The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glu... See more...

Aliases for MAP2K3 Gene

Aliases for MAP2K3 Gene

  • Mitogen-Activated Protein Kinase Kinase 3 2 3 5
  • MAP Kinase Kinase 3 2 3 4
  • MAPK/ERK Kinase 3 2 3 4
  • Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 3 4
  • Stress-Activated Protein Kinase Kinase 2 3 4
  • SAPK Kinase 2 3 4
  • EC 2.7.12.2 4 52
  • MAPKK 3 3 4
  • SAPKK-2 3 4
  • PRKMK3 3 4
  • SAPKK2 3 4
  • MEK 3 3 4
  • MEK3 3 4
  • MKK3 3 4
  • Dual Specificity Mitogen Activated Protein Kinase Kinase 3 2
  • MAPKK3 3
  • SKK2 4

External Ids for MAP2K3 Gene

Previous HGNC Symbols for MAP2K3 Gene

  • PRKMK3

Previous GeneCards Identifiers for MAP2K3 Gene

  • GC17M021362
  • GC17P022837
  • GC17P021092
  • GC17P021350
  • GC17P021128
  • GC17P020390
  • GC17P021187
  • GC17P021835
  • GC17P021870
  • GC17P025024
  • GC17P025236
  • GC17P025396
  • GC17P022695
  • GC17P023026
  • GC17P023313
  • GC17P023602
  • GC17P023903
  • GC17P024252
  • GC17P024532
  • GC17P024821

Summaries for MAP2K3 Gene

Entrez Gene Summary for MAP2K3 Gene

  • The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP2K3 Gene

MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3) is a Protein Coding gene. Diseases associated with MAP2K3 include Inhalation Anthrax and Cutaneous Anthrax. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Amyotrophic lateral sclerosis (ALS). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K6.

UniProtKB/Swiss-Prot Summary for MAP2K3 Gene

  • Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.

Gene Wiki entry for MAP2K3 Gene

Additional gene information for MAP2K3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP2K3 Gene

Genomics for MAP2K3 Gene

GeneHancer (GH) Regulatory Elements for MAP2K3 Gene

Promoters and enhancers for MAP2K3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J021281 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 519.7 +1.5 1504 9.2 FOXK2 ZBTB40 ZNF217 ZSCAN5C TCF12 SIN3A NRF1 POLR2G SP1 NCOR1 MAP2K3 NONHSAG021195.2 KCNJ12 DHRS7B NATD1 5MWI_A-080
GH17J021411 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 10.7 +127.1 127068 1.9 ZNF217 CTCF USF1 CLOCK ZNF423 KLF4 EP300 CTBP1 SREBF2 ESRRA KCNJ12 MEIS3P2 ENSG00000266050 MAP2K3 lnc-MAP2K3-6
GH17J021322 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas 10.8 +38.5 38548 1 ZBTB40 ZNF217 NRF1 POLR2G USF1 SP1 SIX5 FOS ZBTB5 KDM6A UPF3AP2 MEIS3P2 KCNJ12 MAP2K3 RPL21P120 HSALNG0115267 piR-60403
GH17J021126 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.4 -157.3 -157255 3.6 FOXK2 ZBTB40 ZNF217 EP300 CTCF NRF1 POLR2G SP1 PHF8 ZFX DHRS7B TMEM11 MAP2K3 KCNJ18 NATD1 FJ601684-172
GH17J021257 Enhancer 1 Ensembl ENCODE 12.6 -27.3 -27344 1.4 ZSCAN5C ZNF639 ZNF623 CTBP1 OSR2 NCOR1 ESRRA WT1 ZNF316 FOSL1 MAP2K3 TMEM11 LOC107984969 DHRS7B NATD1 EIF1P5 lnc-NATD1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP2K3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP2K3

Top Transcription factor binding sites by QIAGEN in the MAP2K3 gene promoter:
  • AP-1
  • C/EBPalpha

Genomic Locations for MAP2K3 Gene

Genomic Locations for MAP2K3 Gene
chr17:21,284,656-21,315,240
(GRCh38/hg38)
Size:
30,585 bases
Orientation:
Plus strand
chr17:21,187,968-21,218,552
(GRCh37/hg19)
Size:
30,585 bases
Orientation:
Plus strand

Genomic View for MAP2K3 Gene

Genes around MAP2K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2K3 Gene

Proteins for MAP2K3 Gene

  • Protein details for MAP2K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46734-MP2K3_HUMAN
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 3
    Protein Accession:
    P46734
    Secondary Accessions:
    • B3KSK7
    • Q99441
    • Q9UE71
    • Q9UE72

    Protein attributes for MAP2K3 Gene

    Size:
    347 amino acids
    Molecular mass:
    39318 Da
    Quaternary structure:
    • Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). Binds to DYRK1B/MIRK and increases its kinase activity (PubMed:11980910). Part of a complex with MAP3K3, RAC1 and CCM2 (By similarity). Interacts with ARRB1 (PubMed:16709866). Interacts with Yersinia yopJ (PubMed:16728640).

    Alternative splice isoforms for MAP2K3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2K3 Gene

Selected DME Specific Peptides for MAP2K3 Gene

P46734:
  • SWGTPFQQLKQVVEEPSPQLPAD
  • FYGALFREGD
  • IMAVKRIRATVN
  • DAGCKPYMAPERINPELNQKGY
  • WICMELM
  • AILRFPY
  • LSVIHRDVKPSNVLIN

Post-translational modifications for MAP2K3 Gene

  • Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity (PubMed:8622669). Phosphorylated by TAOK2 (PubMed:11279118).
  • Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Ubiquitination at Lys243
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for MAP2K3

Domains & Families for MAP2K3 Gene

Gene Families for MAP2K3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for MAP2K3 Gene

Suggested Antigen Peptide Sequences for MAP2K3 Gene

GenScript: Design optimal peptide antigens:
  • Mitogen activated protein kinase kinase 3 (C7DUW4_HUMAN)
  • MAPK/ERK kinase 3 (MP2K3_HUMAN)
  • MAP2K3 protein (Q6FHG1_HUMAN)
  • cDNA, FLJ96569, Homo sapiens mitogen-activated protein kinase kinase 3 (MAP2K3),transcript variant B, mRNA (Q6FI23_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P46734

UniProtKB/Swiss-Prot:

MP2K3_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
genes like me logo Genes that share domains with MAP2K3: view

Function for MAP2K3 Gene

Molecular function for MAP2K3 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by dual phosphorylation on Ser-218 and Thr-222.
GENATLAS Biochemistry:
mitogen-activated protein kinase kinase 3,critical component of TNF-stimulated signaling pathway that causes increased expression of inflammatory cytokines

Enzyme Numbers (IUBMB) for MAP2K3 Gene

Phenotypes From GWAS Catalog for MAP2K3 Gene

Gene Ontology (GO) - Molecular Function for MAP2K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0004708 MAP kinase kinase activity TAS,IBA 21873635
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with MAP2K3: view
genes like me logo Genes that share phenotypes with MAP2K3: view

Animal Models for MAP2K3 Gene

MGI Knock Outs for MAP2K3:

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP2K3 Gene

Localization for MAP2K3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP2K3 gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP2K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with MAP2K3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP2K3 Gene

Pathways & Interactions for MAP2K3 Gene

PathCards logo

SuperPathways for MAP2K3 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 IL-2 Pathway
.59
.59
.54
.51
.49
.48
.47
.43
.37
.36
.34
3 4-1BB Pathway
.54
.54
.48
.46
.36
.30
4 Toll-like Receptor Signaling Pathway
5 CNTF Signaling
.50
.50
.46
.46
.45
genes like me logo Genes that share pathways with MAP2K3: view

Pathways by source for MAP2K3 Gene

21 GeneGo (Thomson Reuters) pathways for MAP2K3 Gene
  • Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2
  • Cell adhesion_Plasmin signaling
  • Development A1 receptor signaling
  • Development A2B receptor- action via G-protein alpha s
  • Development Beta-adrenergic receptors signaling via cAMP
78 Qiagen pathways for MAP2K3 Gene
  • 14-3-3 Induced Intracellular Signaling
  • 4-1BB Pathway
  • Aldosterone Signaling in Epithelial Cells
  • Alpha-Adrenergic Signaling
  • AMPK Enzyme Complex Pathway
1 Cell Signaling Technology pathway for MAP2K3 Gene
1 GeneTex pathway for MAP2K3 Gene

SIGNOR curated interactions for MAP2K3 Gene

Gene Ontology (GO) - Biological Process for MAP2K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS --
GO:0006468 protein phosphorylation IEA --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction TAS 7839144
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with MAP2K3: view

Drugs & Compounds for MAP2K3 Gene

(26) Drugs for MAP2K3 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Dabrafenib Approved, Investigational Pharma Inhibition, inhibitor BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 109
Trametinib Approved Pharma inhibitor, Biomarker MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 181
TAK-733 Investigational Pharma MEK allosteric site inhibitor, MEK inhibitor, Kinase Inhibitors 0
PD-0325901 Investigational Pharma inhibitor 0

(3) Additional Compounds for MAP2K3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(5) ApexBio Compounds for MAP2K3 Gene

Compound Action Cas Number
AZD6244 (Selumetinib) MEK inhibitor 606143-52-6
PD0325901 MEK inhibitor 391210-10-9
PD184352 (CI-1040) Selective MEK inhibitor 212631-79-3
PD98059 MEK inhibitor,selective and reversible 167869-21-8
TAK-733 MEK allosteric site inhibitor 1035555-63-5
genes like me logo Genes that share compounds with MAP2K3: view

Drug Products

Transcripts for MAP2K3 Gene

mRNA/cDNA for MAP2K3 Gene

4 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c
SP1: - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: -
SP8:
SP9: -

Relevant External Links for MAP2K3 Gene

GeneLoc Exon Structure for
MAP2K3

Expression for MAP2K3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP2K3 Gene

mRNA differential expression in normal tissues according to GTEx for MAP2K3 Gene

This gene is overexpressed in Whole Blood (x10.8).

Protein differential expression in normal tissues from HIPED for MAP2K3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.9) and Heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP2K3 Gene



Protein tissue co-expression partners for MAP2K3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP2K3

SOURCE GeneReport for Unigene cluster for MAP2K3 Gene:

Hs.514012

mRNA Expression by UniProt/SwissProt for MAP2K3 Gene:

P46734-MP2K3_HUMAN
Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Evidence on tissue expression from TISSUES for MAP2K3 Gene

  • Blood(4.6)
  • Muscle(4.6)
  • Nervous system(4.6)
  • Skin(3.3)
  • Lung(2.9)
  • Kidney(2.8)
  • Heart(2.5)
  • Liver(2.3)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with MAP2K3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP2K3 Gene

Orthologs for MAP2K3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP2K3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP2K3 31 30
  • 99.62 (n)
OneToMany
-- 31
  • 95 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MAP2K3 31
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP2K3 31 30
  • 92.03 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP2K3 31
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP2K3 31 30
  • 90.78 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Map2k3 17 31 30
  • 90.59 (n)
rat
(Rattus norvegicus)
Mammalia Map2k3 30
  • 89.91 (n)
chicken
(Gallus gallus)
Aves MAP2K3 31 30
  • 82.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP2K3 31
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000310 30
  • 67.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta lic 31 32 30
  • 63.47 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sek-1 31 32
  • 50 (a)
OneToMany
VZC374L.1 32
  • 45 (a)
jkk-1 32
  • 40 (a)
F35C8.1 32
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3213 31
  • 60 (a)
OneToMany
Species where no ortholog for MAP2K3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MAP2K3 Gene

ENSEMBL:
Gene Tree for MAP2K3 (if available)
TreeFam:
Gene Tree for MAP2K3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP2K3: view image

Paralogs for MAP2K3 Gene

(22) SIMAP similar genes for MAP2K3 Gene using alignment to 9 proteins:

  • MP2K3_HUMAN
  • C7DUW4_HUMAN
  • E9PMA8_HUMAN
  • E9PRZ0_HUMAN
  • J3KRV4_HUMAN
  • J3QL77_HUMAN
  • J3QR49_HUMAN
  • Q6FHG1_HUMAN
  • Q6FI23_HUMAN

Pseudogenes.org Pseudogenes for MAP2K3 Gene

genes like me logo Genes that share paralogs with MAP2K3: view

Variants for MAP2K3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP2K3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs1339756947 Colon cancer p.Arg175Trp
rs74575904 Uncertain Significance: not specified 21,304,501(+) T/G MISSENSE_VARIANT
rs989026404 Colon cancer p.Leu215Val
rs2305873 - p.Ala84Thr
rs2363198 - p.Val339Met

Additional dbSNP identifiers (rs#s) for MAP2K3 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAP2K3 Gene

Variant ID Type Subtype PubMed ID
dgv1433n106 CNV duplication 24896259
esv2484557 CNV deletion 19546169
esv2640649 CNV gain 19546169
esv3389999 CNV duplication 20981092
nsv1059146 CNV gain 25217958
nsv1076442 CNV duplication 25765185
nsv1078306 OTHER inversion 25765185
nsv1116197 CNV deletion 24896259
nsv1123102 CNV deletion 24896259
nsv1127546 CNV deletion 24896259
nsv1134612 CNV deletion 24896259
nsv1134613 CNV deletion 24896259
nsv1138509 CNV deletion 24896259
nsv1150229 CNV duplication 26484159
nsv435679 CNV deletion 17901297
nsv511592 CNV loss 21212237
nsv512480 CNV loss 21212237
nsv953853 CNV duplication 24416366
nsv978395 CNV duplication 23825009

Variation tolerance for MAP2K3 Gene

Residual Variation Intolerance Score: 98.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP2K3 Gene

Human Gene Mutation Database (HGMD)
MAP2K3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP2K3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2K3 Gene

Disorders for MAP2K3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MAP2K3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
inhalation anthrax
  • pulmonary anthrax
cutaneous anthrax
  • anthrax, skin type
anthrax disease
  • cutaneous anthrax
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

MP2K3_HUMAN
  • Note=Defects in MAP2K3 may be involved in colon cancer.

Additional Disease Information for MAP2K3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAP2K3: view

No data available for Genatlas for MAP2K3 Gene

Publications for MAP2K3 Gene

  1. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. (PMID: 8622669) Raingeaud J … Davis RJ (Molecular and cellular biology 1996) 3 4 23 54
  2. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PMID: 7839144) Dérijard B … Davis RJ (Science (New York, N.Y.) 1995) 3 4 23 54
  3. Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. (PMID: 20805296) Coulthard LR … McDermott MF (Annals of the rheumatic diseases 2011) 3 41 54
  4. DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1. (PMID: 20213747) Mo JS … Park HS (Journal of cellular biochemistry 2010) 3 23 54
  5. MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2. (PMID: 20067578) Hsu CH … Wolozin B (Journal of neurochemistry 2010) 3 23 54

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