MAP2K2 Gene (Protein Coding)

Mitogen-Activated Protein Kinase Kinase 2

GC19M004090
GIFtS:
54
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases... See more...

Aliases for MAP2K2 Gene

Aliases for MAP2K2 Gene

  • Mitogen-Activated Protein Kinase Kinase 2 2 3 5
  • MEK2 2 3 4
  • Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 3 4
  • ERK Activator Kinase 2 3 4
  • MAP Kinase Kinase 2 3 4
  • MAPK/ERK Kinase 2 3 4
  • EC 2.7.12.2 4 51
  • PRKMK2 3 4
  • MKK2 3 4
  • Mitogen-Activated Protein Kinase Kinase 2, P45 3
  • MAPKK 2 4
  • MAPKK2 3
  • MAP2K2 5
  • MEK 2 4
  • CFC4 3

External Ids for MAP2K2 Gene

Previous HGNC Symbols for MAP2K2 Gene

  • PRKMK2

Previous GeneCards Identifiers for MAP2K2 Gene

  • GC19M004183
  • GC19M004030
  • GC19M004041
  • GC19M003854

Summaries for MAP2K2 Gene

Entrez Gene Summary for MAP2K2 Gene

  • The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]

CIViC Summary for MAP2K2 Gene

GeneCards Summary for MAP2K2 Gene

MAP2K2 (Mitogen-Activated Protein Kinase Kinase 2) is a Protein Coding gene. Diseases associated with MAP2K2 include Cardiofaciocutaneous Syndrome 4 and Cardiofaciocutaneous Syndrome 1. Among its related pathways are MAPK Signaling: Oxidative Stress Pathway and Bladder cancer. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ENSG00000230626.

UniProtKB/Swiss-Prot Summary for MAP2K2 Gene

  • Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126).

Gene Wiki entry for MAP2K2 Gene

Additional gene information for MAP2K2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP2K2 Gene

Genomics for MAP2K2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAP2K2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP2K2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP2K2

Top Transcription factor binding sites by QIAGEN in the MAP2K2 gene promoter:
  • CREB
  • deltaCREB
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Genomic Locations for MAP2K2 Gene

Latest Assembly
chr19:4,090,321-4,124,184
(GRCh38/hg38)
Size:
33,864 bases
Orientation:
Minus strand

Previous Assembly
chr19:4,090,319-4,124,119
(GRCh37/hg19 by Entrez Gene)
Size:
33,801 bases
Orientation:
Minus strand

chr19:4,090,319-4,124,126
(GRCh37/hg19 by Ensembl)
Size:
33,808 bases
Orientation:
Minus strand

Genomic View for MAP2K2 Gene

Genes around MAP2K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2K2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAP2K2 Gene

Proteins for MAP2K2 Gene

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  • Protein details for MAP2K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36507-MP2K2_HUMAN
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 2
    Protein Accession:
    P36507

    Protein attributes for MAP2K2 Gene

    Size:
    400 amino acids
    Molecular mass:
    44424 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MORG1 (By similarity). Interacts with SGK1 (PubMed:19447520). Interacts with KSR1 (PubMed:10409742). Interacts with KSR1 and BRAF; the interaction with KSR1 mediates KSR1-BRAF dimerization (PubMed:29433126). Interacts with GLS (PubMed:22538822).

    Three dimensional structures from OCA and Proteopedia for MAP2K2 Gene

neXtProt entry for MAP2K2 Gene

Protein Expression for MAP2K2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MAP2K2 Gene

P36507:
  • MARKLIHLE
  • KNPAERADLK
  • ILGKVSIAV
  • VDFAGWLC
  • LQKKLEEL
  • FYSDGEISICMEHMDGGSLDQVLK
  • RKPVLPALTI
  • CNSPYIV
  • KVGELKDDDFE
  • GEIKLCDFGVSG
  • PIPPPDAKELE
  • ELELDEQQ
  • RLEAFLTQK
  • MAIFELLDYIVNEPP
  • GRYPIPPPD
  • LIDSMANSFVGTRSYM

Post-translational modifications for MAP2K2 Gene

  • MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity).
  • (Microbial infection) Acetylation of Ser-222 and Ser-226 by Yersinia YopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Ubiquitination at Lys88
  • Modification sites at PhosphoSitePlus

Other Protein References for MAP2K2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

Domains & Families for MAP2K2 Gene

Gene Families for MAP2K2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for MAP2K2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP2K2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ35806 fis, clone TESTI2005987, highly similar to Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (B3KS97_HUMAN)
  • MAPK/ERK kinase 2 (MP2K2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P36507

UniProtKB/Swiss-Prot:

MP2K2_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
genes like me logo Genes that share domains with MAP2K2: view

Function for MAP2K2 Gene

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  6. Cell Lines for research

Molecular function for MAP2K2 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence={ECO:0000269|PubMed:10409742};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence={ECO:0000269|PubMed:10409742};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence={ECO:0000269|PubMed:10409742};.

Enzyme Numbers (IUBMB) for MAP2K2 Gene

Phenotypes From GWAS Catalog for MAP2K2 Gene

Gene Ontology (GO) - Molecular Function for MAP2K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004708 MAP kinase kinase activity IBA,IDA 8388392
GO:0004712 protein serine/threonine/tyrosine kinase activity TAS 19565474
genes like me logo Genes that share ontologies with MAP2K2: view
genes like me logo Genes that share phenotypes with MAP2K2: view

Human Phenotype Ontology for MAP2K2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAP2K2 Gene

MGI Knock Outs for MAP2K2:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP2K2

No data available for Transcription Factor Targets and HOMER Transcription for MAP2K2 Gene

Localization for MAP2K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP2K2 Gene

Cytoplasm. Membrane. Peripheral membrane protein. Note=Membrane localization is probably regulated by its interaction with KSR1. {ECO:0000269 PubMed:10409742}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP2K2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
endosome 5
cytosol 5
golgi apparatus 5
peroxisome 4
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP2K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 8388392
GO:0005634 nucleus TAS 19565474
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion TAS 19565474
GO:0005769 early endosome TAS 19565474
genes like me logo Genes that share ontologies with MAP2K2: view

Pathways & Interactions for MAP2K2 Gene

PathCards logo

SuperPathways for MAP2K2 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 IL-2 Pathway
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
PACAP Signaling
.37
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
IL-4 Pathway
.34
3 Regulation of lipid metabolism Insulin signaling-generic cascades
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
Transcription Receptor-mediated HIF regulation
.51
Translation Regulation of EIF2 activity
.47
Translation Regulation of EIF4F activity
.44
Development CNTF receptor signaling
.43
Cell adhesion PLAU signaling
.35
Insulin signaling pathway
.32
ErbB2/ErbB3 signaling events
.31
4 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
IL-21 Signaling Pathways
.90
IL-7 Signaling Pathways
.90
IL-9 Signaling Pathways
.90
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
.90
IL-15 Signaling Pathways
.88
IL-2 Signaling Pathways
.88
IL-4 Signaling Pathways
.84
Immune response IL-9 signaling pathway
.42
Adipokines and Insulin Signaling Pathways
.34
5 Endometrial cancer
Colorectal cancer
.50
Endometrial cancer
.50
Chronic myeloid leukemia
.45
Signal transduction PTEN pathway
.44
Thyroid cancer
.36
Prostate cancer
.32
Acute myeloid leukemia
.30
genes like me logo Genes that share pathways with MAP2K2: view

Pathways by source for MAP2K2 Gene

71 GeneGo (Thomson Reuters) pathways for MAP2K2 Gene
  • Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
  • Apoptosis and survival BAD phosphorylation
  • Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2
  • Cell adhesion PLAU signaling
  • Chemotaxis CXCR4 signaling pathway
97 Qiagen pathways for MAP2K2 Gene
  • 14-3-3 Induced Intracellular Signaling
  • 4-1BB Pathway
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
1 Cell Signaling Technology pathway for MAP2K2 Gene
2 GeneTex pathways for MAP2K2 Gene

SIGNOR curated interactions for MAP2K2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAP2K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity TAS 19565474
GO:0006468 protein phosphorylation IEA --
GO:0010629 negative regulation of gene expression IGI 23626836
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with MAP2K2: view

Drugs & Compounds for MAP2K2 Gene

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(60) Drugs for MAP2K2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selumetinib Approved, Investigational Pharma Target, inhibitor, Biomarker MEK inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 0
Trametinib Approved Pharma Target, antagonist, inhibitor, Biomarker MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 212
cobimetinib Approved, Investigational Pharma inhibitor Selective MEK inhibitor 0
binimetinib Approved, Investigational Pharma Target, inhibitor 0
bosutinib Approved Pharma Target, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0

(6) Additional Compounds for MAP2K2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0

(2) Tocris Compounds for MAP2K2 Gene

Compound Action Cas Number
10Z-Hymenialdisine Pan kinase inhibitor; potently inhibits MEK1 82005-12-7
BIX 02189 Selective MEK5 and ERK5 inhibitor 1265916-41-3

(30) ApexBio Compounds for MAP2K2 Gene

Compound Action Cas Number
Arctigenin Anti-inflammatory, antiproliferative 7770-78-7
AZD6244 (Selumetinib) MEK inhibitor 606143-52-6
AZD8330 MEK 1/2 inhibitor 869357-68-6
BI-847325 dual inhibitor of MEK and Aurora kinases 1207293-36-4
BIX 02188 MEK5 inhibitor,potent and selective 1094614-84-2
BIX 02189 Selective MEK5 inhibitor 1094614-85-3
Cobimetinib Selective MEK inhibitor 934660-93-2
Cobimetinib (racemate) Selective MEK inhibitor 934662-91-6
Cobimetinib (R-enantiomer) Selective MEK inhibitor 934660-94-3
GDC-0994 ERK1/2 inhibitor 1453848-26-4
MEK inhibitor Potent MEK inhibitor, Antitumor agent 334951-92-7
MEK Inhibitor Set For phosphorylation and dephosphorylation applications
MEK162 (ARRY-162, ARRY-438162) MEK1/2 inhibitor,potent and selective 606143-89-9
PD 198306 MEK inhibitor 212631-61-3
PD0325901 MEK inhibitor 391210-10-9
PD184352 (CI-1040) Selective MEK inhibitor 212631-79-3
PD318088 Allosteric MEK1/2 inhibitor, non-ATP competitive 391210-00-7
PD98059 MEK inhibitor,selective and reversible 167869-21-8
Pimasertib (AS-703026) MEK1/2 inhibitor 1236699-92-5
Refametinib MEK 1/ MEK 2 inhibitor 923032-37-5
RO4987655 MEK inhibitor 874101-00-5
RO5126766(CH5126766) Raf/MEK dual inhibitor 946128-88-7
SCH772984 HCl
SCH772984 TFA
SL-327 Selective MEK1/2 inhibitor 305350-87-2
TAK-733 MEK allosteric site inhibitor 1035555-63-5
Trametinib (GSK1120212) MEK1 and MEK2 inhibitor, potent and selective 871700-17-3
Trametinib DMSO solvate Allosteric MEK1/MEK2 kinase inhibitor 1187431-43-1
U0124 108923-79-1
U0126-EtOH MEK1/2 inhibitor 1173097-76-1
genes like me logo Genes that share compounds with MAP2K2: view

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Transcripts for MAP2K2 Gene

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mRNA/cDNA for MAP2K2 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP2K2

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: - - - - - - -
SP2: - - - -
SP3: -
SP4:
SP5: -
SP6: -
SP7:
SP8:

Relevant External Links for MAP2K2 Gene

GeneLoc Exon Structure for
MAP2K2

Expression for MAP2K2 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP2K2 Gene

mRNA expression in normal human tissues for MAP2K2 Gene
mRNA expression by BioGPS for MAP2K2 GenemRNA expression by GTEx for MAP2K2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP2K2 Gene

This gene is overexpressed in Bone marrow stromal cell (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP2K2 Gene



Protein tissue co-expression partners for MAP2K2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP2K2

SOURCE GeneReport for Unigene cluster for MAP2K2 Gene:

Hs.465627

Evidence on tissue expression from TISSUES for MAP2K2 Gene

  • Skin(4.7)
  • Muscle(4.6)
  • Liver(4.5)
  • Blood(4.5)
  • Nervous system(4.2)
  • Lung(3.7)
  • Intestine(3.3)
  • Pancreas(2.8)
  • Kidney(2.5)
  • Heart(2.4)
  • Adrenal gland(2.3)
  • Bone marrow(2.3)
  • Lymph node(2.2)
  • Spleen(2.1)
  • Eye(2.1)
  • Thyroid gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP2K2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • nose
  • outer ear
  • scalp
  • skull
  • tongue
  • tooth
Thorax:
  • aorta
  • chest wall
  • clavicle
  • esophagus
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • abdominal wall
  • intestine
  • kidney
  • large intestine
  • spleen
  • stomach
Pelvis:
  • pelvis
  • placenta
  • rectum
  • testicle
  • ureter
  • uterus
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • coagulation system
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • sweat gland
  • vertebrae
genes like me logo Genes that share expression patterns with MAP2K2: view

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No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAP2K2 Gene

Orthologs for MAP2K2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAP2K2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MAP2K2 31
  • 100 (a)
 OneToOne
LOC100611792 30
  • 95.71 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia MAP2K2 31
  • 96 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MAP2K2 31
  • 95 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MAP2K2 30 31
  • 90.5 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MAP2K2 30 31
  • 90.17 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Map2k2 30 17 31
  • 87.25 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Map2k2 30
  • 86 (n)
Chicken
(Gallus gallus)
 Aves MAP2K2 30 31
  • 82.08 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MAP2K2 31
  • 85 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii map2k2b 31
  • 82 (a)
 OneToMany
map2k2a 30 31
  • 76.26 (n)
 OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.3525 30
Fruit Fly
(Drosophila melanogaster)
 Insecta Dsor1 31 32
  • 60 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea mek-2 31 32
  • 53 (a)
 OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_ACR196C 30
  • 51.08 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes STE7 30
  • 50.06 (n)
PBS2 31 33
  • 22 (a)
 OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0C16577g 30
  • 46.5 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons MKK6 30
  • 50.16 (n)
Rice
(Oryza sativa)
 Liliopsida Os01g0510100 30
  • 51.09 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.8484 31
  • 62 (a)
 OneToMany
Species where no ortholog for MAP2K2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for MAP2K2 Gene

ENSEMBL:
Gene Tree for MAP2K2 (if available)
TreeFam:
Gene Tree for MAP2K2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP2K2: view image

Paralogs for MAP2K2 Gene

Paralogs for MAP2K2 Gene

(15) SIMAP similar genes for MAP2K2 Gene using alignment to 4 proteins:

  • MP2K2_HUMAN
  • B3KS97_HUMAN
  • G5E9C7_HUMAN
  • M0R1B6_HUMAN

Pseudogenes.org Pseudogenes for MAP2K2 Gene

genes like me logo Genes that share paralogs with MAP2K2: view

Variants for MAP2K2 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP2K2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
40812 Uncertain Significance: Rasopathy 4,101,120(-) C/T
NM_030662.3(MAP2K2):c.604G>A (p.Val202Met) 		MISSENSE
837134 Uncertain Significance: Rasopathy 4,101,256(-) G/A
NM_030662.4(MAP2K2):c.553C>T (p.Arg185Ter) 		NONSENSE
837201 Likely Pathogenic: Rasopathy 4,110,624(-) C/A
NM_030662.4(MAP2K2):c.335G>T (p.Arg112Leu) 		MISSENSE
837895 Uncertain Significance: Rasopathy; not specified 4,090,624(-) C/T
NM_030662.4(MAP2K2):c.1177G>A (p.Gly393Ser) 		MISSENSE
843844 Uncertain Significance: Rasopathy 4,101,042(-) C/G
NM_030662.4(MAP2K2):c.682G>C (p.Val228Leu) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MAP2K2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MAP2K2 Gene

Variant ID Type Subtype PubMed ID
dgv1694n106 CNV deletion 24896259
esv1448615 CNV insertion 17803354
esv2717979 CNV deletion 23290073
esv3555894 CNV deletion 23714750
nsv1072846 CNV deletion 25765185
nsv2393 CNV insertion 18451855
nsv470115 CNV loss 18288195
nsv578435 CNV loss 21841781
nsv833716 CNV loss 17160897

Variation tolerance for MAP2K2 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP2K2 Gene

Human Gene Mutation Database (HGMD)
MAP2K2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP2K2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2K2 Gene

Disorders for MAP2K2 Gene

MalaCards: The human disease database

(33) MalaCards diseases for MAP2K2 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
cardiofaciocutaneous syndrome 4
  • cfc4
cardiofaciocutaneous syndrome 1
  • cfc1
tafro syndrome
  • thrombocytopenia-anasarca-fever-renal insufficiency-organomegaly syndrome
rasopathy
  • ras/mitogen-activated protein kinase syndrome
neurofibromatosis-noonan syndrome
  • nfns
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

MP2K2_HUMAN
  • Cardiofaciocutaneous syndrome 4 (CFC4) [MIM:615280]: A form of cardiofaciocutaneous syndrome, a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. {ECO:0000269 PubMed:16439621, ECO:0000269 PubMed:18042262, ECO:0000269 PubMed:20358587}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for MAP2K2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MAP2K2: view

No data available for Genatlas for MAP2K2 Gene

Publications for MAP2K2 Gene

  1. Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome. (PMID: 18042262) Schulz AL … Zenker M (Clinical genetics 2008) 3 4 23 74
  2. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. (PMID: 8388392) Zheng CF … Guan KL (The Journal of biological chemistry 1993) 2 3 4 23
  3. Molecular and functional analysis of a novel MEK2 mutation in cardio-facio-cutaneous syndrome: transmission through four generations. (PMID: 20358587) Rauen KA … Lacassie Y (American journal of medical genetics. Part A 2010) 3 4 23
  4. Investigation of gene dosage imbalances in patients with Noonan syndrome using multiplex ligation-dependent probe amplification analysis. (PMID: 20302979) Nyström AM … Bondeson ML (European journal of medical genetics 2010) 3 23 41
  5. Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum. (PMID: 19206169) Sarkozy A … Tartaglia M (Human mutation 2009) 3 23 41

ExternalLinks

View latest publications for MAP2K2 gene in Mastermind

Products for MAP2K2 Gene