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Aliases for MAP1LC3C Gene

Aliases for MAP1LC3C Gene

  • Microtubule Associated Protein 1 Light Chain 3 Gamma 2 3 5
  • Autophagy-Related Ubiquitin-Like Modifier LC3 C 3 4
  • MAP1 Light Chain 3-Like Protein 3 3 4
  • Autophagy-Related Protein LC3 C 3 4
  • MAP1A/MAP1B Light Chain 3 C 3 4
  • MAP1A/MAP1B LC3 C 3 4
  • Microtubule-Associated Proteins 1A/1B Light Chain 3C 3
  • Microtubule-Associated Protein 1 Light Chain 3 Gamma 4
  • MAP1 Light Chain 3-Like Protein 2 3
  • LC3-Like Protein 2 3
  • ATG8J 3
  • LC3C 3

External Ids for MAP1LC3C Gene

Previous GeneCards Identifiers for MAP1LC3C Gene

  • GC01M238485
  • GC01M240225
  • GC01M242158
  • GC01M212618

Summaries for MAP1LC3C Gene

Entrez Gene Summary for MAP1LC3C Gene

  • Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]

GeneCards Summary for MAP1LC3C Gene

MAP1LC3C (Microtubule Associated Protein 1 Light Chain 3 Gamma) is a Protein Coding gene. Among its related pathways are Autophagy Pathway and Senescence and Autophagy in Cancer. Gene Ontology (GO) annotations related to this gene include microtubule binding. An important paralog of this gene is MAP1LC3B.

UniProtKB/Swiss-Prot for MAP1LC3C Gene

  • Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium (PubMed:23022382). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643).

Additional gene information for MAP1LC3C Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1LC3C Gene

Genomics for MAP1LC3C Gene

GeneHancer (GH) Regulatory Elements for MAP1LC3C Gene

Promoters and enhancers for MAP1LC3C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I241998 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +2.6 2551 1.3 PKNOX1 ATF1 SIN3A ZNF2 GLIS2 CBX5 E2F8 ZNF143 KLF7 ATF7 MAP1LC3C PIR42992
GH01I242006 Enhancer 0.6 ENCODE 0.8 -4.9 -4870 0.4 CEBPB EP300 ZNF121 JUND GATA3 MAFF FOS NFE2 NFE2L2 MAP1LC3C GC01M242024
GH01I242005 Enhancer 0.5 ENCODE 0.8 -3.9 -3935 0.2 SP1 CTBP1 GATA3 CEBPB RCOR1 MAP1LC3C GC01M242024
GH01I242011 Enhancer 0.2 ENCODE 0.4 -10.8 -10751 0.8 MAP1LC3C GC01M242024
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAP1LC3C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP1LC3C gene promoter:

Genomic Locations for MAP1LC3C Gene

Genomic Locations for MAP1LC3C Gene
chr1:241,995,490-242,001,399
(GRCh38/hg38)
Size:
5,910 bases
Orientation:
Minus strand
chr1:242,158,792-242,162,385
(GRCh37/hg19)

Genomic View for MAP1LC3C Gene

Genes around MAP1LC3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP1LC3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP1LC3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1LC3C Gene

Proteins for MAP1LC3C Gene

  • Protein details for MAP1LC3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXW4-MLP3C_HUMAN
    Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3C
    Protein Accession:
    Q9BXW4
    Secondary Accessions:
    • A0PJY8
    • A2RUP0

    Protein attributes for MAP1LC3C Gene

    Size:
    147 amino acids
    Molecular mass:
    16852 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with TP53INP1 and TP53INP2. Interacts with CALCOCO2. Interacts with TECPR2. Interacts with TBC1D5 (PubMed:22354992). Found in a complex with UBQLN1 and UBQLN2 (PubMed:20529957). Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4 (PubMed:23459205). Interacts with TRIM5 (PubMed:25127057). Interacts with ATG13 (PubMed:24290141). Interacts with MEFV and TRIM21 (PubMed:26347139). Interacts with WDR81; recruits MAP1LC3C to ubiquitinated protein aggregates in the aggrephagy process (PubMed:28404643).

    Three dimensional structures from OCA and Proteopedia for MAP1LC3C Gene

neXtProt entry for MAP1LC3C Gene

Post-translational modifications for MAP1LC3C Gene

  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).

Other Protein References for MAP1LC3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP1LC3C Gene

Domains & Families for MAP1LC3C Gene

Gene Families for MAP1LC3C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAP1LC3C Gene

Suggested Antigen Peptide Sequences for MAP1LC3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXW4

UniProtKB/Swiss-Prot:

MLP3C_HUMAN :
  • Belongs to the ATG8 family.
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with MAP1LC3C: view

Function for MAP1LC3C Gene

Molecular function for MAP1LC3C Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium (PubMed:23022382). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643).

Gene Ontology (GO) - Molecular Function for MAP1LC3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19250911
GO:0031625 ubiquitin protein ligase binding IPI 25127057
genes like me logo Genes that share ontologies with MAP1LC3C: view

Phenotypes for MAP1LC3C Gene

genes like me logo Genes that share phenotypes with MAP1LC3C: view

Animal Model Products

miRNA for MAP1LC3C Gene

miRTarBase miRNAs that target MAP1LC3C

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP1LC3C Gene

Localization for MAP1LC3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1LC3C Gene

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP1LC3C gene
Compartment Confidence
cytoskeleton 4
cytosol 4
mitochondrion 3
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP1LC3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane TAS --
GO:0005737 cytoplasm IEA --
GO:0005776 autophagosome ISS 12740394
GO:0005829 cytosol IBA,TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with MAP1LC3C: view

Pathways & Interactions for MAP1LC3C Gene

genes like me logo Genes that share pathways with MAP1LC3C: view

Pathways by source for MAP1LC3C Gene

1 GeneTex pathway for MAP1LC3C Gene
1 BioSystems pathway for MAP1LC3C Gene
2 Reactome pathways for MAP1LC3C Gene
1 KEGG pathway for MAP1LC3C Gene

SIGNOR curated interactions for MAP1LC3C Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAP1LC3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0000422 autophagy of mitochondrion IBA --
GO:0006914 autophagy IEA --
GO:0006995 cellular response to nitrogen starvation IBA --
GO:0009267 cellular response to starvation IDA 28223137
genes like me logo Genes that share ontologies with MAP1LC3C: view

Drugs & Compounds for MAP1LC3C Gene

No Compound Related Data Available

Transcripts for MAP1LC3C Gene

mRNA/cDNA for MAP1LC3C Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAP1LC3C Gene

Microtubule-associated protein 1 light chain 3 gamma:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3C Gene

No ASD Table

Relevant External Links for MAP1LC3C Gene

GeneLoc Exon Structure for
MAP1LC3C
ECgene alternative splicing isoforms for
MAP1LC3C

Expression for MAP1LC3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP1LC3C Gene

mRNA differential expression in normal tissues according to GTEx for MAP1LC3C Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x7.6), Adipose - Subcutaneous (x7.2), and Breast - Mammary Tissue (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of MAP1LC3C Gene:

MAP1LC3C

SOURCE GeneReport for Unigene cluster for MAP1LC3C Gene:

Hs.534971

mRNA Expression by UniProt/SwissProt for MAP1LC3C Gene:

Q9BXW4-MLP3C_HUMAN
Tissue specificity: Most abundant in placenta, lung and ovary.
genes like me logo Genes that share expression patterns with MAP1LC3C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP1LC3C Gene

Orthologs for MAP1LC3C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP1LC3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP1LC3C 33 34
  • 98.87 (n)
cow
(Bos Taurus)
Mammalia LOC507432 33
  • 88.66 (n)
MAP1LC3C 34
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP1LC3C 33 34
  • 87.95 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP1LC3C 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP1LC3C 33 34
  • 74.93 (n)
lizard
(Anolis carolinensis)
Reptilia MAP1LC3C 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map1lc3c 33
  • 68.68 (n)
zebrafish
(Danio rerio)
Actinopterygii map1lc3c 33 34
  • 72.22 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 34
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
OneToOne
Species where no ortholog for MAP1LC3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP1LC3C Gene

ENSEMBL:
Gene Tree for MAP1LC3C (if available)
TreeFam:
Gene Tree for MAP1LC3C (if available)

Paralogs for MAP1LC3C Gene

Paralogs for MAP1LC3C Gene

(8) SIMAP similar genes for MAP1LC3C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAP1LC3C: view

Variants for MAP1LC3C Gene

Sequence variations from dbSNP and Humsavar for MAP1LC3C Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000237875 -- 242,002,893(-) G/A upstream_transcript_variant
rs1000324821 -- 242,003,152(-) C/T upstream_transcript_variant
rs1000486300 -- 241,997,849(-) T/C intron_variant
rs1000793861 -- 241,996,457(-) C/T intron_variant
rs1001278802 -- 242,002,151(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP1LC3C Gene

Variant ID Type Subtype PubMed ID
dgv16e55 CNV gain 17911159
nsv1002309 CNV gain 25217958
nsv1008886 CNV gain 25217958
nsv508703 CNV deletion 20534489

Variation tolerance for MAP1LC3C Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP1LC3C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP1LC3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1LC3C Gene

Disorders for MAP1LC3C Gene

Additional Disease Information for MAP1LC3C

No disorders were found for MAP1LC3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP1LC3C Gene

Publications for MAP1LC3C Gene

  1. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. (PMID: 12740394) He H … Yu L (The Journal of biological chemistry 2003) 2 3 4 58
  2. The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. (PMID: 28404643) Liu X … Yang C (The Journal of cell biology 2017) 3 4 58
  3. TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. (PMID: 26347139) Kimura T … Deretic V (The Journal of cell biology 2015) 3 4 58
  4. Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism. (PMID: 24290141) Suzuki H … Wakatsuki S (Structure (London, England : 1993) 2014) 3 4 58
  5. TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. (PMID: 25127057) Mandell MA … Deretic V (Developmental cell 2014) 3 4 58

Products for MAP1LC3C Gene

Sources for MAP1LC3C Gene

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