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MAP2K4 Gene(Protein Coding)

Mitogen-Activated Protein Kinase Kinase 4

GCID:
GC17P012020
GIFtS:
52
Genes Participants
UDN Logo

Aliases for MAP2K4 Gene

Aliases for MAP2K4 Gene

  • Mitogen-Activated Protein Kinase Kinase 4 2 3 5
  • Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 3 4
  • Stress-Activated Protein Kinase Kinase 1 3 4
  • C-Jun N-Terminal Kinase Kinase 1 3 4
  • JNK-Activating Kinase 1 3 4
  • MAP Kinase Kinase 4 3 4
  • MAPK/ERK Kinase 4 3 4
  • SAPK/ERK Kinase 1 3 4
  • EC 2.7.12.2 4 56
  • MAPKK 4 3 4
  • SAPKK-1 3 4
  • PRKMK4 3 4
  • SAPKK1 3 4
  • SERK1 3 4
  • JNKK1 3 4
  • MEK 4 3 4
  • JNKK 3 4
  • MEK4 3 4
  • MKK4 3 4
  • SEK1 3 4
  • SKK1 3 4
  • JNK-Activated Kinase 1 3
  • SAPK Kinase 1 4
  • MAPKK4 3

External Ids for MAP2K4 Gene

Previous HGNC Symbols for MAP2K4 Gene

  • SERK1

Previous GeneCards Identifiers for MAP2K4 Gene

  • GC17P012290
  • GC17P013039
  • GC17P011868
  • GC17P012124
  • GC17P011864

Summaries for MAP2K4 Gene

Entrez Gene Summary for MAP2K4 Gene

  • This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for MAP2K4 Gene

MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4) is a Protein Coding gene. Diseases associated with MAP2K4 include Cerebral Cavernous Malformations 2 and Neuroblastoma. Among its related pathways are PEDF Induced Signaling and CNTF Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K7.

UniProtKB/Swiss-Prot for MAP2K4 Gene

  • Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.

Gene Wiki entry for MAP2K4 Gene

Additional gene information for MAP2K4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP2K4 Gene

Genomics for MAP2K4 Gene

GeneHancer (GH) Regulatory Elements for MAP2K4 Gene

Promoters and enhancers for MAP2K4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J012020 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 1010.2 +0.7 683 2.6 MNT SP1 ZFX ZNF687 POLR2A ZNF384 YY1 SP5 CREB1 PKNOX1 MAP2K4 ENSG00000241185 GC17P012021
GH17J012046 Enhancer 1 Ensembl ENCODE 18.7 +28.1 28083 10.2 ZSCAN21 MAFK SMARCA4 SP7 MZF1 SOX6 ZSCAN5C JUND ZEB1 RUNX3 MAP2K4 MIR744 RNU11-2P
GH17J011987 Enhancer 0.9 Ensembl ENCODE 17.8 -33.3 -33318 1.8 SP1 CEBPG CTCF PRDM1 REST CEBPA SOX13 FOXA2 SAP130 RAD21 MAP2K4 GC17M011978 ZNF18
GH17J011996 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.8 -23.5 -23517 2.6 MNT SP1 ZFX ELF3 GTF2F1 ZNF687 POLR2A ZSCAN21 NFRKB MLLT1 ZNF18 MAP2K4 GC17M011978 ENSG00000241185
GH17J011990 Enhancer 0.4 Ensembl ENCODE 19.5 -29.2 -29240 1.2 MAP2K4 ZNF18 GC17M011978
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP2K4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP2K4 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • CUTL1
  • ER-alpha
  • GR
  • GR-alpha
  • NF-E2
  • NF-E2 p45

Genomic Locations for MAP2K4 Gene

Genomic Locations for MAP2K4 Gene
chr17:12,020,818-12,143,831
(GRCh38/hg38)
Size:
123,014 bases
Orientation:
Plus strand
chr17:11,924,135-12,047,147
(GRCh37/hg19)
Size:
123,013 bases
Orientation:
Plus strand

Genomic View for MAP2K4 Gene

Genes around MAP2K4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2K4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2K4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAP2K4 Gene

Proteins for MAP2K4 Gene

Products:

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  • Protein details for MAP2K4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P45985-MP2K4_HUMAN
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 4
    Protein Accession:
    P45985
    Secondary Accessions:
    • B2R7N7
    • B3KYB2
    • D3DTS5
    • Q5U0B8
    • Q6FHX4
    • Q6P9H2
    • Q6PIE6

    Protein attributes for MAP2K4 Gene

    Size:
    399 amino acids
    Molecular mass:
    44288 Da
    Quaternary structure:
    • Interacts with SPAG9 (By similarity). Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2, MAPK10/JNK3, MAPK11 and MAPK14. Interacts (via its DVD domain) with MAP3Ks activators like MAP3K1/MEKK1 and MAP3K11/MLK3. Interacts with ARRB1, ARRB2 and MAPK8IP3/JIP3.

    Three dimensional structures from OCA and Proteopedia for MAP2K4 Gene

    Alternative splice isoforms for MAP2K4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2K4 Gene

Protein Expression for MAP2K4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MAP2K4 Gene

P45985:
  • FYGALFREGD
  • IKLCDFGISG
  • YDVRSDVWSLGITLYE
  • WICMELM

Post-translational modifications for MAP2K4 Gene

  • Activated by phosphorylation on Ser-257 and Thr-261 by MAP kinase kinase kinases (MAP3Ks).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP2K4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MAP2K4

Domains & Families for MAP2K4 Gene

Gene Families for MAP2K4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAP2K4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP2K4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52538, highly similar to Dual specificity mitogen-activated proteinkinase kinase 4 (EC 2.7.12.2) (B4DH44_HUMAN)
  • c-Jun N-terminal kinase kinase 1 (MP2K4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P45985

UniProtKB/Swiss-Prot:

MP2K4_HUMAN :
  • The DVD domain (residues 364-387) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Domain:
  • The DVD domain (residues 364-387) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.
  • The D domain (residues 34-52) contains a conserved docking site and is required for the binding to MAPK substrates.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
genes like me logo Genes that share domains with MAP2K4: view

Function for MAP2K4 Gene

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  2. CRISPR
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Molecular function for MAP2K4 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated in response to a variety of cellular stresses, including UV and gamma-irradiation, heat shock, hyperosmolarity, T-cell receptor stimulation, peroxide and inflammatory cytokines. Also activated by developmental cues. MAP2K4/MKK4 is activated by the majority of MKKKs, such as MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K7/TAK1, MAP3K10/MLK2, MAP3K11/MLK3, MAP3K12/DLK and MAP3K13/LZK.
GENATLAS Biochemistry:
mitogen-activated protein kinase kinase 4,binding to JUN transactivation domain and phosphorylating it,involved in signal transduction,also involved in Ras pathway and hepatogenesis

Enzyme Numbers (IUBMB) for MAP2K4 Gene

Phenotypes From GWAS Catalog for MAP2K4 Gene

Gene Ontology (GO) - Molecular Function for MAP2K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity TAS 7716521
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0004708 MAP kinase kinase activity IBA,IEA 21873635
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with MAP2K4: view
genes like me logo Genes that share phenotypes with MAP2K4: view

Animal Models for MAP2K4 Gene

MGI Knock Outs for MAP2K4:

Animal Model Products

CRISPR Products

miRNA for MAP2K4 Gene

miRTarBase miRNAs that target MAP2K4

Clone Products

  • Applied Biological Materials (abm): Clones for MAP2K4 - Now 50% OFF >
  • * MAP2K4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * MAP2K4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP2K4 Gene

Localization for MAP2K4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP2K4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP2K4 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
mitochondrion 2
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP2K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IEA,TAS --
GO:0030424 axon IEA --
GO:0032839 dendrite cytoplasm IEA --
genes like me logo Genes that share ontologies with MAP2K4: view

Pathways & Interactions for MAP2K4 Gene

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SuperPathways for MAP2K4 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
.01
2 IL-2 Pathway
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
TREM1 Pathway
.43
PACAP Signaling
.37
HMGB1 Pathway
.36
IL-4 Pathway
.34
3 Toll-like Receptor Signaling Pathway
Toll-like receptor signaling pathway
.92
Toll-like Receptor Signaling Pathway
.92
Regulation of toll-like receptor signaling pathway
.71
NOD-like Receptor Signaling Pathways
.39
Hepatitis B
.36
Epstein-Barr virus infection
.32
Chagas disease (American trypanosomiasis)
.31
4 4-1BB Pathway
4-1BB Pathway
.54
CD40 Signaling
.54
CD27 Pathway
.48
NF-KappaB Activation by EBV
.42
PKR Pathway
.36
SUMO Pathway
.30
5 TNFR1 Pathway
TNFR1 Pathway
.56
TNF Signaling
.55
Apoptosis and survival TNFR1 signaling pathway
.52
Apoptosis through Death Receptors
.42
Fas Signaling
.35
TNF alpha Signaling Pathway
.30
genes like me logo Genes that share pathways with MAP2K4: view

Pathways by source for MAP2K4 Gene

1 Cell Signaling Technology pathway for MAP2K4 Gene
2 GeneTex pathways for MAP2K4 Gene

SIGNOR curated interactions for MAP2K4 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAP2K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IBA 21873635
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 7716521
genes like me logo Genes that share ontologies with MAP2K4: view

Drugs & Compounds for MAP2K4 Gene

Products:

  1. Drug
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(39) Drugs for MAP2K4 Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dabrafenib Approved, Investigational Pharma Inhibition, inhibitor BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 102
Trametinib Approved Pharma inhibitor, Biomarker MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 172
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
PD-0325901 Investigational Pharma inhibitor 0
Selumetinib Investigational Pharma inhibitor, Biomarker MEK inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 0

(9) Additional Compounds for MAP2K4 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MAP2K4: view

Transcripts for MAP2K4 Gene

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  1. CRISPR
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  3. Inhibitory RNA
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mRNA/cDNA for MAP2K4 Gene

(2) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(191) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for MAP2K4 Gene

Mitogen-activated protein kinase kinase 4:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for MAP2K4 - Now 50% OFF >
  • * MAP2K4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * MAP2K4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - - -
SP5:
SP6:

Relevant External Links for MAP2K4 Gene

GeneLoc Exon Structure for
MAP2K4
ECgene alternative splicing isoforms for
MAP2K4

Expression for MAP2K4 Gene

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  1. Primer
  2. Gene Expression Assay
GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP2K4 Gene

mRNA expression in normal human tissues for MAP2K4 Gene
mRNA expression by BioGPS for MAP2K4 GenemRNA expression by GTEx for MAP2K4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP2K4 Gene

This gene is overexpressed in Frontal cortex (9.5) and Brain (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP2K4 Gene



Protein tissue co-expression partners for MAP2K4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP2K4 Gene:

MAP2K4

SOURCE GeneReport for Unigene cluster for MAP2K4 Gene:

Hs.514681

mRNA Expression by UniProt/SwissProt for MAP2K4 Gene:

P45985-MP2K4_HUMAN
Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Evidence on tissue expression from TISSUES for MAP2K4 Gene

  • Nervous system(5)
  • Liver(4.4)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with MAP2K4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP2K4 Gene

Orthologs for MAP2K4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP2K4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MAP2K4 35 34
  • 99.59 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 96 (a)
 OneToMany
-- 35
  • 77 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia MAP2K4 35 34
  • 95.49 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Map2k4 17 35 34
  • 95.21 (n)
rat
(Rattus norvegicus)
 Mammalia Map2k4 34
  • 94.41 (n)
cow
(Bos Taurus)
 Mammalia MAP2K4 35 34
  • 94.29 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MAP2K4 35
  • 49 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MAP2K4 35 34
  • 89.18 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MAP2K4 35
  • 76 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia map2k4 34
  • 80.39 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.13308 34
zebrafish
(Danio rerio)
 Actinopterygii map2k4b 35
  • 81 (a)
 OneToMany
map2k4a 35 34
  • 77.78 (n)
 OneToMany
Dr.10451 34
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.4083 34
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003365 34
  • 59.33 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Mkk4 35 36 34
  • 57.38 (n)
 OneToOne
lic 36
  • 52 (a)
worm
(Caenorhabditis elegans)
 Secernentea sek-1 36
  • 51 (a)
VZC374L.1 36
  • 48 (a)
mkk-4 35
  • 46 (a)
 OneToMany
sek-6 35
  • 40 (a)
 OneToMany
jkk-1 36
  • 39 (a)
F35C8.1 36
  • 39 (a)
sek-3 35
  • 37 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 53 (a)
 OneToOne
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes wis1 34
  • 52.56 (n)
Species where no ortholog for MAP2K4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP2K4 Gene

ENSEMBL:
Gene Tree for MAP2K4 (if available)
TreeFam:
Gene Tree for MAP2K4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP2K4: view image

Paralogs for MAP2K4 Gene

Paralogs for MAP2K4 Gene

(9) SIMAP similar genes for MAP2K4 Gene using alignment to 5 proteins:

  • MP2K4_HUMAN
  • J3QLE2_HUMAN
  • K7EP58_HUMAN
  • R4GN37_HUMAN
  • R4GN68_HUMAN

Pseudogenes.org Pseudogenes for MAP2K4 Gene

genes like me logo Genes that share paralogs with MAP2K4: view

Variants for MAP2K4 Gene

Products:

  1. SNP Genotyping and Copy Number Assay
Varelect - NGS phenotyyper. Rapid prioritization of variants from NGS data powered by 100+ GeneCards sources

Sequence variations from dbSNP and Humsavar for MAP2K4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1555550018 other, Neuroblastoma 12,107,814(+) C/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs753665559 A colorectal adenocarcinoma sample 12,125,315(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
VAR_040818 A lung squamous cell carcinoma sample p.Gln142Leu
VAR_040819 A colorectal adenocarcinoma sample p.Arg154Trp
VAR_040820 An ovarian serous carcinoma sample p.Asn234Ile

Structural Variations from Database of Genomic Variants (DGV) for MAP2K4 Gene

Variant ID Type Subtype PubMed ID
esv25918 CNV loss 19812545
esv3639963 CNV gain 21293372
esv991595 CNV gain 20482838
nsv1983 CNV insertion 18451855

Variation tolerance for MAP2K4 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP2K4 Gene

Human Gene Mutation Database (HGMD)
MAP2K4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP2K4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2K4 Gene

Disorders for MAP2K4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAP2K4 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cerebral cavernous malformations 2
  • cavernous angiomatous malformations
neuroblastoma
  • neuroblastoma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAP2K4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAP2K4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP2K4 Gene

Publications for MAP2K4 Gene

  1. The association between -1304T>G polymorphism in the promoter of MKK4 gene and the risk of sporadic colorectal cancer in southern Chinese population. (PMID: 19610067) Wei Y … Wang J (International journal of cancer 2009) 3 23 45 58
  2. A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates. (PMID: 12788955) Ho DT … Bardwell L (The Journal of biological chemistry 2003) 3 4 23 58
  3. Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. (PMID: 9622070) Su GH … Kern SE (Cancer research 1998) 3 4 23 58
  4. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PMID: 7839144) Dérijard B … Davis RJ (Science (New York, N.Y.) 1995) 3 4 23 58
  5. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. (PMID: 7716521) Lin A … Karin M (Science (New York, N.Y.) 1995) 2 3 4 58

ExternalLinks

Products for MAP2K4 Gene

Sources for MAP2K4 Gene

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