Aliases for MANCR Gene

Data sources for MANCR Gene:

RNA type for MANCR Gene

lncRNA

Aliases for MANCR Gene

External Ids for MANCR Gene

Previous HGNC Symbols for MANCR Gene

  • LINC00704

Previous GeneCards Identifiers for MANCR Gene

  • GC10M004650

Summaries for MANCR Gene

GeneCards Summary for MANCR Gene

MANCR (Mitotically Associated Long Non Coding RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with MANCR include Breast Cancer and Bardet-Biedl Syndrome 10.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MANCR Gene

Genomics for MANCR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MANCR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J004669 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 262.1 +35.2 35248 10.5 CEBPA JUND CEBPB MAX EP300 FOXA2 REST MAFF STAT3 FOSL2 MANCR ENSG00000229672 AKR1E2 LOC105376373 HSALNG0075802 LINC00705 KLF6
GH10J004656 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 250.2 +52.1 52100 3.2 ZNF654 YY1 CTCF REST FOXA1 TRIM22 FOXA2 RXRA RAD21 CUX1 MANCR RNU6-163P KLF6 LINC00705 LOC105376373 AKR1E2
GH10J004709 Enhancer 0.6 Ensembl 250.7 +1.0 1000 0.2 ATF2 CTCF ZNF18 CREM CREB1 RAD21 ATF1 ATF3 ZNF143 TRIM22 MANCR HSALNG0075808 LOC107984197 LOC105376375 ENSG00000287023 AKR1E2 KLF6
GH10J004708 Enhancer 0.4 Ensembl 250.7 +1.4 1399 0.2 CTCF ATF1 ATF7 EP300 MANCR HSALNG0075808 LOC107984197 LOC105376375 ENSG00000287023 AKR1E2 KLF6
GH10J004700 Enhancer 0.9 Ensembl ENCODE dbSUPER 4.9 +6.1 6099 6 JUND CEBPB MAX EP300 FOXA2 STAT3 ZNF316 MAFK NFE2L2 POLR2A HSALNG0075808 piR-41406-009 MANCR LOC107984197 HSALNG0075807 LOC105376375 AKR1E2 ENSG00000287023 KLF6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MANCR on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MANCR Gene

Latest Assembly
chr10:4,577,227-4,709,700
(GRCh38/hg38)
Size:
132,474 bases
Orientation:
Minus strand

Previous Assembly
chr10:4,692,377-4,720,262
(GRCh37/hg19 by Entrez Gene)
Size:
27,886 bases
Orientation:
Minus strand

chr10:4,692,377-4,720,346
(GRCh37/hg19 by Ensembl)
Size:
27,970 bases
Orientation:
Minus strand

Genomic View for MANCR Gene

Genes around MANCR on UCSC Golden Path with GeneCards custom track
MANCR in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MANCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MANCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MANCR Gene

Proteins for MANCR Gene

Post-translational modifications for MANCR Gene

No Post-translational modifications

No data available for DME Specific Peptides for MANCR Gene

Domains & Families for MANCR Gene

Gene Families for MANCR Gene

genes like me logo Genes that share domains with MANCR: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MANCR Gene

Function for MANCR Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MANCR Gene

Localization for MANCR Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MANCR Gene

Pathways & Interactions for MANCR Gene

PathCards logo

SuperPathways for MANCR Gene

No Data Available

Gene Ontology (GO) - Biological Process for MANCR Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MANCR Gene

Drugs & Compounds for MANCR Gene

No Compound Related Data Available

Transcripts for MANCR Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MANCR Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075AF3D_9606 lncRNA 1398 4

RefSeq: NR_024475,

LncBook: HSALNT0158041,

LNCipedia: MANCR:36,

NONCODE: NONHSAT011106.2,

URS00000C8E52_9606 lncRNA 703 4

Ensembl: ENST00000449712 (view in UCSC) ,

LncBook: HSALNT0158050,

LNCipedia: MANCR:32,

NONCODE: NONHSAT011108.2,

URS00003BE81A_9606 lncRNA 421 4

Ensembl: ENST00000443994 (view in UCSC) ,

LncBook: HSALNT0158046,

LNCipedia: MANCR:40,

NONCODE: NONHSAT011107.2,

URS0000EEE7FE_9606 lncRNA 1528 1

Ensembl: ENST00000430998 (view in UCSC) ,

URS0000EEFA04_9606 lncRNA 1448 1

Ensembl: ENST00000659646 (view in UCSC) ,

MANCR in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MANCR Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MANCR Gene

No ASD Table

Relevant External Links for MANCR Gene

GeneLoc Exon Structure for
MANCR

Expression for MANCR Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MANCR

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MANCR Gene

Orthologs for MANCR Gene

Evolution for MANCR Gene

ENSEMBL:
Gene Tree for MANCR (if available)
TreeFam:
Gene Tree for MANCR (if available)
Alliance of Genome Resources:
Additional Orthologs for MANCR

No data available for Orthologs for MANCR Gene

Paralogs for MANCR Gene

No data available for Paralogs for MANCR Gene

Variants for MANCR Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MANCR Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MANCR Gene

Variant ID Type Subtype PubMed ID
dgv20n73 CNV deletion 24416366
dgv347n106 CNV deletion 24896259
dgv945n54 CNV gain 21841781
dgv946n54 CNV gain+loss 21841781
dgv947n54 CNV gain 21841781
dgv948n54 CNV loss 21841781
esv22743 CNV gain 19812545
esv2306271 CNV deletion 18987734
esv2527644 CNV deletion 19546169
esv2731650 CNV deletion 23290073
esv3265051 CNV deletion 24192839
esv3545805 CNV deletion 23714750
esv3622204 CNV loss 21293372
esv3781 CNV loss 18987735
esv9415 CNV loss 19470904
esv991699 CNV deletion 20482838
nsv1072110 CNV deletion 25765185
nsv1151067 CNV deletion 26484159
nsv511436 CNV loss 21212237
nsv512140 CNV loss 21212237
nsv549863 CNV gain 21841781
nsv549864 CNV gain+loss 21841781
nsv549865 CNV gain 21841781
nsv549870 CNV gain+loss 21841781
nsv549877 CNV loss 21841781
nsv820963 CNV deletion 20802225

Additional Variant Information for MANCR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MANCR
Leiden Open Variation Database (LOVD)
MANCR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MANCR Gene

Disorders for MANCR Gene

MalaCards: The human disease database

(2) MalaCards diseases for MANCR Gene - From: LNC and COP

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
bardet-biedl syndrome 10
  • bbs10
- elite association - COSMIC cancer census association via MalaCards
Search MANCR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MANCR

genes like me logo Genes that share disorders with MANCR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MANCR Gene

Publications for MANCR Gene

  1. Mitotically-Associated lncRNA (MANCR) Affects Genomic Stability and Cell Division in Aggressive Breast Cancer. (PMID: 29378907) Tracy KM … Lian JB (Molecular cancer research : MCR 2018) 2 3 72
  2. LncRNA CR749391 acts as a tumor suppressor to upregulate KLF6 expression via interacting with miR-181a in gastric cancer. (PMID: 31853323) Shi S … Nie Y (Experimental and therapeutic medicine 2020) 2 3
  3. Long non-coding RNA MANCR is a target of BET bromodomain protein BRD4 and plays a critical role in cellular migration and invasion abilities of prostate cancer. (PMID: 32199616) Nagasawa M … Agata Y (Biochemical and biophysical research communications 2020) 3
  4. Downregulation of MANCR inhibits cancer cell proliferation in mantle cell lymphoma possibly by interacting with RUNX2. (PMID: 31650163) Wen S … Yang S (Acta biochimica et biophysica Sinica 2019) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3

Products for MANCR Gene

Sources for MANCR Gene