Aliases for MAP1LC3B Gene
External Ids for MAP1LC3B Gene
Previous GeneCards Identifiers for MAP1LC3B Gene
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP1LC3B Gene
MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 Beta) is a Protein Coding gene. Diseases associated with MAP1LC3B include Hermansky-Pudlak Syndrome and Parkinson Disease 1, Autosomal Dominant. Among its related pathways are Vesicle-mediated transport and Senescence and Autophagy in Cancer. Gene Ontology (GO) annotations related to this gene include microtubule binding. An important paralog of this gene is MAP1LC3B2.
UniProtKB/Swiss-Prot Summary for MAP1LC3B Gene
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:28017329). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).