Aliases for MANEAL Gene

Aliases for MANEAL Gene

  • Mannosidase Endo-Alpha Like 2 3 5
  • Glycoprotein Endo-Alpha-1,2-Mannosidase-Like Protein 3 4
  • Mannosidase, Endo-Alpha-Like 2
  • EC 54
  • EC 3.2.1.- 4

External Ids for MANEAL Gene

Previous GeneCards Identifiers for MANEAL Gene

  • GC01P037930
  • GC01P038032
  • GC01P038259
  • GC01P036378

Summaries for MANEAL Gene

GeneCards Summary for MANEAL Gene

MANEAL (Mannosidase Endo-Alpha Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is MANEA.

Additional gene information for MANEAL Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MANEAL Gene

Genomics for MANEAL Gene

GeneHancer (GH) Regulatory Elements for MANEAL Gene

Promoters and enhancers for MANEAL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J037793 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 750.6 +0.8 799 2.4 ZNF785 ZBTB40 POLR2A L3MBTL2 MNT ZNF148 NKRF ZFX NCOA3 SP7 MANEAL SNIP1 SF3A3 C1orf109 INPP5B CDCA8 FTH1P1 ZC3H12A GNL2 LINC01137
GH01J038008 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11 +219.1 219108 9.3 ZNF785 ZBTB40 SP1 SIX5 MLX SMARCE1 RBPJ POLR2A USF2 HDAC2 UTP11 SF3A3 SNIP1 C1orf109 INPP5B GNL2 FTH1P1 ZC3H12A MYCBP RSPO1
GH01J037944 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11 +152.8 152784 3.2 ZBTB40 SIX5 RBPJ USF2 CREB1 HCFC1 MIXL1 MYC ELF1 L3MBTL2 INPP5B HSALNG0002674 SF3A3 SNIP1 FHL3 C1orf109 MANEAL MYCBP GNL2 ACTN4P2
GH01J037688 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 -102.4 -102358 5.5 ZBTB40 SP1 CTCF SIX5 FOXA1 ZBTB6 SMARCE1 RBPJ POLR2A USF2 C1orf109 CDCA8 lnc-C1orf109-1 SF3A3 GNL2 ZC3H12A FTH1P1 EPHA10 LINC01137 INPP5B
GH01J037552 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11 -239.9 -239901 2.2 E2F8 ZNF785 SIN3A SP1 ZBTB40 SREBF1 SIX5 RBPJ POLR2A MCM5 SNIP1 lnc-GNL2-2 SF3A3 GNL2 C1orf109 FTH1P1 CDCA8 INPP5B ZC3H12A YRDC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MANEAL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MANEAL gene promoter:
  • COUP
  • COUP-TF1
  • HFH-1
  • HNF-4alpha1

Genomic Locations for MANEAL Gene

Genomic Locations for MANEAL Gene
7,805 bases
Plus strand
7,805 bases
Plus strand

Genomic View for MANEAL Gene

Genes around MANEAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MANEAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MANEAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MANEAL Gene

Proteins for MANEAL Gene

  • Protein details for MANEAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycoprotein endo-alpha-1,2-mannosidase-like protein
    Protein Accession:
    Secondary Accessions:
    • Q6DD86
    • Q6P497
    • Q8N5P8
    • Q96G55
    • Q96N42

    Protein attributes for MANEAL Gene

    457 amino acids
    Molecular mass:
    51317 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MANEAL Gene


neXtProt entry for MANEAL Gene

Selected DME Specific Peptides for MANEAL Gene


Post-translational modifications for MANEAL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MANEAL Gene

Gene Families for MANEAL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MANEAL Gene


Suggested Antigen Peptide Sequences for MANEAL Gene

GenScript: Design optimal peptide antigens:
  • Glycoprotein endo-alpha-1,2-mannosidase-like protein (MANEL_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 99 family.
  • Belongs to the glycosyl hydrolase 99 family.
genes like me logo Genes that share domains with MANEAL: view

Function for MANEAL Gene

Enzyme Numbers (IUBMB) for MANEAL Gene

Phenotypes From GWAS Catalog for MANEAL Gene

Gene Ontology (GO) - Molecular Function for MANEAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004559 alpha-mannosidase activity IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with MANEAL: view
genes like me logo Genes that share phenotypes with MANEAL: view

Animal Models for MANEAL Gene

MGI Knock Outs for MANEAL:
  • Maneal Maneal<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for MANEAL Gene

miRTarBase miRNAs that target MANEAL

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MANEAL

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MANEAL Gene

Localization for MANEAL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MANEAL Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MANEAL gene
Compartment Confidence
golgi apparatus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MANEAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MANEAL: view

Pathways & Interactions for MANEAL Gene

PathCards logo

SuperPathways for MANEAL Gene

No Data Available

Gene Ontology (GO) - Biological Process for MANEAL Gene


No data available for Pathways by source and SIGNOR curated interactions for MANEAL Gene

Drugs & Compounds for MANEAL Gene

No Compound Related Data Available

Transcripts for MANEAL Gene


CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MANEAL

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MANEAL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for MANEAL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MANEAL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MANEAL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MANEAL Gene

This gene is overexpressed in Vitreous humor (43.6) and Fetal Brain (25.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MANEAL Gene

Protein tissue co-expression partners for MANEAL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MANEAL Gene:


SOURCE GeneReport for Unigene cluster for MANEAL Gene:


Evidence on tissue expression from TISSUES for MANEAL Gene

  • Nervous system(4.5)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with MANEAL: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MANEAL Gene

Orthologs for MANEAL Gene

This gene was present in the common ancestor of animals.

Orthologs for MANEAL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MANEAL 33 32
  • 99.64 (n)
(Bos Taurus)
Mammalia MANEAL 33 32
  • 93.33 (n)
(Canis familiaris)
Mammalia MANEAL 33
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia MANEAL 33
  • 88 (a)
(Mus musculus)
Mammalia Maneal 17 33 32
  • 87.76 (n)
(Monodelphis domestica)
Mammalia MANEAL 33
  • 86 (a)
(Rattus norvegicus)
Mammalia Maneal 32
  • 84.22 (n)
(Gallus gallus)
Aves MANEAL 33 32
  • 77.23 (n)
(Anolis carolinensis)
Reptilia MANEAL 33
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia manea 32
  • 69.44 (n)
(Danio rerio)
Actinopterygii MANEAL 33
  • 68 (a)
si:ch211-30b16.2 32
  • 67.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14015 33
  • 24 (a)
Species where no ortholog for MANEAL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MANEAL Gene

Gene Tree for MANEAL (if available)
Gene Tree for MANEAL (if available)
Evolutionary constrained regions (ECRs) for MANEAL: view image

Paralogs for MANEAL Gene

Paralogs for MANEAL Gene

(1) SIMAP similar genes for MANEAL Gene using alignment to 3 proteins:

  • H0YCZ3_HUMAN Pseudogenes for MANEAL Gene

genes like me logo Genes that share paralogs with MANEAL: view

Variants for MANEAL Gene

Sequence variations from dbSNP and Humsavar for MANEAL Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000486232 -- 37,793,775(+) G/C upstream_transcript_variant
rs1000991413 -- 37,799,087(+) A/T intron_variant
rs1001059145 -- 37,794,153(+) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001493216 -- 37,798,711(+) C/T intron_variant
rs1002696405 -- 37,799,081(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MANEAL Gene

Variant ID Type Subtype PubMed ID
nsv1136077 CNV deletion 24896259

Variation tolerance for MANEAL Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MANEAL Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MANEAL Gene

Disorders for MANEAL Gene

Additional Disease Information for MANEAL

No disorders were found for MANEAL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MANEAL Gene

Publications for MANEAL Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Coexisting variants in OSTM1 and MANEAL cause a complex neurodegenerative disorder with NBIA-like brain abnormalities. (PMID: 28612835) Herebian D … Distelmaier F (European journal of human genetics : EJHG 2017) 3 56

Products for MANEAL Gene

Sources for MANEAL Gene