Aliases for MANSC4 Gene

Aliases for MANSC4 Gene

  • MANSC Domain Containing 4 2 3 5
  • MANSC Domain-Containing Protein 4 3 4
  • MANSC Domain-Containing Protein ENSP00000370673 3
  • MANSC4 5

External Ids for MANSC4 Gene

Previous GeneCards Identifiers for MANSC4 Gene

  • GC12M027917

Summaries for MANSC4 Gene

GeneCards Summary for MANSC4 Gene

MANSC4 (MANSC Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is MANSC1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MANSC4 Gene

Genomics for MANSC4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MANSC4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MANSC4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MANSC4

Genomic Locations for MANSC4 Gene

Latest Assembly
17,810 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
17,810 bases
Minus strand

(GRCh37/hg19 by Ensembl)
8,539 bases
Minus strand

Genomic View for MANSC4 Gene

Genes around MANSC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MANSC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MANSC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MANSC4 Gene

Proteins for MANSC4 Gene

  • Protein details for MANSC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MANSC domain-containing protein 4
    Protein Accession:

    Protein attributes for MANSC4 Gene

    340 amino acids
    Molecular mass:
    37879 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MANSC4 Gene

Post-translational modifications for MANSC4 Gene

  • Glycosylation at Asn118, Asn187, and Asn260
  • Modification sites at PhosphoSitePlus

Other Protein References for MANSC4 Gene

No data available for DME Specific Peptides for MANSC4 Gene

Domains & Families for MANSC4 Gene

Gene Families for MANSC4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MANSC4 Gene


Suggested Antigen Peptide Sequences for MANSC4 Gene

GenScript: Design optimal peptide antigens:
  • MANSC domain-containing protein 4 (MANS4_HUMAN)
genes like me logo Genes that share domains with MANSC4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MANSC4 Gene

Function for MANSC4 Gene

Phenotypes From GWAS Catalog for MANSC4 Gene

Phenotypes for MANSC4 Gene

MGI mutant phenotypes for MANSC4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with MANSC4: view

Animal Models for MANSC4 Gene

MGI Knock Outs for MANSC4:
  • Mansc4 Mansc4<tm1b(KOMP)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MANSC4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MANSC4 Gene

Localization for MANSC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MANSC4 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MANSC4 gene
Compartment Confidence
extracellular 2
plasma membrane 1
peroxisome 0
lysosome 0

Gene Ontology (GO) - Cellular Components for MANSC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MANSC4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MANSC4 Gene

Pathways & Interactions for MANSC4 Gene

PathCards logo

SuperPathways for MANSC4 Gene

No Data Available

Interacting Proteins for MANSC4 Gene

Gene Ontology (GO) - Biological Process for MANSC4 Gene


No data available for Pathways by source and SIGNOR curated interactions for MANSC4 Gene

Drugs & Compounds for MANSC4 Gene

No Compound Related Data Available

Transcripts for MANSC4 Gene

mRNA/cDNA for MANSC4 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MANSC4

Alternative Splicing Database (ASD) splice patterns (SP) for MANSC4 Gene

No ASD Table

Relevant External Links for MANSC4 Gene

GeneLoc Exon Structure for

Expression for MANSC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MANSC4 Gene

mRNA differential expression in normal tissues according to GTEx for MANSC4 Gene

This gene is overexpressed in Testis (x7.4), Brain - Cerebellar Hemisphere (x5.5), and Brain - Cerebellum (x5.4).

Protein differential expression in normal tissues from HIPED for MANSC4 Gene

This gene is overexpressed in Placenta (11.6), Stomach (8.6), and Lung (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MANSC4 Gene

Protein tissue co-expression partners for MANSC4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MANSC4

SOURCE GeneReport for Unigene cluster for MANSC4 Gene:

genes like me logo Genes that share expression patterns with MANSC4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MANSC4 Gene

Orthologs for MANSC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MANSC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MANSC4 30 31
  • 99.41 (n)
(Canis familiaris)
Mammalia MANSC4 30 31
  • 87.14 (n)
(Bos Taurus)
Mammalia MANSC4 30 31
  • 86.63 (n)
(Mus musculus)
Mammalia Mansc4 30 17 31
  • 71.85 (n)
(Rattus norvegicus)
Mammalia Mansc4 30
  • 70.56 (n)
(Monodelphis domestica)
Mammalia MANSC4 31
  • 63 (a)
(Gallus gallus)
Aves MANSC4 30 31
  • 60.71 (n)
(Anolis carolinensis)
Reptilia MANSC4 31
  • 58 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mansc4 30
  • 48.57 (n)
Species where no ortholog for MANSC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MANSC4 Gene

Gene Tree for MANSC4 (if available)
Gene Tree for MANSC4 (if available)
Evolutionary constrained regions (ECRs) for MANSC4: view image

Paralogs for MANSC4 Gene

Paralogs for MANSC4 Gene

genes like me logo Genes that share paralogs with MANSC4: view

Variants for MANSC4 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MANSC4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MANSC4 Gene

Variant ID Type Subtype PubMed ID
esv2668845 CNV deletion 23128226
esv2745664 CNV deletion 23290073
esv3628948 CNV loss 21293372
nsv557824 CNV gain 21841781

Variation tolerance for MANSC4 Gene

Gene Damage Index Score: 5.27; 70.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MANSC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MANSC4 Gene

Disorders for MANSC4 Gene

Additional Disease Information for MANSC4

No disorders were found for MANSC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MANSC4 Gene

Publications for MANSC4 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4
  2. BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A. (PMID: 33001583) Mao CG … Deng B (Thoracic cancer 2020) 3
  3. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3

Products for MANSC4 Gene

Sources for MANSC4 Gene