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Aliases for MANSC4 Gene
Aliases for MANSC4 Gene
External Ids for MANSC4 Gene
- HGNC: 40023
- Entrez Gene: 100287284
- Ensembl: ENSG00000205693
- UniProtKB: A6NHS7
Previous GeneCards Identifiers for MANSC4 Gene
- GC12M027917
Summaries for MANSC4 Gene
GeneCards Summary for MANSC4 Gene
MANSC4 (MANSC Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is MANSC1.
Additional gene information for MANSC4 Gene
- HGNC(40023)
- Entrez Gene(100287284)
- Ensembl(ENSG00000205693)
- UniProtKB(A6NHS7)
- Open Targets Platform(ENSG00000205693)
- Search for MANSC4 at DataMed
- Search for MANSC4 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MANSC4 Gene
Genomics for MANSC4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MANSC4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MANSC4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MANSC4
Genomic Locations for MANSC4 Gene
Genomic Locations for MANSC4 Gene
- chr12:27,762,427-27,780,236
- (GRCh38/hg38)
- Size:
- 17,810 bases
- Orientation:
- Minus strand
- chr12:27,915,599-27,924,209
- (GRCh37/hg19)
- Size:
- 8,611 bases
- Orientation:
- Minus strand
Genomic View for MANSC4 Gene
Genes around MANSC4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p11.22 by HGNC
- 12p11.22 by Entrez Gene
- 12p11.22 by Ensembl
MANSC4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MANSC4 Gene
Proteins for MANSC4 Gene
-
Protein details for MANSC4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NHS7-MANS4_HUMAN
- Recommended name:
- MANSC domain-containing protein 4
- Protein Accession:
- A6NHS7
Protein attributes for MANSC4 Gene
- Size:
- 340 amino acids
- Molecular mass:
- 37879 Da
- Quaternary structure:
- No Data Available
Protein Expression for MANSC4 Gene
Post-translational modifications for MANSC4 Gene
Other Protein References for MANSC4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-MANSC4 (aa 207-284) polyclonal antibody
- Novus Biologicals Antibodies for MANSC4
- Invitrogen Antibodies for MANSC4 (AFLGC-MANSC4)
Protein Products
-
OriGene Purified Proteins for MANSC4
- Search Origene for MassSpec and Protein Over-expression Lysates for MANSC4
- Origene Custom Protein Services for MANSC4
- Novus Biologicals proteins for MANSC4
No data available for DME Specific Peptides for MANSC4 Gene
Domains & Families for MANSC4 Gene
Gene Families for MANSC4 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for MANSC4 Gene
- GenScript: Design optimal peptide antigens:
-
- MANSC domain-containing protein 4 (MANS4_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MANSC4 Gene
Function for MANSC4 Gene
Phenotypes From GWAS Catalog for MANSC4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MANSC4 - Select products 50% OFF >
- * MANSC4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MANSC4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MANSC4
-
Santa Cruz Biotechnology (SCBT) CRISPR for MANSC4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MANSC4
- Browse OriGene Inhibitory RNA Products For MANSC4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MANSC4
Clone Products
- Applied Biological Materials (abm): Clones for MANSC4 - Select products 50% OFF >
- * MANSC4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MANSC4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MANSC4
Cell Line Products
-
Horizon Cell Lines for MANSC4
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MANSC4 Gene
Localization for MANSC4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MANSC4 Gene
- Membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| plasma membrane | 1 |
| peroxisome | 0 |
| lysosome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MANSC4 Gene
Transcripts for MANSC4 Gene
mRNA/cDNA for MANSC4 Gene
- 1 REFSEQ mRNAs :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000381273 1023 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MANSC4 - Select products 50% OFF >
- * MANSC4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MANSC4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MANSC4
-
Santa Cruz Biotechnology (SCBT) CRISPR for MANSC4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MANSC4
- Browse OriGene Inhibitory RNA Products For MANSC4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MANSC4
Clone Products
- Applied Biological Materials (abm): Clones for MANSC4 - Select products 50% OFF >
- * MANSC4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MANSC4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MANSC4
Relevant External Links for MANSC4 Gene
- GeneLoc Exon Structure for
- MANSC4
Expression for MANSC4 Gene
mRNA differential expression in normal tissues according to GTEx for MANSC4 Gene
This gene is overexpressed in Testis (x7.4), Brain - Cerebellar Hemisphere (x5.5), and Brain - Cerebellum (x5.4).
This gene is overexpressed in Placenta (11.6), Stomach (8.6), and Lung (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MANSC4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MANSC4
SOURCE GeneReport for Unigene cluster for MANSC4 Gene:
Hs.202178Primer Products
-
OriGene qPCR primer pairs for MANSC4
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MANSC4 Gene
Orthologs for MANSC4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MANSC4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MANSC4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MANSC4 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mansc4 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mansc4 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | MANSC4 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MANSC4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MANSC4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mansc4 30 |
|
- Species where no ortholog for MANSC4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for MANSC4 Gene
- ENSEMBL:
- Gene Tree for MANSC4 (if available)
- TreeFam:
- Gene Tree for MANSC4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MANSC4: view image
Paralogs for MANSC4 Gene
Variants for MANSC4 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2668845 | CNV | deletion | 23128226 |
| esv2745664 | CNV | deletion | 23290073 |
| esv3628948 | CNV | loss | 21293372 |
| nsv557824 | CNV | gain | 21841781 |
Gene Damage Index Score:
5.27;
70.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MANSC4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MANSC4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MANSC4 Gene
Disorders for MANSC4 Gene
Additional Disease Information for MANSC4
No disorders were found for MANSC4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MANSC4 Gene
Publications for MANSC4 Gene
- The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4
- Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
ExternalLinks
Products for MANSC4 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MANSC4
- Search Origene for MassSpec and Protein Over-expression Lysates for MANSC4
- Origene Custom Protein Services for MANSC4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MANSC4
- Browse OriGene Inhibitory RNA Products For MANSC4
- OriGene qPCR primer pairs for MANSC4
- OriGene CRISPR knockouts for MANSC4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MANSC4
- Sino Biological Human cDNA Clone for MANSC4
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MANSC4
- Novus Biologicals proteins for MANSC4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for MANSC4 (AFLGC-MANSC4)
- VectorBuilder Custom and pre-made DNA vectors for MANSC4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MANSC4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MANSC4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MANSC4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MANSC4
- antibodies-online: Search results for available MANSC4 related products ranked by validation data
- antibodies-online: Search results for available MANSC4 related products ranked by validation data
- antibodies-online: Search results for available MANSC4 related products ranked by validation data
- Horizon Cell Lines for MANSC4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MANSC4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MANSC4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MANSC4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MANSC4
Sources for MANSC4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB