pathways are Focal Adhesion and EGF/EGFR Signaling Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K2.

UniProtKB/Swiss-Prot for MAP2K5 Gene

  • Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.

Gene Wiki entry for MAP2K5 Gene

Additional gene information for MAP2K5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP2K5 Gene

Genomics for MAP2K5 Gene

GeneHancer (GH) Regulatory Elements for MAP2K5 Gene

Promoters and enhancers for MAP2K5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J067540 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 678.7 -0.1 -117 3.6 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF207 MAP2K5 ENSG00000270964 IQCH-AS1 SKOR1 PIAS1 ENSG00000260657
GH15J067838 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE 21 +297.5 297495 3.3 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 LOC101929076 RNU6-1 GC15M067840 SKOR1 MAP2K5 IQCH-AS1 FEM1B PIAS1 CALML4 ENSG00000259410
GH15J067520 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 17.9 -20.8 -20849 3 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 IQCH-AS1 C15orf61 MAP2K5 SKOR1
GH15J067782 Enhancer 1.7 UCNEbase FANTOM5 Ensembl ENCODE 21.4 +241.4 241385 3.6 HDGF PKNOX1 NFIB BMI1 RAD21 ZNF335 ZNF366 ZNF143 ATF7 BCLAF1 MAP2K5 LOC101929076 SKOR1 RNU6-1 IQCH-AS1 PIAS1 HNRNPA1P5
GH15J066700 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12 -838.3 -838343 8.4 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 SMAD6 ENSG00000260773 ENSG00000259202 HNRNPA1P44 MAP2K5 IQCH-AS1 ZWILCH SNORD16 MAP2K1 PIR60751
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP2K5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP2K5 gene promoter:
  • AP-1
  • NF-kappaB1
  • NF-kappaB
  • ATF-2
  • c-Jun

Genomic Locations for MAP2K5 Gene

Genomic Locations for MAP2K5 Gene
264,518 bases
Plus strand
264,441 bases
Plus strand

Genomic View for MAP2K5 Gene

Genes around MAP2K5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2K5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2K5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2K5 Gene

Proteins for MAP2K5 Gene

  • Protein details for MAP2K5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 5
    Protein Accession:
    Secondary Accessions:
    • B4DE43
    • Q92961
    • Q92962

    Protein attributes for MAP2K5 Gene

    448 amino acids
    Molecular mass:
    50112 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity). Interacts with Yersinia yopJ.

    Three dimensional structures from OCA and Proteopedia for MAP2K5 Gene

    Alternative splice isoforms for MAP2K5 Gene


neXtProt entry for MAP2K5 Gene

Post-translational modifications for MAP2K5 Gene

  • Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.
  • Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAP2K5 Gene

Domains & Families for MAP2K5 Gene

Gene Families for MAP2K5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the PB1 domain. This domain also mediates interactions with SQSTM1 and PARD6A (By similarity).
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
  • Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the PB1 domain. This domain also mediates interactions with SQSTM1 and PARD6A (By similarity).
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
genes like me logo Genes that share domains with MAP2K5: view

Function for MAP2K5 Gene

Molecular function for MAP2K5 Gene

UniProtKB/Swiss-Prot Function:
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for MAP2K5 Gene

Phenotypes From GWAS Catalog for MAP2K5 Gene

Gene Ontology (GO) - Molecular Function for MAP2K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,TAS 7759517
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005515 protein binding IPI 7759517
genes like me logo Genes that share ontologies with MAP2K5: view
genes like me logo Genes that share phenotypes with MAP2K5: view

Animal Models for MAP2K5 Gene

MGI Knock Outs for MAP2K5:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAP2K5

miRNA for MAP2K5 Gene

miRTarBase miRNAs that target MAP2K5

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP2K5 Gene

Localization for MAP2K5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP2K5 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 4
extracellular 3
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP2K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005819 spindle IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with MAP2K5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP2K5 Gene

Pathways & Interactions for MAP2K5 Gene

genes like me logo Genes that share pathways with MAP2K5: view

SIGNOR curated interactions for MAP2K5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAP2K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity ISS 20551324
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 7759517
genes like me logo Genes that share ontologies with MAP2K5: view

Drugs & Compounds for MAP2K5 Gene

(16) Drugs for MAP2K5 Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Dabrafenib Approved, Investigational Pharma Inhibition, inhibitor BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 92
Trametinib Approved Pharma inhibitor, Biomarker MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 151
Magnesium Approved Nutra 0
PD-0325901 Investigational Pharma inhibitor 0

(3) Additional Compounds for MAP2K5 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MAP2K5: view

Transcripts for MAP2K5 Gene

Unigene Clusters for MAP2K5 Gene

Mitogen-activated protein kinase kinase 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K5 Gene

No ASD Table

Relevant External Links for MAP2K5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP2K5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP2K5 Gene

Protein differential expression in normal tissues from HIPED for MAP2K5 Gene

This gene is overexpressed in CD8 Tcells (20.5), Retina (18.8), Adipocyte (17.5), and Spinal cord (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP2K5 Gene

Protein tissue co-expression partners for MAP2K5 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP2K5 Gene:


SOURCE GeneReport for Unigene cluster for MAP2K5 Gene:


mRNA Expression by UniProt/SwissProt for MAP2K5 Gene:

Tissue specificity: Expressed in many adult tissues. Abundant in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for MAP2K5 Gene

  • Nervous system(4.7)
  • Heart(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with MAP2K5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP2K5 Gene

Orthologs for MAP2K5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP2K5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP2K5 34 33
  • 99.85 (n)
(Canis familiaris)
Mammalia MAP2K5 34 33
  • 95.83 (n)
(Bos Taurus)
Mammalia MAP2K5 34 33
  • 95.24 (n)
(Ornithorhynchus anatinus)
Mammalia MAP2K5 34
  • 93 (a)
(Rattus norvegicus)
Mammalia Map2k5 33
  • 91.37 (n)
(Mus musculus)
Mammalia Map2k5 16 34 33
  • 91.07 (n)
(Monodelphis domestica)
Mammalia MAP2K5 34
  • 85 (a)
(Gallus gallus)
Aves MAP2K5 34 33
  • 85 (n)
(Anolis carolinensis)
Reptilia MAP2K5 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia map2k5 33
  • 77.35 (n)
Str.18661 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13316 33
(Danio rerio)
Actinopterygii map2k5 34 33
  • 72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBS2 34
  • 24 (a)
MKK1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
Species where no ortholog for MAP2K5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP2K5 Gene

Gene Tree for MAP2K5 (if available)
Gene Tree for MAP2K5 (if available)
Evolutionary constrained regions (ECRs) for MAP2K5: view image

Paralogs for MAP2K5 Gene

Paralogs for MAP2K5 Gene

(36) SIMAP similar genes for MAP2K5 Gene using alignment to 3 proteins:

  • A6NK28_HUMAN
genes like me logo Genes that share paralogs with MAP2K5: view

Variants for MAP2K5 Gene

Sequence variations from dbSNP and Humsavar for MAP2K5 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000006673 -- 67,576,564(+) T/A intron_variant
rs1000009955 -- 67,621,505(+) G/C intron_variant
rs1000021981 -- 67,577,061(+) G/A/T intron_variant
rs1000056320 -- 67,570,927(+) C/G intron_variant
rs1000070866 -- 67,627,616(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP2K5 Gene

Variant ID Type Subtype PubMed ID
esv1001492 CNV deletion 20482838
esv1065122 CNV deletion 17803354
esv1090385 CNV deletion 17803354
esv2352022 CNV deletion 18987734
esv2571443 CNV insertion 19546169
esv2671430 CNV deletion 23128226
esv27062 CNV loss 19812545
esv2749801 CNV deletion 23290073
esv2749802 CNV deletion 23290073
esv2749803 CNV deletion 23290073
esv2749804 CNV deletion 23290073
esv2749805 CNV deletion 23290073
esv2749806 CNV deletion 23290073
esv2749809 CNV deletion 23290073
esv3552599 CNV deletion 23714750
esv3636790 CNV loss 21293372
esv3636792 CNV loss 21293372
esv3636793 CNV loss 21293372
esv991898 CNV deletion 20482838
nsv1070280 CNV deletion 25765185
nsv1113721 CNV deletion 24896259
nsv1116083 CNV deletion 24896259
nsv1138382 CNV deletion 24896259
nsv1576 CNV deletion 18451855
nsv472445 CNV novel sequence insertion 20440878
nsv476158 CNV novel sequence insertion 20440878
nsv569799 CNV loss 21841781
nsv569800 CNV loss 21841781
nsv569801 CNV loss 21841781
nsv569802 CNV loss 21841781
nsv569803 CNV gain 21841781
nsv827374 CNV loss 20364138
nsv94879 CNV deletion 16902084
nsv974593 CNV duplication 23825009

Variation tolerance for MAP2K5 Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP2K5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2K5 Gene

Disorders for MAP2K5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAP2K5 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
caroli disease
  • caroli disease isolated
restless legs syndrome
  • ekbom syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAP2K5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAP2K5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP2K5 Gene

Publications for MAP2K5 Gene

  1. Components of a new human protein kinase signal transduction pathway. (PMID: 7759517) Zhou G … Dixon JE (The Journal of biological chemistry 1995) 2 3 4 22 58
  2. Meta-analysis identifies common variants associated with body mass index in east Asians. (PMID: 22344219) Wen W … Shu XO (Nature genetics 2012) 3 44 58
  3. Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. (PMID: 21779176) Winkelmann J … Meitinger T (PLoS genetics 2011) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 44 58

Products for MAP2K5 Gene

Sources for MAP2K5 Gene

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