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Aliases for MAP1S Gene

Aliases for MAP1S Gene

  • Microtubule Associated Protein 1S 2 3 5
  • Variable Charge Y Chromosome 2-Interacting Protein 1 3 4
  • Microtubule-Associated Protein 8 3 4
  • BPY2-Interacting Protein 1 3 4
  • VCY2-Interacting Protein 1 3 4
  • VCY2IP-1 3 4
  • BPY2IP1 3 4
  • C19orf5 3 4
  • VCY2IP1 3 4
  • MAP-1S 3 4
  • MAP8 3 4
  • Chromosome 19 Open Reading Frame 5 2
  • Microtubule-Associated Protein 1S 3
  • VCY2 Interacting Protein 1 2
  • BPY2 Interacting Protein 1 2

External Ids for MAP1S Gene

Previous HGNC Symbols for MAP1S Gene

  • C19orf5
  • VCY2IP1
  • BPY2IP1

Previous GeneCards Identifiers for MAP1S Gene

  • GC19P017694
  • GC19P017832
  • GC19P017396
  • GC19P017932
  • GC19P018136
  • GC19P018154
  • GC19P018321
  • GC19P018697
  • GC19P019008
  • GC19P019326

Summaries for MAP1S Gene

GeneCards Summary for MAP1S Gene

MAP1S (Microtubule Associated Protein 1S) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding and actin filament binding. An important paralog of this gene is MAP1B.

UniProtKB/Swiss-Prot for MAP1S Gene

  • Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).

Gene Wiki entry for MAP1S Gene

Additional gene information for MAP1S Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1S Gene

Genomics for MAP1S Gene

GeneHancer (GH) Regulatory Elements for MAP1S Gene

Promoters and enhancers for MAP1S Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I017718 Promoter/Enhancer 1.5 Ensembl ENCODE 556.4 +1.3 1337 3.8 PKNOX1 ARID4B DMAP1 ZNF2 YY1 ETS1 ZNF213 ELK1 ZNF143 KLF7 MAP1S FCHO1 UNC13A B3GNT3 GC19P020228
GH19I017716 Enhancer 1.1 Ensembl ENCODE 557.5 -1.7 -1696 1.3 HDGF ATF1 YY1 TCF12 ATF7 NCOA1 REST ZNF592 SMARCA4 NBN MAP1S UNC13A B3GNT3 PIR50741
GH19I017764 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.2 +46.6 46596 3.1 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 GTF3C2 SLC30A9 GC19M017755 B3GNT3 UNC13A MAP1S INSL3 MVB12A PLVAP FCHO1
GH19I017762 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.5 +43.5 43468 1.1 HDGF HDAC1 YBX3 PKNOX1 BMI1 RFX5 ZNF366 RCOR1 FOS KLF13 MAP1S B3GNT3 INSL3 PLVAP NXNL1 F2RL3 GC19M017755 GC19P020271 FCHO1
GH19I017738 Enhancer 1.1 Ensembl ENCODE 13.1 +20.1 20067 1.2 RB1 KLF17 BMI1 IRF4 GTF3C2 ZNF121 EGR1 ZNF143 ATF7 BCLAF1 MAP1S B3GNT3 FCHO1 GC19P020228 LOC105372299
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAP1S on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP1S gene promoter:

Genomic Locations for MAP1S Gene

Genomic Locations for MAP1S Gene
chr19:17,719,242-17,734,516
(GRCh38/hg38)
Size:
15,275 bases
Orientation:
Plus strand
chr19:17,830,051-17,845,325
(GRCh37/hg19)

Genomic View for MAP1S Gene

Genes around MAP1S on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP1S Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP1S Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1S Gene

Proteins for MAP1S Gene

  • Protein details for MAP1S Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66K74-MAP1S_HUMAN
    Recommended name:
    Microtubule-associated protein 1S
    Protein Accession:
    Q66K74
    Secondary Accessions:
    • B4DH53
    • Q27QB1
    • Q6NXF1
    • Q8N3L8
    • Q8N3W5
    • Q8NI88
    • Q96H94
    • Q96IT4
    • Q96SP8
    • Q9BRC6
    • Q9H928
    • Q9NVK7

    Protein attributes for MAP1S Gene

    Size:
    1059 amino acids
    Molecular mass:
    112211 Da
    Quaternary structure:
    • Heterodimer of a heavy and a light chain. Interacts with microtubules and actin. Both MAP1S heavy and light chains interact with microtubules. MAP1S light chain interacts with actin. Interacts (via C-terminus) with GAN (via Kelch domains) (By similarity). Interacts with ESR1, LRPPRC, RASSF1 isoform A and isoform C, microtubules and VCY2. Interacts with WDR47 (via N-terminus of light chain).
    Miscellaneous:
    • Depletion of MAP1S by RNAi causes mitotic abnormalities that consist of failure to form a stable metaphase plate, premature sister chromatid separation, lagging chromosomes, and multipolar spindles.
    SequenceCaution:
    • Sequence=AAH07253.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH07253.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. At the N-terminus.; Evidence={ECO:0000305}; Sequence=AAH67115.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91743.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14415.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55242.1; Type=Frameshift; Positions=851; Evidence={ECO:0000305}; Sequence=BAB93493.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38911.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP1S Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP1S Gene

Post-translational modifications for MAP1S Gene

  • Ubiquitination at posLast=7373, posLast=380380, and posLast=10001000

No data available for DME Specific Peptides for MAP1S Gene

Domains & Families for MAP1S Gene

Gene Families for MAP1S Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAP1S Gene

Graphical View of Domain Structure for InterPro Entry

Q66K74

UniProtKB/Swiss-Prot:

MAP1S_HUMAN :
  • The N-terminus of the heavy chain associates with the C-terminus of the light chain to form the heterodimer complex (By similarity). Its C-terminal part of the heavy chain interacts with ESR1.
  • Belongs to the MAP1 family.
Domain:
  • The N-terminus of the heavy chain associates with the C-terminus of the light chain to form the heterodimer complex (By similarity). Its C-terminal part of the heavy chain interacts with ESR1.
Family:
  • Belongs to the MAP1 family.
genes like me logo Genes that share domains with MAP1S: view

Function for MAP1S Gene

Molecular function for MAP1S Gene

UniProtKB/Swiss-Prot Function:
Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).

Phenotypes From GWAS Catalog for MAP1S Gene

Gene Ontology (GO) - Molecular Function for MAP1S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 15907802
GO:0004536 NOT deoxyribonuclease activity IDA 15907802
GO:0005515 protein binding IPI 12762840
GO:0008017 microtubule binding TAS,IEA 12762840
GO:0015631 tubulin binding IDA 15528209
genes like me logo Genes that share ontologies with MAP1S: view
genes like me logo Genes that share phenotypes with MAP1S: view

Animal Models for MAP1S Gene

MGI Knock Outs for MAP1S:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP1S Gene

Localization for MAP1S Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1S Gene

Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Detected in filopodia-like protrusions and synapses (By similarity). Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP1S gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAP1S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12762840
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol IEA,IDA 12762840
genes like me logo Genes that share ontologies with MAP1S: view

Pathways & Interactions for MAP1S Gene

SuperPathways for MAP1S Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP1S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IMP 15528209
GO:0006914 autophagy TAS 21262964
GO:0006915 apoptotic process IEA --
GO:0007399 nervous system development ISS 16297881
GO:0007420 brain development ISS 15528209
genes like me logo Genes that share ontologies with MAP1S: view

No data available for Pathways by source and SIGNOR curated interactions for MAP1S Gene

Drugs & Compounds for MAP1S Gene

No Compound Related Data Available

Transcripts for MAP1S Gene

Unigene Clusters for MAP1S Gene

Microtubule-associated protein 1S:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1S Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5:

Relevant External Links for MAP1S Gene

GeneLoc Exon Structure for
MAP1S
ECgene alternative splicing isoforms for
MAP1S

Expression for MAP1S Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP1S Gene

Protein differential expression in normal tissues from HIPED for MAP1S Gene

This gene is overexpressed in Lymph node (7.1), Peripheral blood mononuclear cells (6.2), and Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP1S Gene



Protein tissue co-expression partners for MAP1S Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP1S Gene:

MAP1S

SOURCE GeneReport for Unigene cluster for MAP1S Gene:

Hs.66048

mRNA Expression by UniProt/SwissProt for MAP1S Gene:

Q66K74-MAP1S_HUMAN
Tissue specificity: Expressed in neurons (at protein level). Expressed in spermatocytes, spermatids and spermatozoa. Expressed in the cerebral cortex. Highly expressed in testis. Moderately expressed in the brain, colon, heart, kidney, liver, lung, placenta, small intestine, spleen and stomach. Weakly expressed in muscle.

Evidence on tissue expression from TISSUES for MAP1S Gene

  • Nervous system(5)
  • Lung(4.7)
  • Liver(4.3)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with MAP1S: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP1S Gene

Orthologs for MAP1S Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP1S Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP1S 33 34
  • 98.99 (n)
cow
(Bos Taurus)
Mammalia MAP1S 33 34
  • 83.29 (n)
dog
(Canis familiaris)
Mammalia MAP1S 33 34
  • 82.96 (n)
rat
(Rattus norvegicus)
Mammalia Map1s 33
  • 71.57 (n)
mouse
(Mus musculus)
Mammalia Map1s 33 16 34
  • 70.82 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP1S 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP1S 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP1S 34
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MAP1S (2 of 2) 34
  • 35 (a)
OneToMany
MAP1S (1 of 2) 34
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta futsch 34
  • 5 (a)
ManyToMany
dp 34
  • 1 (a)
ManyToMany
Species where no ortholog for MAP1S was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP1S Gene

ENSEMBL:
Gene Tree for MAP1S (if available)
TreeFam:
Gene Tree for MAP1S (if available)

Paralogs for MAP1S Gene

Paralogs for MAP1S Gene

genes like me logo Genes that share paralogs with MAP1S: view

Variants for MAP1S Gene

Sequence variations from dbSNP and Humsavar for MAP1S Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000031049 -- 17,732,948(+) A/G intron_variant
rs1000096095 -- 17,733,988(+) G/T intron_variant
rs1000269953 -- 17,718,778(+) C/T upstream_transcript_variant
rs1000604272 -- 17,717,590(+) C/T upstream_transcript_variant
rs1000838586 -- 17,727,722(+) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP1S Gene

Variant ID Type Subtype PubMed ID
nsv1117214 CNV tandem duplication 24896259
esv1349147 CNV insertion 17803354
dgv50n68 CNV loss 17160897

Variation tolerance for MAP1S Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.86; 87.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP1S Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP1S

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1S Gene

Disorders for MAP1S Gene

Additional Disease Information for MAP1S

No disorders were found for MAP1S Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP1S Gene

Publications for MAP1S Gene

  1. Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein. (PMID: 14627543) Wong EY … Yeung WS (Biology of reproduction 2004) 2 3 4 22 58
  2. Microtubule-associated protein 8 contains two microtubule binding sites. (PMID: 16297881) Ding J … Yang Y (Biochemical and biophysical research communications 2006) 2 3 4 58
  3. Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family. (PMID: 15528209) Orbán-Németh Z … Propst F (The Journal of biological chemistry 2005) 2 3 22 58
  4. Putative tumor suppressor RASSF1 interactive protein and cell death inducer C19ORF5 is a DNA binding protein. (PMID: 15907802) Liu L … McKeehan WL (Biochemical and biophysical research communications 2005) 3 4 22 58
  5. Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity. (PMID: 11827465) Liu L … McKeehan WL (Genomics 2002) 2 3 4 58

Products for MAP1S Gene

Sources for MAP1S Gene

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