Aliases for MAP1LC3C Gene
External Ids for MAP1LC3C Gene
Previous GeneCards Identifiers for MAP1LC3C Gene
Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]
GeneCards Summary for MAP1LC3C Gene
MAP1LC3C (Microtubule Associated Protein 1 Light Chain 3 Gamma) is a Protein Coding gene. Among its related pathways are Autophagy Pathway and Senescence and Autophagy in Cancer. Gene Ontology (GO) annotations related to this gene include microtubule binding. An important paralog of this gene is MAP1LC3B.
UniProtKB/Swiss-Prot for MAP1LC3C Gene
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium (PubMed:23022382). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643).