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Aliases for MAN2B2 Gene

Aliases for MAN2B2 Gene

  • Mannosidase Alpha Class 2B Member 2 2 3 4 5
  • Core-Specific Lysosomal Alpha-1,6-Mannosidase 2 3
  • Mannosidase, Alpha, Class 2B, Member 2 2
  • Epididymis-Specific Alpha-Mannosidase 3
  • EC 4
  • KIAA0935 4

External Ids for MAN2B2 Gene

Previous GeneCards Identifiers for MAN2B2 Gene

  • GC04P006642
  • GC04P006694
  • GC04P006627
  • GC04P006509

Summaries for MAN2B2 Gene

GeneCards Summary for MAN2B2 Gene

MAN2B2 (Mannosidase Alpha Class 2B Member 2) is a Protein Coding gene. Among its related pathways are Metabolism and Other glycan degradation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and alpha-mannosidase activity. An important paralog of this gene is MAN2B1.

Tocris Summary for MAN2B2 Gene

  • Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose.

Gene Wiki entry for MAN2B2 Gene

Additional gene information for MAN2B2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAN2B2 Gene

Genomics for MAN2B2 Gene

GeneHancer (GH) Regulatory Elements for MAN2B2 Gene

Promoters and enhancers for MAN2B2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J006574 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 +0.4 375 2 ARID4B SIN3A ETS1 POLR2B GLIS2 ELK1 ZNF143 RUNX3 SP3 SP5 MAN2B2 GC04P006620
GH04J006576 Enhancer 0.5 ENCODE 650.7 +1.6 1555 0.2 SP1 JUND RXRA EGR1 HNF4A MAN2B2 GC04P006620
GH04J006914 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.3 +341.5 341465 5.1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 KIAA0232 TBC1D14 BLOC1S4 GRPEL1 TADA2B MAN2B2 S100P GC04M006908 GC04P006943
GH04J006828 Enhancer 0.2 dbSUPER 5.1 +254.4 254406 1.8 KIAA0232 MAN2B2 GC04P006842
GH04J006591 Enhancer 0.6 FANTOM5 0.4 +16.1 16109 0.1 SMAD5 MEF2B MNT ZIC2 NCOR1 POLR2A ZNF341 TRIM24 EGR2 PPP2R2C MRFAP1 LOC93622 LINC02482 MAN2B2 GC04P006620
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAN2B2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAN2B2 gene promoter:
  • ATF6
  • AML1a
  • AP-4
  • Bach2
  • E47
  • Hand1
  • HTF
  • Elk-1
  • NCX

Genomic Locations for MAN2B2 Gene

Genomic Locations for MAN2B2 Gene
48,189 bases
Plus strand
48,188 bases
Plus strand

Genomic View for MAN2B2 Gene

Genes around MAN2B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAN2B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAN2B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAN2B2 Gene

Proteins for MAN2B2 Gene

  • Protein details for MAN2B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Epididymis-specific alpha-mannosidase
    Protein Accession:
    Secondary Accessions:
    • Q66MP2
    • Q86T67

    Protein attributes for MAN2B2 Gene

    1009 amino acids
    Molecular mass:
    113979 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAN2B2 Gene


neXtProt entry for MAN2B2 Gene

Post-translational modifications for MAN2B2 Gene

  • Glycosylation at isoforms=2890, isoforms=2812, isoforms=2808, posLast=748748, posLast=675675, isoforms=2670, isoforms=2608, isoforms=2516, isoforms=2336, isoforms=2294, posLast=249249, and posLast=226226
  • Modification sites at PhosphoSitePlus

Other Protein References for MAN2B2 Gene

No data available for DME Specific Peptides for MAN2B2 Gene

Domains & Families for MAN2B2 Gene

Gene Families for MAN2B2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MAN2B2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 38 family.
  • Belongs to the glycosyl hydrolase 38 family.
genes like me logo Genes that share domains with MAN2B2: view

Function for MAN2B2 Gene

Molecular function for MAN2B2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Enzyme Numbers (IUBMB) for MAN2B2 Gene

Gene Ontology (GO) - Molecular Function for MAN2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004559 alpha-mannosidase activity IEA,IBA --
GO:0008496 mannan endo-1,6-alpha-mannosidase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with MAN2B2: view
genes like me logo Genes that share phenotypes with MAN2B2: view

Animal Models for MAN2B2 Gene

MGI Knock Outs for MAN2B2:
  • Man2b2 Man2b2<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAN2B2

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAN2B2 Gene

Localization for MAN2B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAN2B2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAN2B2 gene
Compartment Confidence
extracellular 5
lysosome 5
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MAN2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005774 vacuolar membrane IBA --
GO:0043202 lysosomal lumen TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with MAN2B2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAN2B2 Gene

Pathways & Interactions for MAN2B2 Gene

genes like me logo Genes that share pathways with MAN2B2: view

Pathways by source for MAN2B2 Gene

1 KEGG pathway for MAN2B2 Gene

Gene Ontology (GO) - Biological Process for MAN2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006013 mannose metabolic process IEA,IBA --
GO:0006517 protein deglycosylation IBA --
GO:0008152 metabolic process IEA --
GO:0009313 oligosaccharide catabolic process TAS --
genes like me logo Genes that share ontologies with MAN2B2: view

No data available for SIGNOR curated interactions for MAN2B2 Gene

Drugs & Compounds for MAN2B2 Gene

(6) Drugs for MAN2B2 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Acarbose Approved, Investigational Pharma Alpha-glucosidase inhibitor, Glucosidase alpha inhibitor (intestinal) 91
1-Deoxynojirimycin Experimental Pharma Glucosidase I and II inhibitor 26
Castanospermine Experimental Pharma Glucosidases alpha and beta inhibitor 0
mannose Investigational Pharma 0

(1) Additional Compounds for MAN2B2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Miglustat hydrochloride

(5) Tocris Compounds for MAN2B2 Gene

Compound Action Cas Number
1-Deoxymannojirimycin hydrochloride alpha-Mannosidase I inhibitor 73465-43-7
1-Deoxynojirimycin Glucosidase I and II inhibitor 19130-96-2
Acarbose Glucosidase alpha inhibitor (intestinal) 56180-94-0
Castanospermine Glucosidases alpha and beta inhibitor 79831-76-8
Miglustat hydrochloride alpha-glucosidase I and II inhibitor. Also inhibits ceramide-specific glycosyltransferases 210110-90-0
genes like me logo Genes that share compounds with MAN2B2: view

Transcripts for MAN2B2 Gene

mRNA/cDNA for MAN2B2 Gene

Unigene Clusters for MAN2B2 Gene

Mannosidase, alpha, class 2B, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAN2B2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAN2B2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - -

Relevant External Links for MAN2B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAN2B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAN2B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAN2B2 Gene

This gene is overexpressed in Bone marrow stromal cell (10.8), Skin (10.7), Pancreas (9.9), and Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAN2B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAN2B2 Gene:


SOURCE GeneReport for Unigene cluster for MAN2B2 Gene:


Evidence on tissue expression from TISSUES for MAN2B2 Gene

  • Nervous system(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MAN2B2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAN2B2 Gene

Orthologs for MAN2B2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAN2B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAN2B2 33
  • 92.5 (n)
(Rattus norvegicus)
Mammalia Man2b2 33
  • 79.76 (n)
(Canis familiaris)
Mammalia MAN2B2 33
  • 79.05 (n)
-- 34
  • 68 (a)
-- 34
  • 68 (a)
(Mus musculus)
Mammalia Man2b2 16 34 33
  • 79.03 (n)
(Bos Taurus)
Mammalia LOC532207 33
  • 75.47 (n)
-- 34
  • 66 (a)
-- 34
  • 66 (a)
-- 34
  • 58 (a)
-- 34
  • 49 (a)
(Monodelphis domestica)
Mammalia MAN2B2 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia MAN2B2 34
  • 55 (a)
(Gallus gallus)
Aves MAN2B2 34 33
  • 65.82 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia man2b2 33
  • 62.11 (n)
(Danio rerio)
Actinopterygii man2b2 33
  • 61.24 (n)
MAN2B2 34
  • 58 (a)
Dr.2357 33
fruit fly
(Drosophila melanogaster)
Insecta alpha-Man-IIb 34
  • 18 (a)
Species where no ortholog for MAN2B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAN2B2 Gene

Gene Tree for MAN2B2 (if available)
Gene Tree for MAN2B2 (if available)
Evolutionary constrained regions (ECRs) for MAN2B2: view image

Paralogs for MAN2B2 Gene

Paralogs for MAN2B2 Gene

(1) SIMAP similar genes for MAN2B2 Gene using alignment to 5 proteins:

  • H0YA68_HUMAN
  • Q05BN7_HUMAN
  • Q4VC00_HUMAN
genes like me logo Genes that share paralogs with MAN2B2: view

Variants for MAN2B2 Gene

Sequence variations from dbSNP and Humsavar for MAN2B2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs10000264 -- 6,605,444(+) G/A intron_variant
rs1000079264 -- 6,621,623(+) C/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000138745 -- 6,612,848(+) T/C intron_variant
rs1000247550 -- 6,593,054(+) A/T intron_variant
rs1000377278 -- 6,604,168(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAN2B2 Gene

Variant ID Type Subtype PubMed ID
esv2657120 CNV deletion 23128226
esv2727004 CNV deletion 23290073
esv2759220 CNV loss 17122850
esv34196 OTHER inversion 12058347
esv3569271 CNV loss 25503493
esv3599506 CNV loss 21293372
nsv1007724 CNV gain 25217958
nsv10440 CNV loss 18304495
nsv10441 CNV loss 18304495
nsv4215 CNV deletion 18451855
nsv461189 CNV loss 19166990
nsv470006 CNV loss 18288195
nsv526206 CNV gain 19592680
nsv593502 CNV loss 21841781
nsv829849 CNV loss 17160897
nsv949778 CNV deletion 24416366

Variation tolerance for MAN2B2 Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.02; 95.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAN2B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAN2B2 Gene

Disorders for MAN2B2 Gene

Additional Disease Information for MAN2B2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MAN2B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAN2B2 Gene

Publications for MAN2B2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  4. Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding properties. (PMID: 19722277) Venkatesan M … Rose DR (Protein science : a publication of the Protein Society 2009) 3 22 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58

Products for MAN2B2 Gene

Sources for MAN2B2 Gene

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