Aliases for MANSC4 Gene

Aliases for MANSC4 Gene

  • MANSC Domain Containing 4 2 3 5
  • MANSC Domain-Containing Protein 4 3 4
  • MANSC Domain-Containing Protein ENSP00000370673 3

External Ids for MANSC4 Gene

Previous GeneCards Identifiers for MANSC4 Gene

  • GC12M027917

Summaries for MANSC4 Gene

GeneCards Summary for MANSC4 Gene

MANSC4 (MANSC Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is MANSC1.

Additional gene information for MANSC4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MANSC4 Gene

Genomics for MANSC4 Gene

GeneHancer (GH) Regulatory Elements for MANSC4 Gene

Promoters and enhancers for MANSC4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J027772 Enhancer 0.8 Ensembl ENCODE 500.7 +0.7 683 2.8 ZNF623 CUX1 ZBTB17 JUND FOS DPF2 SCRT1 TCF7L2 PRDM6 FEZF1 MANSC4 ENSG00000256377 ENSG00000257042 ENSG00000252585
GH12J027709 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 34.3 +62.0 62000 3 ZNF217 EP300 ZSCAN5C TCF12 SIN3A MYC NRF1 POLR2G SP1 GTF2E2 ENSG00000256377 MRPS35 MANSC4 C12orf71 KLHL42 MED21 HMGB1P49 piR-35674-097
GH12J026830 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +940.4 940383 5 ZNF217 CTCF TCF12 SIN3A POLR2G SP1 RBAK GTF2E2 ZFX ZIC2 ITPR2 ENSG00000247903 MANSC4 lnc-INTS13-3
GH12J027695 Enhancer 0.9 Ensembl ENCODE 17.1 +76.3 76301 2.4 EP300 NCOR1 FOXA1 SMARCC2 TEAD1 TBX3 FOXA2 CEBPB JUND CREM REP15 MANSC4 KLHL42 SMCO2 ENSG00000247903 ENSG00000276261 ENSG00000256377
GH12J027820 Enhancer 1.1 FANTOM5 ENCODE 11.5 -49.1 -49079 3 CTCF USF1 FOS TEAD4 ZNF10 EP300 POLR2A JUND REST RELA LOC105369709 MANSC4 ENSG00000257042 MF281437-017
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MANSC4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MANSC4

Genomic Locations for MANSC4 Gene

Genomic Locations for MANSC4 Gene
chr12:27,762,641-27,773,083
(GRCh38/hg38)
Size:
10,443 bases
Orientation:
Minus strand
chr12:27,915,599-27,924,209
(GRCh37/hg19)
Size:
8,611 bases
Orientation:
Minus strand

Genomic View for MANSC4 Gene

Genes around MANSC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MANSC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MANSC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MANSC4 Gene

Proteins for MANSC4 Gene

  • Protein details for MANSC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHS7-MANS4_HUMAN
    Recommended name:
    MANSC domain-containing protein 4
    Protein Accession:
    A6NHS7

    Protein attributes for MANSC4 Gene

    Size:
    340 amino acids
    Molecular mass:
    37879 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MANSC4 Gene

Post-translational modifications for MANSC4 Gene

  • Glycosylation at Asn118, Asn187, and Asn260
  • Modification sites at PhosphoSitePlus

Other Protein References for MANSC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MANSC4 Gene

Domains & Families for MANSC4 Gene

Gene Families for MANSC4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MANSC4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MANSC4 Gene

GenScript: Design optimal peptide antigens:
  • MANSC domain-containing protein 4 (MANS4_HUMAN)
genes like me logo Genes that share domains with MANSC4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MANSC4 Gene

Function for MANSC4 Gene

Phenotypes From GWAS Catalog for MANSC4 Gene

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MANSC4 Gene

Localization for MANSC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MANSC4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MANSC4 gene
Compartment Confidence
extracellular 2
plasma membrane 1
peroxisome 0
lysosome 0

Gene Ontology (GO) - Cellular Components for MANSC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MANSC4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MANSC4 Gene

Pathways & Interactions for MANSC4 Gene

PathCards logo

SuperPathways for MANSC4 Gene

No Data Available

Interacting Proteins for MANSC4 Gene

;

Gene Ontology (GO) - Biological Process for MANSC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MANSC4 Gene

Drugs & Compounds for MANSC4 Gene

No Compound Related Data Available

Transcripts for MANSC4 Gene

mRNA/cDNA for MANSC4 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MANSC4 Gene

No ASD Table

Relevant External Links for MANSC4 Gene

GeneLoc Exon Structure for
MANSC4

Expression for MANSC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MANSC4 Gene

mRNA differential expression in normal tissues according to GTEx for MANSC4 Gene

This gene is overexpressed in Testis (x7.4), Brain - Cerebellar Hemisphere (x5.5), and Brain - Cerebellum (x5.4).

Protein differential expression in normal tissues from HIPED for MANSC4 Gene

This gene is overexpressed in Placenta (11.6), Stomach (8.6), and Lung (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MANSC4 Gene



Protein tissue co-expression partners for MANSC4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MANSC4

SOURCE GeneReport for Unigene cluster for MANSC4 Gene:

Hs.202178
genes like me logo Genes that share expression patterns with MANSC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MANSC4 Gene

Orthologs for MANSC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MANSC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MANSC4 31 30
  • 99.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MANSC4 31 30
  • 87.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MANSC4 31 30
  • 86.63 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mansc4 17 31 30
  • 71.85 (n)
rat
(Rattus norvegicus)
Mammalia Mansc4 30
  • 70.56 (n)
oppossum
(Monodelphis domestica)
Mammalia MANSC4 31
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MANSC4 31 30
  • 60.71 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MANSC4 31
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mansc4 30
  • 48.57 (n)
Species where no ortholog for MANSC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MANSC4 Gene

ENSEMBL:
Gene Tree for MANSC4 (if available)
TreeFam:
Gene Tree for MANSC4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MANSC4: view image

Paralogs for MANSC4 Gene

Paralogs for MANSC4 Gene

genes like me logo Genes that share paralogs with MANSC4: view

Variants for MANSC4 Gene

Additional dbSNP identifiers (rs#s) for MANSC4 Gene

Structural Variations from Database of Genomic Variants (DGV) for MANSC4 Gene

Variant ID Type Subtype PubMed ID
esv2668845 CNV deletion 23128226
esv2745664 CNV deletion 23290073
esv3628948 CNV loss 21293372
nsv557824 CNV gain 21841781

Variation tolerance for MANSC4 Gene

Gene Damage Index Score: 5.27; 70.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MANSC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MANSC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MANSC4 Gene

Disorders for MANSC4 Gene

Additional Disease Information for MANSC4

No disorders were found for MANSC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MANSC4 Gene

Publications for MANSC4 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 54
  2. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3 54

Products for MANSC4 Gene

Sources for MANSC4 Gene