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Aliases for MAN1C1 Gene

Aliases for MAN1C1 Gene

  • Mannosidase Alpha Class 1C Member 1 2 3 4 5
  • Processing Alpha-1,2-Mannosidase IC 3 4
  • EC 4 56
  • MAN1A3 3 4
  • MAN1C 3 4
  • HMIC 3 4
  • Mannosyl-Oligosaccharide 1,2-Alpha-Mannosidase IC 3
  • Mannosidase, Alpha, Class 1C, Member 1 2
  • 1,2-Alpha-Mannosidase IC 3
  • Alpha-1,2-Mannosidase IC 4
  • Pp6318 3

External Ids for MAN1C1 Gene

Previous GeneCards Identifiers for MAN1C1 Gene

  • GC01P025424
  • GC01P024964
  • GC01P025177
  • GC01P025548
  • GC01P025816
  • GC01P025943
  • GC01P024197

Summaries for MAN1C1 Gene

GeneCards Summary for MAN1C1 Gene

MAN1C1 (Mannosidase Alpha Class 1C Member 1) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. An important paralog of this gene is MAN1A1.

UniProtKB/Swiss-Prot for MAN1C1 Gene

  • Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.

Tocris Summary for MAN1C1 Gene

  • Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose.

Additional gene information for MAN1C1 Gene

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAN1C1 Gene

Genomics for MAN1C1 Gene

GeneHancer (GH) Regulatory Elements for MAN1C1 Gene

Promoters and enhancers for MAN1C1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I025614 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 552.5 -0.2 -241 4.6 PKNOX1 ARID4B SIN3A ZNF2 ZNF48 ETS1 ZNF766 GLIS2 ZNF213 ZNF143 MAN1C1 ENSG00000225643 RHD EXTL1
GH01I025030 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.3 -583.9 -583910 6.2 HDGF PKNOX1 SMAD1 FEZF1 YBX1 GLI4 IRF4 ZNF207 ATF7 RUNX3 SRRM1 MAN1C1 RUNX3 SYF2 LOC105376878 ENSG00000261349 STMN1 RSRP1 SDHDP6 LOC105376879
GH01I026470 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.4 +855.2 855187 4.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 HMGN2 GC01M026474 ARID1A GPN2 ACTG1P20 RPL17P9 LOC101928324 DHDDS MAN1C1 NPM1P39
GH01I024641 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.1 -974.1 -974064 4.1 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 SRRM1 SRSF10 ENSG00000261349 ELOA NCMAP SYF2 RPL11 PNRC2 FUCA1 MAN1C1
GH01I025246 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 -370.4 -370414 3.4 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC RSRP1 ENSG00000272432 SRRM1 ENSG00000261349 SYF2 ZNF593 STPG1 MAN1C1 PAQR7 ENSG00000284657
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAN1C1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAN1C1 gene promoter:

Genomic Locations for MAN1C1 Gene

Genomic Locations for MAN1C1 Gene
168,740 bases
Plus strand

Genomic View for MAN1C1 Gene

Genes around MAN1C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAN1C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAN1C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAN1C1 Gene

Proteins for MAN1C1 Gene

  • Protein details for MAN1C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
    Protein Accession:
    Secondary Accessions:
    • A6NNE2
    • B2RNP2
    • Q9Y545

    Protein attributes for MAN1C1 Gene

    630 amino acids
    Molecular mass:
    70911 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for MAN1C1 Gene

Selected DME Specific Peptides for MAN1C1 Gene


Post-translational modifications for MAN1C1 Gene

  • Glycosylation at posLast=132132, isoforms=250, and isoforms=618

Other Protein References for MAN1C1 Gene

Domains & Families for MAN1C1 Gene

Gene Families for MAN1C1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MAN1C1 Gene

Suggested Antigen Peptide Sequences for MAN1C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 47 family.
  • Belongs to the glycosyl hydrolase 47 family.
genes like me logo Genes that share domains with MAN1C1: view

Function for MAN1C1 Gene

Molecular function for MAN1C1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by both 1-deoxymannojirimycin and kifunensine.
UniProtKB/Swiss-Prot Function:
Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.

Enzyme Numbers (IUBMB) for MAN1C1 Gene

Phenotypes From GWAS Catalog for MAN1C1 Gene

Gene Ontology (GO) - Molecular Function for MAN1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA,TAS 10915796
GO:0005509 calcium ion binding TAS,IEA 10915796
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MAN1C1: view
genes like me logo Genes that share phenotypes with MAN1C1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAN1C1 Gene

Localization for MAN1C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAN1C1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAN1C1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 3
plasma membrane 1
mitochondrion 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAN1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum IBA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MAN1C1: view

Pathways & Interactions for MAN1C1 Gene

genes like me logo Genes that share pathways with MAN1C1: view

UniProtKB/Swiss-Prot Q9NR34-MA1C1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for MAN1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006487 protein N-linked glycosylation TAS 10915796
GO:0006491 N-glycan processing IBA --
GO:0008152 metabolic process IEA --
GO:1904381 Golgi apparatus mannose trimming TAS --
genes like me logo Genes that share ontologies with MAN1C1: view

No data available for SIGNOR curated interactions for MAN1C1 Gene

Drugs & Compounds for MAN1C1 Gene

(8) Drugs for MAN1C1 Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
calcium Approved Nutra 0
Acarbose Approved, Investigational Pharma Alpha-glucosidase inhibitor, Glucosidase alpha inhibitor (intestinal) 91
Kifunensine Experimental Pharma 0
1-Deoxynojirimycin Experimental Pharma Glucosidase I and II inhibitor 26

(1) Additional Compounds for MAN1C1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Miglustat hydrochloride

(5) Tocris Compounds for MAN1C1 Gene

Compound Action Cas Number
1-Deoxymannojirimycin hydrochloride alpha-Mannosidase I inhibitor 73465-43-7
1-Deoxynojirimycin Glucosidase I and II inhibitor 19130-96-2
Acarbose Glucosidase alpha inhibitor (intestinal) 56180-94-0
Castanospermine Glucosidases alpha and beta inhibitor 79831-76-8
Miglustat hydrochloride alpha-glucosidase I and II inhibitor. Also inhibits ceramide-specific glycosyltransferases 210110-90-0

(2) ApexBio Compounds for MAN1C1 Gene

Compound Action Cas Number
1-Deoxymannojirimycin hydrochloride 73465-43-7
Kifunensine 109944-15-2
genes like me logo Genes that share compounds with MAN1C1: view

Drug Products

Transcripts for MAN1C1 Gene

Unigene Clusters for MAN1C1 Gene

Mannosidase, alpha, class 1C, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAN1C1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - - - - -
SP4: -
SP5: -

Relevant External Links for MAN1C1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAN1C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAN1C1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAN1C1 Gene

This gene is overexpressed in Uterus (15.2), Cardia (14.7), Placenta (11.3), Esophagus (7.2), and Colon (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAN1C1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAN1C1 Gene:


SOURCE GeneReport for Unigene cluster for MAN1C1 Gene:


mRNA Expression by UniProt/SwissProt for MAN1C1 Gene:

Tissue specificity: Expressed in most tissues with the exception of lung, muscle and pancreas. Highly expressed in placenta.

Evidence on tissue expression from TISSUES for MAN1C1 Gene

  • Liver(4.3)
  • Nervous system(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with MAN1C1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAN1C1 Gene

Orthologs for MAN1C1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAN1C1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAN1C1 33 34
  • 99.47 (n)
(Canis familiaris)
Mammalia MAN1C1 33 34
  • 90.92 (n)
(Bos Taurus)
Mammalia MAN1C1 33 34
  • 89.7 (n)
(Rattus norvegicus)
Mammalia Man1c1 33
  • 85.65 (n)
(Mus musculus)
Mammalia Man1c1 33 16 34
  • 85.36 (n)
(Monodelphis domestica)
Mammalia MAN1C1 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia MAN1C1 34
  • 57 (a)
(Gallus gallus)
Aves MAN1C1 33 34
  • 73.94 (n)
(Anolis carolinensis)
Reptilia MAN1C1 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia man1c1 33
  • 60.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31202 34
  • 39 (a)
alpha-Man-I 34
  • 38 (a)
(Caenorhabditis elegans)
Secernentea mans-1 34
  • 44 (a)
mans-2 34
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MNS1 34
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
Species where no ortholog for MAN1C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MAN1C1 Gene

Gene Tree for MAN1C1 (if available)
Gene Tree for MAN1C1 (if available)

Paralogs for MAN1C1 Gene

Paralogs for MAN1C1 Gene

(6) SIMAP similar genes for MAN1C1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MAN1C1: view

Variants for MAN1C1 Gene

Sequence variations from dbSNP and Humsavar for MAN1C1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000013016 -- 25,710,070(+) C/T intron_variant
rs1000027293 -- 25,769,586(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000046062 -- 25,622,149(+) T/C intron_variant
rs1000057079 -- 25,624,998(+) A/T intron_variant
rs1000059828 -- 25,769,445(+) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAN1C1 Gene

Variant ID Type Subtype PubMed ID
nsv950335 CNV deletion 24416366
nsv947417 CNV duplication 23825009
nsv834491 CNV loss 17160897
nsv819900 CNV gain 19587683
nsv545883 CNV loss 21841781
nsv545882 CNV loss 21841781
nsv460884 CNV loss 19166990
esv3585533 CNV loss 21293372
esv3381476 CNV duplication 20981092
esv3358130 CNV insertion 20981092
esv3357351 CNV duplication 20981092
esv2745630 CNV deletion 23290073
esv2745619 CNV deletion 23290073
esv2671844 CNV deletion 23128226
esv2116011 CNV deletion 18987734

Variation tolerance for MAN1C1 Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAN1C1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAN1C1 Gene

Disorders for MAN1C1 Gene

Additional Disease Information for MAN1C1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MAN1C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAN1C1 Gene

Publications for MAN1C1 Gene

  1. Characterization of a cDNA encoding a novel human Golgi alpha 1, 2-mannosidase (IC) involved in N-glycan biosynthesis. (PMID: 10915796) Tremblay LO … Herscovics A (The Journal of biological chemistry 2000) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58

Products for MAN1C1 Gene

Sources for MAN1C1 Gene

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