This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizin... See more...

Aliases for MAP2 Gene

Aliases for MAP2 Gene

  • Microtubule Associated Protein 2 2 3 5
  • Microtubule-Associated Protein 2 3 4
  • MAP-2 3 4
  • MAP2A 2 3
  • MAP2B 2 3
  • MAP2C 2 3
  • MAP2 5

External Ids for MAP2 Gene

Previous GeneCards Identifiers for MAP2 Gene

  • GC02P208719
  • GC02P209169
  • GC02P210252
  • GC02P210491
  • GC02P210646
  • GC02P210114
  • GC02P209997
  • GC02P202133

Summaries for MAP2 Gene

Entrez Gene Summary for MAP2 Gene

  • This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]

GeneCards Summary for MAP2 Gene

MAP2 (Microtubule Associated Protein 2) is a Protein Coding gene. Diseases associated with MAP2 include Central Neurocytoma and Olivopontocerebellar Atrophy. Among its related pathways are Melatonin metabolism and effects and Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include structural molecule activity and calmodulin binding. An important paralog of this gene is MAPT.

UniProtKB/Swiss-Prot Summary for MAP2 Gene

  • The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

Gene Wiki entry for MAP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAP2 Gene

Genomics for MAP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MAP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J209423 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 273 +1.5 1454 4.6 POLR2A REST ZEB1 KLF7 CTCF MAX THAP11 SP2 RAD21 SMC3 MAP2 piR-48820-059 UNC80
GH02J209579 Promoter 1.4 EPDnew Ensembl CraniofacialAtlas 260.6 +155.8 155754 4 CTCF RFX1 MAFK PKNOX1 CHD2 RAD21 POLR2A BMI1 MAP2 HSALNG0021935 NONHSAG030393.2 UNC80
GH02J209382 Enhancer 0.9 Ensembl ENCODE 34.7 -40.7 -40676 1.3 JUND CEBPA CEBPB MAX ZNF217 EP300 ELF1 FOXA2 CTBP1 RARA MAP2 ENSG00000286249 piR-31292-106
GH02J209391 Enhancer 0.7 Ensembl ENCODE 33.7 -31.8 -31825 1.2 CEBPB EP300 JUND MAFF HNF4A MAFK SP1 MAP2 piR-33303-093
GH02J209472 Enhancer 1 Ensembl ENCODE 19 +49.0 48954 4 JUND ZSCAN16 CEBPB FEZF1 ZNF217 EP300 PRDM1 MAFF RFX5 STAT3 MAP2 piR-48820-059 NONHSAG030393.2 UNC80
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAP2

Top Transcription factor binding sites by QIAGEN in the MAP2 gene promoter:
  • AP-1
  • C/EBPalpha
  • MyoD

Genomic Locations for MAP2 Gene

Latest Assembly
chr2:209,424,047-209,734,118
(GRCh38/hg38)
Size:
310,072 bases
Orientation:
Plus strand

Previous Assembly
chr2:210,288,771-210,598,836
(GRCh37/hg19 by Entrez Gene)
Size:
310,066 bases
Orientation:
Plus strand

chr2:210,288,782-210,598,842
(GRCh37/hg19 by Ensembl)
Size:
310,061 bases
Orientation:
Plus strand

Genomic View for MAP2 Gene

Genes around MAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2 Gene

Proteins for MAP2 Gene

  • Protein details for MAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11137-MTAP2_HUMAN
    Recommended name:
    Microtubule-associated protein 2
    Protein Accession:
    P11137
    Secondary Accessions:
    • Q17S04
    • Q8IUX2
    • Q99975
    • Q99976

    Protein attributes for MAP2 Gene

    Size:
    1827 amino acids
    Molecular mass:
    199526 Da
    Quaternary structure:
    • Interacts with KNDC1 (via KIND2); the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites.

    Alternative splice isoforms for MAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2 Gene

Post-translational modifications for MAP2 Gene

  • Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

No data available for DME Specific Peptides for MAP2 Gene

Domains & Families for MAP2 Gene

Gene Families for MAP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAP2 Gene

InterPro:
Blocks:
  • Tubulin-binding Tau protein
  • MAP2/Tau projection

Suggested Antigen Peptide Sequences for MAP2 Gene

GenScript: Design optimal peptide antigens:
  • Microtubule-associated protein 2 (MAP2_HUMAN)
  • MAP2 protein (Q6NYC5_HUMAN)
  • Microtubule-associated protein (Q8IUX2_HUMAN)
genes like me logo Genes that share domains with MAP2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MAP2 Gene

Function for MAP2 Gene

Molecular function for MAP2 Gene

UniProtKB/Swiss-Prot Function:
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
GENATLAS Biochemistry:
microtubule (beta) associated protein 2,expressed in the cytoplasm of neural tissue and predominantly nuclear in germ cells,with an alternatively spliced isoform expressing exon 13 (MAP2+13),expressed in fetal oligodendrocytes during process extension and myelination,minimally expressed in normal mature CNS,expressed again in generating oligodendrocytes in multiple slcerosis lesions

Phenotypes From GWAS Catalog for MAP2 Gene

Gene Ontology (GO) - Molecular Function for MAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002162 dystroglycan binding IPI 18341635
GO:0005198 structural molecule activity NAS 9588626
GO:0005515 protein binding IPI 20195357
GO:0005516 calmodulin binding IEA --
GO:0008017 microtubule binding IEA,TAS 26609151
genes like me logo Genes that share ontologies with MAP2: view
genes like me logo Genes that share phenotypes with MAP2: view

Animal Models for MAP2 Gene

MGI Knock Outs for MAP2:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP2

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP2 Gene

Localization for MAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP2 Gene

Cytoplasm, cytoskeleton. Cell projection, dendrite.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP2 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 4
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS --
GO:0005829 cytosol ISS --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS 9588626
genes like me logo Genes that share ontologies with MAP2: view

Pathways & Interactions for MAP2 Gene

genes like me logo Genes that share pathways with MAP2: view

Pathways by source for MAP2 Gene

1 Qiagen pathway for MAP2 Gene
  • JNK Pathway
1 Cell Signaling Technology pathway for MAP2 Gene

SIGNOR curated interactions for MAP2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization ISS --
GO:0001578 microtubule bundle formation IEA --
GO:0016358 dendrite development TAS 26609151
GO:0021954 central nervous system neuron development IEA,IEP 20846339
GO:0030517 negative regulation of axon extension ISS --
genes like me logo Genes that share ontologies with MAP2: view

Drugs & Compounds for MAP2 Gene

(47) Drugs for MAP2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Estramustine Approved, Investigational Pharma Target, antagonist 54
Docetaxel Approved, Investigational Pharma Target Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2429
Paclitaxel Approved, Vet_approved Pharma Target Tubulin and Bcl2 inhibitor, Taxanes 3989

(32) Additional Compounds for MAP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAP2: view

Transcripts for MAP2 Gene

mRNA/cDNA for MAP2 Gene

59 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAP2

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: - - - - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - - -
SP10: - - - - - - - -
SP11: - -
SP12: -
SP13: - - - - -
SP14: - -
SP15:
SP16:

ExUns: 20b · 20c · 20d ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b · 25c · 25d
SP1: -
SP2: - - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MAP2 Gene

GeneLoc Exon Structure for
MAP2

Expression for MAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.7), Brain - Frontal Cortex (BA9) (x5.5), Brain - Cortex (x5.3), Brain - Amygdala (x5.2), Brain - Hypothalamus (x4.4), Brain - Nucleus accumbens (basal ganglia) (x4.3), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for MAP2 Gene

This gene is overexpressed in Brain (36.2), Frontal cortex (16.1), and Fetal Brain (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAP2

SOURCE GeneReport for Unigene cluster for MAP2 Gene:

Hs.368281

Evidence on tissue expression from TISSUES for MAP2 Gene

  • Nervous system(5)
  • Pancreas(4.4)
  • Liver(4.4)
  • Skin(2.8)
  • Intestine(2.6)
  • Eye(2.5)
  • Adrenal gland(2.4)
  • Blood(2.3)
  • Heart(2.2)
  • Muscle(2.2)
  • Kidney(2.2)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with MAP2: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP2 Gene

Orthologs for MAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MAP2 29 30
  • 99.64 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MAP2 29
  • 88.51 (n)
MAP-2 30
  • 87 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Map2 29 16 30
  • 86.8 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MAP2 29 30
  • 86.12 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Map2 29
  • 82.94 (n)
Oppossum
(Monodelphis domestica)
Mammalia MAP2 30
  • 70 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MAP2 30
  • 51 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MAP2 29 30
  • 68.5 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MAP2 30
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia map2 29
  • 72.82 (n)
African clawed frog
(Xenopus laevis)
Amphibia a730034c02-prov 29
Zebrafish
(Danio rerio)
Actinopterygii map2 30
  • 32 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta tau 30
  • 24 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ptl-1 30
  • 14 (a)
OneToMany
Species where no ortholog for MAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MAP2 Gene

ENSEMBL:
Gene Tree for MAP2 (if available)
TreeFam:
Gene Tree for MAP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAP2: view image
Alliance of Genome Resources:
Additional Orthologs for MAP2

Paralogs for MAP2 Gene

Paralogs for MAP2 Gene

genes like me logo Genes that share paralogs with MAP2: view

Variants for MAP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAP2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs1281334154 Likely Benign: not provided 209,694,627(+) G/A
NM_001039538.2(MAP2):c.455-5650G>A
SYNONYMOUS_VARIANT,INTRON
rs1289033026 Likely Benign: not provided 209,695,632(+) A/G
NM_001039538.2(MAP2):c.455-4645A>G
SYNONYMOUS_VARIANT,INTRON
rs13425372 Benign: not provided 209,695,097(+) A/Tp.His976Leu
NM_001039538.2(MAP2):c.455-5180A>T
MISSENSE_VARIANT,INTRON
rs139310749 Benign: not provided 209,653,333(+) G/A
NM_001039538.2(MAP2):c.163G>A (p.Glu55Lys)
MISSENSE
rs141459532 Likely Benign: not provided 209,693,575(+) G/A
NM_001039538.2(MAP2):c.455-6702G>A
MISSENSE_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MAP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MAP2 Gene

Variant ID Type Subtype PubMed ID
esv1055449 CNV insertion 17803354
esv2608148 CNV deletion 19546169
esv2678028 CNV deletion 23128226
esv3594149 CNV gain 21293372
esv3594150 CNV loss 21293372
nsv1005298 CNV gain 25217958
nsv1131545 CNV deletion 24896259
nsv1132522 CNV duplication 24896259
nsv214706 CNV deletion 16902084
nsv3141 CNV insertion 18451855
nsv478034 CNV novel sequence insertion 20440878
nsv507065 OTHER sequence alteration 20534489
nsv834518 CNV loss 17160897
nsv834519 CNV loss 17160897

Variation tolerance for MAP2 Gene

Residual Variation Intolerance Score: 2.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP2 Gene

Human Gene Mutation Database (HGMD)
MAP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP2
Leiden Open Variation Database (LOVD)
MAP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2 Gene

Disorders for MAP2 Gene

MalaCards: The human disease database

(41) MalaCards diseases for MAP2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
central neurocytoma
  • neurolipocytoma
olivopontocerebellar atrophy
  • dejerine-thomas syndrome
ganglioglioma
  • adult ganglioglioma
dysembryoplastic neuroepithelial tumor
  • dysembryoplastic neuroepithelial neoplasm
pituicytoma
- elite association - COSMIC cancer census association via MalaCards
Search MAP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAP2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP2 Gene

Publications for MAP2 Gene

  1. Fyn phosphorylates human MAP-2c on tyrosine 67. (PMID: 15536091) Zamora-Leon SP … Shafit-Zagardo B (The Journal of biological chemistry 2005) 3 4 22
  2. Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms. (PMID: 7479905) Kalcheva N … Shafit-Zagardo B (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 22
  3. Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2). (PMID: 8294038) Albala JS … Shafit-Zagardo B (Gene 1993) 3 4 22
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40

Products for MAP2 Gene

Sources for MAP2 Gene