Aliases for MAP1LC3B Gene
- Microtubule Associated Protein 1 Light Chain 3 Beta 2 3 5
- Autophagy-Related Ubiquitin-Like Modifier LC3 B 3 4
- MAP1 Light Chain 3-Like Protein 2 3 4
- MAP1A/MAP1B Light Chain 3 B 3 4
- MAP1A/MAP1B LC3 B 3 4
- Microtubule-Associated Proteins 1A/1B Light Chain 3B 3
- Microtubule-Associated Protein 1 Light Chain 3 Beta 4
External Ids for MAP1LC3B Gene
Previous GeneCards Identifiers for MAP1LC3B Gene
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP1LC3B Gene
MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 Beta) is a Protein Coding gene. Diseases associated with MAP1LC3B include Spastic Paraplegia 49, Autosomal Recessive and Sporadic Pheochromocytoma. Among its related pathways are Pink/Parkin Mediated Mitophagy and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include microtubule binding. An important paralog of this gene is MAP1LC3B2.
UniProtKB/Swiss-Prot for MAP1LC3B Gene
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.