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Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008] See more...
Aliases for MAN1A2 Gene
Aliases for MAN1A2 Gene
External Ids for MAN1A2 Gene
- HGNC: 6822
- NCBI Entrez Gene: 10905
- Ensembl: ENSG00000198162
- OMIM®: 604345
- UniProtKB/Swiss-Prot: O60476
Previous GeneCards Identifiers for MAN1A2 Gene
- GC01P118369
- GC01P116748
- GC01P117057
- GC01P117256
- GC01P117623
- GC01P117711
- GC01P117910
- GC01P115766
Summaries for MAN1A2 Gene
-
Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]
GeneCards Summary for MAN1A2 Gene
MAN1A2 (Mannosidase Alpha Class 1A Member 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. An important paralog of this gene is MAN1A1.
UniProtKB/Swiss-Prot Summary for MAN1A2 Gene
-
Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
-
Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose.
Additional gene information for MAN1A2 Gene
- HGNC (6822)
- NCBI Entrez Gene (10905)
- Ensembl (ENSG00000198162)
- OMIM® (604345)
- UniProtKB/Swiss-Prot (O60476)
- Open Targets Platform(ENSG00000198162)
- Search for MAN1A2 at DataMed
- Search for MAN1A2 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAN1A2 Gene
Genomics for MAN1A2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MAN1A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAN1A2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAN1A2
- Top Transcription factor binding sites by QIAGEN in the MAN1A2 gene promoter:
-
- aMEF-2
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- Evi-1
- FAC1
- MEF-2
Genomic Locations for MAN1A2 Gene
Latest Assembly
- chr1:117,367,393-117,528,872
- (GRCh38/hg38)
- Size:
- 161,480 bases
- Orientation:
- Plus strand
Previous Assembly
- chr1:117,910,071-118,071,494
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 161,424 bases
- Orientation:
- Plus strand
- chr1:117,910,071-118,071,494
- (GRCh37/hg19 by Ensembl)
- Size:
- 161,424 bases
- Orientation:
- Plus strand
Genomic View for MAN1A2 Gene
Genes around MAN1A2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p12 by HGNC
- 1p12 by Entrez Gene
- 1p12 by Ensembl
MAN1A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAN1A2 Gene
Proteins for MAN1A2 Gene
-
Protein details for MAN1A2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60476-MA1A2_HUMAN
- Recommended name:
- Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
- Protein Accession:
- O60476
- Q9H510
Protein attributes for MAN1A2 Gene
- Size:
- 641 amino acids
- Molecular mass:
- 73004 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
- No Data Available
Protein Expression for MAN1A2 Gene
Selected DME Specific Peptides for MAN1A2 Gene
- O60476:
-
- AYYLSGEEIF
- SAFITLCFGA
- GATIVDALDTL
- GLYPNYLNP
- FFLPDSSK
- YEYLLKAWL
- LGAEIARTCHESY
- GSSILAEFGTLH
- DSFYEYL
- FNTEAHP
- LLPAFNTP
- QSFFLAE
Post-translational modifications for MAN1A2 Gene
Other Protein References for MAN1A2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for MAN1A2
- Novus Biologicals Antibodies for MAN1A2
-
Abcam antibodies for MAN1A2
- Invitrogen Antibodies for MAN1A2 (AFLGC-MAN1A2)
-
Boster Bio Antibodies for MAN1A2
- Sino Biological Antibodies for MAN1A2
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MAN1A2
- Origene Custom Protein Services for MAN1A2
- Sino Biological Recombinant Proteins for MAN1A2
- Sino Biological Cell Lysates for MAN1A2
- antibodies-online: Show 5 available MAN1A2 Proteins ranked by validation data
- Compare Top MAN1A2 Proteins
-
Quality Products:
-
Abcam proteins for MAN1A2
Assay products for research
Domains & Families for MAN1A2 Gene
Gene Families for MAN1A2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for MAN1A2 Gene
- InterPro:
- Blocks:
-
- Glycosyl hydrolase family 47 signature
- ProtoNet:
Suggested Antigen Peptide Sequences for MAN1A2 Gene
- GenScript: Design optimal peptide antigens:
-
- Processing alpha-1,2-mannosidase IB (MA1A2_HUMAN)
- Mannosidase, alpha, class 1A, member 2 (Q5T9E2_HUMAN)
- Mannosidase, alpha, class 1A, member 2 (Q5T9E3_HUMAN)
- Mannosidase, alpha, class 1A, member 2 (Q5T9E4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60476- Family:
-
- Belongs to the glycosyl hydrolase 47 family.
Function for MAN1A2 Gene
Molecular function for MAN1A2 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2); Xref=Rhea:RHEA:56008, Rhea:RHEA-COMP:14356, Rhea:RHEA-COMP:14367, ChEBI:CHEBI:15377, ChEBI:CHEBI:28563, ChEBI:CHEBI:59087, ChEBI:CHEBI:139493; EC=3.2.1.113; Evidence={ECO:0000250|UniProtKB:P32906};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2); Xref=Rhea:RHEA:56028, Rhea:RHEA-COMP:14358, Rhea:RHEA-COMP:14367, ChEBI:CHEBI:15377, ChEBI:CHEBI:28563, ChEBI:CHEBI:59087, ChEBI:CHEBI:60628; EC=3.2.1.113; Evidence={ECO:0000250|UniProtKB:P32906};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by both 1-deoxymannojirimycin and kifunensine.
- GENATLAS Biochemistry:
- alpha-mannosidase,class 1A,member 2,membrane type,expressed in brain placenta and lymphocytes,involved in processing of Asp-linked (N) glycans
Enzyme Numbers (IUBMB) for MAN1A2 Gene
Phenotypes From GWAS Catalog for MAN1A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | IEA,IBA | 21873635 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEA | -- |
Phenotypes for MAN1A2 Gene
- MGI mutant phenotypes for MAN1A2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for MAN1A2:
Animal Models for MAN1A2 Gene
- MGI Knock Outs for MAN1A2:
-
- Man1a2 Man1a2<tm1.1Ahe>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MAN1A2 - Starting at $85 >
- * MAN1A2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MAN1A2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAN1A2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAN1A2
miRNA for MAN1A2 Gene
- miRTarBase miRNAs that target MAN1A2
-
- mmu-miR-340-5p (MIRT010425)
- mmu-miR-9-5p (MIRT015304)
- hsa-miR-155-5p (MIRT020840)
- hsa-miR-142-3p (MIRT021625)
- hsa-miR-30a-5p (MIRT028615)
- hsa-miR-130b-3p (MIRT044165)
- hsa-miR-541-5p (MIRT440292)
- hsa-miR-3653-3p (MIRT446338)
- hsa-miR-6869-5p (MIRT446339)
- hsa-miR-496 (MIRT446340)
- hsa-miR-8087 (MIRT446341)
- hsa-miR-7161-5p (MIRT446342)
- hsa-miR-548u (MIRT446343)
- hsa-miR-4455 (MIRT513002)
- hsa-miR-640 (MIRT513003)
- hsa-miR-6867-5p (MIRT513004)
- hsa-miR-4286 (MIRT513005)
- hsa-miR-4262 (MIRT513006)
- hsa-miR-216b-3p (MIRT513007)
- hsa-miR-181d-5p (MIRT513008)
- hsa-miR-181c-5p (MIRT513009)
- hsa-miR-181b-5p (MIRT513010)
- hsa-miR-181a-5p (MIRT513011)
- hsa-miR-190a-3p (MIRT522656)
- hsa-miR-5011-5p (MIRT522657)
- hsa-miR-3976 (MIRT522658)
- hsa-miR-6856-5p (MIRT522659)
- hsa-miR-6758-5p (MIRT522660)
- hsa-miR-1277-5p (MIRT522662)
- mmu-miR-33-5p (MIRT594866)
- mmu-miR-669g (MIRT594867)
- mmu-miR-1941-3p (MIRT594868)
- mmu-miR-369-3p (MIRT594869)
- mmu-miR-374b-5p (MIRT594870)
- hsa-miR-3125 (MIRT764842)
- hsa-miR-3916 (MIRT767647)
- hsa-miR-4662a-3p (MIRT770788)
- hsa-miR-4662a-5p (MIRT770794)
- hsa-miR-6124 (MIRT775786)
- hsa-miR-6832-5p (MIRT780016)
- hsa-miR-6859-5p (MIRT780533)
- hsa-miR-8081 (MIRT782398)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAN1A2
- Browse OriGene Inhibitory RNA Products For MAN1A2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAN1A2
Clone products for research
- Applied Biological Materials (abm): Clones for MAN1A2 - Starting at $45 >
- * MAN1A2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MAN1A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAN1A2
Cell Lines for research
-
Horizon Cell Lines for MAN1A2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAN1A2 Gene
Localization for MAN1A2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAN1A2 Gene
- Golgi apparatus membrane. Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| extracellular | 4 |
| endoplasmic reticulum | 4 |
| mitochondrion | 2 |
| cytosol | 2 |
| nucleus | 1 |
| plasma membrane | 0 |
- Golgi apparatus (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005783 | endoplasmic reticulum | IBA | 21873635 |
| GO:0005794 | Golgi apparatus | IEA,IDA | -- |
| GO:0016020 | membrane | IEA,HDA | 19946888 |
| GO:0016021 | integral component of membrane | TAS,IEA | -- |
Pathways & Interactions for MAN1A2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport to the Golgi and subsequent modification | ||
| 2 | N-Glycan biosynthesis | ||
| 3 | Vesicle-mediated transport | ||
| 4 | Metabolism of proteins | ||
| 5 | Metabolism | ||
Pathways by source for MAN1A2 Gene
10 Reactome pathways for MAN1A2 Gene
4 KEGG pathways for MAN1A2 Gene
UniProtKB/Swiss-Prot O60476-MA1A2_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for MAN1A2 Gene
Selected Interacting proteins:
O60476-MA1A2_HUMAN
ENSP00000348959
for MAN1A2 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for MAN1A2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0006486 | protein glycosylation | IEA | -- |
| GO:0006491 | N-glycan processing | TAS,IBA | 21873635 |
| GO:0007585 | respiratory gaseous exchange | IEA | -- |
| GO:0008152 | metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for MAN1A2 Gene
Drugs & Compounds for MAN1A2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Water | Approved | Pharma | 0 | |||
| Acarbose | Approved, Investigational | Pharma | Alpha-glucosidase inhibitor, Glucosidase alpha inhibitor (intestinal) | 102 | ||
| Kifunensine | Experimental | Pharma | 0 | |||
| Castanospermine | Experimental | Pharma | Glucosidases alpha and beta inhibitor | 0 | ||
| 1-Deoxynojirimycin | Investigational | Pharma | Glucosidase I and II inhibitor | 12 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Miglustat hydrochloride |
|
210110-90-0 |
|
|
(5) Tocris Compounds for MAN1A2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 1-Deoxymannojirimycin hydrochloride | alpha-Mannosidase I inhibitor | 73465-43-7 |
| 1-Deoxynojirimycin | Glucosidase I and II inhibitor | 19130-96-2 |
| Acarbose | Glucosidase alpha inhibitor (intestinal) | 56180-94-0 |
| Castanospermine | Glucosidases alpha and beta inhibitor | 79831-76-8 |
| Miglustat hydrochloride | alpha-glucosidase I and II inhibitor. Also inhibits ceramide-specific glycosyltransferases | 210110-90-0 |
(2) ApexBio Compounds for MAN1A2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 1-Deoxymannojirimycin hydrochloride | 73465-43-7 | |
| Kifunensine | 109944-15-2 |
Transcripts for MAN1A2 Gene
mRNA/cDNA for MAN1A2 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000356554 8576 nts (view in UCSC)
- ENST00000421535 678 nts (view in UCSC)
- ENST00000422329 487 nts (view in UCSC)
- ENST00000449370 2082 nts (view in UCSC)
- ENST00000482811 724 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MAN1A2 - Starting at $85 >
- * MAN1A2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MAN1A2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAN1A2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAN1A2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAN1A2
- Browse OriGene Inhibitory RNA Products For MAN1A2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAN1A2
Clone products for research
- Applied Biological Materials (abm): Clones for MAN1A2 - Starting at $45 >
- * MAN1A2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MAN1A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAN1A2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - |
Relevant External Links for MAN1A2 Gene
- GeneLoc Exon Structure for
- MAN1A2
Expression for MAN1A2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Placenta (21.9), Stomach (9.1), and Lymph node (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAN1A2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAN1A2
SOURCE GeneReport for Unigene cluster for MAN1A2 Gene:
Hs.435938mRNA Expression by UniProt/SwissProt for MAN1A2 Gene:
O60476-MA1A2_HUMAN
Tissue specificity:
Highest levels of expression in placenta and testis.
Evidence on tissue expression from TISSUES for MAN1A2 Gene
- Nervous system(4.6)
- Kidney(2.3)
- Liver(2.3)
- Lung(2.2)
- Heart(2.2)
Primer products for research
-
OriGene qPCR primer pairs for MAN1A2
-
OriGene qPCR primer pairs and template standards for MAN1A2
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAN1A2 Gene
Orthologs for MAN1A2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MAN1A2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MAN1A2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MAN1A2 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MAN1A2 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Man1a2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Man1a2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | MAN1A2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MAN1A2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MAN1A2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | man1a2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | MAN1A2 31 |
|
OneToOne | |
| wu:fj20e02 30 |
|
||||
| Dr.18766 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000558 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | alpha-Man-I 30 31 32 |
|
ManyToMany | |
| CG31202 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | C52E4.5 30 32 |
|
||
| mans-1 31 |
|
ManyToMany | |||
| D2030.1 32 |
|
|
|||
| mans-2 31 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MNS1 31 |
|
OneToMany | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU02235 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1038 30 |
|
- Species where no ortholog for MAN1A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MAN1A2 Gene
- ENSEMBL:
- Gene Tree for MAN1A2 (if available)
- TreeFam:
- Gene Tree for MAN1A2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAN1A2: view image
Paralogs for MAN1A2 Gene
(6) SIMAP similar genes for MAN1A2 Gene using alignment to 4 proteins:
- MA1A2_HUMAN
- H0Y543_HUMAN
- H0Y7H1_HUMAN
- Q5T9E3_HUMAN
Pseudogenes.org Pseudogenes for MAN1A2 Gene
Variants for MAN1A2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAN1A2 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs34355735 | Benign: not provided | 117,466,336(+) |
T/G NM_006699.5(MAN1A2):c.1077T>G (p.Val359=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv294n100 | CNV | loss | 25217958 |
| dgv295n100 | CNV | loss | 25217958 |
| dgv296n100 | CNV | loss | 25217958 |
| esv1005427 | CNV | deletion | 20482838 |
| esv2224574 | CNV | deletion | 18987734 |
| esv2661362 | CNV | deletion | 23128226 |
| esv3587315 | CNV | loss | 21293372 |
| esv3587318 | CNV | loss | 21293372 |
| nsv1001257 | CNV | loss | 25217958 |
| nsv1006415 | CNV | loss | 25217958 |
| nsv1009706 | CNV | gain | 25217958 |
| nsv506956 | OTHER | sequence alteration | 20534489 |
| nsv519780 | CNV | gain | 19592680 |
| nsv819679 | CNV | loss | 19587683 |
| nsv831170 | CNV | gain | 17160897 |
| nsv951404 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.61;
31.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAN1A2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAN1A2 Gene
Disorders for MAN1A2 Gene
Additional Disease Information for MAN1A2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for MAN1A2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAN1A2 Gene
Publications for MAN1A2 Gene
- Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation. (PMID: 9592125) Tremblay LO … Herscovics A (Glycobiology 1998) 2 3 4 23
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Screening for replication of genome-wide SNP associations in sporadic ALS. (PMID: 18987618) Cronin S … Hardiman O (European journal of human genetics : EJHG 2009) 3 41
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for MAN1A2 Gene
- Custom Antibody ServicesOriGene Antibodies for MAN1A2
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Sino Biological Human cDNA Clone for MAN1A2
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- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MAN1A2
- Novus Biologicals proteins and lysates for MAN1A2
- Browse Antibodies
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- Invitrogen Antibodies for MAN1A2 (AFLGC-MAN1A2)
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- VectorBuilder Custom and pre-made DNA vectors for MAN1A2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MAN1A2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MAN1A2 (ie. knockout, knockin, CRISPRa, CRISPRi)
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- VectorBuilder Stable cell line generation for MAN1A2
- antibodies-online: Show 4 available MAN1A2 Antibodies ranked by validation data
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- antibodies-online: Show 5 available MAN1A2 Proteins ranked by validation data
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- Quality Products:
- Horizon Cell Lines for MAN1A2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAN1A2
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for MAN1A2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAN1A2
- Boster Bio Antibodies for MAN1A2
- Browse Boster Bio ELISA Kits
Sources for MAN1A2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB