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MAP2K1 Gene(Protein Coding)

Mitogen-Activated Protein Kinase Kinase 1

GCID:
GC15P066386
GIFtS:
62
Genes Participants
UDN Logo

Aliases for MAP2K1 Gene

Aliases for MAP2K1 Gene

  • Mitogen-Activated Protein Kinase Kinase 1 2 3 5
  • ERK Activator Kinase 1 3 4
  • MAPK/ERK Kinase 1 3 4
  • MAPKK 1 3 4
  • PRKMK1 3 4
  • MEK 1 3 4
  • MEK1 3 4
  • MKK1 3 4
  • Protein Kinase, Mitogen-Activated, Kinase 1 (MAP Kinase Kinase 1) 3
  • Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 3
  • MAP Kinase Kinase 1 4
  • EC 2.7.12.2 4
  • MAPKK1 3
  • CFC3 3

External Ids for MAP2K1 Gene

Previous HGNC Symbols for MAP2K1 Gene

  • PRKMK1

Previous GeneCards Identifiers for MAP2K1 Gene

  • GC15U990039
  • GC15P059778
  • GC15P064258
  • GC15P064395
  • GC15P064356
  • GC15P064466
  • GC15P066679
  • GC15P043515

Summaries for MAP2K1 Gene

Entrez Gene Summary for MAP2K1 Gene

  • The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]

CIViC summary for MAP2K1 Gene

  • MAP2K1 is a dual-specificity kinase known for it's involvement in the ERK pathway by activation of ERK1 and ERK2. MAP2K1 activating mutations have been observed in a number of cancers including ovarian, melanoma and lung. These activating mutations are generally found in the N-terminal negative regulatory region or the ATP-binding region of the N-terminal lobe. Inhibitors of MEK genes have been shown to inhibit tumor growth in these cases.

GeneCards Summary for MAP2K1 Gene

MAP2K1 (Mitogen-Activated Protein Kinase Kinase 1) is a Protein Coding gene. Diseases associated with MAP2K1 include Cardiofaciocutaneous Syndrome 3 and Cardiofaciocutaneous Syndrome 1. Among its related pathways are Focal Adhesion and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K2.

UniProtKB/Swiss-Prot for MAP2K1 Gene

  • Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

Gene Wiki entry for MAP2K1 Gene

Additional gene information for MAP2K1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP2K1 Gene

Genomics for MAP2K1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MAP2K1 Gene

Promoters and enhancers for MAP2K1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH15J066385 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 650.7 +2.3 2262 6.5 ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 TIPIN MAP2K1 SNAPC5 ZWILCH INTS14 SLC24A1 RPL35AP32 ENSG00000260773 SNORD16 DIS3L
GH15J066292 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.2 -92.9 -92890 3.2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 CBX5 KLF13 DIS3L LOC105370868 SNAPC5 TIPIN MAP2K1 ENSG00000260773
GH15J066452 Enhancer 1 Ensembl ENCODE 11.2 +66.4 66435 1.5 FOXA2 ZSCAN9 RAD21 RARA CREM THAP11 MIXL1 NFKBIZ RXRA CEBPB MAP2K1 SNORD16 SNORD18C SNORD18B ZWILCH SNORD18A TIPIN ENSG00000261351 LOC105370868 RPL35AP32
GH15J066369 Enhancer 1.4 FANTOM5 Ensembl ENCODE 8 -16.7 -16656 1.8 HDGF FEZF1 ZNF2 YY1 ZNF213 ZFP91 ATF7 RUNX3 ZNF518A ZNF592 MAP2K1 LOC105370868 TIPIN RPL9P25 ENSG00000223271
GH15J066616 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.7 +233.3 233250 6.9 HDGF ATF1 FOXA2 ARNT ARID4B ZNF2 YY1 ZNF766 ZNF143 FOS MAP2K1 SMAD3 SMAD6 LINC01169 GC15P070014
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAP2K1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP2K1 gene promoter:
  • STAT3
  • COUP-TF
  • COUP
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • ARP-1
  • USF-1:USF-2

Genomic Locations for MAP2K1 Gene

Genomic Locations for MAP2K1 Gene
chr15:66,386,817-66,492,312
(GRCh38/hg38)
Size:
105,496 bases
Orientation:
Plus strand
chr15:66,679,155-66,784,650
(GRCh37/hg19)
Size:
105,496 bases
Orientation:
Plus strand

Genomic View for MAP2K1 Gene

Genes around MAP2K1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2K1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2K1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAP2K1 Gene

Proteins for MAP2K1 Gene

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  • Protein details for MAP2K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02750-MP2K1_HUMAN
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 1
    Protein Accession:
    Q02750

    Protein attributes for MAP2K1 Gene

    Size:
    393 amino acids
    Molecular mass:
    43439 Da
    Quaternary structure:
    • Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3/ERK1 and RGS14. Forms a heterodimer with MAP2K2/MEK2. Forms heterodimers with KSR2 which further dimerize to form tetramers. Interacts with ARBB2, LAMTOR3, MAPK1/ERK2, MORG1 and RAF1 (By similarity). Interacts with PPARG and with isoform 1 of VRK2 (PubMed:20679487, PubMed:17101779). Interacts with Yersinia yopJ (PubMed:16728640). Interacts with SGK1 (PubMed:19447520). Interacts with BIRC6/bruce (PubMed:18329369). Interacts with KSR1 (PubMed:10409742). Interacts with KAT7; the interaction promotes KAT7 phosphorylation (By similarity).

    Three dimensional structures from OCA and Proteopedia for MAP2K1 Gene

    Alternative splice isoforms for MAP2K1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2K1 Gene

Protein Expression for MAP2K1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MAP2K1 Gene

  • Phosphorylation at Ser-218 and Ser-222 by MAP kinase kinase kinases (RAF or MEKK1) positively regulates kinase activity. Also phosphorylated at Thr-292 by MAPK1/ERK2 and at Ser-298 by PAK. MAPK1/ERK2 phosphorylation of Thr-292 occurs in response to cellular adhesion and leads to inhibition of Ser-298 phosphorylation by PAK.
  • Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Ubiquitination at isoforms=2353
  • Modification sites at PhosphoSitePlus

Other Protein References for MAP2K1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MAP2K1 Gene

Domains & Families for MAP2K1 Gene

Gene Families for MAP2K1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for MAP2K1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP2K1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02750

UniProtKB/Swiss-Prot:

MP2K1_HUMAN :
  • The proline-rich region localized between residues 270 and 307 is important for binding to RAF1 and activation of MAP2K1/MEK1.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Domain:
  • The proline-rich region localized between residues 270 and 307 is important for binding to RAF1 and activation of MAP2K1/MEK1.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
genes like me logo Genes that share domains with MAP2K1: view

Function for MAP2K1 Gene

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Molecular function for MAP2K1 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Ras proteins such as HRAS mediate the activation of RAF proteins such as RAF1 or BRAF which in turn activate extracellular signal-regulated kinases (ERK) through MAPK (mitogen-activated protein kinases) and ERK kinases MAP2K1/MEK1 and MAP2K2/MEK2. Activation occurs through phosphorylation of Ser-218 and Ser-222. MAP2K1/MEK1 is also the target of negative feed-back regulation by its substrate kinases, such as MAPK1/ERK2. These phosphorylate MAP2K1/MEK1 on Thr-292, thereby facilitating dephosphorylation of the activating residues Ser-218 and Ser-222. Inhibited by serine/threonine phosphatase 2A (By similarity). Many inhibitors have been identified including pyrrole derivatives, TAK-733 (one of a series of 8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione derivatives), CH4987655 and RDEA119/BAY 869766.
GENATLAS Biochemistry:
mitogen-activated protein kinase kinase 1,nucleocytoplasmic shuttling protein,involved in signal transduction

Enzyme Numbers (IUBMB) for MAP2K1 Gene

Phenotypes From GWAS Catalog for MAP2K1 Gene

Gene Ontology (GO) - Molecular Function for MAP2K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,IDA 28166211
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004708 MAP kinase kinase activity IDA 8388392
GO:0004712 protein serine/threonine/tyrosine kinase activity TAS 19565474
genes like me logo Genes that share ontologies with MAP2K1: view
genes like me logo Genes that share phenotypes with MAP2K1: view

Human Phenotype Ontology for MAP2K1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAP2K1 Gene

MGI Knock Outs for MAP2K1:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAP2K1

miRNA for MAP2K1 Gene

miRTarBase miRNAs that target MAP2K1

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for MAP2K1 Gene

Localization for MAP2K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP2K1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm. Nucleus. Membrane; Peripheral membrane protein. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis (PubMed:14737111). Membrane localization is probably regulated by its interaction with KSR1 (PubMed:10409742). {ECO:0000269 PubMed:10409742, ECO:0000269 PubMed:14737111}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP2K1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
golgi apparatus 5
endosome 5
cytoskeleton 4
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP2K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 19565474
GO:0005737 cytoplasm IEA,IBA --
GO:0005739 mitochondrion TAS 19565474
GO:0005769 early endosome TAS 19565474
GO:0005770 late endosome TAS 19565474
genes like me logo Genes that share ontologies with MAP2K1: view

Pathways & Interactions for MAP2K1 Gene

SuperPathways for MAP2K1 Gene

PathCards logo More details on SuperPathways for MAP2K1
SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
3 IL-2 Pathway
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
PACAP Signaling
.37
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
IL-4 Pathway
.34
4 Regulation of lipid metabolism Insulin signaling-generic cascades
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
Transcription Receptor-mediated HIF regulation
.51
Translation Regulation of EIF2 activity
.47
Translation Regulation of EIF4F activity
.44
Development CNTF receptor signaling
.43
Cell adhesion PLAU signaling
.35
Development Growth hormone signaling via PI3K/AKT and MAPK cascades
.34
Insulin signaling pathway
.32
ErbB2/ErbB3 signaling events
.31
Class IB PI3K non-lipid kinase events
.01
5 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
IL-21 Signaling Pathways
.90
IL-7 Signaling Pathways
.90
IL-9 Signaling Pathways
.90
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
.90
IL-15 Signaling Pathways
.88
IL-2 Signaling Pathways
.88
IL-4 Signaling Pathways
.84
Immune response IL-9 signaling pathway
.42
Development Thrombopoietin-regulated cell processes
.38
Adipokines and Insulin Signaling Pathways
.34
genes like me logo Genes that share pathways with MAP2K1: view

Pathways by source for MAP2K1 Gene

1 GeneTex pathway for MAP2K1 Gene
1 Cell Signaling Technology pathway for MAP2K1 Gene

SIGNOR curated interactions for MAP2K1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAP2K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity TAS,IDA 19565474
GO:0001932 regulation of protein phosphorylation IEA --
GO:0006468 protein phosphorylation IEA,IDA 28166211
GO:0006935 chemotaxis TAS 10570282
genes like me logo Genes that share ontologies with MAP2K1: view

Drugs & Compounds for MAP2K1 Gene

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  1. Drug

(143) Drugs for MAP2K1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cobimetinib Approved, Investigational Pharma inhibitor, Target Selective MEK inhibitor 0
Trametinib Approved Pharma inhibitor, Biomarker, Target, antagonist MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 151
Mekinist Approved May of 2013 Pharma Inhibition 0
bosutinib Approved Pharma Target, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
Dabrafenib Approved, Investigational Pharma Inhibition, inhibitor BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 92

(49) Additional Compounds for MAP2K1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(2) Tocris Compounds for MAP2K1 Gene

Compound Action Cas Number
10Z-Hymenialdisine Pan kinase inhibitor; potently inhibits MEK1 82005-12-7
BIX 02189 Selective MEK5 and ERK5 inhibitor 1265916-41-3

(37) ApexBio Compounds for MAP2K1 Gene

Compound Action Cas Number
10Z-Hymenialdisine 82005-12-7
Arctigenin Anti-inflammatory, antiproliferative 7770-78-7
AZD6244 (Selumetinib) MEK inhibitor 606143-52-6
AZD8330 MEK 1/2 inhibitor 869357-68-6
BI-847325 dual inhibitor of MEK and Aurora kinases 1207293-36-4
BIX 02188 MEK5 inhibitor,potent and selective 1094614-84-2
BIX 02189 Selective MEK5 inhibitor 1094614-85-3
Cobimetinib Selective MEK inhibitor 934660-93-2
Cobimetinib (racemate) Selective MEK inhibitor 934662-91-6
Cobimetinib (R-enantiomer) Selective MEK inhibitor 934660-94-3
FR 180204 ERK inhibitor 865362-74-9
GDC-0623 MEK1 inhibitor, potent and ATP-uncompetitive 1168091-68-6
GDC-0994 ERK1/2 inhibitor 1453848-26-4
MEK inhibitor Potent MEK inhibitor, Antitumor agent 334951-92-7
MEK Inhibitor Set For phosphorylation and dephosphorylation applications
MEK162 (ARRY-162, ARRY-438162) MEK1/2 inhibitor,potent and selective 606143-89-9
PD 198306 MEK inhibitor 212631-61-3
PD 334581 548756-68-9
PD0325901 MEK inhibitor 391210-10-9
PD184352 (CI-1040) Selective MEK inhibitor 212631-79-3
PD318088 Allosteric MEK1/2 inhibitor, non-ATP competitive 391210-00-7
PD98059 MEK inhibitor,selective and reversible 167869-21-8
Pimasertib (AS-703026) MEK1/2 inhibitor 1236699-92-5
Refametinib MEK 1/ MEK 2 inhibitor 923032-37-5
Refametinib R enantiomer MEK1/2 allosteric inhibitor 923032-38-6
RO4987655 MEK inhibitor 874101-00-5
RO5126766(CH5126766) Raf/MEK dual inhibitor 946128-88-7
SCH772984 ERK1 and ERK2 inhibitor 942183-80-4
SCH772984 HCl
SCH772984 TFA
SL-327 Selective MEK1/2 inhibitor 305350-87-2
TAK-733 MEK allosteric site inhibitor 1035555-63-5
Trametinib (GSK1120212) MEK1 and MEK2 inhibitor, potent and selective 871700-17-3
Trametinib DMSO solvate Allosteric MEK1/MEK2 kinase inhibitor 1187431-43-1
U0124 108923-79-1
U0126-EtOH MEK1/2 inhibitor 1173097-76-1
Vemurafenib (PLX4032, RG7204) BRAF kinase inhibitor 918504-65-1
genes like me logo Genes that share compounds with MAP2K1: view

Drug Products

Transcripts for MAP2K1 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MAP2K1 Gene

(5) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(190) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAP2K1 Gene

Mitogen-activated protein kinase kinase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K1 Gene

No ASD Table

Relevant External Links for MAP2K1 Gene

GeneLoc Exon Structure for
MAP2K1
ECgene alternative splicing isoforms for
MAP2K1

Expression for MAP2K1 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP2K1 Gene

mRNA expression in normal human tissues for MAP2K1 Gene
mRNA expression by BioGPS for MAP2K1 GenemRNA expression by GTEx for MAP2K1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP2K1 Gene

This gene is overexpressed in Frontal cortex (12.5), Bone marrow mesenchymal stem cell (10.0), and Brain (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP2K1 Gene



Protein tissue co-expression partners for MAP2K1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP2K1 Gene:

MAP2K1

SOURCE GeneReport for Unigene cluster for MAP2K1 Gene:

Hs.145442

mRNA Expression by UniProt/SwissProt for MAP2K1 Gene:

Q02750-MP2K1_HUMAN
Tissue specificity: Widely expressed, with extremely low levels in brain.

Evidence on tissue expression from TISSUES for MAP2K1 Gene

  • Liver(4.6)
  • Blood(4.5)
  • Nervous system(3.5)
  • Heart(3.2)
  • Muscle(3.1)
  • Intestine(2.9)
  • Kidney(2.8)
  • Lung(2.7)
  • Adrenal gland(2.5)
  • Skin(2.5)
  • Stomach(2.5)
  • Bone marrow(2.3)
  • Lymph node(2.2)
  • Spleen(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP2K1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • nose
  • outer ear
  • scalp
  • skull
  • tongue
  • tooth
Thorax:
  • aorta
  • chest wall
  • clavicle
  • esophagus
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • intestine
  • kidney
  • large intestine
  • spleen
  • stomach
Pelvis:
  • pelvis
  • placenta
  • rectum
  • testicle
  • ureter
  • uterus
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • sweat gland
  • vertebrae
genes like me logo Genes that share expression patterns with MAP2K1: view

No data available for mRNA differential expression in normal tissues for MAP2K1 Gene

Orthologs for MAP2K1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAP2K1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MAP2K1 34 33
  • 98.64 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia MAP2K1 34
  • 97 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia MAP2K1 34 33
  • 94.49 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia MAP2K1 34 33
  • 94.25 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Map2k1 33
  • 91.26 (n)
mouse
(Mus musculus)
 Mammalia Map2k1 16 34 33
  • 90.67 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia MAP2K1 34
  • 80 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MAP2K1 34 33
  • 81.51 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 81 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia map2k1 33
  • 78.12 (n)
Str.10686 33
African clawed frog
(Xenopus laevis)
 Amphibia mek-2-prov 33
zebrafish
(Danio rerio)
 Actinopterygii map2k1 34 33
  • 76.41 (n)
 OneToOne
Dr.25154 33
fruit fly
(Drosophila melanogaster)
 Insecta Dsor1 34 35 33
  • 64.62 (n)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001103 33
  • 61.1 (n)
worm
(Caenorhabditis elegans)
 Secernentea mek-2 34 35 33
  • 52.46 (n)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PBS2 34
  • 22 (a)
 OneToMany
STE7 36
thale cress
(Arabidopsis thaliana)
 eudicotyledons MEK1 33
  • 51.19 (n)
rice
(Oryza sativa)
 Liliopsida Os06g0147800 33
  • 49.4 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.8484 34
  • 65 (a)
 OneToMany
Cin.141 33
bread mold
(Neurospora crassa)
 Ascomycetes NCU04612 33
  • 56.14 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes byr1 33
  • 49.9 (n)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.141 33
Species where no ortholog for MAP2K1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP2K1 Ge