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Aliases for MANSC4 Gene

Aliases for MANSC4 Gene

  • MANSC Domain Containing 4 2 3 5

External Ids for MANSC4 Gene

Previous GeneCards Identifiers for MANSC4 Gene

  • GC12M027917

Summaries for MANSC4 Gene

GeneCards Summary for MANSC4 Gene

MANSC4 (MANSC Domain Containing 4) is a Protein Coding gene.

Additional gene information for MANSC4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MANSC4 Gene

Genomics for MANSC4 Gene

GeneHancer (GH) Regulatory Elements for MANSC4 Gene

Promoters and enhancers for MANSC4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I027772 Enhancer 0.6 ENCODE 550.8 +0.2 240 0.2 DPF2 PRDM6 GATA3 CUX1 FOS PRDM10 TCF7L2 SP7 MANSC4 ENSG00000252585
GH12I027771 Promoter 0.6 EPDnew 550.8 +1.8 1767 0.1 ZBTB17 MANSC4 ENSG00000252585
GH12I027709 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 34.3 +62.0 62043 3 HDGF FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ENSG00000256377 MRPS35 MANSC4 C12orf71 KLHL42 MED21 HMGB1P49 ENSG00000252585
GH12I026830 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 +940.1 940127 4.5 HDGF FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YBX1 ITPR2 ENSG00000247903 MANSC4 ENSG00000256640
GH12I027695 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 17.1 +76.1 76126 2 SOX13 FOXA2 MAX ZNF384 CEBPG ZSCAN9 HNF4G SMARCC2 CREM GATAD2A REP15 MANSC4 KLHL42 ENSG00000276261 ENSG00000256377
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MANSC4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MANSC4 Gene

Genomic Locations for MANSC4 Gene
chr12:27,762,641-27,773,083
(GRCh38/hg38)
Size:
10,443 bases
Orientation:
Minus strand
chr12:27,915,599-27,924,209
(GRCh37/hg19)

Genomic View for MANSC4 Gene

Genes around MANSC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MANSC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MANSC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MANSC4 Gene

Proteins for MANSC4 Gene

  • Protein details for MANSC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHS7-MANS4_HUMAN
    Recommended name:
    MANSC domain-containing protein 4
    Protein Accession:
    A6NHS7

    Protein attributes for MANSC4 Gene

    Size:
    340 amino acids
    Molecular mass:
    37879 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MANSC4 Gene

Post-translational modifications for MANSC4 Gene

  • Glycosylation at posLast=118118, posLast=187187, and isoforms=260

Other Protein References for MANSC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MANSC4 Gene

Domains & Families for MANSC4 Gene

Gene Families for MANSC4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MANSC4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MANSC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MANSC4: view

No data available for UniProtKB/Swiss-Prot for MANSC4 Gene

Function for MANSC4 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MANSC4 Gene

Localization for MANSC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MANSC4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MANSC4 gene
Compartment Confidence
extracellular 2
plasma membrane 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MANSC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MANSC4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MANSC4 Gene

Pathways & Interactions for MANSC4 Gene

SuperPathways for MANSC4 Gene

No Data Available

Interacting Proteins for MANSC4 Gene

Gene Ontology (GO) - Biological Process for MANSC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MANSC4 Gene

Drugs & Compounds for MANSC4 Gene

No Compound Related Data Available

Transcripts for MANSC4 Gene

mRNA/cDNA for MANSC4 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MANSC4 Gene

MANSC domain containing 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MANSC4 Gene

No ASD Table

Relevant External Links for MANSC4 Gene

GeneLoc Exon Structure for
MANSC4
ECgene alternative splicing isoforms for
MANSC4

Expression for MANSC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MANSC4 Gene

mRNA differential expression in normal tissues according to GTEx for MANSC4 Gene

This gene is overexpressed in Testis (x7.4), Brain - Cerebellar Hemisphere (x5.5), and Brain - Cerebellum (x5.4).

Protein differential expression in normal tissues from HIPED for MANSC4 Gene

This gene is overexpressed in Placenta (11.6), Stomach (8.6), and Lung (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MANSC4 Gene



Protein tissue co-expression partners for MANSC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MANSC4 Gene:

MANSC4

SOURCE GeneReport for Unigene cluster for MANSC4 Gene:

Hs.202178
genes like me logo Genes that share expression patterns with MANSC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MANSC4 Gene

Orthologs for MANSC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MANSC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MANSC4 33 34
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia MANSC4 33 34
  • 87.14 (n)
cow
(Bos Taurus)
Mammalia MANSC4 33 34
  • 86.63 (n)
mouse
(Mus musculus)
Mammalia Mansc4 33 16 34
  • 71.85 (n)
rat
(Rattus norvegicus)
Mammalia Mansc4 33
  • 70.56 (n)
oppossum
(Monodelphis domestica)
Mammalia MANSC4 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MANSC4 33 34
  • 60.71 (n)
lizard
(Anolis carolinensis)
Reptilia MANSC4 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mansc4 33
  • 48.57 (n)
Species where no ortholog for MANSC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MANSC4 Gene

ENSEMBL:
Gene Tree for MANSC4 (if available)
TreeFam:
Gene Tree for MANSC4 (if available)

Paralogs for MANSC4 Gene

No data available for Paralogs for MANSC4 Gene

Variants for MANSC4 Gene

Sequence variations from dbSNP and Humsavar for MANSC4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000153874 -- 27,767,476(-) G/C intron_variant
rs1000206585 -- 27,767,685(-) G/A intron_variant
rs1000740075 -- 27,763,672(-) G/A intron_variant
rs1001056456 -- 27,772,359(-) C/T upstream_transcript_variant
rs1001198951 -- 27,764,226(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MANSC4 Gene

Variant ID Type Subtype PubMed ID
nsv557824 CNV gain 21841781
esv3628948 CNV loss 21293372
esv2745664 CNV deletion 23290073
esv2668845 CNV deletion 23128226

Variation tolerance for MANSC4 Gene

Gene Damage Index Score: 5.27; 70.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MANSC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MANSC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MANSC4 Gene

Disorders for MANSC4 Gene

Additional Disease Information for MANSC4

No disorders were found for MANSC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MANSC4 Gene

Publications for MANSC4 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 58

Products for MANSC4 Gene

Sources for MANSC4 Gene

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