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Aliases for MANEA Gene

Aliases for MANEA Gene

  • Mannosidase Endo-Alpha 2 3 5
  • Endomannosidase 2 3 4
  • Glycoprotein Endo-Alpha-1,2-Mannosidase 2 3
  • Endo-Alpha Mannosidase 3 4
  • Mandaselin 3 4
  • HEndo 3 4
  • Alpha 1,2-Endomannosidase 3
  • Mannosidase, Endo-Alpha 2
  • EC 4
  • ENDO 3

External Ids for MANEA Gene

Previous GeneCards Identifiers for MANEA Gene

  • GC06P096025
  • GC06P096071
  • GC06P096132
  • GC06P093458

Summaries for MANEA Gene

Entrez Gene Summary for MANEA Gene

  • N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C., such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM, Sep 2008]

GeneCards Summary for MANEA Gene

MANEA (Mannosidase Endo-Alpha) is a Protein Coding gene. Diseases associated with MANEA include Dracunculiasis and Substance Dependence. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include alpha-mannosidase activity and glycoprotein endo-alpha-1,2-mannosidase activity. An important paralog of this gene is MANEAL.

Gene Wiki entry for MANEA Gene

Additional gene information for MANEA Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MANEA Gene

Genomics for MANEA Gene

GeneHancer (GH) Regulatory Elements for MANEA Gene

Promoters and enhancers for MANEA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J095575 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 671.2 0.0 -14 3.8 HDGF PKNOX1 SMAD1 SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF213 MANEA-DT MANEA
GH06J095587 Enhancer 0.3 dbSUPER 21 +10.4 10440 0.9 SCRT2 MANEA ENSG00000219549
GH06J095598 Enhancer 0.3 dbSUPER 21 +22.3 22301 2.4 ZNF680 MANEA ENSG00000219549
GH06J095545 Enhancer 0.6 ENCODE 10 -32.1 -32073 0.1 RXRA REST RAD21 YY1 NR2F2 SP1 JUND ATF3 POLR2A ZBTB33 MANEA GC06P095555 CYCSP17
GH06J095814 Enhancer 1 dbSUPER 4.1 +238.2 238163 3.1 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 ATF7 NFKBIZ RXRA MANEA GC06M095664 KRT18P50
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MANEA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MANEA gene promoter:
  • Nkx2-5
  • TBP
  • HSF2
  • LUN-1
  • POU3F2
  • Meis-1
  • Meis-1a
  • Meis-1b
  • FOXJ2 (long isoform)

Genomic Locations for MANEA Gene

Genomic Locations for MANEA Gene
31,961 bases
Plus strand
31,961 bases
Plus strand

Genomic View for MANEA Gene

Genes around MANEA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MANEA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MANEA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MANEA Gene

Proteins for MANEA Gene

  • Protein details for MANEA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycoprotein endo-alpha-1,2-mannosidase
    Protein Accession:
    Secondary Accessions:
    • A6H8M6
    • Q5SRJ0
    • Q6MZV0
    • Q70JE9
    • Q7Z3V7
    • Q8WWX5
    • Q9H9D2

    Protein attributes for MANEA Gene

    462 amino acids
    Molecular mass:
    53671 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAL07306.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAD97640.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI17346.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MANEA Gene

Post-translational modifications for MANEA Gene

  • Undergoes proteolytic cleavage in the C-terminal region.
  • Glycosylation at posLast=7878 and isoforms=73
  • Modification sites at PhosphoSitePlus

Other Protein References for MANEA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MANEA Gene

Domains & Families for MANEA Gene

Gene Families for MANEA Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MANEA Gene

Suggested Antigen Peptide Sequences for MANEA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 99 family.
  • Belongs to the glycosyl hydrolase 99 family.
genes like me logo Genes that share domains with MANEA: view

Function for MANEA Gene

Molecular function for MANEA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GlcMan(9)GlcNAc(2)-[protein] + H(2)O = Man(8)GlcNAc(2)-[protein] (isomer 8A(1,2,3)B(1,2)) + alpha-D-glucosyl-(1->3)-alpha-D-mannopyranose.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.2. {ECO:0000269 PubMed:15677381}; Temperature dependence: Optimum temperature is 37 degrees Celsius. {ECO:0000269 PubMed:15677381};

Enzyme Numbers (IUBMB) for MANEA Gene

Gene Ontology (GO) - Molecular Function for MANEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004559 alpha-mannosidase activity IEA --
GO:0004569 glycoprotein endo-alpha-1,2-mannosidase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with MANEA: view
genes like me logo Genes that share phenotypes with MANEA: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MANEA

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MANEA Gene

Localization for MANEA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MANEA Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MANEA gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MANEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA,IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MANEA: view

Pathways & Interactions for MANEA Gene

genes like me logo Genes that share pathways with MANEA: view

Gene Ontology (GO) - Biological Process for MANEA Gene


No data available for SIGNOR curated interactions for MANEA Gene

Drugs & Compounds for MANEA Gene

No Compound Related Data Available

Transcripts for MANEA Gene

mRNA/cDNA for MANEA Gene

Unigene Clusters for MANEA Gene

Mannosidase, endo-alpha:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MANEA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - -

Relevant External Links for MANEA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MANEA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MANEA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MANEA Gene

This gene is overexpressed in Islet of Langerhans (48.6) and Ovary (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MANEA Gene

Protein tissue co-expression partners for MANEA Gene

NURSA nuclear receptor signaling pathways regulating expression of MANEA Gene:


SOURCE GeneReport for Unigene cluster for MANEA Gene:


mRNA Expression by UniProt/SwissProt for MANEA Gene:

Tissue specificity: Highly expressed in the liver and kidney. Expressed at lower levels in muscle, pancreas, heart, placenta, lung and brain.

Evidence on tissue expression from TISSUES for MANEA Gene

  • Liver(4.4)
  • Nervous system(4)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with MANEA: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MANEA Gene

Orthologs for MANEA Gene

This gene was present in the common ancestor of animals.

Orthologs for MANEA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MANEA 34 33
  • 99.28 (n)
(Canis familiaris)
Mammalia MANEA 34 33
  • 89.37 (n)
(Bos Taurus)
Mammalia MANEA 34 33
  • 87.38 (n)
(Mus musculus)
Mammalia Manea 16 34 33
  • 85.5 (n)
(Rattus norvegicus)
Mammalia Manea 33
  • 84.92 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 71 (a)
(Gallus gallus)
Aves MANEA 33
  • 72.55 (n)
-- 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485932 33
  • 69.2 (n)
(Danio rerio)
Actinopterygii manea 34 33
  • 61.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011905 33
  • 47.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14015 34 33
  • 43 (n)
Species where no ortholog for MANEA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MANEA Gene

Gene Tree for MANEA (if available)
Gene Tree for MANEA (if available)
Evolutionary constrained regions (ECRs) for MANEA: view image

Paralogs for MANEA Gene

Paralogs for MANEA Gene

(1) SIMAP similar genes for MANEA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MANEA: view

Variants for MANEA Gene

Sequence variations from dbSNP and Humsavar for MANEA Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs780723017 A breast cancer sample 95,606,008(+) A/C/G coding_sequence_variant, missense_variant
rs1000005056 -- 95,575,540(+) G/C upstream_transcript_variant
rs1000085965 -- 95,583,794(+) T/G intron_variant
rs1000135596 -- 95,608,922(+) G/A 3_prime_UTR_variant
rs1000162269 -- 95,592,727(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MANEA Gene

Variant ID Type Subtype PubMed ID
dgv6110n100 CNV loss 25217958
esv2656633 CNV deletion 23128226
esv2667481 CNV deletion 23128226
esv3610059 CNV loss 21293372
nsv1034550 CNV gain 25217958
nsv463980 CNV loss 19166990
nsv518549 CNV loss 19592680
nsv604165 CNV loss 21841781
nsv604236 CNV loss 21841781
nsv604238 CNV loss 21841781
nsv819429 CNV gain 19587683

Variation tolerance for MANEA Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.67; 78.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MANEA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MANEA Gene

Disorders for MANEA Gene

MalaCards: The human disease database

(2) MalaCards diseases for MANEA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • dracontiasis
substance dependence
- elite association - COSMIC cancer census association via MalaCards
Search MANEA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MANEA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MANEA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MANEA Gene

Publications for MANEA Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Association of variants in MANEA with cocaine-related behaviors. (PMID: 19255376) Farrer LA … Gelernter J (Archives of general psychiatry 2009) 3 44 58
  3. Substance dependence low-density whole genome association study in two distinct American populations. (PMID: 18438686) Yu Y … Gelernter J (Human genetics 2008) 3 44 58
  4. Intact {alpha}-1,2-endomannosidase is a typical type II membrane protein. (PMID: 15677381) Hamilton SR … Gerngross TU (Glycobiology 2005) 3 4 58
  5. Human endo-alpha1,2-mannosidase is a Golgi-resident type II membrane protein. (PMID: 15760709) Hardt B … Bause E (Biochimie 2005) 3 4 58

Products for MANEA Gene

Sources for MANEA Gene

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