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Aliases for MAP1LC3B2 Gene

Aliases for MAP1LC3B2 Gene

  • Microtubule Associated Protein 1 Light Chain 3 Beta 2 2 3 5
  • Microtubule-Associated Proteins 1A/1B Light Chain 3B-Like Protein 3
  • Microtubule-Associated Proteins 1A/1B Light Chain 3 Beta 2 3
  • Microtubule-Associated Proteins 1A/1B Light Chain 3B-Like 4
  • ATG8G 3

External Ids for MAP1LC3B2 Gene

Previous GeneCards Identifiers for MAP1LC3B2 Gene

  • GC12P115483
  • GC12P116997
  • GC12P114006

Summaries for MAP1LC3B2 Gene

GeneCards Summary for MAP1LC3B2 Gene

MAP1LC3B2 (Microtubule Associated Protein 1 Light Chain 3 Beta 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include microtubule binding. An important paralog of this gene is MAP1LC3B.

UniProtKB/Swiss-Prot for MAP1LC3B2 Gene

  • Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).

Additional gene information for MAP1LC3B2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1LC3B2 Gene

Genomics for MAP1LC3B2 Gene

GeneHancer (GH) Regulatory Elements for MAP1LC3B2 Gene

Promoters and enhancers for MAP1LC3B2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I116556 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 550.4 +11.2 11242 5 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT IRF4 YY1 POLR2B ZNF766 MAP1LC3B2 LINC00173 ENSG00000275898
GH12I116547 Enhancer 1.1 Ensembl ENCODE dbSUPER 550.8 +0.1 119 1.7 CTCF MEIS2 PKNOX1 MAX CTBP1 ZNF316 POLR2A MAFK RUNX3 CREM MAP1LC3B2 LINC00173 ENSG00000275898
GH12I116546 Enhancer 0.7 ENCODE 550.8 -2.0 -1994 0.2 HDAC1 ZFHX2 ZNF316 EGR1 VEZF1 NFE2 PRDM10 EGR2 ZBTB2 L3MBTL2 GC12P116544 MAP1LC3B2 LINC00173
GH12I116520 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 53.4 -27.0 -27039 1.7 BCOR PKNOX1 ZBTB21 ZMYM3 ZNF384 ZIC2 ZNF335 TCF7L2 SMARCA5 ZNF362 GC12M116512 MAP1LC3B2 MED13L LINC02457
GH12I116536 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 40.9 -9.4 -9394 4.3 BMI1 BATF IRF4 RFX5 ZNF335 SCRT2 RCOR1 ETV6 BCLAF1 IKZF2 MAP1LC3B2 MED13L LINC00173 GC12P116544
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAP1LC3B2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP1LC3B2 gene promoter:

Genomic Locations for MAP1LC3B2 Gene

Genomic Locations for MAP1LC3B2 Gene
chr12:116,548,105-116,576,620
(GRCh38/hg38)
Size:
28,516 bases
Orientation:
Plus strand
chr12:116,997,186-117,014,425
(GRCh37/hg19)

Genomic View for MAP1LC3B2 Gene

Genes around MAP1LC3B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP1LC3B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP1LC3B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1LC3B2 Gene

Proteins for MAP1LC3B2 Gene

  • Protein details for MAP1LC3B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCE7-MP3B2_HUMAN
    Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3 beta 2
    Protein Accession:
    A6NCE7

    Protein attributes for MAP1LC3B2 Gene

    Size:
    125 amino acids
    Molecular mass:
    14628 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins.

neXtProt entry for MAP1LC3B2 Gene

Post-translational modifications for MAP1LC3B2 Gene

  • The precursor molecule is cleaved by APG4B/ATG4B to form LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form LC3-II.

Other Protein References for MAP1LC3B2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP1LC3B2 Gene

Domains & Families for MAP1LC3B2 Gene

Gene Families for MAP1LC3B2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAP1LC3B2 Gene

Suggested Antigen Peptide Sequences for MAP1LC3B2 Gene

Graphical View of Domain Structure for InterPro Entry

A6NCE7

UniProtKB/Swiss-Prot:

MP3B2_HUMAN :
  • Belongs to the ATG8 family.
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with MAP1LC3B2: view

Function for MAP1LC3B2 Gene

Molecular function for MAP1LC3B2 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).

Phenotypes From GWAS Catalog for MAP1LC3B2 Gene

Phenotypes for MAP1LC3B2 Gene

GenomeRNAi human phenotypes for MAP1LC3B2:
genes like me logo Genes that share phenotypes with MAP1LC3B2: view

miRNA for MAP1LC3B2 Gene

miRTarBase miRNAs that target MAP1LC3B2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP1LC3B2 Gene

Localization for MAP1LC3B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1LC3B2 Gene

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP1LC3B2 gene
Compartment Confidence
cytosol 4
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for MAP1LC3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IBA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with MAP1LC3B2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAP1LC3B2 Gene

Pathways & Interactions for MAP1LC3B2 Gene

SuperPathways for MAP1LC3B2 Gene

No Data Available

Interacting Proteins for MAP1LC3B2 Gene

Gene Ontology (GO) - Biological Process for MAP1LC3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0000422 autophagy of mitochondrion IBA --
GO:0006914 autophagy IEA --
GO:0006995 cellular response to nitrogen starvation IBA --
genes like me logo Genes that share ontologies with MAP1LC3B2: view

No data available for Pathways by source and SIGNOR curated interactions for MAP1LC3B2 Gene

Drugs & Compounds for MAP1LC3B2 Gene

No Compound Related Data Available

Transcripts for MAP1LC3B2 Gene

mRNA/cDNA for MAP1LC3B2 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAP1LC3B2 Gene

Microtubule-associated protein 1 light chain 3 beta 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3B2 Gene

No ASD Table

Relevant External Links for MAP1LC3B2 Gene

GeneLoc Exon Structure for
MAP1LC3B2
ECgene alternative splicing isoforms for
MAP1LC3B2

Expression for MAP1LC3B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP1LC3B2 Gene

mRNA differential expression in normal tissues according to GTEx for MAP1LC3B2 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for MAP1LC3B2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP1LC3B2 Gene



Protein tissue co-expression partners for MAP1LC3B2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP1LC3B2 Gene:

MAP1LC3B2

SOURCE GeneReport for Unigene cluster for MAP1LC3B2 Gene:

Hs.506947

Evidence on tissue expression from TISSUES for MAP1LC3B2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with MAP1LC3B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP1LC3B2 Gene

Orthologs for MAP1LC3B2 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAP1LC3B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP1LC3B2 33
  • 99.2 (n)
rat
(Rattus norvegicus)
Mammalia LOC100359928 33
  • 84.68 (n)
Species where no ortholog for MAP1LC3B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAP1LC3B2 Gene

ENSEMBL:
Gene Tree for MAP1LC3B2 (if available)
TreeFam:
Gene Tree for MAP1LC3B2 (if available)

Paralogs for MAP1LC3B2 Gene

Paralogs for MAP1LC3B2 Gene

(8) SIMAP similar genes for MAP1LC3B2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MAP1LC3B2 Gene

genes like me logo Genes that share paralogs with MAP1LC3B2: view

Variants for MAP1LC3B2 Gene

Sequence variations from dbSNP and Humsavar for MAP1LC3B2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000336060 -- 116,575,037(+) G/A intron_variant
rs1000783233 -- 116,570,481(+) T/C intron_variant
rs1000845966 -- 116,569,230(+) A/G intron_variant
rs1000880112 -- 116,575,337(+) C/T intron_variant
rs1000880255 -- 116,572,735(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP1LC3B2 Gene

Variant ID Type Subtype PubMed ID
nsv983366 CNV duplication 23825009
nsv528118 CNV gain 19592680
nsv1040904 CNV gain 25217958
esv3630852 CNV loss 21293372
esv3630848 CNV gain 21293372
esv2675163 CNV deletion 23128226

Variation tolerance for MAP1LC3B2 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP1LC3B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP1LC3B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1LC3B2 Gene

Disorders for MAP1LC3B2 Gene

Additional Disease Information for MAP1LC3B2

No disorders were found for MAP1LC3B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP1LC3B2 Gene

Publications for MAP1LC3B2 Gene

  1. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PMID: 19684603) Treviño LR … Relling MV (Nature genetics 2009) 3 44 58
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration. (PMID: 26115100) Campbell GR … Spector SA (PLoS pathogens 2015) 3 58

Products for MAP1LC3B2 Gene

Sources for MAP1LC3B2 Gene

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